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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis显示文摘 | Mary Eapen Vanderson Rocha Guillermo Sanz Andromachi Scaradavou Mei-Jie Zhang William Arcese Anne Sirvent Richard E Champlin Nelson Chao Adrian P Gee Luis Isola Mary J Laughlin David I Marks Samir Nabhan Annalisa Ruggeri Robert Soiffer Mary M Horowitz Eli | 2010 | Lancet Oncology2010，，7： | 2 |
| 3 | How to monitor semi-natural key habitats in relation to grazing preferences of cattle in mountain summer farming areas an aerial photo and GPS method study显示文摘 | Hanne S Margareta I Ann N | 2004 | Landscape and Urban Planning2004，67，： | 1 |
| 4 | Membrane filtration characteristics in membrane coupled activated sludge system: rile effect of flock structure of activated sludge on membrane fouling显示文摘 | Chang I S Lee C H Ann K H | 1999 | Water Science Technology1999，34，9： | 1 |
| 5 | Interracial polycondensation and characterization of polyphosphates and poly-phosphonates 显示文摘 | Pdchards M Dahiyat B I Ann D M | 1991 | J Polym Science Part A:Polym Chem1991，29，8： | 1 |
| 6 | Induce of chitinase, fl- 1,3- glucanase, andphenylalanine ammonia lyase in peach fruit by UV-C t~eatment显示文摘 | Ahmed E I Ghaouth Charles L Wilson Ann M Callahan | 2003 | Phytopathology J2003，93，3： | 1 |
| 7 | Measuring corporate environmental performance显示文摘 | ANNE Y I NAOMI S THOMAS T E | 1998 | Journal of Accounting and Public Policy1998，17，： | 1 |
| 8 | Inflammatory mechanisms in preeclampsia显示文摘 | Ann - Charlotte I | 2013 | Pregnancy Hypertens2013，3，2： | 1 |
| 9 | Metabolomic changes in fatty liver can be modified by dietary protein and calcium during energy restriction显示文摘AIM: To characterise the effect of energy restriction (ER) on liver lipid and primary metabolite profile by using metabolomic approach. We also investigated whether the effect of energy restriction can be further enhanced by modif ication of dietary protein source and calcium. METHODS: Liver metabolomic profile of lean and obese C57Bl/6J mice (n = 10/group) were compared with two groups of weight-reduced mice. ER was performed on control diet and whey protein-based high-calcium diet (whey + Ca). The metabolomicanalyses were performed using the UPLC/MS based lipidomic platform and the HPLC/MS/MS based primary metabolite platform. RESULTS: ER on both diets significantly reduced hepatic lipid accumulation and lipid droplet size, while only whey + Ca diet significantly decreased blood glucose (P < 0.001) and serum insulin (P < 0.01). In hepatic lipid species the biggest reduction was in the level of triacylglycerols and ceramides while the level of cholesterol esters was significantly increased during ER. Interestingly, diacylglycerol to phospholipid ratio, an indicator of relative amount of diabetogenic diglyceride species, was increased in the control ER group, but decreased in the whey + Ca ER group (P < 0.001, vs obese). ER on whey + Ca diet also totally reversed the obesity induced increase in the relative level of lipotoxic ceramides (P < 0.001, vs obese; P > 0.05, vs lean). These changes were accompanied with up-regulated TCA cycle and pentose phosphate pathway metabolites. CONCLUSION: ER-induced changes on hepatic metabolomic profile can be significantly affected by dietary protein source. The therapeutic potential of whey protein and calcium should be further studied. | Taru K Pilvi Tuulikki Seppnen-Laakso Helena Simolin Piet Finckenberg Anne Huotari Karl-Heinz Herzig Riitta Korpela Matej Orei Eero M Mervaala | 2008 | World Journal of Gastroenterology2008，14，28： | 1 |
| 10 | Reduction of sludge by ozone treatment and production of carbon source for denitrifieation显示文摘 | Ann K H Yeom I T Park K Y | 2002 | Water Science & Technology2002，46，11： | 1 |
| 11 | Sonochemi-cal approach to the synthesis of Fe3 04 @ Si02 core-shell nanoparticles with tunable properties 显示文摘 | Anne L M Sergei I N Karine G | 2008 | ACSnano2008，2，5： | 1 |
| 12 | Electrochemical lithium intercalation in disordered mangan ese oxides显示文摘 | Palos A I Anne M Strobel P | 2001 | Solid State Ionics2001，138，： | 1 |
| 13 | Numerical modelling of inhibited electrical discharges in air显示文摘 | Larsson A Anne B C Gallimberti I | 1998 | J Phys D: Appl Phys1998，31，2： | 1 |
| 14 | Fundamental processes in long air gap discharges显示文摘 | Gallimberti I Bacchiega G Anne B C | 2002 | C R Physique2002，3，13： | 1 |
| 15 | Efficacy and side effects of praziquantel against Schistosoma mansoni in a community of western C?te d’Ivoire显示文摘 | Giovanna Raso Eliézer K N'Goran Abale Toty Anne Luginbühl Cynthia A Adjoua Norbert T Tian-Bi Isaac I Bogoch Penelope Vounatsou Marcel Tanner Jürg Utzinger | 2003 | Transactions of the Royal Society of Tropical Medicine and Hygiene2003，，1： | 1 |
| 16 | The Application of Methyl Glucoside Shale Inhibitor in Sodium Chloride Mud 显示文摘 | ISSAM I ANN P H | 2009 | Jurnal Teknologi2009，，： | 1 |
| 17 | Murine spinal cord explants: A model for evaluating axonal growth and myelination in vitro显示文摘 | Thomson C E Anne M Greffiths I R | 2006 | Neurosci Res2006，84，8： | 1 |
| 18 | Reduction of sludge by ozone treatment and production of carbon source for denitrification显示文摘 | ANN K H YEOM I T PARK K Y | 2002 | Water Science and Technology2002，46，11： | 1 |
| 19 | Serrated polyps of the colon: how reproducible is their classification?显示文摘 | Arzu Ensari Banu Bilezik?i Fatima Carneiro Gülen Bülbül Do?usoy Ann Driessen Ay?e Dursun Jean-Fran?ois Flejou Karel Geboes Gert de Hertogh Anne Jouret-Mourin Cord Langner Ir?s D. Nagtegaal Johan Offerhaus Janina Orlowska Ari Ristim?ki Julian Sanz-Ortega B | 2012 | Virchows Archiv2012，，5： | 1 |
| 20 | Workflow-based application显示文摘 | I EYM ANN F ROLLER D | 1997 | BM System Journal1997，36，1： | 1 |
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