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| 1 | Phase Ⅰ/Ⅱ randomized controlled trial of autologous bone marrow-derived mesenchymal stem cell therapy for chronic stroke显示文摘AIM To examine the safety and efficacy of mesenchymal stem cell(MSC) therapy for intracerebral haemorrhage with neurological dysfunctions for a year.METHODS MSC were ex vivo expanded from 29 mL(17-42 mL) autologous bone marrow. Patients were randomized to have two intravenous injections of autologous MSC or placebos in four weeks apart. Neurological functions and clinical outcomes were monitored before treatment and at 12^(th), 16^(th), 24^(th), 36^(th) and 60^(th) week upon completion of^(th)e treatment. RESULTS A mean of 4.57 × 10~7(range: 1.43 × 10~7-8.40 × 10~7) MSC per infusion was administered accounting to 8.54 × 10~5(2.65 × 10~5-1.45 × 10~6) per kilogram body weight in two occasions. There was neither adverse event at time of administration nor sign of de novo tumour development among patients after monitoring for a year post MSC therapy. Neuro-restoration and clinical improvement in terms of modified Barthel index, functional independence measure and extended Glasgow Outcome Scale were evident among patients having MSC therapy compared to patients receiving placebos. CONCLUSION Intravenous administration of autologous bone marrowderived MSC is safe and has the potential of improving neurological functions in chronic stroke patients with severe disability. | Kam Sze Tsang Chi Ping Stephanie Ng Xian Lun Zhu George Kwok Chu Wong Gang Lu Anil Tejbhan Ahuja Ka Sing Lawrence Wong Ho Keung Ng Wai Sang Poon | 2017 | World Journal of Stem Cells2017，9，8： | 3 |
| 2 | Optimization of media components for chitinase production by chickpea rhizosphere associated Lysinibacillus fusiformis B-CM18 显示文摘 | Rajesh KS Praveen K Manoj KS Pratiksha S Alok KS Sudheer K Prem LK Anil KS Pradeep KS Dilip KA | 2013 | J Basic Microbiol2013，53，5： | 1 |
| 3 | Acute basal ganglia infarcts in poststroke fatigue: an MRI study显示文摘 | Wai Kwong Tang Yang Kun Chen Vincent Mok Winnie C. W. Chu Gabor S. Ungvari Anil T. Ahuja Ka Sing Wong | 2010 | Journal of Neurology2010，，2： | 1 |
| 4 | Use of Transcranial Doppler Ultrasound to Predict Outcome in Patients With Intracranial Large-Artery Occlusive Disease显示文摘 | Ka Sing Wong Huan Li Yu Leung Chan Anil Ahuja Wynnie W. M. Lam Agatha Wong Richard Kay | 2000 | Stroke: Journal of the American Heart Association2000，，11： | 1 |
| 5 | Ionotropic cross-linked chitosan microspheres for controlled release of ampiciUin 显示文摘 | Anil KA Willem FS Carmen RL | 2006 | International Journal of Pharmaceutics2006，312，： | 1 |
| 6 | Ionotropic cross- linked chitosan microspheres for controlled release of ampicillin显示文摘 | Anil KA Willem FS Carmen RL | 2006 | Intern J Pharmaceutic2006，312，12： | 1 |
| 7 | 香港儿童服用低剂量三聚氰胺后肾脏并发症的现况调查研究显示文摘目的 调查香港儿童服用小剂量三聚氰胺后的肾脏并发症。
设计 横断面调查方法。
机构 香港专业评估中心。
调查对象 根据全港初级医疗保健中心的记录,研究包括3170例(1748例男童,1422例女童)≤12岁、连续1个月或以上服用被三聚氰胺污染奶制品的儿童。
主要评估指标 是否存在肾结石和血尿。
结果 1例儿童存在肾结石,7例儿童肾脏内可疑存在三聚氰胺结晶,应用尿试纸检查发现208例(6.6%)儿童存在血尿。这些儿童在专业评估中心进一步检查后,仅有7.4%的儿童确实存在显微镜下血尿,所以总体儿童血尿出现率低于1%。
结论:在曾服用小剂量三聚氰胺的儿童中,没有急性肾功能衰竭或尿路梗阻等严重不良事件发生。我们的研究结果与全港调查一致。即使将7例肾内可疑存在三聚氰胺结晶的患儿包括在内,应用超声检查发现的可疑三聚氰胺相关不良事件发生率也仅为0.2%,且这些患儿尚不需要进一步治疗。应用尿试纸检测是否存在血尿,可能会过高估计血尿的发生率。研究结果提示对于曾服用小剂量三聚氰胺的儿童进行大范围、积极的检查可能并不会得到更多有意义的资料,所以不值得投入更多的经费去进行这种检查。 | Hugh S Lam Pak C Ng Winnie C W Chu William Wong Dorothy F Y Chan Stella S Ho Ka T Wong Anil T Ahuja Chi K Li 张宁(译) 杨勇(校) | 2009 | 英国医学杂志中文版2009，12，3： | 0 |
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