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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 3 | Analysis of a Successful Immune Response against Hepatitis C Virus显示文摘 | Stewart Cooper Ann L Erickson Erin J Adams Joe Kansopon Amy J Weiner David Y Chien Michael Houghton Peter Parham Christopher M Walker | 1999 | Immunity1999，，4： | 3 |
| 4 | Factors influen- cing chloride transport and chloride threshold level for the prediction of service life of concrete structures 显示文摘 | SONG H ANN K Y PACK S | 2010 | International Journal of Structural Engineering2010，1，2： | 1 |
| 5 | Mechanisms of hypoxic regulation of plasminogen activator inhibitor-1 gene expression in keloid fibroblasts 显示文摘 | Zhang Q Wu Y Ann DK | 2003 | J Invest Dermatol2003，121，5： | 1 |
| 6 | Characterization of a chitinase gene from Stenotrophomonas maltophilia strain 34S1 and its involvement in biological control显示文摘 | DONALD Y K RALPH M R JULIE ANN B | 2002 | Appl Environ Microbiol2002，68，： | 1 |
| 7 | Durabilityof recycled aggregate concrete using pozzolanicmaterials显示文摘 | ANN K Y MOON H Y KIM Y B | 2008 | Waste Management2008，28，6： | 1 |
| 8 | A stable Ni-B catalyst in hydrogen generation 'via NaBH4 hydrolysis显示文摘 | LEE J K ANN H YI Y | 2011 | Catalysis Communications2011，16，1： | 1 |
| 9 | Atherosclerotic lesions in lymphoma survivors treated with radiotherapy显示文摘 | Torgeir Wethal B?rd Nedregaard Rune Andersen Alexander Foss? May Brit Lund Anne Günther Stein Kval?y Sophie D. Foss? John Kjekshus | 2013 | Radiotherapy and Oncology2013，，： | 1 |
| 10 | Antioxidant activity of grape extracts in a lecithin liposome syste 显示文摘 | Ock-snook Y Anne S M Edwin N F | 1997 | JAOCS1997，74，10： | 1 |
| 11 | The GAPS in practice显示文摘 | Anne G Shannon B Margaret Y | 2003 | Arch Pediatr Adolesc Med2003，157，5： | 1 |
| 12 | Variation in the chloride threshold level for steel corrosion in concrete arising from different chloride sources显示文摘 | RYOU J S ANN K Y | 2008 | Magazine of Con- crete Research2008，60，： | 1 |
| 13 | Increased vascular endothelial growth factor may account for elevated level of plasminogen activator inhibitor-1 via activating ERK1/2 in keloid fibroblasts显示文摘 | ZHANG Q ANN D K | 2004 | Am J Physiol Cell Physiol2004，286，4： | 1 |
| 14 | Measuring corporate environmental performance显示文摘 | ANNE Y I NAOMI S THOMAS T E | 1998 | Journal of Accounting and Public Policy1998，17，： | 1 |
| 15 | Educating students with TBI: Themes and recommendations显示文摘 | Mark Y Bonnie T Ann G | 2001 | The Journal of Head Trauma Rehabilitation2001，16，1： | 1 |
| 16 | Increased vascular endothelial growth factor may account for elevated level of plasminogen activator inhibitor-1 via activating ERK1/2 in keloid fibroblasts显示文摘 | Wu Y Zhang Q Ann DK | 2004 | Am J Physiol Cell Physiol2004，286，4： | 1 |
| 17 | Blood-brain barrier pathophysiology and ischaemic brain edema 显示文摘 | Gasche Y Copin JC Ann Fr Anesth Reanim | 2003 | Anesth Reanim2003，22，4： | 1 |
| 18 | Factors influencing chlo- ride transport in concrete structures exposed to marine envi- ronments显示文摘 | SONG H W LEE C H ANN K Y | 2008 | Cement and Concrete Composites2008，30，2： | 1 |
| 19 | Reduction of sludge by ozone treatment and production of carbon source for denitrifieation显示文摘 | Ann K H Yeom I T Park K Y | 2002 | Water Science & Technology2002，46，11： | 1 |
| 20 | Antioxidant activity of grape ex tracts in a lecithin liposome system显示文摘 | Ock-snook Y Anne SM Edwin NF | 1997 | JAOCS1997，74，10： | 1 |
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