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| 1 | Symposia Report Immunoglobulin G for the Treatment of Chronic Pain:Report of an Expert Workshop显示文摘背景:慢性疼痛的治疗效果仍不理想。尽管现在治疗慢性疼痛的药物种类较多,但许多患者对疗效仍不满意或诉药物的副作用太大。越来越多的证据表明,免疫系统参与了伤害性和神经病理性慢性疼痛的病理过程。设计:在英国利物浦的专题会议上,专家们出示了免疫系统参与慢性疼痛的证据。近来的研究表明,静脉(IVIg)或皮下(SCIg)注射免疫调节药物——多价免疫球蛋白(Ig G)可缓解外周神经病理性疼痛和其他疼痛性疾病。专题会议讨论了IVIg和SCIg治疗的适应证、效价比及其副作用。结果:Ig G可缓解某些伤害性和神经病理性慢性疼痛,如糖尿病、干燥综合征、纤维肌痛症、复杂性区域疼痛综合征、小儿麻痹后遗症和继发于病理性自身抗体的疼痛。结论:Ig G对某些慢性疼痛具有一定的治疗前景。Ig G是一种相对安全的治疗方法,副作用少而轻,但价格较贵。今后有必要对Ig G治疗顽固性疼痛进行随机对照研究和预测性临床试验。 | Stefano Tamburin Kristian Borg Xavier J. Caro Stefano Jann Alexander J. Clark Francesca Magrinelli Gen Sobue Lars Werhagen Giampietro Zanette Haruki Koike Peter J. Spath Angela Vincent Andreas Goebel | 2014 | 中国疼痛医学杂志2014，20，11： | 3 |
| 2 | Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features显示文摘AIM To investigate the association between 16 insertiondeletions(INDEL) polymorphisms, colorectal cancer(CRC) risk and clinical features in an admixed population.METHODS O n e h u n d re d a n d fo r ty p a t i e n t s w i t h C R C a n d 140 cancer-free subjects were examined. Genomic DNA was extracted from peripheral blood samples. Polymorphisms and genomic ancestry distribution were assayed by Multiplex-PCR reaction, separated by capillary electrophoresis on the ABI 3130 Genetic Analyzer instrument and analyzed on Gene Mapper ID v3.2. Clinicopathological data were obtained by consulting the patients' clinical charts, intra-operative documentation, and pathology scoring.RESULTS Logistic regression analysis showed that polymorphism variations in IL4 gene was associated with increased CRC risk, while TYMS and UCP2 genes were associated with decreased risk. Reference to anatomical localization of tumor Del allele of NFKB1 and CASP8 were associated with more colon related incidents than rectosigmoid. In relation to the INDEL association with tumor node metastasis(TNM) stage risk, the Ins alleles of ACE, HLAG and TP53(6 bp INDEL) were associated with higher TNM stage. Furthermore, regarding INDEL association with relapse risk, the Ins alleles of ACE, HLAG, and UGT1A1 were associated with early relapse risk, as well as the Del allele of TYMS. Regarding INDEL association with death risk before 10 years, the Ins allele of SGSM3 and UGT1A1 were associated with death risk.CONCLUSION The INDEL variations in ACE, UCP2, TYMS, IL4, NFKB1, CASP8, TP53, HLAG, UGT1A1, and SGSM3 were associated with CRC risk and clinical features in an admixed population. These data suggest that this cancer panel might be useful as a complementary tool for better clinical management, and more studies need to be conducted to confirm these findings. | Diego Marques Layse Raynara Ferreira-Costa Lorenna Larissa Ferreira-Costa Romualdo da Silva Correa Aline Maciel Pinheiro Borges Fernanda Ribeiro Ito Carlos Cesar de Oliveira Ramos Raul Hernandes Bortolin André Ducati Luchessi Andrea Ribeiro-dos-Santos Sidney Santos Vivian Nogueira Silbiger | 2017 | World Journal of Gastroenterology2017，23，37： | 2 |
| 3 | A wavelet-based algorithm to estimate ocean wave group parameters from radar images显示文摘 | Andreas Niedermeier Jose Carlos Nieto Borge Susanne Lehner | 2005 | IEEE Transcations on Geoscience and Remote Sensing2005，43，2： | 1 |
| 4 | Cripto-independent Nodal signaling promotes positioning of the A-P axis in the early mouse embryo显示文摘 | Liguori GL Borges AC D' Andrea D | 2008 | Dev Biol2008，315，2： | 1 |
| 5 | Probabilistic Wind Farms Generation Model forReliability Studies Applied to Brazilian Sites 显示文摘 | Andrea P Leite Carmen L T Borges Djalma M Fal-cao | 2006 | IEEE Transactions on Power Systems?2006，21，4： | 1 |
| 6 | A Wavelet-Based Algorithm to Estimate Ocean Wave Group Parameters From Radar Images 显示文摘 | Andreas Niedermeier Jos e Carlos Nieto Borge Susanne Lehner Johannes chultz-Stellenfleth | 2005 | IEEE Trans On Robotics GEOSCIENCE AND REMOTE SENSING2005，43，2： | 1 |
| 7 | Composite system well-being evaluation based on non-sequential Monte Carlo simulation显示文摘 | Tiago S. Amaral Carmen L.T. Borges Andrea M. Rei | 2009 | Electric Power Systems Research2009，，1： | 1 |
| 8 | On the In- fluence of the Near Wall Formulation of Turbulence Mod- els for Prediction of Aerodynamics Coefficients for Ground Vehicles 显示文摘 | Andreas Borg Sven Perzon Olga Roditcheva | 2003 | SAE Paper2003，，1： | 1 |
| 9 | Head-to-Head Comparison of Left Ventricular Function Assessment with 64-Row Computed Tomography, Biplane Left Cineventriculography, and Both 2- and 3-Dimensional Transthoracic Echocardiography显示文摘 | Johannes Greupner Elke Zimmermann Andrea Grohmann Hans-Peter Dübel Till Althoff Adrian C. Borges Wolfgang Rutsch Peter Schlattmann Bernd Hamm Marc Dewey | 2012 | Journal of the American College of Cardiology2012，，21： | 1 |
| 10 | Temporary Dysarthria Induced by Irinotecan-Case Report of This Rare Adverse Event显示文摘 | Mayndra Mychelle Landgrat] Cinthia Leite Frizzera Borges Bognar Raquel Bezerra Guerra Andrea Morais Borges Fernando Silva Picont Gislaine Femandes Silva Pamela Carvalho Muniz Pedro Nazareth Aguiar Junior Gilberto de Lima Lopes Junior Michelle Samora de Almeida | 2017 | Journal of Pharmacy and Pharmacology2017，5，9： | 0 |
| 11 | Crustal architecture and metallogeny associated with the Paleo-Tethys evolution in the Eastern Kunlun Orogenic Belt,Northern Tibetan Plateau显示文摘The Eastern Kunlun Orogenic Belt(EKOB)in the Northern Tibet Plateau hosts a wide variety of metal deposits related to the Late Paleozoic to Mesozoic magmatism.In this study,we investigate the spatiotemporal distribution of the Late Paleozoic to Mesozoic granitic rocks and associated metal deposits in the EKOB and provide a comprehensive compilation of the geochronological,geochemical and isotopic data on these rocks.We compute regional zircon Hf isotope and crustal thickness maps from the data,based on which a comprehensive model is proposed involving subduction(ca.270–240 Ma),continental collision(ca.240–224 Ma),and post-collisional extension(ca.224–200 Ma)for the Late Paleozoic to Mesozoic Paleo-Tethys evolution in the EKOB.Zircon Hf isotopic and crustal thickness mapping of Late Paleozoic to Mesozoic magmatic rocks was carried out to evaluate their spatio-temporal and genetic links with the regional metallogeny.The polymetallic Fe-skarn and porphyry Cu(Mo)deposits in the EKOB are located above the Moho uplift region,featuring a comparatively thin crust.Granites associated with porphyry Cu(Mo)and polymetallic Fe skarn mineralization are commonly characterized by highε_(Hf)(t)and younger T_(DM)cvalues,whereas granite related to Cu-Mo-Sn skarn deposits exhibit more variableε_(Hf)(t)values,T_(DM)c ages,and the crust thickness,which suggest that more crustal materials contributed to the formation of Cu-Mo-Sn skarn deposits than those for porphyry Cu(Mo)and polymetallic Fe skarn mineralization.In contrast,vein-type Au deposits are located primarily where the Moho surface displays a depression,i.e.,where the continental crust is relatively thick.The magmatic rocks associated with Au mineralization are characterized by lowε_(Hf)(t)and high T_(DM)cvalues,representing reworked ancient crustal components,similar to those associated with porphyry Mo and epithermal Ag-Pb-Zn-(Au)deposits.Our study indicates that the emplacement of magmatic-hydrothermal deposits was controlled by the crustal structure and magma sources. | Xinming Zhang Xu Zhao Lebing Fu Yanjun Li Andreas Kamradt M.Santosh Chongwen Xu Xiaokun Huang Gregor Borg Junhao Wei | 2023 | Geoscience Frontiers2023，14，6： | 0 |
| 12 | Detection of Gram-Negative Bacteria Carrying the blaKPC-2 Gene from Mangrove Sediments显示文摘Mangroves are environments that have fast cycles associated with high concentration of bacterial decomposers.These are impacted by anthropogenic pollution due to contamination of bacterial species carrying resistance genes.This study aims to evaluate the metabolic profile of the microbiota in mangrove sediments,and verify the presence of Gram-negative bacteria resistant to meropenem.The samples were obtained from location along the Anil river and were seeded in medium supplemented with the antibiotic meropenem in increasing concentrations.The DNA was analyzed by multiplex PCR for detecting resistance genes forβ-lactam antibiotics.The bacteria were identified by Matrix-assisted laser desorption ionization–time of flight mass spectrometry(MALDI-TOF MS).The genes were sequenced by ABI PRISM 3100,analyzed by MEGA 6.0 program,and the sequence identified was assessed by GenBank using the BLAST algorithm.Ecoplate■the kit was used to determine the metabolic profile of the microbiota.The results of the six bacterial isolates showed the blaKPC-2 gene and were identified as Stenotrophomonas maltophilia and Pseudomonas putida.The samples showed a greater diversity Shannon index,a rich substrate consumption and high equity.There was a metabolic richness such as carbon consumption profiles,being a factor of adaptation of pathogenic bacteria carrying resistance genes toβ-lactamics antibiotics. | Wallace Ribeiro Nunes Neto Jessica Mayara Mendes Araujo Darlan Ferreira da Silva Joveliane de Melo Monteiro Wallace Borges Pachêco Jessflan Rafael Nascimento Santos Maria Raimunda Chagas Silva Maria Rosa Quaresma Bomfim Andrea de Souza Monteiro | 2019 | Journal of Pharmacy and Pharmacology2019，7，8： | 0 |
| 13 | Transcranial direct current electrical stimulation in combination with aerobic exercise:A pilot study in post-COVID-19 systemic autoimmune rheumatic patients显示文摘BACKGROUND Systemic autoimmune rheumatic diseases(SARDs)are a group of diseases with multiorgan involvement and a high prevalence of chronic pain and fatigue.Patients with SARDs and post-coronavirus disease 2019(COVID-19)syndrome experience aggravation of symptoms.In this context,it is essential to establish strategies to reduce chronic pain and fatigue and improve quality of life.AIM To assess the efficacy of transcranial direct current stimulation(tDCS)for the treatment of fatigue and pain-associated post-COVID-19 syndrome in patients with SARDs.METHODS This study included nine patients with different types of SARDs.All patients had reverse transcription-polymerase chain reaction(RT-PCR)test confirmed COVID-19 as well as significant,persistent fatigue and pain that began to worsen after infection.Anodal tDCS was administered in five daily sessions(2mA,20 min).Concomitantly,patients were involved in aerobic exercise program.All participants were evaluated using specific questionnaires and strength assessment by handgrip and physical function by timed-up-and-go test and sit-to-stand test at baseline(within one week before tDCS protocol),and one week after tDCS protocol.During all procedures,the patients’treatments remained unchanged.RESULTS The sample comprised eight women and one man with a mean age of 48.7±9.6 years.After the tDCS protocol,pain and fatigue significantly improved on the visual analog scale(P<0.05).The physical function also improved 9.5±2.7 vs 6.8±0.8(P=0.001)for timed-up-go-test and 10.3±3.7 vs 15.1±4.0(P=0.037)for sit-to-stand test.None of the patients experienced any adverse events.CONCLUSION The present study showed that tDCS in combination with aerobic exercise was effective in improving physical function,and reducing fatigue/pain in SARDs patients with post-COVID-19 syndrome. | Rafael Giovani Missé Alexandre Moura dos Santos Isabela Bruna Pires Borges Marlise Sítima Mendes Simões Lorenza Rosa Silvério Bruna Lindoso Correia Ana Wook Sook Kim Aline Marques Caetano Sandra Gofinet Pasoto Carla Gonçalves Schahin Saad Diogo Souza Domiciano Clarice Tanaka Julia Maria D’Andrea Greve Abrahão Fontes Baptista Samuel Katsuyuki Shinjo | 2023 | World Journal of Rheumatology2023，11，1： | 0 |
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