|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Challenges for land system science显示文摘 | Mark D.A. Rounsevell Bas Pedroli Karl-Heinz Erb Marc Gramberger Anne Gravsholt Busck Helmut Haberl S?ren Kristensen Tobias Kuemmerle Sandra Lavorel Marcus Lindner Hermann Lotze-Campen Marc J. Metzger David Murray-Rust Alexander Popp Marta Pérez-Soba Anett | 2012 | Land Use Policy2012，，4： | 2 |
| 2 | Gut microbiota disturbance during antibiotic therapy: a multi-omic approach显示文摘 | Ana Elena Pérez-Cobas María José Gosalbes Anette Friedrichs Henrik Knecht Alejandro Artacho Kathleen Eismann Wolfgang Otto David Rojo Rafael Bargiela Martin von Bergen Sven C Neulinger Carolin D?umer Femke-Anouska Heinsen Amparo Latorre Coral Barbas Jana | 2013 | Gut2013，，11： | 2 |
| 3 | Training of a sensory panel and profiling of winter hardy and coloured carrot genotypes显示文摘 | Stine K Anette K T Wender L P B | 2007 | Food Quality and Preference2007，18，： | 1 |
| 4 | Human papillomavirus type 16 E7 oncoprotein-induced abnormal centrOsome synthesis is an eraly event in the evolving malingnant phenotype 显示文摘 | Stefan D Anette D Christopher P C | 2002 | Cancer Res2002，61，6： | 1 |
| 5 | Human papillomavirus type 16 E7 oncoprotein-induced abnormal centrosome synthesis is an early event in the evolving malignant phenotype显示文摘 | Stefan D Anette D Christopher P C | 2001 | Cancer Res2001，61，6： | 1 |
| 6 | Hydrology and nutrient effects on food-web structure in the Lake Superior Coastal Wetlands 显示文摘 | Michael E S Gregory S P Anett S T | 2006 | Wetlands2006，26，4： | 1 |
| 7 | Mutation analysis of the prepro Ghrelin gene: No association with obesity and type 2 diabetes 显示文摘 | Lesli H Larsenab T Anette P | 2005 | Clin Biochem2005，38，： | 1 |
| 8 | AZD 1080, a novel GSK 3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans显示文摘 | Biljana Georgievska Johan Sandin James Doherty Anette M?rtberg Jan Neelissen Anita Andersson Susanne Gruber Yvonne Nilsson P?r Sch?tt Per I. Arvidsson Sven Hellberg Gunilla Osswald Stefan Berg Johanna F?lting Ratan V. Bhat | 2013 | J Neurochem2013，，3： | 1 |
| 9 | Interstitial laser ablation (Indigo TM) of the prostate-a randomized prospective study,three years follow up显示文摘 | Anett P Faiyaz H | 2001 | J Urol2001，165，： | 1 |
| 10 | Event-based low frequency impedance modeling using well logs and seismic attributes显示文摘 | RADMILA P T ANETTE U NILS L T | | 0，，05： | 1 |
| 11 | MEMS device for bending test:measurements of fatigue and creep of electroplated nickel 显示文摘 | Kristian P Larsen Anette A Rasmussen Jan T Ravnkildeb | 2003 | Sensors and Actuators A : Physical2003，103，： | 1 |
| 12 | A dual role of lysophosphatidic acid type 2 receptor(LPAR2)in nonsteroidal anti-inflammatory drug-induced mouse enteropathy显示文摘Lysophosphatidic acid(LPA)is a bioactive phospholipid mediator that has been found to ameliorate nonsteroidal anti-inflammatory drug(NSAID)-induced gastric injury by acting on lysophosphatidic acid type 2 receptor(LPAR2).In this study,we investigated whether LPAR2 signaling was implicated in the development of NSAID-induced small intestinal injury(enteropathy),another major complication of NSAID use.Wild-type(WT)and Lpar2 deficient(Lpar2^(^(^(−/−))))mice were treated with a single,large dose(20 or 30 mg/kg,i.g.)of indomethacin(IND).The mice were euthanized at 6 or 24 h after IND treatment.We showed that IND-induced mucosal enteropathy and neutrophil recruitment occurred much earlier(at 6 h after IND treatment)in Lpar2^(^(^(−/−)))mice compared to WT mice,but the tissue levels of inflammatory mediators(IL-1β,TNF-α,inducible COX-2,CAMP)remained at much lower levels.Administration of a selective LPAR2 agonist DBIBB(1,10 mg/kg,i.g.,twice at 24 h and 30 min before IND treatment)dose-dependently reduced mucosal injury and neutrophil activation in enteropathy,but it also enhanced IND-induced elevation of several proinflammatory chemokines and cytokines.By assessing caspase-3 activation,we found significantly increased intestinal apoptosis in IND-treated Lpar2^(^(^(−/−)))mice,but it was attenuated after DBIBB administration,especially in non-obese diabetic/severe combined immunodeficiency(NOD/SCID)mice.Finally,we showed that IND treatment reduced the plasma activity and expression of autotaxin(ATX),the main LPA-producing enzyme,and also reduced the intestinal expression of Lpar2 mRNA,which preceded the development of mucosal damage.We conclude that LPAR2 has a dual role in NSAID enteropathy,as it contributes to the maintenance of mucosal integrity after NSAID exposure,but also orchestrates the inflammatory responses associated with ulceration.Our study suggests that IND-induced inhibition of the ATX-LPAR2 axis is an early event in the pathogenesis of enteropathy. | Barbara Hutka Anett Várallyay Szilvia B.László András S.Tóth Bálint Scheich Sándor Paku Imre Vörös Zoltán Pós Zoltán V.Varga Derek D.Norman Andrea Balogh Zoltán Benyó Gábor Tigyi Klára Gyires Zoltán S.Zádori | 2024 | Acta Pharmacologica Sinica2024，45，2： | 0 |
| 13 | One in four patients with gastrointestinal bleeding develops shock or hemodynamic instability:A systematic review and meta-analysis显示文摘BACKGROUND Hemodynamic instability and shock are associated with untoward outcomes in gastrointestinal bleeding.However,there are no studies in the existing literature on the proportion of patients who developed these outcomes after gastrointestinal bleeding.AIM To determine the pooled event rates in the available literature and specify them based on the bleeding source.METHODS The protocol was registered on PROSPERO in advance(CRD42021283258).A systematic search was performed in three databases(PubMed,EMBASE,and CENTRAL)on 14^(th) October 2021.Pooled proportions with 95%CI were calculated with a random-effects model.A subgroup analysis was carried out based on the time of assessment(on admission or during hospital stay).Heterogeneity was assessed by Higgins and Thompson’s I^(2) statistics.The Joanna Briggs Institute Prevalence Critical Appraisal Tool was used for the risk of bias assessment.The Reference Citation Analysis(https://www.referencecitationanalysis.com/)tool was applied to obtain the latest highlight articles.RESULTS We identified 11589 records,of which 220 studies were eligible for data extraction.The overall proportion of shock and hemodynamic instability in general gastrointestinal bleeding patients was 0.25(95%CI:0.17-0.36,I^(2)=100%).In non-variceal bleeding,the proportion was 0.22(95%CI:0.14-0.31,I^(2)=100%),whereas it was 0.25(95%CI:0.19-0.32,I^(2)=100%)in variceal bleeding.The proportion of patients with colonic diverticular bleeding who developed shock or hemodynamic instability was 0.12(95%CI:0.06-0.22,I^(2)=90%).The risk of bias was low,and heterogeneity was high in all analyses.CONCLUSION One in five,one in four,and one in eight patients develops shock or hemodynamic instability on admission or during hospitalization in the case of non-variceal,variceal,and colonic diverticular bleeding,respectively. | Mahmoud Obeidat Brigitta Teutsch Anett Rancz Edina Tari Katalin Márta Dániel Sándor Veres Nóra Hosszúfalusi Emese Mihály Péter Hegyi Bálint Erőss | 2023 | World Journal of Gastroenterology2023，29，28： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员