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11篇 您的检索式：作者名="Alex Loukas"

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		题名	作者	年代	出处	被引量
	1	Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis.	Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels	2010	World Journal of Gastroenterology2010，16，6：	11
	2	Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm显示文摘	Jeffrey Bethony Simon Brooker Marco Albonico Stefan M Geiger Alex Loukas David Diemert Peter J Hotez	2006	The Lancet2006，，9521：	2
	3	Opisthorchiasis and Opisthorchis -associated cholangiocarcinoma in Thailand and Laos显示文摘	Banchob Sripa Jeffrey M. Bethony Paiboon Sithithaworn Sasithorn Kaewkes Eimorn Mairiang Alex Loukas Jason Mulvenna Thewarach Laha Peter J. Hotez Paul J. Brindley	2010	Acta Tropica2010，，：	2
	4	The tumorigenic liver fluke Opisthorchis viverrini – multiple pathways to cancer显示文摘	Banchob Sripa Paul J. Brindley Jason Mulvenna Thewarach Laha Michael J. Smout Eimorn Mairiang Jeffrey M. Bethony Alex Loukas	2012	Trends in Parasitology2012，，10：	1
	5	Cloning and expression of an aquaporin-like gene from a parasitic nematode显示文摘	Alex Loukas Peter Hunt Rick M. Maizels	1999	Molecular & Biochemical Parasitology1999，，2：	1
	6	Ultrasonography assessment of hepatobiliary abnormalities in 3359 subjects with Opisthorchis viverrini infection in endemic areas of Thailand显示文摘	Eimorn Mairiang Thewarach Laha Jeffrey M. Bethony Bandit Thinkhamrop Sasithorn Kaewkes Paiboon Sithithaworn Smarn Tesana Alex Loukas Paul J. Brindley Banchob Sripa	2011	Parasitology International2011，，1：	1
	7	Current Status of Vaccines for schistoso miasis显示文摘	Donald PM Alex Loukas	2008	Clin Microbiol Rev2008，21，1：	1
	8	Schistosomiasis vaccine discovery using immunomics 显示文摘	Patrick Driguez Denise L Doolan Alex Loukas	2010	Parasit Vector2010，3，：	1
	9	Worms and the Treatment of Inflammatory Bowel Disease: Are Molecules the Answer?显示文摘	Nathalie E. Ruyssers Benedicte Y. De Winter Joris G. De Man Alex Loukas Arnold G. Herman Paul A. Pelckmans Tom G. Moreels Jiri Mestecky	2008	Clinical and Developmental Immunology2008，，：	1
	10	Prognostic significance of peroxiredoxin 1 and ezrin-radixin-moesin–binding phosphoprotein 50 in cholangiocarcinoma显示文摘	Ponlapat Yonglitthipagon Chawalit Pairojkul Yaovalux Chamgramol Alex Loukas Jason Mulvenna Jeffrey Bethony Vajarabhongsa Bhudhisawasdi Banchob Sripa	2012	Human Pathology2012，，10：	1
	11	Proteomic profile of Bithynia siamensis goniomphalos snails upon infection with the carcinogenic liver fluke Opisthorchis viverrini显示文摘	Sattrachai Prasopdee Smarn Tesana Cinzia Cantacessi Thewarach Laha Jason Mulvenna Rudi Grams Alex Loukas Javier Sotillo	2015	Journal of Proteomics2015，，：	1

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