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| 1 | Postreperfusion syndrome during orthotopic liver transplantation:a single-center experience显示文摘BACKGROUND: Marked hemodynamic alteration, commonly referred to as postreperfusion syndrome (PRS), often occurs after revascularization of the donor organ during orthotopic liver transplantation (OLT) and is associated with poor outcomes. This study aimed to investigate the incidence, predictive factors and clinical outcomes of PRS in Chinese patients following OLT at a liver transplantation center in China. METHODS: Over a 5-year period, 330 consecutive patients who had undergone OLT for hepatocellular carcinoma or cirrhosis were included in this retrospective study. PRS was defined as a >30% decrease in the mean arterial pressure compared with that before revascularization for more than 1 minute during the first 5 minutes of graft reperfusion. The patients were divided into 2 groups according to the development of PRS: group 1 (patients with PRS, n=56) and group 2 (patients without PRS, n=274). The demographic characteristics, operative and postoperative courses, and outcomes of the patients were analyzed using SPSS version 18.0. RESULTS: Multivariate regression analysis showed that left ventricular diastolic dysfunction determined by echocardiography and prolonged cold ischemia time were the independent risk factors for PRS. More patients in group 1 showed postoperative renal dysfunction than those in group 2 (19.23% vs 8.4%). Moreover, patients in group 1 also had higher intraoperative (7.14% vs 0%) and postoperative mortalities (26.92% vs 12.04%).CONCLUSION: Left ventricular diastolic dysfunction and prolonged cold ischemia time contribute to a high incidence of PRS, which is associated with adverse outcomes in Chinese patients following OLT. | Zhen-Dong Xu, Hai-Tao Xu, Hong-Bin Yuan, Hao Zhang, Rui-Hua Ji, Zui Zou, Zhi-Ren Fu and Xue-Yin Shi Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai 200040, China Department of Anesthesiology Organ Transplantation Center , Changzheng Hospital, Second Military Medical University, Shanghai 200003, China | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，1： | 15 |
| 2 | Harmine induces apoptosis in HepG2 cells via mitochondrial signaling pathway显示文摘BACKGROUND:Harmine has antitumor and antinociceptive effects,and inhibits human DNA topoisomerase.However no detailed data are available on the mechanisms of action of harmine in hepatocellular carcinoma.This study aimed to investigate the effects of harmine on proliferation and apoptosis and the underlying mechanisms in the human hepatocellular carcinoma cell line HepG2.METHODS:The proliferation of HepG2 cells was determined by the cell counting kit-8 (CCK-8) assay and the clone formation test.The morphology of HepG2 cells was examined using fluorescence microscopy after Hoechst 33258 staining Annexin V/propidium iodide (PI) was used to analyze apoptosis and PI to analyze the cell cycle.Western blotting was used to assess expression of the apoptosis-regulated genes Bcl-2,Bax,Bcl-xl,Mcl-1,caspase-3,and caspase-9 Mitochondrial transmembrane potential (Ψ m) was determined using JC-1.RESULTS:Harmine inhibited the proliferation of HepG2 cells in a dose-dependent manner.Hoechst 33258 staining revealed nuclear fragmentation and chromosomal condensation,cell shrinkage,and attachment loss in HepG2 cells treated with harmine.The percentage of the sub/G1 fraction was increased in a concentration-dependent manner,indicating apoptotic cell death.PI staining showed that harmine changed the cell cycle distribution,by decreasing the proportion of cells inG0/G1 and increasing the proportion in S and G2/M.Harmine induced apoptosis in a concentration-dependent manner,with rates of 20.0%,32.7% and 64.9%,respectively.JC-1 revealed a decrease in Ψ m.Apoptosis of HepG2 cells was associated with caspase-3 and caspase-9 activation,down-regulation of Bcl-2,Mcl-1,and Bcl-xl,and no change in Bax.CONCLUSIONS:Harmine had an anti-proliferative effect in HepG2 cells by inducing apoptosis.Mitochondrial signal pathways were involved in the apoptosis.The cancer-specific selectivity shown in this study suggested that harmine is a promising novel drug for human hepatocellular carcinoma. | Ming-Rong Cao,Qiang Li,Zhi-Long Liu,Hui-Hui Liu,Wei Wang,Xiao-Li Liao,Yun-Long Pan and Jian-Wei Jiang Department of General Surgery,First Affiliated Hospital,Jinan University,Guangzhou 510632,China Department of Anesthesiology,First Affiliated Hospital,Guangzhou University of TCM,Guangzhou 510632,China Department of Biochemistry,Medical College of Jinan University,Guangzhou 510632,China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，6： | 11 |
| 3 | Cardiac arrest after graft reperfusion during liver transplantation显示文摘BACKGROUND: Cardiac arrest ( CA) during orthotopic liver transplantation (OLT) is rare but it threatens the lives of patients. The cause of perioperitive CA is not fully understood. We reported the occurrence of CA in 5 patients after unclamping of the vena cava and investigated the relationship between CA and associated variables. METHODS: Five patients with CA after graft reperfusion during OLT in our unit from November 1996 to September 2003 were retrospectively reviewed. Analyzed data included donor and recipient demographic data, and recipient operative and postoperative events. RESULTS: Five (2.1%) of 240 patients undergoing OLT experienced CA 5 minutes after graft reperfusion. Two patients died of resuscitation failure. Hyperkalemia and metabolic acidosis after revascularization were observed in some patients. The five patients had hypothermia and hypocalce-mia, and one had pulmonary embolism. CONCLUSIONS: CA is one of the syndromes after reperfusion. Many factors such as hyperkalemia, acidosis or pulmonary embolism combined with hypothermia and hy-pocalcemia during the operation seem to contribute to the occurrence of CA. | Xue-Yin Shi, Zhen-Dong Xu, Hai-Tao Xu, Jin-Jin Jiang and Gang Liu Department of Anesthesiology, Changzheng Hospital, Second Military Medical University,Shanghai 200003 , China | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，2： | 10 |
| 4 | Evidences for vagus nerve in-maintenance of immune balance and transmission of immune information from gut to brain in STM-infected rats显示文摘AIM:To determine whether salmonella Typhimurium(STM) in gastrointestinal tract can induce the functional activation of brain,whether the vagus nerve involves in signaling immune infomation from gastrointestinal tract to brain and how it influences the immune function under natural infection condition.METHODS:Animal model of gastrointestinal tract infection in the rat was established by an intuation of Salmonella Typhimurium(STM) into stomach to minic the condition of natural bacteria infection,Subdiagphragmatic vagotomy was performed in some of the animals 28 days before infection The changes of Fos expression visualized with immunohistochemistry technique in hypothalamic paraventricular nucleus(pVN) and superaoptic nuclesu (SON)were conted.Meanwhilie,the percentage and the Mean Intensities of Flurescent (MIFs)of CD4+ and CD8+ T cells in peripheral blood were measured by using flow cytometry(FCM),and the pathological changes in ileum and mesenteric lymph node were observed in HE stained sections.RESULTS:In bacteria-stimulated groups,inflammatory pathological changes were seen in ileum and mesenteric lymph node,The percentages of CD4+ T cells in peripheral blood were decreased from 43%±4.5%to 34%±4.9%(P<0.5)and MIFs of CD8+ T cells were also decreased from 2.9±0.39to 2.1±0.36(P<0.05)with STM stimulation.All of them proved that our STM-infection model was reliable Fos immunoreactive(Fos-ir) cells in PVN and SON incerased significantly with STM stimulation,from 189±41 to467±62(P<0.05)and from 64±21 to 282±47(P<0.05)individually,which suggested that STM in gastointestinal tract induced the functional activation of brain Subdiagphragmatic vagotomy attenuated FOs expression in PVN and SON induced by STM,from 467±62to 226±45(P<0.05)and from 282±47to 71±19(P<0.05)individually,and restored the decreased percentages of CD4+ T cells induced by STM from 34%±4.9% to original level 44%±6.0%(P<0.05).In addition,subdiagphragmatic vagotomy itself also decreased the percentages of CD8+ T cells (from 28%±3.0%to 21%±5.9%),P<0.05 and MIFs of CD4+(from 6.6±0.6to4.9±1.0P<0.05)and CD8+ T cells (from 2.9±0.39to 1.4±0.34,P<0.05).Both of them manifested the important role of vagus nerve in transmitting immune information from gut to brain and maintaining the immune balance of the organism.CONCLUSION:Vagus nerve dose involve in transmitting adbominal immune informaton into the brain in STM infection condition and play an important role in maintenance of the immune balance of the oranism. | Xi Wang Bai-Ren Wang Zhen Xu Yu-Qiang Ding Gong Ju,Institute of Neuroscience,Fourth Military Medical University,Xi’an 710032,Shaanxi Province,China Xi-Jing Zhang,Department of Anesthesiology,Xi Jing Hospital,Fourth Military Medical University,Xi’an 710032,Shaanxi Province,China | 2002 | World Journal of Gastroenterology2002，8，3： | 10 |
| 5 | Effects of extract F of red-rooted Salvia on mucosal lesions of gastric corpus and antrum induced by hemorrhagic shock-reperfusion in rats显示文摘AIM To compare the effects of extract F of red-rooted Salvia (EFRRS) on mucosal lesions of gastric corpus and antrum induced by hemorrhagic shock and reperfusion in rats.``METHODS The rats were subject to hemorrhagic shock and followed by reperfusion, and were divided randomly into two groups. Group 1 received saline, and group 2received EFRRS intravenously. The index of gastric mucosal lesions (IGML) was expressed as the percentage of lesional area in the corpus or antrum. The degree of gastric mucosal lesions (DGML) was catalogued grade 0,1. 2 and 3. The concentrations of prostaglandins (lags)were measured by radioimmunoassay. The concentration of MDA was measured according to the procedures of Asakawa. The activity of SOD was measured by the biochemical way. The growth rates or inhibitory rates of above-mentioned parametes were calculated.``RESULTS As compared with IGML (%), grade 3 damage (%) and MDA content (nmol/g tissue) of gastric antrum which were respectively 7.96 ± 0.59, 34.86± 4.96 and 156.98± 16.12. those of gastric corpus which were respectively 23.18 ± 6.82, 58.44 ± 9.07 and 230.56 ± 19.37increased markedly (P<0.01), whereas the grade 0damage, grade 1 damage, the concentrations of PGE2 and PGI2(pg/ mg tissue), the ratio of PGI2/ TXA2 and the activity of SOD (U/ g tissue) of corpus which were respectively 3.01 _- 1.01, 8.35 + 1.95, 540.48 _+ 182.78,714.38 ± 123.74, 17.38 ± 5.93 and 134.29 ± 13.35 were markedly lower than those of antrum which were respectively 13.92 ± 2.25, 26.78 ± 6.06, 2218.56 ± 433.12,2531.76 ± 492.35, 43.46 ± 8.51 and 187.45 ± 17.67( P<0.01 ) after hemorrhagic shock and reperfusion. After intravenous EFRRS, the growth rates (%) of grade 0damage, grade 1 damage, the concentrations of PGE2 and PGI2, the ratio of PGI2/TXA2 and the activity of SOD of corpus which were respectively 632.56, 308.62, 40.75,74.75, 92.29 and 122.25 were higher than those in antrum which were respectively 104,89, 58.40, 11.12, 56.58,30.65 and 82.64, whereas the inhibitory rates (%) ofIGML, grade 3 damage and MDA content of gastric corpus were 82.93, 65.32 and 59.09, being higher than those of gastric antrum which were 76.64, 53.18 and 42.37.``CONCLUSION After hemorrhagic shock-reperfusion, the gastric mucosal lesions in the corpus were more severe than those in the antrum, which were related not only to the different distribution of endogenous PGs in the mucosa, but also to the different ability of anti-oxidation of the mucosa. The protective effect of EFRRS on the gastric mucosa in the corpus was more evident than that in the antrum, which was related to higher growth degree of PGs contents and anti-oxitative ability in gastric corpus after administration of EFRRS. | Li-Hong Zhang~1 Chang-Bai Yao~2 He-Quan Li~3 1 Department of Anesthesiology,Second Clinical College,China Medical University,Shenyang 110003,Liaoning Province,China2 Department of General Surgery,Second Clinical College,China Medical University3 Department of Pathophysiology,China medical University | 2001 | World Journal of Gastroenterology2001，7，5： | 5 |
| 6 | Cerebral protective effect of nicorandil premedication on patients undergoing liver transplantation显示文摘BACKGROUND:Neurological injury is a common complication in the early period after liver transplantation,posing an enormous obstacle to treatment efficiency and patient survival.Nicorandil is a mitochondrial ATP-sensitive potassium channel(mitoK ATP) opener.It has been reported to be effective in reducing brain injury in recent studies.However,it is still unclear whether nicorandil has cerebral protective effect in patients undergoing liver transplantation.METHODS:Fifty patients scheduled for liver transplantation were randomly divided into a nicorandil group(group N)(n=25),in which patients received 10 mg nicorandil through a nasogastric tube 30 minutes before induction of anesthesia,and a control group(group C)(n=25) who received 10 mL normal saline.The Mini-Mental State Examination(MMSE) was performed before anesthesia(day 0),and on days 3 and 7 after surgery.Blood samples were obtained before induction of anesthesia(T1),and at 12(T2) and 36 hours(T3) after surgery for determination of serum neuron-specific enolase(NSE) and S100β protein(S100β) concentrations.RESULTS:During surgery,5 patients in each group were eliminated due to severe reperfusion or renal insufficiency.Therefore,20 patients remained in each group.The MMSE scores after operation were significantly lower than those before operation in group C.However,there was no difference at days 3 and 7 compared with day 0 in group N.Serum NSE concentrations after surgery were significantly higher than baseline(at T1) in both groups,except at T3 in group N.Serum S100β concentration after surgery was significantly higher than baseline(at T1) in both groups.The MMSE scores at days 3 and 7 in group N were significantly higher than those in group C.The concentrations of serum NSE and S100β at T2 and T3 in group N were significantly lower than those in group C.CONCLUSIONS:Oral nicorandil,as a premedication before liver transplantation,improves postoperative MMSE scores.It also attenuates the increase of NSE and S100β in blood,indicating its cerebral protective effect. | Yun-Fei Xia,Zheng-Ping Wang,Ya-Chun Zhou,Tao Yan and Shi-Tong Li Department of Anesthesiology, Shanghai First People’s Hospital, Medical College, Shanghai Jiaotong University, Shanghai 200080, China | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，2： | 3 |
| 7 | POSTNATAL DEVELOPMENT OF PERSISTENT SPONTANEOUS PAIN AND HYPERALGESIA INDUCED BY SUBCUTANEOUS INTRAPLANTAR BEE VENOM INJECTION IN RATS显示文摘Aim: The present study was designed to investigate the postnatal development of persistent spontaneous pain and hyperalgesia induced by subcutaneous (s. c. ) intraplantar bee venom (BV) injection in pup rats and changes in pain behaviors in the mature rats receiving postnatal BV injection. Methods: Twenty four litters of pup rats were divided into six groups: P1 (postnatal day), P4, P7, P14, P21, P28. | Meng-Meng LI~2, Hui-Sheng CHEN~1, Ying-Min ZHANG~2 and Jun CHEN~1 ~1Department of Anatomy and K.K. Leung Brain Research Centre, ~2Department of Anesthesiology, The Fourth Military Medical University, Xi’an 710032 | 2001 | 神经解剖学杂志2001，17，B07： | 2 |
| 8 | Efficacy of liver transplantation for acute hepatic failure:asingle-center experience显示文摘BACKGROUND:Acute hepatic failure (AHF) is a devastating clinical syndrome with a high mortality rate.The outcome of AHF varies with etiology,but liver transplantation (LT) can significantly improve the prognosis and survival rate of such patients.This study aimed to detect the role of LT and artificial liver support systems (ALSS) for AHF patients and to analyze the etiology and outcome of patients with this disease.METHODS:A retrospective analysis was made of 48 consecutive patients with AHF who fulfilled the Kings College Criteria for LT at our center.We analyzed and compared the etiology,outcome,prognosis,and survival rates of patients between the transplantation (LT) group and the non-transplantation (N-LT) group.RESULTS:AHF was due to viral hepatitis in 25 patients (52.1%;hepatitis B virus in 22),drug or toxic reactions in 14 (29.2%;acetaminophen in 6),Wilson disease in 4 (8.3%),unknown reasons in 3 (6.3%),and miscellaneous conditions in 2 (4.2%).In the LT group,36 patients (7 underwent living donor LT,and 29 cadaveric LT) had an average model for endstage liver disease score (MELD) of 35.7.Twenty-eight patients survived with good graft function after a follow-up of 27.3± 4.5 months.During the waiting time,6 patients were treated with ALSS and 2 of them died during hospitalization.The 30-day,12-month,and 18-month survival rates were 77.8%,72.2%,and 66.7%,respectively.In the N-LT group,12 patients had an average MELD score of 34.5.Four patients were treated with ALSS and all died during hospitalization.The 90-day and 1-year survival rates were only 16.7% and 8.3%,respectively.CONCLUSIONS:Hepatitis is the most prominent cause of AHF at our center.Most patients with AHF,who fulfill the Kings College Criteria for LT,did not survive longer without LT.ALSS did not improve the prognosis of AHF patients,but may extend the waiting time for a donor.Currently,LT is still the most effective way to improve the prognosis of AHF patients. | Xian-Jie Shi,Hong-Bin Xu,Wen-Bin Ji,Yu-Rong Liang,Wei-Dong Duan,Lei He,Ming-Jun Wang and Zhi-Ming Zhao Department of Hepatobiliary Surgery Department of Anesthesiology General Hospital of PLA,Beijing 100853,China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 2 |
| 9 | MicroRNAs in cardiovascular diseases:From bench to bedside显示文摘MicroRNAs(miRNAs) are a novel class of endogenous,small,noncoding RNAs that regulate gene expression via degradation or translational inhibition of their target mRNAs.Functionally,an individual miRNA is important as a transcription factor because it is able to regulate the expression of its multiple target genes.As a group,miRNAs are able to directly regulate at least 30%of genes in a cell.In addition,other genes may also be regulated indirectly by miRNAs.It is therefore not surprising that miRNAs could be the pivotal regulators in normal development,physiology,and pathology. Recent studies have demonstrated that miRNAs are highly expressed in cardiovasculature and their expression is dysregulated in diseased hearts and vessels. miRNAs are found to be critical modulators for cardiovascular cell functions such as cell differentiation, contraction,migration,proliferation,and apoptosis.Accordingly,miRNAs are involved in the many cardiovascular diseases such as cardiac hypertrophy and heart failure,ischemic heart disease, cardiac arrhythmias,angiogenesis,atherosclerosis and restenosis after angioplasty.Both basic and clinical studies have revealed miRNAs are a novel class of biomarkers and therapeutic targets for cardiovascular diseases.In this talk,we will report a translational study about the roles of circulating miRNAs in the diagnosis of myocardial infraction.We identified that miR-1 could be a novel sensitive diagnostic biomarker for myocardial infraction.In addition, the research progress of miRNAs in cardiovascular diseases from bench to bedside and the research perspective summarized by NIH microRNA working group will be reported. | Chunxiang Zhang (Cardiovascular Research Laboratory,Department of Anesthesiology,New Jersey Medical School,University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue,MSB-E548,Newark,NJ 07101) | 2011 | 岭南心血管病杂志2011，17，S1： | 2 |
| 10 | Liver cold preservation induce lung surfactant changes and acute lung injury in rat liver transplantation显示文摘AIM:To investigate the relationship between donor liver cold preservation,lung surfactant (LS) changes and acute lung injury (ALI) after liver transplantation.METHODS:Liver transplantation models were estab-lished using male Wistar rats.Donor livers were pre-served in University of Wisconsin solution at 4 ℃ for different lengths of time.The effect of ammonium pyr-rolidinedithiocarbamate (PDTC) on ALI was also detect-ed.All samples were harvested after 3 h reperfusion.The severity of ALI was evaluated by lung weight/body weight ratio,lung histopathological score,serum nitric oxide (NO) and endothelin (ET)-1 levels,lung tumor necrosis factor (TNF)-α and interleukin (IL)-1β levels.Lung surfactants (LSs) were determined by micellar electrokinetic capillary chromatography.RESULTS:With extended donor liver cold preservation time (CPT),lung histopathological scores,serum ET-1 levels,lung weight/body weight ratio and the level of TNF-α and IL-1β in lung were increased significantly in the 180-min group compared with the sham group (3.16 ± 0.28 vs 1.12 ± 0.21,P < 0.001;343.59 ± 53.97 vs 141.53 ± 48.48,P < 0.001;0.00687 ± 0.00037 vs 0.00557 ± 0.00056,P < 0.001;17.5 ± 3.0 vs 1.3 ± 0.3,P < 0.001;10.8 ± 2.3 vs 1.8 ± 0.4,P < 0.001),but se-rum NO levels decreased remarkably (74.67 ± 10.01 vs 24.97 ± 3.18,P < 0.001).The expression of lung phos-phatidylcholine (PC),phosphatidylethanolamine (PE),phosphatidylinositol (PI) and phosphatidylserine (PS) increased when CPT was < 120 min,and decreased when CPT was > 180 min (PC:1318.89 ± 54.79 vs 1011.18 ± 59.99,P < 0.001;PE:1504.45 ± 119.96 vs 1340.80 ± 76.39,P=0.0019;PI:201.23 ± 34.82 vs 185.88 ± 17.04,P=0.2265;PS:300.43 ± 32.95 vs 286.55 ± 55.55,P=0.5054).All these ALI-associated indexes could be partially reversed by PDTC treatment.CONCLUSION:Prolonged CPT could induce or inhibit the expression of LSs at the compensation or decom-pensation stage,and some antioxidants (e.g.,PDTC) may reverse the pathological process partially. | An Jiang,Chang Liu,Liang Yu,Yi Lv,Department of Hepatobiliary Surgery,the First Affiliated Hospital,School of Medicine,Xi’an Jiaotong University,Xi’an 710061,Shannxi Province,China An Jiang,Department of VIP Clinic,The Second Affiliated Hospital,School of Medicine,Xi’an Jiaotong University,Xi’an 710004,Shannxi Province,China Feng Liu,Department of Liver Transplantation,Qianfoshan Hospital,Jinan 250014,Shandong Province,China Yu-Long Song,Department of Anesthesiology,Renmin Hospital of Shannxi Province,Xi’an 710061,Shannxi Province,China Quan-Yuan Li,Department of Transplantation,Dongfeng Hospital,Shiyan 442008,Hubei Province,China | 2012 | World Journal of Gastroenterology2012，18，4： | 2 |
| 11 | 中度低温对心脏停跳复苏后脑组织PGI_2及TXA_2含量的影响显示文摘心脏停跳复苏后将脑温降低至30~32℃时,测定脑组织PGI2及TXA2含量。结果表明:全脑中度低温可明显抑制TXA2的产生,而PGI2含量无明显变化。提示中度低温能早期有效地抑制脑内花生四烯酸环氧酶途径代谢,减轻缺血后脑损伤。 | Guo Qulian Tan Xiujuan Cai Hongwei Lei Baiping Xu Qiming(Department of Anesthesiology, Xiangya Hospital, Hunan Medical University, Changsha 410008) | 1998 | 湖南医科大学学报1998，23，4： | 1 |
| 12 | Is there any difference in anesthetic management of different post-OLT stage patients undergoing nontransplant organ surgery?显示文摘BACKGROUND: Little information is available about anesthesia management of nontransplant organ surgery of recipients after adult liver transplantation. The aim of this study was to discuss the anesthesia management of recipients for different stages after liver transplantation. METHODS: The medical records of 16 patients were reviewed after OLT scheduled for elective nontransplant organ surgery at our institution from September 2002 to October 2005. The patients were divided into perioperative stage (group A) and mid-term and long-term stage (group B) groups according to post-OLT time. The data of 16 patients preoperation, intraoperation and postoperation were analyzed. RESULTS: The measurements of alanine transaminase (ALT), total bilirubin (TB), prothrombin time (PT), and lung infection were significantly higher in group A than in group B (P<0.05). The incidence of hyperglycaemia was significantly higher in group B than in group A (P<0.05). During operation the incidence of hypotension was significantly higher in group A than in group B (P<0.05). After operation, the number of patients in ICU was significantly larger and the extubation time was longer in group A than in group B. General anesthesia was induced in 14 patients, and regional anesthesia in 2 patients. CONCLUSIONS: Regional or general anesthesia can be safely delivered to adult OLT recipients except for contraindications. Special considerations include protection of the function of important organs, correction of hemodynamic instability in perioperative stage patients after OLT, and measurement of the side-effects of immunosuppression in mid-term and long-term stage patients. | Zhi-Ying Feng, Jian Zhang, Sheng-Mei Zhu and Shu-Sen Zheng Department of Anesthesiology, and Department of General Surgery First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，3： | 1 |
| 13 | Low- and hydroxyethyl starches: on blood coagulation 显示文摘 | JAMNICKI M BOMBELI T medium-molecular-weight comparison of their effect Anesthesiology 2000 93(5) SEIFERT B | 2000 | 1231-12372000，，： | 1 |
| 14 | Prevention and management of pain and stress in the neonate显示文摘 | American Academy of Pediatrics Committee on Fetus and New-born Committee on Drug Section on Anesthesiology Section on Surgery | | 0，，2： | 1 |
| 15 | 胸腔镜下行肺癌手术时单肺通气的麻醉分析(英文)[J]显示文摘 | Lairong Sun Lianbing Gu Department of Anesthesiology Jiangsu province tumor hospital Nanjing 210009 China | 2012 | Chinese-GermanJournalofClinicalOncology2012，06，6： | 1 |
| 16 | Treatment of acute postoperative pain 显示文摘 | Anesthetic care of stiff person syn- Journal of Anesthesiology and Clinical Wu CL Raja SN | 2011 | Lancet2011，377，9784： | 1 |
| 17 | Hyperbaric oxygen preconditioning induces tolerance against spinal cord ischemia in rabbits显示文摘 | DONG Hai Long XIONG Li Ze ZHU Zheng Hua Department of Anesthesiology Xijing Hospital Fourth Military Medical University Xi’an 710033 China | 2000 | 第四军医大学学报2000，，04： | 1 |
| 18 | Practice guidelines for pulmonary artery catheteri-zation显示文摘 | American Society of Anesthesiology | 1993 | Anesthesiology1993，78，： | 1 |
| 19 | Retraction Statement显示文摘As the corresponding author of a paper appearing in J Huazhong Univ Sci Technolog [Med Sci], here I retract the articletitled 'Effect of Inhalational Anesthetics on Cytotoxicity and Intracellular Calcium Differently in Rat Pheochromocytoma Cells(PC12)' | Wang Qiujun Department of Anesthesiology The Third Hospital Hebei Medical University Shijiazhuang 050041,PR China | 2008 | Journal of Huazhong University of Science and Technology(Medical Sciences)2008，28，3： | 1 |
| 20 | Do the lungs contribute to propofol elimination in patients during orthotopic liver transplantation without veno-venous bypass?显示文摘BACKGROUND: The clearance of propofol is very rapid, and its transformation takes place mainly in the liver. Some reports indicated extrahepatic clearance of the drug and that the lungs are the likely place where the process occurs. This study was undertaken to compare the plasma concentrations of propofol both in the pulmonary and radial arteries after constant infusion during the dissection, anhepatic and reperfusion phases of orthotopic liver transplantation (OLT) without veno-venous bypass, attempting to investigate extrahepatic clearance and to determine whether the human lungs take part in the elimination of propofol. METHODS: Fifteen patients undergoing OLT without veno-venous bypass were enrolled in the study, and propofol was infused via a forearm vein at a rate of 2 mg· kg-1·h-1. Blood samples were simultaneously collected from pulmonary and radial arteries at the end of the first hepatic portal dissection (T0), at the clamping of the portal vein (T1), 30, and 60 minutes after the beginning of the anhepatic phase (T2, T3), and 30, 60, and 120 minutes after the unclamping of the new liver (T4, T5, T6). Plasma propofol concentrations were measured using a reversed- phase, high-performance liquid chromatographic method with fluorescence detection. RESULTS: The concentrations of plasma propofol in the pulmonary and radial arteries at T2 and T3 rose significantly compared with T0 and T1 (P<0.01) respectively. After reperfusion, the drug concentrations at T4, T5 and T6 decreased significantly compared with T2, T3 (P<0.01)respectively. There were no significant differences in plasma propofol concentrations between the pulmonary and radial arteries at any time points. CONCLUSIONS: Propofol is eliminated mainly by the liver, and also by extrahepatic organs. The lungs seem to be not a major site contributing to the extrahepatic metabolism of propofol in humans. | Yi-Zhong Chen, Sheng-Mei Zhu, Hui-Liang He, Jian-Hong Xu, Su-Qin Huang and Qing-Lian Chen Department of Anesthesiology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，4： | 1 |
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