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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Aortic valve repair using a differentiated surgical strategy 显示文摘 | Frank L Diana A Anke K | 2004 | Circulation2004，110，11： | 1 |
| 3 | Phenotypie and eyto- toxic characteristics of the immune cells of the human placenta 显示文摘 | GOLDSOBEL A ANK B SPINA C | 1986 | Cell Immunol1986，97，2： | 1 |
| 4 | 测定血清S100蛋白用于诊断克-雅病:前瞻性病例对照研究显示文摘目的:分析克-雅病(Creutzfeldt-Jakob dis-ease,CJD)患者及对照组血清中脑特异性 S100蛋白浓度。设计:前瞻性病例对照研究。研究单位:国家 CJD 监测站。研究对象:224例疑为 CJD 的转诊患者及35例无痴呆的对照病例。主要结果测定:CJD 患者、其他疾病引起的痴呆患者及对照组血清 S100浓度。结果:224例疑为 CJD 的患者中,65例经病理证实确诊;6例有基因突变而肯定诊断;43例很可能患 CJD;36例可能患 CJD;74例患有其他疾病。108例为肯定或很可能 CJD 患者,其血清 S100浓度中位数为395 pg/ml(SD 387 pg/ml)。这明显高于患其他疾病的74例患者(S100浓度中位数为109pg/ml,SDl77pg/ml;P=0.0001)。以213pg/ml为界值,S100测定用于 CJD 诊断的敏感性为77.8%(95%的可信区间为66.8%~85.2%),特异性为81.1%(70.3%~89.3%)。在 Kaplan-Meier 曲线上,不同浓度 S100患者的存活时间差异有显著性(P=0.023)。结论:S100血清浓度测定是一种有价值的工具,在 CJD 的鉴别诊断中,较测定脑脊液更有价值。尚需更多的研究以确定连续测定是否有助于提高此病的诊断准确性。 | Markus Otto Jens Wiltfang Ekkehard Schtz Ingo Zerr Anke Otto Annette Pfahlberg Olaf Gefeller Manfred Uhr Armin Giese Thomas Weber Hans A Kretzschmar Sigrid Poser 张星虎 | 1998 | 英国医学杂志中文版1998，0，1： | 1 |
| 5 | Fatty acids and other compounds with nematicidal activity from cultures of Basidiomycetcs显示文摘 | STADLER M MAYER A ANKE H | 1994 | Planta Medics1994，60，2： | 1 |
| 6 | Cycloepoxydon,1-hydroxy-2-hydroxymethyl-3-pent-1-enylbenzene and 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene,new inhibitors of eukaryotic signal transduction显示文摘 | Gehrt A Erkel G Anke T | | 0，，： | 1 |
| 7 | Secondary metabolites with nematicidal activity from nematophagous fungi and ascomycetes显示文摘 | ANKE H STADLER M MAYER A | 1995 | Can J Botany1995，72，： | 1 |
| 8 | Lung volumes in tetraplegic patients according to cervical spinal cord injury level显示文摘 | Anke A Aksnes AK Stanghelle JK et el | 1993 | Scand J Rehabil Med1993，25，： | 1 |
| 9 | Lung development in the mouse em-bryo显示文摘 | Ten H O Ank A W | | 0，，02： | 1 |
| 10 | Chemical-induced apoptotoc cell death in tomato cells:involvement of caspase-like proteases显示文摘 | ANKE J De JONG FRANK A H | 2000 | Planta2000，211，： | 1 |
| 11 | Lung volumes in tetraplegic patients according to cervical spinal cord injury level 显示文摘 | Anke A Aksnes AK Stanghelle JK | 1993 | Scand J Rehabil Med1993，25，： | 1 |
| 12 | Dermatolactone,a cytotoxic fungal sesquiterpene with a novel skeleton显示文摘 | Mayer A Anke H Sterner O 1996 | 1996 | Phytochemistry1996，43，2： | 1 |
| 13 | Fungal natural products in research and develnpmem 显示文摘 | Schueffler A Anke T | 2014 | Nat Pro Rep2014，31，： | 1 |
| 14 | Fatty acids and other compounds with nematicidal activity from cultures of basidio mycetes显示文摘 | Stadler M Mayer A Anke H | 1994 | Planta Med1994，60，： | 1 |
| 15 | Fatty acids and other components with nematicidal activities from cultures of basidiomycetes显示文摘 | Stadler M Mayer A Anke H 1994 | 1994 | Planta Med1994，60，1： | 1 |
| 16 | Fungal natural products in research and development 显示文摘 | Schueffler A Anke T | 2014 | Nat Prod Rep2014，31，10： | 1 |
| 17 | A meta-analysis of con- straint-induced movement therapy after stroke 显示文摘 | Thrane G Friborg O Anke A | 2014 | J Rehabil Med2014，46，9： | 1 |
| 18 | Chemical - induced apoptotic cell death in tomato cells: involvement of caspase-like proteases显示文摘 | Anke J J Frank A H Elena T Y | | 0，，： | 1 |
| 19 | Eating problems and nutritional status during hospital stay of patients with severe stroke显示文摘 | Asplund K Norberg A | 1998 | J Am Diet Assoc1998，89，： | 1 |
| 20 | Secondary metabolites with nematicldal activity from nematophagous fungi and ascomycetes显示文摘 | Anke H Stadler M Mayer A | 1995 | Canadian Journal of Botany1995，72，： | 1 |
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