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| 1 | Cilostazol for secondary stroke prevention:systematic review and meta-analysis显示文摘Background Stroke is one of the leading causes of death worldwide.Cilostazol,an antiplatelet and phosphodiesterase 3 inhibitor,has not been clearly established for ischaemic stroke use.We aim to determine the efficacy and safety of cilostazol for secondary stroke prevention.Methods MEDLINE,EMBASE,Cochrane Library,Web of Science and ClinicalTrials.gov were searched from inception to 25 September 2020,for randomised trials comparing the efficacy and safety of cilostazol monotherapy or dual therapy with another antiplatelet regimen or placebo,in patients with ischaemic stroke.Version 2 of the Cochrane risk-of-bias tool for randomised trials(RoB 2)was used to assess study quality.This meta-analysis was reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)statement.Results Eighteen randomised trials comprising 11429 participants were included in this meta-analysis.Most trials possessed low risk of bias and were of low heterogeneity.Cilostazol significantly reduced the rate of ischaemic stroke recurrence(risk ratio,RR=0.69,95%CI 0.58 to 0.81),any stroke recurrence(RR=0.64,95%CI 0.54 to 0.74)and major adverse cardiovascular events(RR=0.67,95%CI 0.56 to 0.81).Cilostazol did not significantly decrease mortality(RR=0.90,95%CI 0.64 to 1.25)or increase the rate of good functional outcome(Modified Rankin Scale score of 0–1;RR=1.07,95%CI 0.95 to 1.19).Cilostazol demonstrated favourable safety profile,significantly reducing the risk of intracranial haemorrhage(RR=0.46,95%CI 0.31 to 0.68)and major haemorrhagic events(RR=0.49,95%CI 0.34 to 0.70).Conclusions Cilostazol demonstrated superior efficacy and safety profiles compared with traditional antiplatelet regimens such as aspirin and clopidogrel for secondary stroke prevention but does not appear to affect functional outcomes.Future randomised trials can be conducted outside East Asia,or compare cilostazol with a wider range of antiplatelet agents. | Choon Han Tan Andrew GR Wu Ching-Hui Sia Aloysius ST Leow Bernard PL Chan Vijay Kumar Sharma Leonard LL Yeo Benjamin YQ Tan | 2021 | Stroke & Vascular Neurology2021，6，3： | 2 |
| 2 | The Cognitive Perspective in Entrepreneurship: An Agenda for Future Research显示文摘 | Denis A. Grégoire Andrew C. Corbett Jeffery S. McMullen | 2010 | Journal of Management Studies2010，，6： | 2 |
| 3 | Prevalence and incidence of urinary incontinencein the elderly:a longitudinal study in South Australia显示文摘 | Liu CJ Andrews GR | 2002 | Chin Med J2002，11，5： | 1 |
| 4 | Prevalence and incidence of urinary incontinence in the elderly: a longitudinal study in South Australia显示文摘 | Liu C Andrews GR | 2002 | Chin Med J2002，115，1： | 1 |
| 5 | Prevalence of obstructive sleep apnea,associated risk factors,and quality of life among Indian congestive heart failure patients:a cross-sectional survey显示文摘 | Patidar AB Andrews GR Seth S | 2011 | J Cardiovasc Nurs2011，26，6： | 1 |
| 6 | The determinants of cigaretteconsumption:A meta-analysis显示文摘 | Andrews RL Franke GR | 1991 | Journal of Public Policy and Marketing1991，10，1： | 1 |
| 7 | Anatomic Pattern of Intracerebral Hemorrhage Expansion: Relation to CT Angiography Spot Sign and Hematoma Center显示文摘 | Grégoire Boulouis Andrew Dumas Rebecca A. Betensky H. Bart Brouwers Panagiotis Fotiadis Anastasia Vashkevich Alison Ayres Kristin Schwab Javier M. Romero Eric E. Smith Anand Viswanathan Joshua N. Goldstein Jonathan Rosand M. Edip Gurol Steven M. Greenberg | 2014 | Stroke2014，，： | 1 |
| 8 | Relative androgen deficiency in relation to obesity and metabolic sta- tus in older men 显示文摘 | Chen RY Wittert GA Andrews GR | 2006 | Diabetes Obes Metab2006，8，4： | 1 |
| 9 | Garlic oil and vitamin E prevent the adverse effects of lead acetate and ethanol separately as well as in combination in the drinking water of rats显示文摘 | Sajitha GR Jose R Andrews A | | 0，，： | 1 |
| 10 | Fatigue associated with cancer and its treatment显示文摘 | Morrow GR Andrews PL Hickok JT | 2002 | Support Care Cancer2002，10，5： | 1 |
| 11 | The cultural shaping of depression:somatic symptoms in China,psychological symptoms in north americ1显示文摘 | Andrew GR Yang J Zhu X | | 0，，04： | 1 |
| 12 | Contrast nephropathy显示文摘 | David EK Abdallah GR Andrew W | 2003 | Am J Cardiovasc Drugs2003，3，6： | 1 |
| 13 | Fatigue associated with cancer and its treatment显示文摘 | Morrow GR Andrews PL Hickok JT | 2002 | Support Care Cancer2002，10，5： | 1 |
| 14 | Garlic Oil and Vitamin E Prevent the Adverse Effects of Lead Acetate and Ethanol Separately as well as in Combination in the Drinking Water of Rats显示文摘 | GR Sajitha Regi Jose A Andrews | 2010 | Indian J Clin Biochem2010，25，3： | 1 |
| 15 | Fatigue associated with cancer and its treatment显示文摘 | Morrow GR Andrews PL Hickok JT | 2002 | Support Care Cancer2002，10，5： | 1 |
| 16 | The determinants of cigarette consumption: A meta-analysis 显示文摘 | Andrews RL Franke GR | 1991 | Journal of Public Policy and Marketing1991，10，： | 1 |
| 17 | Soil acidification without pH drop under intensivecropping systems in Northeast Thailand Agriculture显示文摘 | Grégory L Roland P Andrew N Olivier G Woraphan C Daniel T | 2006 | Ecosystems and Environment2006，114，23： | 1 |
| 18 | Fatigue associated with cancer and its treatment显示文摘 | Morrw GR Andrews PL Hickok JT | 2002 | Support Care Cancer2002，10，5： | 1 |
| 19 | Fatigue associated with cancer and its trestment显示文摘 | Morrow GR Andrews PL Hickok JT | 2002 | Support Care Cancer2002，10，： | 1 |
| 20 | Fatigue associated with cancer and its treatment显示文摘 | Morrow GR Andrews PL Hickok JT | 2002 | Support Care Cancer2002，10，5： | 1 |
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