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| 1 | SARS-CoV-2 infects human neural progenitor cells and brain organoids显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)caused by the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)1 has resulted in over 13 million confirmed cases and more than 580,045 deaths across 218 countries and geographical regions as of July 16,2020.This novel coronavirus primarily causes respiratory illness with clinical manifestations largely resembling those of SARS.However,neurological symptoms including headache,anosmia,ageusia,confusion,seizure,and encephalopathy have also been frequently reported in COVID-19 patients. | Bao-Zhong Zhang Hin Chu Shuo Han Huiping Shuai Jian Deng Ye-fan Hu Hua-rui Gong Andrew Chak-Yiu Lee Zijiao Zou Thomas Yau Wutian Wu Ivan Fan-Ngai Hung Jasper Fuk-Woo Chan Kwok-Yung Yuen Jian-Dong Huang | 2020 | Cell Research2020，30，10： | 8 |
| 2 | Identification of Ca2+ signaling components in neural stem/progenitor cells during differentiation into neurons and glia in intact and dissociated zebrafish neurospheres显示文摘The development of the CNS in vertebrate embryos involves the generation of different sub-types of neurons and glia in a complex but highly-ordered spatio-temporal manner. Zebrafish are commonly used for exploring the development, plasticity and regeneration of the CNS, and the recent development of reliable protocols for isolating and culturing neural stem/progenitor cells(NSCs/NPCs) from the brain of adult fish now enables the exploration of mechanisms underlying the induction/specification/differentiation of these cells. Here, we refined a protocol to generate proliferating and differentiating neurospheres from the entire brain of adult zebrafish. We demonstrated via RT-qPCR that some isoforms of ip3 r, ryr and stim are upregulated/downregulated significantly in differentiating neurospheres, and via immunolabelling that 1,4,5-inositol trisphosphate receptor(IP3 R) type-1 and ryanodine receptor(RyR) type-2 are differentially expressed in cells with neuron-or radial glial-like properties. Furthermore, ATP but not caffeine(IP3 R and RyR agonists, respectively), induced the generation of Ca^(2+) transients in cells exhibiting neuron-or glial-like morphology. These results indicate the differential expression of components of the Ca^(2+) -signaling toolkit in proliferating and differentiating cells. Thus, given the complexity of the intact vertebrate brain, neurospheres might be a useful system for exploring neurodegenerative disease diagnosis protocols and drug development using Ca^(2+) signaling as a read-out. | Man Kit Tse Ting Shing Hung Ching Man Chan Tiffany Wong Mike Dorothea Catherine Leclerc Marc Moreau Andrew L.Miller Sarah E.Webb | 2018 | Science China(Life Sciences)2018，61，11： | 4 |
| 3 | Accuracy of Risk Scores for Patients With Chronic Hepatitis B Receiving Entecavir Treatment显示文摘 | Grace Lai–Hung Wong Henry Lik–Yuen Chan Hoi–Yun Chan Pete Chi–Hang Tse Yee–Kit Tse Christy Wing–Hin Mak Stanley King–Yeung Lee Zoe Man–Yi Ip Andrew Ting–Ho Lam Henry Wing–Hang Iu Joyce May–Sum Leung Vincent Wai–Sun Wong | 2013 | Gastroenterology2013，，5： | 2 |
| 4 | Entecavir treatment reduces hepatic events and deaths in chronic hepatitis B patients With liver cirrhosis显示文摘 | Grace Lai‐Hung Wong Henry Lik‐Yuen Chan Christy Wing‐Hin Mak Stanley King‐Yeung Lee Zoe Man‐Yi Ip Andrew Ting‐Ho Lam Henry Wing‐Hang Iu Joyce May‐Sum Leung Jennifer Wing‐Yan Lai Angeline Oi‐Shan Lo Hoi‐Yun Chan Vincent Wai‐Sun Wong | 2013 | Hepatology2013，，5： | 1 |
| 5 | Thermal resistance calculation of AlGaN-GaN devices显示文摘 | Darwish Ali Mohamed Bayba Andrew J Hung H Alfred | 2004 | IEEE Transactions on Microwave Theory and Techniques2004，52，11： | 1 |
| 6 | Early detection of nasopharyngeal carcinoma by plasma Epstein‐Barr virus DNA analysis in a surveillance program显示文摘 | K. C. Allen Chan Emily C. W. Hung John K. S. Woo Paul K. S. Chan Sing‐Fai Leung Franco P. T. Lai Anita S. M. Cheng Sze Wan Yeung Yin Wah Chan Teresa K. C. Tsui Jeffrey S. S. Kwok Ann D. King Anthony T. C. Chan Andrew C. van Hasselt Y. M. Dennis Lo | 2013 | Cancer2013，，10： | 1 |
| 7 | Jaagsiekte sheep retrovirus biology and oncogenesis 显示文摘 | Andrew H Hung F | 2010 | Viruses2010，2，： | 1 |
| 8 | Anatomic Renal Artery Branch Microdissection to Facilitate Zero-Ischemia Partial Nephrectomy显示文摘 | Casey K. Ng Inderbir S. Gill Mukul B. Patil Andrew J. Hung Andre K. Berger Andre Luis de Castro Abreu Masahiko Nakamoto Manuel S. Eisenberg Osamu Ukimura Duraiyah Thangathurai Monish Aron Mihir M. Desai | 2011 | European Urology2011，，1： | 1 |
| 9 | Surgical repair of left internal jugular phlebectasia显示文摘 | Tawny Hung Andrew Iain Campbell | 2008 | Journal of Vascular Surgery2008，，6： | 1 |
| 10 | Targeted tumor coating with antigenic, CTL-recognizable peptides via Annexin A5 chimeric constructs following chemotherapy redirects adaptive CD8+ T cell immunity for tumor clearance显示文摘A common drawback of many cancer immunotherapies,including immune checkpoint blockade,is their reliance on the expression of immunogenic tumor antigens by cancer cells for immune recognition and clearance,which limits their efficacy against cancers with weak antigenicity.1 To overcome this obstacle,we and others have explored strategies to harness the immune responses against nontumor antigens and redirect those immune responses to target tumor cells.2,3,4,5 In particular,we have pioneered a therapeutic strategy fusing tumor-targeting proteins with known antigenic peptide epitopes not naturally expressed by tumor cells,which are flanked by peptide sequences that can be recognized and cleaved by proteases overexpressed in most cancers.2,3 This strategy facilitates the targeted delivery of immunogenic peptides into tumor foci,the release of immunogenic peptides into the tumor microenvironment(TME)via tumor protease cleavage,and subsequent loading of these peptides onto major histocompatibility complex class 1(MHC-I)on the tumor cell surface,allowing the recognition of coated tumor cells by the respective peptide-specific cytotoxic CD8+T lymphocytes(CTLs)for elimination. | Tae Heung Kang Andrew Yang Yachea Tsai Louise Ferrall Chien-Fu Hung | 2021 | Cellular & Molecular Immunology2021，18，6： | 1 |
| 11 | Symmetric multiprocessing on programmable chips made easy显示文摘 | Hung A Bishop W Andrew Kennings | | 1530-1591/05 IEEE0，15，： | 1 |
| 12 | A new synthetic approach to poly- and perfluori- nated polyethers显示文摘 | Hung Ming H Farnham William B Felting Andrew E | 1993 | JAm Chem Soe1993，115，20： | 1 |
| 13 | Surgical repair of left internal jugular phlebectasia显示文摘 | Tawny Hung Andrew Iain Campbell | 2008 | Journal of Vascular Surgery2008，，6： | 1 |
| 14 | Microstructural abnormalities are evident by histology but not HR-pQCT at the periosteal cortex of the human tibia under CVD and T2D conditions显示文摘Cortical bone microstructure deficits may increase fracture risk in individuals with cardiovascular disease and diabetes.High resolution peripheral quantitative computed tomography(HR-pQCT)enables in vivo microstructure characterization but is limited in its ability to visualize important biological features.We conducted histological analyses and HR-pQCT imaging of distal tibia bone samples from 6 donors with cardiovascular disease(CVD)and type 2 diabetes mellitus(T2D).Histology but not HR-pQCT identified previously undocumented morphopathological deficits that may contribute to cortical bone fragility.These observations may provide guidance for improved HR-pQCT microstructural characterization as well as insight into mechanisms of cortical bone degradation. | Barbara Garita Jenna Maligro Saghi Sadoughi Po Hung Wu Ellen Liebenberg Andrew Horvai Thomas M.Link Galateia J.Kazakia | 2021 | Medicine in Novel Technology and Devices2021，，2： | 0 |
| 15 | 'God'and'Logos'in Context:Paradox of Ricoeur's Linguistic Hospitality and Chinese Bible Translation显示文摘This paper shows how Paul Ricoeur's hermeneutics of translation and studies of Chinese Bible translations can mutually shed light on each other.To avoid misinterpretations,some missionaries employed phonetic transcription when translating certain controversial religious terms.However,such avoidance of translation was driven by the ideal of perfect translation rejected by Ricoeur.What translation can achieve is equivalence without identity.And by reviewing the debates in the history of Chinese Bible translation,I argue that Bible translators in the past have exemplified the paradigm of Ricoeur's linguistic hospitality and have contributed to cultural transformations in modern China.The debates have illustrated Ricoeur's hermeneutical dialogical translation theory and his notion of semantic cultural innovation.They also show complexities and paradoxes involved in linguistic hospitality when translations occur in a culture containing diverse traditions. | Andrew Tsz Wan Hung | 2023 | Fudan Journal of the Humanities and Social Sciences2023，16，1： | 0 |
| 16 | Structure-based multi-ligand molecular modeling to predict the synergistic effects of limonin and obacunone from Simiao pill against nitric oxide synthase 3 associated with hyperuricemia显示文摘Hyperuricemia(HUA)mainly occurs because of purine metabolism disorders.We recently proposed that limonin from Simiao pill may have therapeutic effects on nitric oxide synthase 3(NOS3)that is related to HUA.Concurrently,our previous work employed a new method,structure-based multi-ligand molecular modeling,to identify potential agents from a herbal formula that may produce synergistic effects and may have the potential to develop combination drugs.Therefore,we employed multi-ligand modeling to seek compounds with potential synergistic effects with limonin against NOS3.We obtained 403 multi-ligand docking results between 403 compounds and the limonin-NOS3 complex(average affinity–8.297 kcal/mol).Then we selected the top 10 highest binding affinity compounds for virtual pharmacokinetic and toxicity screening and we found that only obacunone passed all filters.We further subjected obacunone,bound to limonin and NOS3,to molecular dynamics simulations.We found that the NOS3-limonin-obacunone complex was more stable than the NOS3-limonin complex,based on the root mean square deviation of backbone Cαatoms and root mean square fluctuation,which suggests that synergistic effects may exist between limonin and obacunone.Further cell and animal experimental research is required to verify our results. | Qing-Hong Chen Xiao-Mei Chen Xiao-Hu Chen Yan-Ting You Shu-Xuan Yang Chuang-Hai Wu Mei-Lin Chen Ming-Di Li Akari Komori Yan-Yan Liu Andrew Hung Xiao-Shan Zhao Hong Li | 2023 | Precision Medicine Research2023，5，3： | 0 |
| 17 | Controversies on Cornell Realism显示文摘This article examines the criticisms and debates about Cornell realism.While critics,like Shafer-Landau,Tropman,Oliveira and Perrine,reject the claim by Cornell realism that moral knowledge can be empirically investigated the same as natural science is,I argue that some of their arguments are not sufficient to refute Cornell realism.What is crucial in assessing Cornell realism is distinguishing normative ethics from empirical science.While ethics is normative in nature,that of empirical science is descriptive and predictive.I also show that the debate between Tropman and Long is at cross purposes in their discussion about the nature of moral knowledge.By clarifying different meanings of moral knowledge,I argue that while arguments by Cornell realism can be applied to moral psychology,the study of normative ethics through empirical investigation still faces the problem of an is-ought gap.Indeed,many of Cornell realist arguments are begging many questions.I have also examined recent debates on normativity objection by Parfit and Copp.I argue that Copp’s naturalism is very similar to Huemer’s intuitionism.Copp’s argument of non-analytical naturalism seems to support rather than refute moral intuitionism. | Andrew Tsz Wan Hung | 2023 | Fudan Journal of the Humanities and Social Sciences2023，16，2： | 0 |
| 18 | COVID-19 outbreaks in residential care homes in Hong Kong and effectiveness of vaccine against severe outcomes显示文摘Background:COVID-19 outbreaks in residential care homes for the elderly(RCHEs)and for persons with disability(RCHDs)have caused significant morbidity and mortality during 5th epidemic in Hong Kong.This article reviewed COVID-19 outbreaks situation and estimated the effectiveness of receiving at least two-dose of COVID-19 vaccine in preventing severe outcomes.Methods:To estimate attack rates and vaccination coverage,documentation on COVID-19 infection and their vaccination records of residential care homes(RCH)residents reported between December 31,2021 and May 31,2022 were reviewed,and infected cases were follow-up for 4 weeks for severe outcomes or death.Correlation between vaccination coverage against attack rate by types of homes was examined.Infected RCH residents with available information were included in the analysis of vaccine effectiveness against severe outcomes and death.Results:COVID-19 vaccination coverage was low in RCHDs(median 0.46,IQR:0.24-0.76)and very low in RCHEs(median 0.08,IQR:0.00-0.19).Higher attack rates were recorded among RCHE residents(median 0.84,IQR:0.64-0.93)and higher case fatality rate(CFR:28.1%)than in RCHDs(median 0.58,IQR:0.31-0.84;CFR:3.9%).The attack rate decreased when vaccination coverage increased for both RCHEs(ρ=−0.131,p<0.001)and RCHDs(ρ=−0.333,p<0.001).Comparing with infected residents who were unvaccinated/vaccinated with one-dose,receiving at least two-dose was estimated to be effective in reducing severe outcomes in 31%and 36%of infected RCHE and RCHD residents respectively;with greater reduction in mortality among RCHD than RCHE residents(54%and 38%,respectively).Vaccine effectiveness of two-dose of BNT162b2 against severe outcomes and death are higher than that of CoronaVac.Conclusions:Increasing COVID-19 vaccination could have significant impact on reducing the risk of COVID-19 outbreaks in RCHs.At least two-dose of COVID-19 vaccine is still effective in reducing severe outcomes and death among infected residents in RCHs during Omicron epidemic. | Mei Hung Joanna Leung Kin Hang Kung Ian Siu-kiu Yau Yan Yee Fung Kirran Nazesh Mohammad Cheong Chi Andrew Lau Ka Wing Albert Au Shuk Kwan Chuang | 2023 | Infectious Medicine2023，2，1： | 0 |
| 19 | The effect of tailing lipidation on the bioactivity of antimicrobial peptides and their aggregation tendency Special Issue:Emerging Investigators显示文摘Antimicrobial peptides(AMPs)are potentially powerful alternatives to conven-tional antibiotics in combating multidrug resistance,given their broad spectrum of activity.They mainly interact with cell membranes through surface electrostatic potentials and the formation of secondary structures,resulting in permeability and destruction of target microorganism membranes.Our earlier work showed that two leading AMPs,MSI-78(4–20)and pardaxin(1–22),had potent antimicrobial activ-ity against a range of bacteria.It is known that the attachment of moderate-length lipid carbon chains to cationic peptides can further improve the functionality of these peptides through enhanced interactions with the membrane lipid bilayer,inducing membrane curvature,destabilization,and potential leakage.Thus,in this work,we aimed to investigate the antimicrobial activity,oligomerization propensity,and lipid-membrane binding interactions of a range of N-terminal lipidated analogs of MSI-78(4–20)and pardaxin(1–22).Molecular modeling results suggest that aggregation of the N-lipidated AMPs may impart greater structural stability to the peptides in solu-tion and a greater depth of lipid bilayer insertion for the N-lipidated AMPs over the parental peptide.Our experimental and computationalfindings provide insights into how N-terminal lipidation of AMPs may alter their conformations,with subsequent effects on their functional properties in regard to their self-aggregation behavior,membrane interactions,and antimicrobial activity. | Bruce Lin Andrew Hung William Singleton Kevion K.Darmawan Rachael Moses Bicheng Yao Hongkang Wu Anders Barlow Marc-Antoine Sani Alastair J.Sloan Mohammed Akhter Hossain John D.Wade Yuning Hong Neil M.O’Brien-Simpson Wenyi Li | 2023 | Aggregate2023，4，4： | 0 |
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