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| 1 | A promising diagnostic method:Terahertz pulsed imaging and spectroscopy显示文摘The terahertz band lies between the microwave and infrared regions of the electromagnetic spectrum.This radiation has very low photon energy and thus it does not pose any ionization hazard for biological tissues.It is strongly attenuated by water and very sensitive to water content.Unique absorption spectra due to intermolecular vibrations in this region have been found in different biological materials.These unique features make tera-hertz imaging very attractive for medical applications in order to provide complimentary information to existing imaging techniques.There has been an increasing interest in terahertz imaging and spectroscopy of biologically related applications within the last few years and more and more terahertz spectra are being reported.This paper introduces terahertz technology and provides a short review of recent advances in terahertz imaging and spectroscopy techniques,and a number of applications such as molecular spectroscopy,tissue characterization and skin imaging are discussed. | Ming Yiu Sy Yi-Xiang J Wang Anil T Ahuja Emma Pickwell-MacPherson | 2011 | World Journal of Radiology2011，3，3： | 7 |
| 2 | Circular smooth muscle contributes to esophageal shortening during peristalsis显示文摘AIM:To study the angle between the circular smooth muscle(CSM) and longitudinal smooth muscle(LSM) fibers in the distal esophagus.METHODS:In order to identify possible mechanisms for greater shortening in the distal compared to proximal esophagus during peristalsis,the angles between the LSM and CSM layers were measured in 9 cadavers.The outer longitudinal layer of the muscularis propria was exposed after stripping the outer serosa.The inner circular layer of the muscularis propria was then revealed after dissection of the esophageal mucosa and the underlying muscularis mucosa.Photographs of each specimen were taken with half of the open esophagus folded back showing both the outer longitudinal and inner circular muscle layers.Angles were measured every one cm for 10 cm proximal to the squamocolumnar junction(SCJ) by two independent investigators.Two human esophagi were obtained from organ transplant donors and the angles between the circular and longitudinal smooth muscle layers were measured using micro-computed tomography(micro CT) and Image J software.RESULTS:All data are presented as mean ± SE.The CSM to LSM angle at the SCJ and 1 cm proximal to SCJ on the autopsy specimens was 69.3 ± 4.62 degrees vs 74.9 ± 3.09 degrees,P = 0.32.The CSM to LSM angle at SCJ were statistically significantly lower than at 2,3,4 and 5 cm proximal to the SCJ,69.3 ± 4.62 degrees vs 82.58 ± 1.34 degrees,84.04 ± 1.64 degrees,84.87 ± 1.04 degrees and 83.72 ± 1.42 degrees,P = 0.013,P = 0.008,P = 0.004,P = 0.009 respectively.The CSM to LSM angle at SCJ was also statistically significantly lower than the angles at 6,7 and 8 cm proximal to the SCJ,69.3 ± 4.62 degrees vs 80.18 ± 2.09 degrees,81.81 ± 1.75 degrees and 80.96 ± 2.04 degrees,P = 0.05,P = 0.02,P = 0.03 respectively.The CSM to LSM angle at 1 cm proximal to SCJ was statistically significantly lower than at 3,4 and 5 cm proximal to the SCJ,74.94 ± 3.09 degrees vs 84.04 ± 1.64 degrees,84.87 ± 1.04 degrees and 83.72 ± 1.42 degrees,P = 0.019,P = 0.008,P = 0.02 respectively.At 10 cm above SCJ the angle was 80.06 ± 2.13 degrees which is close to being perpendicular but less than 90 degrees.The CSM to LSM angles measured on virtual dissection of the esophagus and the stomach on micro CT at the SCJ and 1 cm proximal to the SCJ were 48.39 ± 0.72 degrees and 50.81 ± 1.59 degrees.Rather than the angle of the CSM and LSM being perpendicular in the esophagus we found an acute angulation between these two muscle groups throughout the lower 10 cm of the esophagus.CONCLUSION:The oblique angulation of the CSM may contribute to the significantly greater shortening of distal esophagus when compared to the mid and proximal esophagus during peristalsis. | Anil K Vegesna Keng-Yu Chuang Ramashesai Besetty Steven J Phillips Alan S Braverman Mary F Barbe Michael R Ruggieri Larry S Miller | 2012 | World Journal of Gastroenterology2012，18，32： | 7 |
| 3 | Staining for p53 and Ki-67 increases the sensitivity of EUS-FNA to detect pancreatic malignancy显示文摘AIM:To investigate whether tumor marker staining can improve the sensitivity of endoscopic ultrasound-guided fine needle aspiration(EUS-FNA)to diagnose pancreatic malignancy. METHODS:Patients who underwent EUS-FNA were retrospectively identified.Each EUS-FNA specimen was evaluated by routine cytology and stained for tumor markers p53,Ki-67,carcinoembryonic antigen(CEA) and CA19-9.Sensitivity,specificity,positive and negative predictive values(PPV and NPV),and positive and negative likelihood ratios(PLR and NLR)were calculated in order to evaluate the performance of each test to detect malignancy. RESULTS:Sixty-one specimens had complete sets of stains,yielding 49 and 12 specimens from pancreatic adenocarcinomas and benign pancreatic lesions due to pancreatitis,respectively.Cytology alone had sensitivity and specificity of 41%and 100%to detect malignancy, respectively.In 46%of the specimens,routine cytology alone was deemed indeterminate.The addition of either p53 or Ki-67 increased the sensitivity to 51%and 53%,respectively,with perfect specificity,PPV and PLR (100%,100%and infinite).Both stains in combination increased the sensitivity to 57%.While additional staining with CEA and CA19-9 further increased the sensitivity to 86%,the specificity,PPV and PLR were significantly reduced(at minimum 42%,84%and 1,respectively).Markers in all combinations performed poorly as a negative test(NPV 26%to 47%,and NLR 0.27 and 0.70).CONCLUSION:Immunohistochemical staining for p53 and Ki-67 can improve the sensitivity of EUS-FNA to diagnose pancreatic adenocarcinoma. | Alexander W Jahng Sonya Reicher David Chung Donna Varela Rahul Chhablani Anil Dev Binh Pham Jose Nieto Rose J Venegas Samuel W French Bruce E Stabile Viktor E Eysselein | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，11： | 3 |
| 4 | Central role of myeloid MCPIP1 in protecting against LPSinduced inflammation and lung injury显示文摘Although systemic inflammatory responses attributable to infection may lead to significant lung injury,the precise molecular mechanisms leading to lung damage are poorly understood and therapeutic options remain limited.Here,we show that myeloid monocyte chemotactic protein-inducible protein 1(MCPIP1)plays a central role in protecting against LPS-induced inflammation and lung injury.Myeloid-specific MCPIP1 knockout mice developed spontaneous inflammatory syndromes,but at a late age compared to global MCPIP1 knockout mice.Moreover,mice with a myeloid-specific deletion of MCPIP1 were extremely sensitive to LPS-induced lung injury due to overproduction of proinflammatory cytokines and chemokines.We identified C/EBPβand C/EBPδ,two critical transcriptional factors that drive cytokine production and lung injury,as targets of MCPIP1 RNase.LPS administration caused MCPIP1 protein degradation in the lungs.Pharmacological inhibition of MALT1,a paracaspase that cleaves MCPIP1,by MI-2 selectively increased the MCPIP1 protein levels in macrophages and in the lungs.Meanwhile,administration of MI-2 protected mice from LPS-induced inflammation,lung injury and death.Collectively,these results indicate that myeloid MCPIP1 is central in controlling LPS-induced inflammation and lung injury.Pharmacological inhibition of MALT1 protease activity may be a good strategy to treat inflammatory diseases by enhancing MCPIP1 expression in myeloid cells. | Yong Li Xuan Huang Shengping Huang Hui He Tianhua Lei Fatma Saaoud Xiao-Qiang Yu Ari Melnick Anil Kumar Christopher J Papasian Daping Fan Mingui Fu | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 2 |
| 5 | Structural and functional organization of the animal fatty acid synthase显示文摘 | STUART S ANDRZEJ W ANIL K J | 2003 | Prog Lipid Res2003，40，： | 1 |
| 6 | Data clustering:50 years beyond K-Means显示文摘 | Anil K J | | 0，，08： | 1 |
| 7 | Matching of Palmprlnts显示文摘 | Nicolae Duta Anil K J a in Kanti V Mardia | 2002 | Pattern Recognition Letters2002，23，： | 1 |
| 8 | Serum androgen levels in adolescents with type 1 diabetes:relationship to pubertal stage and metabolic control显示文摘 | Meyer K Deutscher J Anil M | 2000 | J Endocrinol Invest2000，23，6： | 1 |
| 9 | Deformable template models : a review 显示文摘 | Anil K J Yu Zhong Dubuisson M P | 1998 | Signal Processing1998，71，2： | 1 |
| 10 | Data clustering: 50 years beyond K-means 显示文摘 | Anil K J | 2010 | Pattern Recognition Letters2010，31，8： | 1 |
| 11 | Resetting semiactives tiffness damper for seismic response control 显示文摘 | Jann N Y Kim J H Anil K A | 2000 | ASCE Journal of Structural Engineering2000，126，14： | 1 |
| 12 | 显示文摘 | Anil Kumar P S Shrotri J J Deshpands C E | 1997 | J Appl Phys1997，81，6： | 1 |
| 13 | Data clustering:50 years beyond K-Means显示文摘 | Anil K J | 2010 | Pattern Recognition Letters2010，31，8： | 1 |
| 14 | Data clustering : 50 years beyond K-means显示文摘 | ANIL K J | 2010 | Pattern Recognition Letters2010，31，8： | 1 |
| 15 | Energy distribution, net energy conserving rate and energy conserving efficiency of Cassia obtusifoliu 显示文摘 | Anil P J | 1981 | Geobios1981，8，6： | 1 |
| 16 | Effect of cylinder speed and feed rate on the performance of thresher显示文摘 | Anil J Guruswamy T Desai S R | 1998 | Karnataka Journal of Agricultural Sciences1998，，4： | 1 |
| 17 | Data clustering:50 years beyond K-means显示文摘 | Anil K J | | 0，，08： | 1 |
| 18 | Text information extraction in images and video: a survey 显示文摘 | KEECHUL J ANIL K J | 2004 | Pattern Recognition2004，37，5： | 1 |
| 19 | Data clustering: 50 years beyond K-Means显示文摘 | ] Anil K J | 2010 | Pattern Recognition Letters2010，31，8： | 1 |
| 20 | Unsupervised learning of finite mixture models 显示文摘 | Mario A T F Anil K J | 2002 | IEEE Transactions on pattern analysis and machine intelligence2002，24，3： | 1 |
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