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| 1 | Contemporary meta-analysis of short-term probiotic consumption on gastrointestinal transit显示文摘AIM: To determine the efficacy of probiotic supplementation on intestinal transit time(ITT) in adults and to identify factors that influence these outcomes. METHODS: We conducted a systematic review of randomized controlled trials of probiotic supplementation that measured ITT in adults. Study quality was assessed using the Jadad scale. A random effects meta-analysis was performed with standardized mean difference(SMD) of ITT between probiotic and control groups as the primary outcome. Meta-regression and subgroup analyses examined the impact of moderator variables on SMD of ITT.RESULTS: A total of 15 clinical trials with 17 treatment effects representing 675 subjects were included in this analysis. Probiotic supplementation was moderately efficacious in decreasing ITT compared to control, with an SMD of 0.38(95%CI: 0.23-0.53, P < 0.001). Subgroup analyses demonstrated statistically greater reductions in ITT with probiotics in subjects with vs without constipation(SMD: 0.57 vs 0.22, P < 0.01) and in studies with high vs low study quality(SMD: 0.45 vs 0.00, P = 0.01). Constipation(R^2 = 38%, P < 0.01), higher study quality(R^2 = 31%, P = 0.01), older age(R^2 = 27%, P = 0.02), higher percentage of female subjects(R^2 = 26%, P = 0.02), and fewer probiotic strains(R^2 = 20%, P < 0.05) were predictive of decreased ITT with probiotics in meta-regression. Medium to large treatment effects were identified with B. lactis HN019(SMD: 0.67, P < 0.001) and B. lactis DN-173 010(SMD: 0.54, P < 0.01) while other probiotic strains yielded negligible reductions in ITT relative to control.CONCLUSION: Probiotic supplementation is moderately efficacious for reducing ITT in adults. Probiotics were most efficacious in constipated subjects, when evaluated in high-quality studies, and with certain probiotic strains. | Larry E Miller Angela K Zimmermann Arthur C Ouwehand | 2016 | World Journal of Gastroenterology2016，22，21： | 2 |
| 2 | Characterization of Hepatitis C Virus Resistance from a Multiple-Dose Clinical Trial of the Novel NS5A Inhibitor GS-5885显示文摘 | Kelly A. Wong Angela Worth Ross Martin Evguenia Svarovskaia Diana M. Brainard Eric Lawitz Michael D. Miller Hongmei Mo | 2013 | Antimicrobial Agents and Chemotherapy2013，，12： | 2 |
| 3 | Necrotizing pancreatitis: Operating for life显示文摘 | Brian J Miller F.R.A.C.S. Alan Henderson F.R.C.A.P. Russell W. Strong F.R.C.A.S. George A. Fielding F.R.A.C.S. Angela M. DiMarco M.B. B.S. Barry S. O’Loughlin F.R.C.A.S | 1994 | World Journal of Surgery1994，，6： | 1 |
| 4 | The TGFBR1*6A/9A polymorphism is not associated with differential risk of breast cancer显示文摘 | Gabrielle Colleran Niall McInerney Andrew Rowan Ella Barclay Angela M. Jones Catherine Curran Nicola Miller Michael Kerin Ian Tomlinson Elinor Sawyer | 2010 | Breast Cancer Research and Treatment2010，，2： | 1 |
| 5 | Low penetrance breast cancer predisposition SNPs are site specific显示文摘 | Niall Mcinerney Gabrielle Colleran Andrew Rowan Axel Walther Ella Barclay Sarah Spain Angela M. Jones Stephen Tuohy Catherine Curran Nicola Miller Michael Kerin Ian Tomlinson Elinor Sawyer | 2009 | Breast Cancer Research and Treatment2009，，1： | 1 |
| 6 | Necrotizing pancreatitis: Operating for life显示文摘 | Brian J Miller F.R.A.C.S. Alan Henderson F.R.C.A.P. Russell W. Strong F.R.C.A.S. George A. Fielding F.R.A.C.S. Angela M. DiMarco M.B. B.S. Barry S. O’Loughlin F.R.C.A.S | 1994 | World Journal of Surgery1994，，6： | 1 |
| 7 | Expansion and contraction of major histocompatibility complex genes: a teleostean example显示文摘 | Kristina M. Miller Karia H. Kaukinen Angela D. Schulze | 2002 | Immunogenetics (-)2002，，10： | 1 |
| 8 | A behavior and physiology-based decision support tool to predict thermal comfort and stress in non-pregnant,mid-gestation,and late-gestation sows显示文摘Background:Although thermal indices have been proposed for swine,none to our knowledge differentiate by reproductive stage or predict thermal comfort using behavioral and physiological data.The study objective was to develop a behavior and physiology-based decision support tool to predict thermal comfort and stress in multiparous(3.28±0.81)non-pregnant(n=11),mid-gestation(n=13),and late-gestation(n=12)sows.Results:Regression analyses were performed using PROC MIXED in SAS 9.4 to determine the optimal environmental indicator[dry bulb temperature(TDB)and dew point]of heat stress(HS)in non-pregnant,mid-gestation,and lategestation sows with respiration rate(RR)and body temperature(TB)successively used as the dependent variable in a cubic function.A linear relationship was observed for skin temperature(T_(S))indicating that TDB rather than the sow HS response impacted T_(S)and so T_(S)was excluded from further analyses.Reproductive stage was significant for all analyses(P<0.05).Heat stress thresholds for each reproductive stage were calculated using the inflections points of RR for mild HS and TB for moderate and severe HS.Mild HS inflection points differed for non-pregnant,mid-gestation,and late gestation sows and occurred at 25.5,25.1,and 24.0℃,respectively.Moderate HS inflection points differed for non-pregnant,mid-gestation,and late gestation sows and occurred at 28.1,27.8,and 25.5℃,respectively.Severe HS inflection points were similar for non-pregnant and mid-gestation sows(32.9℃)but differed for late-gestation sows(30.8℃).These data were integrated with previously collected behavioral thermal preference data to estimate the TDB that non-pregnant,mid-gestation,and late-gestation sows found to be cool(TDB | Betty R.McConn Allan P.Schinckel Lindsey Robbins Brianna N.Gaskill Angela R.Green‑Miller Donald C.Lay Jr Jay S.Johnson | 2023 | Journal of Animal Science and Biotechnology2023，14，2： | 0 |
| 9 | Mass cytometry uncovers a distinct peripheral immune profile and upregulated CD38 expression in patients with hidradenitis suppurativa显示文摘Hidradenitis suppurativa(HS)is a chronic inflammatory skin disease with a worldwide prevalence of 0.3–4.0%,wherein abscesses and dermal sinus tracts form in intertriginous skin[1].HS remains poorly treated due to a lack of knowledge regarding its immunopathogenesis[2]. | Peter Dimitrion Iltefat Hamzavi Congcong Yin Jugmohit Toor Kalpana Subedi Namir Khalasawi Angela Miller Richard Huggins Indra Adrianto Jesse Veenstra Gautham Vellaichamy Aakash Hans Steven Daveluy Mohammad Athar Wilson Liao Henry Lim David Ozog Li Zhou Qing-Sheng Mi | 2023 | Cellular & Molecular Immunology2023，20，8： | 0 |
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