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| 1 | Biometric and ICL-related risk factors associated to sub-optimal vaults in eyes implanted with implantable collamer lenses显示文摘Background:To identify biometric and implantable collamer lens(ICL)-related risk factors associated with suboptimal postoperative vault in eyes implanted with phakic ICL.Methods:This study reports a retrospective case series of the first operated eye in 360 patients implanted with myopic spherical or toric ICL.Preoperatively,white-to-white(WTW),central keratometry(Kc)and central corneal thickness(CCT)were measured using the Pentacam.Anterior-segment optical coherence tomography(AS-OCT,Visante)was applied preoperatively for measuring the horizontal anterior-chamber angle-to-angle distance(ATA),internal anterior chamber depth(ACD),crystalline lens rise(CLR),anterior-chamber angle(ACA)and postoperatively the vault.Eyes were divided into three vault groups:low(LVG:≤250μm),optimal(OVG:>250 and<1000μm)and high(HVG:≥1000μm).Multinomial logistic regression(MLR)was used to find the sub-optimal vault predictors.Results:MLR showed that CLR,ICL size minus the ATA(ICL size-ATA),age,ICL spherical equivalent(ICLSE)and ICL size as contributing factors for sub-optimal vaults(pseudo-R2=0.40).Increased CLR(OR:1.01,CI:1.00-1.01)and less myopic ICLSE(OR:1.22,CI:1.07-1.40)were risk factors for low vaults.Larger ICL size-ATA(OR:41.29,CI:10.57-161.22)and the 13.7mm ICL(OR:7.08,CI:3.16-15.89)were risk factors for high vaults,whereas less myopic ICLSE(OR:0.85,CI:0.76-0.95)and older age(OR:0.92,CI:0.88-0.98)were protective factors.Conclusion:High CLR and low ICLSE were the major risk factors in eyes presenting low vaults.In the opposite direction,ICL size-ATA was the major contributor for high vaults.This relationship was more critical in higher myopic ICLSE,younger eyes and when 13.7mm ICL were used.The findings show that factors influencing the vault have differentiated weight of influence depending on the type of vault(low,optimal or high). | Santiago Cerpa Manito Angel Sánchez Trancón Oscar Torrado Sierra António Manuel Baptista Pedro Miguel Serra | 2021 | Eye and Vision2021，8，1： | 5 |
| 2 | Optimal synthesis of regeneration systems subject to environmental constraints显示文摘 | Monica Carvalho Luis Maria Serra Miguel Angel | 2011 | Energy2011，36，6： | 1 |
| 3 | Polylactones Influence of Various Metals Salts on the Optical Purity of Poly (L-lactide)显示文摘 | SERRA ANGELS | 1995 | Polymer Bulletin1995，14，： | 1 |
| 4 | The EXAMINATION (Everolimus-Eluting Stents Versus Bare-Metal Stents in ST-Segment Elevation Myocardial Infarction) Trial显示文摘 | Manel Sabaté Salvatore Brugaletta Angel Cequier Andrés I?iguez Antonio Serra Rosana Hernádez-Antolín Vicente Mainar Marco Valgimigli Maurizio Tespili Pieter den Heijer Armando Bethencourt Nicolás Vázquez Bianca Backx Patrick W. Serruys | 2013 | JACC: Cardiovascular Interventions2013，，： | 1 |
| 5 | Incidence and risk factors for hepacellular carcinoma in 967 patients with cirrhosis显示文摘 | Juan Angel del Olmo Miguel Angel Serra Felicidad Rodriguez | 1998 | J Cancer Res Clin Oncol1998，124，： | 1 |
| 6 | New aro- matic-aliphatic hyperbranched polyesters with vinylie end groups of different length as modifiers of epoxy/anhydride thermosets 显示文摘 | Adrian Tomuta Francesc Ferrando Angels Serra | 2012 | Reac- tive & Functional Polymers2012，72，： | 1 |
| 7 | Novel epoxy-anhydride thermosets modified with a hyperbranched polyester as toughness enhancer. I. Kinetics study显示文摘 | Marjorie Flores Xavier Fernández-Francos Xavier Ramis Angels Serra | 2012 | Thermochimica Acta2012，，： | 1 |
| 8 | Study on the chemicalmodification of epoxy/anhydride thermosets using a hydroxyl terminatedhyperbranched polymer显示文摘 | DavidFoix Yingfeng Yu Angels Serra | 2009 | European Polymer Journal2009，45，5： | 1 |
| 9 | Fresh embryo transfer versus frozen embryo transfer in in vitro fertilization cycles: a systematic review and meta-analysis显示文摘 | Matheus Roque Karinna Lattes Sandra Serra Ivan Solà Selmo Geber Ramón Carreras Miguel Angel Checa | 2012 | Fertility and Sterility2012，，： | 1 |
| 10 | The EXAMINATION (Everolimus-Eluting Stents Versus Bare-Metal Stents in ST-Segment Elevation Myocardial Infarction) Trial显示文摘 | Manel Sabaté Salvatore Brugaletta Angel Cequier Andrés I?iguez Antonio Serra Rosana Hernádez-Antolín Vicente Mainar Marco Valgimigli Maurizio Tespili Pieter den Heijer Armando Bethencourt Nicolás Vázquez Bianca Backx Patrick W. Serruys | 2013 | JACC: Cardiovascular Interventions2013，，： | 1 |
| 11 | Comparison of Newer-Generation Drug-Eluting Stents With Bare-Metal Stents in Patients With Acute ST-Segment Elevation Myocardial Infarction显示文摘 | Manel Sabaté Lorenz R?ber Dik Heg Salvatore Brugaletta Henning Kelbaek Angel Cequier Miodrag Ostojic Andrés I?iguez David Tüller Antonio Serra Andreas Baumbach Clemens von Birgelen Rosana Hernandez-Antolin Marco Roffi Vicente Mainar Marco Valgimigli Patri | 2013 | JACC: Cardiovascular Interventions2013，，： | 1 |
| 12 | Incidence and risk factors for hepacellular carcinoma in 967 patients with cirrhosis 显示文摘 | Juan Angel del Olmo Miguel Angel Serra Felicidad Rodriguez et al | 1998 | J Cancer Res Clin Oncol1998，124，： | 1 |
| 13 | Biometric and ICL-related risk factors associated to sub-optimal vaults in eyes implanted with implantable collamer lenses显示文摘Background To identify biometric and implantable collamer lens(ICL)-related risk factors associated with sub-optimal postoperative vault in eyes implanted with phakic ICL.Methods This study reports a retrospective case series of the first operated eye in 360 patients implanted with myopic spherical or toric ICL.Preoperatively,white-to-white(WTW),central keratometry(Kc)and central corneal thickness(CCT)were measured using the Pentacam.Anterior-segment optical coherence tomography(AS-OCT,Visante)was applied preoperatively for measuring the horizontal anterior-chamber angle-to-angle distance(ATA),internal anterior chamber depth(ACD),crystalline lens rise(CLR),anterior-chamber angle(ACA)and postoperatively the vault.Eyes were divided into three vault groups:low(LVG:≤250μm),optimal(OVG:>250 and<1000μm)and high(HVG:≥1000μm).Multinomial logistic regression(MLR)was used to find the sub-optimal vault predictors.Results MLR showed that CLR,ICL size minus the ATA(ICL size-ATA),age,ICL spherical equivalent(ICLSE)and ICL size as contributing factors for sub-optimal vaults(pseudo-R2=0.40).Increased CLR(OR:1.01,CI:1.00–1.01)and less myopic ICLSE(OR:1.22,CI:1.07–1.40)were risk factors for low vaults.Larger ICL size-ATA(OR:41.29,CI:10.57–161.22)and the 13.7 mm ICL(OR:7.08,CI:3.16–15.89)were risk factors for high vaults,whereas less myopic ICLSE(OR:0.85,CI:0.76–0.95)and older age(OR:0.92,CI:0.88–0.98)were protective factors.Conclusion High CLR and low ICLSE were the major risk factors in eyes presenting low vaults.In the opposite direction,ICL size-ATA was the major contributor for high vaults.This relationship was more critical in higher myopic ICLSE,younger eyes and when 13.7 mm ICL were used.The findings show that factors influencing the vault have differentiated weight of influence depending on the type of vault(low,optimal or high). | Santiago Cerpa Manito Angel Sánchez Trancón Oscar Torrado Sierra António Manuel Baptista Pedro Miguel Serra | 2023 | Eye and Vision2023，9，5： | 0 |
| 14 | Effectiveness and safety of first-generation protease inhibitors in clinical practice:Hepatitis C virus patients with advanced fibrosis显示文摘AIM:To evaluates the effectiveness and safety of the first generation,NS3/4A protease inhibitors(PIs) in clinical practice against chronic C virus,especially in patients with advanced fibrosis. METHODS:Prospective study and non-experimental analysis of a multicentre cohort of 38 Spanish hospitals that includes patients with chronic hepatitis C genotype 1,treatment-na?ve(TN) or treatment-experienced(TE),who underwent triple therapy with the first generation NS3/4A protease inhibitors,boceprevir(BOC) and telaprevir(TVR),in combination with pegylated interferon and ribavirin. The patients were treatment in routine practice settings. Data on the study population and on adverse clinical and virologic effects were compiled during the treatment period and during follow up.RESULTS:One thousand and fifty seven patients were included,405(38%) were treated with BOC and 652(62%) with TVR. Of this total,30%(n = 319) were TN and the remaining were TE:28%(n = 298) relapsers,12%(n = 123) partial responders(PR),25%(n = 260) null-responders(NR) and for 5%(n = 57) with prior response unknown. The rate of sustained virologic response(SVR) by intention-to-treatment(ITT) was greater in those treated with TVR(65%) than in those treated with BOC(52%)(P < 0.0001),whereas by modified intention-to-treatment(m ITT) no were found significant differences. By degree of fibrosis,56% of patients were F4 and the highest SVR rates were recorded in the non-F4 patients,both TN and TE. In the analysis by groups,the TN patients treated with TVR by ITT showed a higher SVR(P = 0.005). However,by m ITT there were no significant differences between BOC and TVR. In the multivariate analysis by m ITT,the significant SVR factors were relapsers,IL28 B CC and non-F4; the type of treatment(BOC or TVR) was not significant. The lowest SVR values were presented by the F4-NR patients,treated with BOC(46%) or with TVR(45%). 28% of the patients interrupted the treatment,mainly by non-viral response(51%):this outcome was more frequent in the TE than in the TN patients(57% vs 40%,P = 0.01). With respect to severe haematological disorders,neutropaenia was more likely to affect the patients treated with BOC(33% vs 20%,P ≤ 0.0001),and thrombocytopaenia and anaemia,the F4 patients(P = 0.000,P = 0.025,respectively). CONCLUSION:In a real clinical practice setting with a high proportion of patients with advanced fibrosis,effectiveness of first-generation PIs was high except for NR patients,with similar SVR rates being achieved by BOC and TVR. | Javier Salmeron Carmen Vinaixa Ruben Berenguer Juan Manuel Pascasio Juan Jose Sanchez Ruano Miguel angel Serra Ana Gila Moises Diago Manuel Romero-Gomez Jose Maria Navarro Milagros Testillano Conrado Fernandez Dolores Espinosa Isabel Carmona Jose Antonio Pons Francisco Jorquera Francisco Javier Rodriguez Ramon Perez Jose Luis Montero Rafael Granados Miguel Fernandez Ana Belen Martin Paloma Munoz de Rueda Rosa Quiles | 2015 | World Journal of Gastroenterology2015，21，30： | 0 |
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