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| 1 | 急性缺血性卒中静脉阿替普酶溶栓治疗的纳入和排除标准的科学依据美国心脏协会/美国卒中协会对医疗卫生专业人员发布的声明(续前)显示文摘19 颅内出血史
根据最初的 FDA 标签和2013年AHA/ASA指南,颅内出血史是静脉阿替普酶治疗缺血性卒中的一项额外禁忌证或排除标准。最近修订后的标签仅将近期 ICH 列为一项警告,并且在禁忌证中删除了ICH史。与前面讨论的静脉阿替普酶治疗排除标准相似,文献回顾仅在大样本回顾性研究中发现了少量这类病例。缺乏相关数据可能是修订后的FDA 标签不再将 ICH 史作为禁忌证而仅将近期ICH 列为一项警告的原因。在这种情况下,FDA 如何定义“近期”一词尚不清楚。有趣的是,对在静脉阿替普酶治疗前通过 MRI 检测脑微出血( cerebral microbleed, CMBs)存在情况进行的研究可为这个卒中亚组患者提供更多的见解。从病理生理学角度,这种微出血的原因尚不清楚,可能反映再灌注损伤或脑血管自动调节功能破坏。因此,在静脉阿替普酶治疗后出现这些损害可能没有意义或是人为信号。 | Dawn O. Kleindorfer Opeolu M. Adeoye Andrew M. Demchuk Jennifer E. Fugate James C. Grotta Alexander A. Khalessi Elad I. Levy Yuko Y. Palesch Shyam Prabhakaran Gustavo Saposnik Jeffrey L. Saver Eric E. Smith 高圆圆 顾雨铖 徐欣 徐曼曼 张佳慧 李韶雅 冒萧萧 陈歆 徐运 | 2016 | 国际脑血管病杂志2016，24，5： | 98 |
| 2 | Synthesis, properties, and applications of graphene oxide/reduced graphene oxide and their nanocomposites显示文摘Thanks to their remarkable mechanical, electrical, thermal, and barrier properties, graphene-based nanocomposites have been a hot area of research in the past decade. Because of their simple top-down synthesis, graphene oxide (GO) and reduced graphene oxide (rGO) have opened new possibilities for gas barrier, membrane separation, and stimuli-response characteristics in nanocomposites. Herein, we review the synthesis techniques most commonly used to produce these graphene derivatives, discuss how synthesis affects their key material properties, and highlight some examples of nanocomposites with unique and impressive properties. We specifically highlight their performances in separation applications, stimuli-responsive materials, anti-corrosion coatings, and energy storage. Finally, we discuss the outlook and remaining challenges in the field of practical industrial-scale production and use of graphene-derivative-based polymer nanocomposites. | Andrew T. Smith Anna Marie LaChance Songshan Zeng Bin Liu Luyi Sun | 2019 | Nano Materials Science2019，1，1： | 33 |
| 3 | 全球听力障碍的现状及对策——WHO关于听障问题的白皮书简介显示文摘 | Dr Andrew Smith 王树峰 | 2004 | 中国听力语言康复科学杂志2004，，6： | 24 |
| 4 | A matched-pair analysis of laparoscopic versus open pancreaticoduodenectomy: oncological outcomes using Leeds Pathology Protocol显示文摘BACKGROUND: Laparoscopic pancreaticoduodenectomy(LPD)is a safe procedure. Oncological safety of LPD is still a matter for debate. This study aimed to compare the oncological outcomes,in terms of adequacy of resection and recurrence rate following LPD and open pancreaticoduodenectomy(OPD).METHODS: Between November 2005 and April 2009, 12LPDs(9 ampullary and 3 distal common bile duct tumors)were performed. A cohort of 12 OPDs were matched for age,gender, body mass index(BMI) and American Society of Anesthesiologists(ASA) score and tumor site.RESULTS: Mean tumor size LPD vs OPD(19.8 vs 19.2 mm,P=0.870). R0 resection was achieved in 9 LPD vs 8 OPD(P=1.000). The mean number of metastatic lymph nodes and total number resected for LPD vs OPD were 1.1 vs 2.1(P=0.140)and 20.7 vs 18.5(P=0.534) respectively. Clavien complications grade I/II(5 vs 8), III/IV(2 vs 6) and pancreatic leak(2 vs 1)were statistically not significant(LPD vs OPD). The mean high dependency unit(HDU) stay was longer in OPD(3.7 vs 1.4 days,P<0.001). There were 2 recurrences each in LPD and OPD(logrank,P=0.983). Overall mortality for LPD vs OPD was 3 vs 6(log-rank, P=0.283) and recurrence-related mortality was 2 vs 1.There was one death within 30 days in the OPD group secondary to severe sepsis and none in the LPD group.CONCLUSIONS: Compared to open procedure, LPD achieved a similar rate of R0 resection, lymph node harvest and longterm recurrence for tumors less than 2 cm. Though technically challenging, LPD is safe and does not compromise oncological outcome. | Abdul R Hakeem Caroline S Verbeke Alison Cairns Amer Aldouri Andrew M Smith Krishna V Menon | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，4： | 24 |
| 5 | Arsenic uptake by arbuscular mycorrhizal maize (Zea mays L.) grown in an arsenic-contaminated soil with added phosphorus显示文摘arbuscular mycorrhizal (AM ) 的效果真菌(血管球 mosseae ) 和砷上的磷(P) 增加(100 mg/kg 土壤)( 作为) 由从污染言论集的土壤的玉米植物(Zea mays L.) 的举起在一个温室被检验 experiment.Non-mycorrhizal 和 zero-P 增加控制被包括。植物生物资源和集中和举起作为, P,和另外的营养素, AMcolonization,根长度,和菌丝的长度密度被决定。结果显示 P 的增加显著地禁止了根殖民和两个都在 thezero-P 处理,而是 AM 植物的射击和根生物资源下面与 mycorrhizal 殖民显著地增加的 extraradicalmycelium.Root 长度和干燥重量的开发被 P application.AM 压抑真菌的接种减少了当没有 P 被增加时,作为集中射击,并且 AM 植物的射击和根 Asconcentrations 与 P 增加, P 的 respectively.Shoot 和根举起, Mn , Cu ,和增加的 Zn 增加了 2.6 和 1.4 次,但是射击 Fe 举起在44.6%减少了与接种,当 Pwas added.P 增加减少了时,射击 P , Fe , Mn , AM 植物的 Cu ,和 Zn 举起,而是增加的根 Fe andMn nonmycorrhizal ones.AM 殖民的举起因此看起来提高植物忍耐到是在低 P 然而,为 As-contaminatedsoil 的 phytostabilization 玷污,并且有一些潜力 P 申请可以由增加土壤 Asmobility 介绍另外的环境风险。 | XIA Yun-sheng CHEN Bao-dong CHRISTIE Peter SMITH F Andrew WANG You-shan LI Xiao-lin | 2007 | Journal of Environmental Sciences2007，19，10： | 18 |
| 6 | Efficient Silencing of Endogenous MicroRNAs Using Artificial MicroRNAs in Arabidopsis thaliana显示文摘我们这里报导内长的 microRNAs (miRNAs ) 的表示能是高效地在用人工的 miRNA (amiRNA ) 的 Arabidopsis thaliana (Arabidopsis ) 的 silenced 技术。我们证明设计指向成熟 miRNA 的 amiRNA 对所有 miRNA 家庭成员指导 silencing,而设计指向一个 miRNA 先锋抄本的茎环区域的 amiRNA 对指向的仅仅单个家庭成员指导 silencing。而且,我们的结果显示指向成熟 miRNA 和茎环顺序的 amiRNAs 通过 miRNA 先锋抄本的劈开指导 RNA silencing,它大概在 miRNA 生物的续生说的起始的阶段期间发生在一个植物房间的原子核。这建议小 RNA (sRNA ) 指导了 RNA 在植物的劈开不仅在细胞质,而且在原子核发生。许多植物 miRNA 基因家庭经由定序和生物信息的分析被识别了,,但是,迄今为止,仅仅这些的小 tranche 机能上地由于有效前面或反向的基因工具的缺乏被描绘了。我们的调查结果因此在植物为 miRNA 功能的分析提供一个新、强大的颠倒基因的工具。 | Andrew L. Eamens Claire Agius Nell A. Smith Peter M. Waterhouse Ming-Bo Wang | 2011 | Molecular Plant2011，4，1： | 10 |
| 7 | Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer (REAL3): a randomised, open-label phase 3 trial显示文摘 | Tom Waddell Ian Chau David Cunningham David Gonzalez Alicia Frances Clare Okines Andrew Wotherspoon Claire Saffery Gary Middleton Jonathan Wadsley David Ferry Wasat Mansoor Tom Crosby Fareeda Coxon David Smith Justin Waters Timothy Iveson Stephen Falk Sar | 2013 | Lancet Oncology2013，，6： | 10 |
| 8 | Effects of Glomus mosseae on the toxicity of heavy metals to Vicia faba显示文摘A glasshouse pot experiment was conducted to investigate effects of th e arbuscular mycorrhizal fungus Glomus mosseae on the growth of Vicia faba and t oxicity induced by heavy metals (HMs) (Cu, Zn, Pb and Cd) in a field soil contam inated by a mixture of these metals. There was also uninoculation treatment (NM) simultaneously. Mycorrhizal (GM) plants have significantly increased growth and tolerance to toxicity induced by heavy metals compared with NM plants. P uptake was significantly increased in GM plants. Mycorrhizal symbiosis reduced the tra nsportation of HMs from root to shoot by immobilizing HMs in the mycorrhizal, sh own by increasing the ratios of HMs from root to shoot. Oxidative stress, which can induce DNA damage, is an important mechanism of heavy metal toxicity. GM tre atment decreased oxidative stress by intricating antioxidative systems such as p eroxidases and non-enzymic systems including soluble protein. The DNA damage ind uced by heavy metals was detected using comet assay, which showed DNA damage in the plants was decreased by the GM treatment. | ZHANG Xu-hong LIN Ai-jun CHEN Bao-dong WANG You-shan SMITH Sally E SMITH F Andrew | 2006 | Journal of Environmental Sciences2006，18，4： | 10 |
| 9 | Screening and Surveillance for the Early Detection of Colorectal Cancer and Adenomatous Polyps, 2008: A Joint Guideline From the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology显示文摘 | Bernard Levin David A. Lieberman Beth McFarland Kimberly S. Andrews Durado Brooks John Bond Chiranjeev Dash Francis M. Giardiello Seth Glick David Johnson C. Daniel Johnson Theodore R. Levin Perry J. Pickhardt Douglas K. Rex Robert A. Smith Alan Thorson S | 2008 | Gastroenterology2008，，5： | 8 |
| 10 | Effect of Hind Leg Morphology on Performance of a Canine-inspired Quadrupedal Robot显示文摘 | James Andrew Smith Jamil Jivraj | 2015 | Journal of Bionic Engineering2015，12，3： | 5 |
| 11 | 美国公共图书馆2016年度报告显示文摘关于皮尤研究中心皮尤研究中心是一所独立的民调机构,为公众提供影响美国乃至世界的问题、态度与潮流的信息资料。本中心不持任何政治立场。本中心组织民意调查、人口统计学研究、满意度分析和其他数据驱动的社会科学研究,具体研究课题包括美国政治与政策、新闻与媒体、互联网与科技、宗教与公共生活、西班牙裔/拉美裔人口动向、全球态势与趋势,以及美国社会与人口趋势。 | John B.Horrigan Lee Rainie Aaron Smith Andrew Perrin Claudia Deane Margaret Porteus Dana Page Shannon Greenwood 何蕾 | 2016 | 图书馆论坛2016，36，12： | 5 |
| 12 | Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA显示文摘 | Luigi Warren Philip D. Manos Tim Ahfeldt Yuin-Han Loh Hu Li Frank Lau Wataru Ebina Pankaj K. Mandal Zachary D. Smith Alexander Meissner George Q. Daley Andrew S. Brack James J. Collins Chad Cowan Thorsten M. Schlaeger Derrick J. Rossi | 2010 | Cell Stem Cell2010，，5： | 4 |
| 13 | Development of a 100 J,10 Hz laser for compression experiments at the High Energy Density instrument at the European XFEL显示文摘In this paper we review the design and development of a 100 J, 10 Hz nanosecond pulsed laser, codenamed DiPOLE100 X,being built at the Central Laser Facility(CLF). This 1 kW average power diode-pumped solid-state laser(DPSSL) is based on a master oscillator power amplifier(MOPA) design, which includes two cryogenic gas cooled amplifier stages based on DiPOLE multi-slab ceramic Yb:YAG amplifier technology developed at the CLF. The laser will produce pulses between 2 and 15 ns in duration with precise, arbitrarily selectable shapes, at pulse repetition rates up to 10 Hz, allowing real-time shape optimization for compression experiments. Once completed, the laser will be delivered to the European X-ray Free Electron Laser(XFEL) facility in Germany as a UK-funded contribution in kind, where it will be used to study extreme states of matter at the High Energy Density(HED) instrument. | Paul Mason Saumyabrata Banerjee Jodie Smith Thomas Butcher Jonathan Phillips Hauke Hoppner Dominik Moller Klaus Ertel Mariastefania De Vido Ian Hollingham ANDrew Norton Stephanie Tomlinson Tinesimba Zata Jorge Suarez Merchan Chris Hooker Mike Tyldesley Toma Toncian Cristina HernANDez-Gomez Chris Edwards John Collier | 2018 | High Power Laser Science and Engineering2018，6，4： | 4 |
| 14 | Plasma Membrane-Associated SCAR Complex Subunits Promote Cortical F-Actin Accumulation and Normal Growth Characteristics in Arabidopsis Roots显示文摘ARP2/3 建筑群, F 肌动朊聚合的高度保存的 nucleator,和它的使活跃之物, SCAR 建筑群,被显示了在叶起重要作用在 Arabidopsis 的表皮的房间形态发生。然而,疤和 ARP2/3 的细胞内部的地点和功能在植物房间的复杂依赖者的肌动朊聚合仍然保持不清楚。我们证明通常认为的疤建筑群子单元 BRK1 和 SCAR1 在扩展叶子和根的细胞对在细胞生长和墙免职的地点的血浆膜局部性。BRK1 本地化是疤依赖者,提供在在 vivo 的这些蛋白质之间的一个协会的进一步的证据。与疤建筑群子单元的血浆膜本地化一致,在根尖端房间的外皮的 F 肌动朊累积在 brk1 异种被减少。而且,破坏 SCAR 或 ARP2/3 建筑群的变化减少渗透半固体媒介的根和他们的能力的生长率,建议减少的刚硬。变异的根的房间墙在 BRK1 和 SCAR1 在邻近的血浆膜被充实的细胞间的连接展出反常结构和作文。一起拿,我们的结果建议复杂依赖者的肌动朊聚合支持的那个疤和 ARP2/3 在为正常生长和墙汇编是重要的血浆膜处理。 | Julia Dyachok Mon-Ray Shao Kevin Vaughn Andrew Bowling Michelle Facette Stevan Djakovic Lauren Clark Laurie Smith | 2008 | Molecular Plant2008，1，6： | 3 |
| 15 | Cytokine and cytokine receptor gene polymorphisms and their functionality显示文摘 | Andrew J.P. Smith Steve E. Humphries | 2008 | Cytokine and Growth Factor Reviews2008，，1： | 3 |
| 16 | Challenges in Understanding Genome-Wide DNA Methylation显示文摘DNA methylation is a chemical modification of the bases in genomes. This modification, most frequently found at CpG dinucleotides in eukaryotes, has been identified as having multiple critical functions in broad and diverse species of animals and plants, while mysteriously appears to be lacking from several other well-studied species. DNA methylation has well known and important roles in genome stability and defense, its pattern change highly correlates with gene regulation. Much evidence has linked abnormal DNA methylation to human diseases. Most prominently, aberrant DNA methylation is a common feature of cancer genomes. Elucidating the precise functions of DNA methylation therefore has great biomedical significance. Here we provide an update on large-scale experimental technologies for detecting DNA methylation on a genomic scale. We also discuss new prospect and challenges that computational biologist will face when analyzing DNA methylation data. | 张伟奇 Andrew D. Smith | 2010 | Journal of Computer Science & Technology2010，25，1： | 3 |
| 17 | Continuous Autonomic Assessment in Patients With Symptomatic Heart Failure: Prognostic Value of Heart Rate Variability Measured by an Implanted Cardiac Resynchronization Device显示文摘 | Philip B. Adamson Andrew L. Smith William T. Abraham Karen J. Kleckner Robert W. Stadler Alex Shih Melissa M. Rhodes | 2004 | Circulation2004，，16： | 3 |
| 18 | Short-Term Outcomes of the Australasian Randomized Clinical Study Comparing Laparoscopic and Conventional Open Surgical Treatments for Colon Cancer: The ALCCaS Trial显示文摘 | Peter J. Hewett Randall A. Allardyce Philip F. Bagshaw Christopher M. Frampton Francis A. Frizelle Nicholas A. Rieger J Shona Smith Michael J. Solomon Jacqueline H. Stephens Andrew R. L. Stevenson | 2008 | Annals of Surgery2008，，5： | 3 |
| 19 | 临床证据(15) 术后肺部感染显示文摘背景知识 定义 诊断术后肺部感染须具备以下3个或3个以上症状:咳嗽、咳痰、气促、胸痛、体温高于38℃以及脉搏快于每分钟100次。肺炎的诊断需结合胸部X线征象。 发病率/流行情况 术后肺部并发症的发病率与报道者调查的深入程度有关。一项研究发现。 | Andrew Smith 许力 | 2003 | 英国医学杂志中文版2003，6，4： | 2 |
| 20 | Structural basis of gating by the outer membrane transporter feca 显示文摘 | Andrew D Ferguson Ranjan Chakraborty Barbara S Smith | 2002 | Science2002，295，1： | 2 |
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