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| 1 | Evidence for the involvement of infectious agents in the pathogenesis of Crohn's disease显示文摘Many advances have been made in the understanding of Crohn’s disease (CD) pathogenesis during the last decade. CD is currently seen as a predominantly T-lym-phocyte-driven disease characterized by the presence of a complex cocktail of interacting cytokines, chemokines and other mediators produced by a variety of cell types. Prevailing theories of CD pathogenesis suggest that patients’ T-lymphocytes are inappropriately activated in the setting of an immune imbalance, which is itself caused by an unfortunate confluence of genetic and en- vironmental factors. The T-cell response then leads to the chronic inflammation characteristic for the disease. Various environmental factors may play a role in the development of CD, but microbes are most consistently implied. This theory is based on epidemiological, clinico- pathological, genetic and experimental evidence. Despite the abundance of arguments for the implication of bac-teria in the aetiopathogenesis of CD, the precise role of bacteria in this disease still remains elusive. Three not necessarily mutually exclusive theories have been pro- posed: (1) an unidentified persistent pathogen; (2) an abnormally permeable mucosal barrier leading to exces-sive bacterial translocation; and (3) a breakdown in the balance between putative 'protective' versus 'harmful' intestinal bacteria ('dysbiosis'). At present, one cannot exclude with certainty any of these three proposed hy-potheses; they may all apply to CD to a certain extent. | Gert De Hertogh Jeroen Aerssens Karen P Geboes Karel Geboes | 2008 | World Journal of Gastroenterology2008，14，6： | 11 |
| 2 | Regulatory macrophages induced by infliximab are involved in healing in vivo and in vitro显示文摘 | Anne Christine W.Vos Manon E.Wildenberg IngridArijs MarjolijnDuijvestein Auke P.Verhaar Gertde Hertogh SéverineVermeire PaulRutgeerts Gijs R.van den Brink Daniel W.Hommes | 2012 | Inflamm Bowel Dis2012，，3： | 2 |
| 3 | Ornidazole for prophylaxis of postoperative Crohn’s disease recurrence: A randomized, double-blind, placebo-controlled trial显示文摘 | Paul Rutgeerts Gert van Assche Séverine Vermeire Geert D’Haens Filip Baert Maja Noman Isolde Aerden Gert de Hertogh Karel Geboes Martin Hiele Andre D’Hoore Freddy Penninckx | 2005 | Gastroenterology2005，，4： | 2 |
| 4 | Reciprocal changes of Foxp3 expression in blood and intestinal mucosa in IBD patients responding to infliximab 显示文摘 | Li Z Arijs I De Hertogh G | 2010 | Inflamm Bowel Dis2010，16，8： | 1 |
| 5 | Advance directives in dementia : issues of validity and effectiveness显示文摘 | de Boer M E Hertogh C M Dr es R M | 2010 | Int Psychogeriatr2010，22，2： | 1 |
| 6 | Fear of falling in patients with hip fractures:prevalence and related psychological factors显示文摘 | Visschedijk J van Balen R Hertogh C | 2014 | J Am Med Dir Assoc2014，14，3： | 1 |
| 7 | 肠肌层神经丛炎预测克罗恩病术后早期复发的价值 | Ferrante M. de Hertogh G. Hlavaty T. G.van Assche 尹勇 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，0，10： | 1 |
| 8 | Reciprocal changes of Foxp3 expression in blood and intestinal mucosa in IBD patients responding to infliximab 显示文摘 | Li Z Arijs I De Hertogh G | 2010 | Inflamm Bowel Dis2010，16，8： | 1 |
| 9 | Stimulatory and inhibitory effects of glucose and insulin on rat blastocyst development in vitro显示文摘 | De Hertogh R Vanderheyden I Pampfer S | 1991 | Diabetes1991，40，5： | 1 |
| 10 | Sudden death in persons younger than 40 years of age: incidence and cau- ses 显示文摘 | VaarQes I Hendrix A Hertogh EM etal | 2009 | Eur J Cardiovasc Prev Rehabil2009，16，5： | 1 |
| 11 | Morphologic and immunohistochemical characterization of granulomas in the nucleotide oligomerization domain: 2-related disorders Blau syndrome and Crohn disease 显示文摘 | Janssen CE Rose CD de Hertogh G | 2012 | J Allergy Clin Immunol2012，129，： | 1 |
| 12 | Do right PLS and do PLS right: A critical review of the application of PLS-SEM in construction management research显示文摘Partial least squares structural equation modeling(PLS-SEM)is a modern multivariate analysis technique with a demonstrated ability to estimate theoretically established cause-effect relationship models.This technique has been increasingly adopted in construction management research over the last two decades.Accordingly,a critical review of studies adopting PLS-SEM appears to be a timely and valuable endeavor.This paper offers a critical review of 139 articles that applied PLS-SEM from 2002 to 2019.Results show that the misuse of PLS-SEM can be avoided.Critical issues related to the application of PLS-SEM,research design,model development,and model evaluation are discussed in detail.This paper is the first to highlight the use and misuse of PLS-SEM in the construction management area and provides recommendations to facilitate the future application of PLS-SEM in this field. | Ningshuang ZENG Yan LIU Pan GONG Marcel HERTOGH Markus KÖNIG | 2021 | Frontiers of Engineering Management2021，8，3： | 1 |
| 13 | Serrated polyps of the colon: how reproducible is their classification?显示文摘 | Arzu Ensari Banu Bilezik?i Fatima Carneiro Gülen Bülbül Do?usoy Ann Driessen Ay?e Dursun Jean-Fran?ois Flejou Karel Geboes Gert de Hertogh Anne Jouret-Mourin Cord Langner Ir?s D. Nagtegaal Johan Offerhaus Janina Orlowska Ari Ristim?ki Julian Sanz-Ortega B | 2012 | Virchows Archiv2012，，5： | 1 |
| 14 | T cell activation,apoptosis and cytokine dysregulation in the (co)pathogenesis of HIV and pulmonary tuberculosis (TB)显示文摘 | Wajja A Ntambi L | 2000 | Clin Exp Immunol (Clinical & Experimental Immunology)2000，122，3： | 1 |
| 15 | Temperature regulation of endogenous gibberellin actity and development of Tulipa gesneriana L 显示文摘 | Aung L H De hertogh A A Staby G | 1969 | Plant PhysioL1969，44，： | 1 |
| 16 | Intestinalimmune activation in presumed post-infectious functionaldyspepsia 显示文摘 | Kindt S Tertychnyy A de Hertogh G | 2009 | Neurogastroenterol Motil2009，21，8： | 1 |
| 17 | Epithelioid granulomas,pattern recognition receptors,and phenotypes of Crohn' s disease显示文摘 | Pierik M De Hertogh G Vermeire S | 2005 | Gut2005，54，2： | 1 |
| 18 | CD27 defines pheno?typically and functionally different human NK cell subsets 显示文摘 | Vossen M T Matmati M Hertoghs K M et at | 2008 | J Im?munol2008，180，6： | 1 |
| 19 | Sudden death in persons young-er than 40 years of ageiincidence and causes显示文摘 | Vaartjes I Hendrix A Hertogh EM | 2009 | Eur J Cardiovasc PrevRehabil2009，16，3： | 1 |
| 20 | The effects of precooling temperatures and durations on forcing of Lilium longiflorum, 'Nellie White' 显示文摘 | Fanelli F L de Hertogh A A | 2002 | Acta Hort2002，5708，： | 1 |
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