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| 1 | High-resolution microendoscopy for esophageal cancer screening in China: A cost-effectiveness analysis显示文摘AIM:To study the cost-effectiveness of high-resolution microendoscopy(HRME)in an esophageal squamous cell carcinoma(ESCC)screening program in China.METHODS:A decision analytic Markov model of ESCC was developed.Separate model analyses were conducted for cohorts consisting of an averagerisk population or a high-risk population in China.Hypothetical 50-year-old individuals were followed until age 80 or death.We compared three different strategies for both cohorts:(1)no screening;(2)standard endoscopic screening with Lugol’s iodine staining;and(3)endoscopic screening with Lugol’s iodine staining and an HRME.Model parameters were estimated from the literature as well as from GLOBOCAN,the Cancer Incidence and Mortality Worldwide cancer database.Health states in the model included non-neoplasia,mild dysplasia,moderate dysplasia,high-grade dysplasia,intramucosal carcinoma,operable cancer,inoperable cancer,and death.Separate ESCC incidence transition rates were generated for the average-risk and high-risk populations.Costs in Chinese currency were converted to international dollars(I$)and were adjusted to 2012dollars using the Consumer Price Index.RESULTS:The main outcome measurements for this study were quality-adjusted life years(QALYs)and incremental cost-effectiveness ratio(ICER).For the average-risk population,the HRME screening strategy produced 0.043 more QALYs than the no screening strategy at an additional cost of I$646,resulting in an ICER of I$11808 per QALY gained.Standard endoscopic screening was weakly dominated.Among the high-risk population,when the HRME screening strategy was compared with the standard screening strategy,the ICER was I$8173 per QALY.For both the high-risk and average-risk screening populations,the HRME screening strategy appeared to be the most cost-effective strategy,producing ICERs below the willingness-topay threshold,I$23500 per QALY.One-way sensitivity analysis showed that,for the average-risk population,higher specificity of Lugol’s iodine(>40%)and lower specificity of HRME(<70%)could make Lugol’s iodine screening cost-effective.For the high-risk population,the results of the model were not substantially affected by varying the follow-up rate after Lugol’s iodine screening,Lugol’s iodine test characteristics(sensitivity and specificity),or HRME specificity.CONCLUSION:The incorporation of HRME into an ESCC screening program could be cost-effective in China.Larger studies of HRME performance are needed to confirm these findings. | Chin Hur Sung Eun Choi Chung Yin Kong Gui-Qi Wang Hong Xu Alexandros D Polydorides Li-Yan Xue Katherine E Perzan Angela C Tramontano Rebecca R Richards-Kortum Sharmila Anandasabapathy | 2015 | World Journal of Gastroenterology2015，21，18： | 8 |
| 2 | Stability of fruit quality traits in diverse watermelon cultivars tested in multiple environments显示文摘Lycopene is a naturally occurring red carotenoid compound that is found in watermelon.Lycopene has antioxidant properties.Lycopene content,sugar content and hollowheart resistance are subject to significant genotype×environment interaction(G×E),which makes breeding for these fruit quality traits difficult.The objectives of this study were to(i)evaluate the influence of years and locations on lycopene content,sugar content and hollowheart resistance for a set of watermelon genotypes,and(ii)identify genotypes with high stability for lycopene,sugar,and hollowheart resistance.A diverse set of 40 genotypes was tested over 3 years and 8 locations across the southern United States in replicated,multi-harvest trials.Lycopene was tested in a subset of 10 genotypes.Data were analyzed using univariate and multivariate stability statistics(BLUP-GGE biplot)using SASGxE and RGxE programs.There were strong effects of environment as well as G×E interaction on watermelon quality traits.On the basis of stability measures,genotypes were classified as stable or unstable for each quality trait.'Crimson Sweet'is an inbred line with high quality trait performance as well as trait stability.'Stone Mountain','Tom Watson','Crimson Sweet'and'Minilee'were among the best genotypes for lycopene content,sugar content and hollowheart resistance.We developed a stability chart based on marketable yield and average ranking generated from different stability measures for yield attributes and quality traits.The chart will assist in choosing parents for improvement of watermelon cultivars.See http://cuke.hort.ncsu.edu/cucurbit/wmelon/wmelonmain.html. | Mahendra Dia Todd C Wehner Penelope Perkins-Veazie Richard Hassell Daniel S Price George E Boyhan Stephen M Olson Stephen R King Angela R Davis Gregory E Tolla Jerome Bernier Benito Juarez | 2016 | Horticulture Research2016，3，1： | 2 |
| 3 | Benign versus malignant solid breast masses: US differentiation显示文摘 | GUITA R ANGELA C S | 1999 | Radiology1999，213，： | 1 |
| 4 | Mental Workload and Visual Impairment: Differences be- tween Pupil, Blink, and Subjective Rating 显示文摘 | Miguel A R Elisa P Angela C | 2008 | The Spanish Journal of Psychology2008，11，2： | 1 |
| 5 | Synthesis of analogues of calicheamicin and neocarzinostatin chromophore显示文摘 | Alessandra C Angela R M John M | 2004 | Tetrahedron2004，60，： | 1 |
| 6 | Antimicrobial susceptibility, phage types, and pulsetypes of Salmonella typhimurium, in Sao Paulo, Brazil 显示文摘 | ANGELA C R G AANTT SUELI A F | 2006 | Mem Inst Oswaldo Cruz Rio de Janeiro2006，101，3： | 1 |
| 7 | Benign versus malignant solid breast masses: US differentiation显示文摘 | Guitar R Angela C S | 1999 | Radiology1999，21，3： | 1 |
| 8 | Thermogravimetric kinetic model of the combustion of a varnish waste based on polyurethane显示文摘 | ANGELA N C FONT R ESPERANZA M M | 2001 | Energy Fuels2001，15，4： | 1 |
| 9 | Comparison of interfer- on-/ release assays and tuberculin skin test in predicting active tu- berculosis (TB) in children in the UK- apaediatric TB network stud- y显示文摘 | Bamford A R Angela C M Clark J E | 2010 | Arch Dis Child2010，95，： | 1 |
| 10 | 流行病学和临床研究中数据缺失的多重填补:机会和陷阱显示文摘许多研究都存在缺失数据。Jonathan | Jonathan A C Sterne Ian R White John B Carlin Michael Spratt Patrick Royston Michael G Kenward Angela M Wood James R Carpenter 张清(译) 张孔来(校) | 2009 | 英国医学杂志中文版2009，12，6： | 1 |
| 11 | Polypharmacy in elderly patients 显示文摘 | Emily R Hajjar Angela C | 2007 | Am J Geriatric Pharmacotherapy2007，5，4： | 1 |
| 12 | Genetic diversity among Capsicum accessions using RAPD markers显示文摘 | Fabiane R D C Telma N S P Angela P V | 2006 | Crop Breeding and Applied Biotechnology2006，6，： | 1 |
| 13 | An unusual vana- dium (11) promoted hydrogenation of a magnesium tetraim- inediphenolate compound yielding an asymmetric oxovana- dium ( IV ) maerocyclic complex 显示文摘 | Angela C R Vagner R S Henrique E T | 2004 | Polyhedron2004，，23： | 1 |
| 14 | Cbfa1 , a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development显示文摘 | Florian Otto Anders P Thornell Tessa Crompton Angela Denzel Kimberly C Gilmour Ian R Rosewell Gordon W.H Stamp Rosa S.P Beddington Stefan Mundlos Bjorn R Olsen Paul B Selby Michael J Owen | 1997 | Cell1997，，5： | 1 |
| 15 | RNA isolation method for polysaccharide rich algae: agar producing Gracilaria tenuistipitata (Rhodophyta) 显示文摘 | Vanessa D R F Angela P T Mariana C O | 2008 | J Appl Phycol2008，20，： | 1 |
| 16 | Benign versus malignant solid breast masses:US differentiation显示文摘 | GUITA R ANGELA C S | 1999 | Radiology1999，213，： | 1 |
| 17 | Suitability of soil microbial parameters as indicators of heavy metal pollution显示文摘 | Simona C Angela R F Amalia V D S | 2004 | Water Air and Soil Pollution2004，158，1： | 1 |
| 18 | Bactericidal action of illuminated TiO2 on pure Escherichia coli and natural bacterial consortia : post - irradiation events in the dark and assessment of the effective disinfection time显示文摘 | Angela - Guiovana R Pulgarin C | 2004 | Applied Catalysis B :Environmenta2004，151，： | 1 |
| 19 | A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause 显示文摘 | Karl R Hansen Nicholas S Knowlton Angela C Thyer | 2008 | Human Reproduction2008，23，3： | 1 |
| 20 | Analytical modeling of harmonic analysis of line current of VSI-FED drives显示文摘 | Guido C Fabrizio I Angela R | 2004 | IEEE Transactions on Power Delivery2004，19，3： | 1 |
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