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| 1 | Endoscopic submucosal dissection for the treatment of neoplastic lesions in the gastrointestinal tract显示文摘AIM: To investigate the indications, resection rate, and safety of endoscopic submucosal dissection (ESD) for neoplastic lesions in the gastrointestinal tract at a European referral center. METHODS: We carried out a retrospective analysis of the ESD procedures performed in our center for mucosal neoplastic and submucosal lesions of the gastrointestinal tract. The duration of the procedure, en bloc and complete (R0) resection rates, and complication rates were evaluated. Variables were reported as mean ± SD or simple proportions. Univariate analysis and comparisons of procedure times and resection rates were performed using Mann-Whitney U tests, or χ2 tests for dichotomous variables.RESULTS: Between 2007 and 2011, ESD was performed in a total of 103 patients (46.7% male, mean age 64.0 ± 12.7 years). The indications for the procedure were epithelial tumor (n = 54), submucosal tumor (n = 42), or other (n = 7). The total en bloc resection rate was 90.3% (93/103) and R0 resection rate 80.6% (83/103). The median speed of the procedure was 15.0 min/cm2 . The complete resection rate was lower for submucosal tumors arising from the muscle layer (68%, 15/22, P < 0.05). Resection speed was quicker for submucosal tumors localized in the submucosal layer than for lesions arising from the muscularis propria layer (8.1 min/cm 2 vs 17.9 min/cm 2 , P < 0.05). The R0 resection rate and speed were better in the last 24 mo (90.1%, 49/54 and 15.3 min/cm 2 ) compared to the first 3 years of treatment (73.5%, 36/49, P < 0.05 and 22.0 min/cm2 , P < 0.05). Complications occurred in 14.6% (n = 15) of patients, including perforation in 5.8% (n = 6), pneumoperitoneum in 3.9% (n = 4), delayed bleeding in 1.9% (n = 2), and other in 2.9% (n = 3). Only one patient with delayed perforation required surgical treatment. During the mean follow-up of 26 ± 15.3 mo, among patients with R0 resection, recurrence occurred in one patient (1.2%).CONCLUSION: ESD is an effective and safe method for resection of neoplastic lesions with low recurrence. Speed and the R0 resection rate increased after 50 procedures. | Andrzej Biaek Anna Wiechowska-Kozowska Jan Pertkiewicz Katarzyna Karpińska Wojciech Marlicz Piotr Milkiewicz Teresa Starzyńska | 2013 | World Journal of Gastroenterology2013，19，12： | 21 |
| 2 | Knowledge of tuberculosis and associated health - seeking behaviour among rural Vietnamese adults with a cough for at least three weeks 显示文摘 | Nguyen PH Anna EK Nguyen HL | 2003 | Stand J Public Health2003，31，： | 1 |
| 3 | Preparation, characterization and antimicrobial efficiency of Ag/PDDA-diatomite nanocomposite显示文摘 | Ale? Paná?ek Anna Balzerová Robert Prucek Václav Ranc Renata Ve?e?ová Vendula Husi?ková Ji?í Pechou?ek Jan Filip Radek Zbo?il Libor Kvítek | 2013 | Colloids and Surfaces B: Biointerfaces2013，，： | 1 |
| 4 | A comparative study of fuzzy rough set显示文摘 | Anna MR Etienne EK | | 0，，02： | 1 |
| 5 | Kinetic parameters from thermogravimetric study of used rubber granulates–polyurethane composites显示文摘 | W. W. Su?kowski S. Mistarz T. Borecki M. Moczyński A. Danch J. Borek M. Maci??ek Anna Su?kowska | 2006 | Journal of Thermal Analysis and Calorimetry2006，，1： | 1 |
| 6 | Endoscopic submucosal dissection for treatment of gastric subepithelial tumors (with video)显示文摘 | Andrzej Bia?ek Anna Wiechowska-Koz?owska Jan Pertkiewicz Marcin Polkowski Piotr Milkiewicz Katarzyna Karpińska Ma?gorzata ?awniczak Teresa Starzyńska | 2012 | Gastrointestinal Endoscopy2012，，2： | 1 |
| 7 | Heavy metal pollution and lake acidity changes caused by one thousand years of copper mining at Falun central Sweden 显示文摘 | S EK Anna Ingemar Renberg | 2001 | Journal of paleolimnology2001，26，1： | 1 |
| 8 | The present and future role of microfluidics inbiomedical research显示文摘 | Sackmann EK Anna LF David JB | 2014 | Nature2014，507，7491： | 1 |
| 9 | Patient empowerment in intensive care - An interview study显示文摘 | Ingrid W Anna - Christina EK Ewa I | 2006 | Intensive and Critical Care Nursing2006，22，： | 1 |
| 10 | Factors influencing the failure of interferon-free therapy for chronic hepatitis C:Data from the Polish EpiTer-2 cohort study显示文摘BACKGROUND The introduction of direct-acting antiviral drugs into clinical practice has revolutionized the treatment of chronic hepatitis C,making it highly effective and safe for patients.However,few researchers have analyzed the factors causing therapy failure in some patients.AIM To analyze factors influencing the failure of direct antiviral drugs in the large,multicenter EpiTer-2 cohort in a real-world setting.METHODS The study cohort consisted of patients with chronic hepatitis C treated at 22 Polish centers from 2016-2020.Data collected from the online EpiTer-2 database included the following:hepatitis C virus(HCV)genotype,stage of fibrosis,hematology and liver function parameters,Child-Turcotte-Pugh and Model for End-stage Liver Disease scores,prior antiviral therapy,concomitant diseases,and drugs used in relation to hepatitis B virus(HBV)and/or human immunodeficiency virus(HIV)coinfections.Adverse events observed during the treatment and follow-up period were reported.Both standard and machine learning methods were used for statistical analysis.RESULTS During analysis,12614 patients with chronic hepatitis C were registered,of which 11938(mean age:52 years)had available sustained virologic response(SVR)data[11629(97%)achieved SVR and 309(3%)did not].Most patients(78.1%)were infected with HCV genotype 1b.Liver cirrhosis was diagnosed in 2974 patients,while advanced fibrosis(F3)was diagnosed in 1717 patients.We included patients with features of hepatic failure at baseline[ascites in 142(1.2%)and encephalopathy in 68(0.6%)patients].The most important host factors negatively influencing treatment efficacy were liver cirrhosis,clinical and laboratory features of liver failure,history of hepatocellular carcinoma,and higher body mass index.Among viral factors,genotype 3 and viral load also exerted an influence on treatment efficacy.Classical statistical analysis revealed that treatment ineffectiveness seemed to be influenced by the male sex,which was not confirmed by the multivariate analysis using the machine learning algorithm(random forest).Coinfection with HBV(including patients with on-treatment reactivation of HBV infection)or HIV,extrahepatic manifestations,and renal failure did not significantly affect the treatment efficacy.CONCLUSION In patients with advanced liver disease,individualized therapy(testing for resistance-associated variants and response-guided treatment)should be considered to maximize the chance of achieving SVR. | Ewa Janczewska Mateusz Franciszek Kołek Beata Lorenc Jakub Klapaczyński Magdalena Tudrujek-Zdunek Marek Sitko Włodzimierz Mazur Dorota Zarębska-Michaluk Iwona Buczyńska Dorota Dybowska Agnieszka Czauż-Andrzejuk Hanna Berak RafałKrygier Jerzy Jaroszewicz Jolanta Citko Anna Piekarska Beata Dobracka Łukasz Socha Zbigniew Deroń Łukasz Laurans Jolanta Białkowska-Warzecha Olga Tronina Brygida Adamek Krzysztof Tomasiewicz Krzysztof Simon Malgorzata Pawłowska Waldemar Halota Robert Flisiak | 2021 | World Journal of Gastroenterology2021，27，18： | 0 |
| 11 | From individual elements to macroscopic materials: in search of new superconductors via machine learning显示文摘An approach to supervised classification and regression of superconductive materials is proposed which builds on the DeepSet technology.This enables us to provide the chemical constituents of the examined compounds as an input to the algorithm,while avoiding artefacts that could originate from the chosen ordering in the list.The performance of the method are successfully challenged for both classification(tag a given material as superconducting)and regression(quantifying the associated critical temperature).We then searched through the International Mineralogical Association list with the trained neural network.Among the obtained superconducting candidates,three materials were selected to undergo a thorough experimental characterization.Superconductivity has been indeed confirmed for the synthetic analogue of michenerite,PdBiTe,and observed for the first time in monchetundraite,Pd2NiTe2,at critical temperatures in good agreement with the theory predictions.This latter is the first certified superconducting material to be identified by artificial intelligence methodologies. | Claudio Pereti Kevin Bernot Thierry Guizouarn František Laufek Anna Vymazalová Luca Bindi Roberta Sessoli Duccio Fanelli | 2023 | npj Computational Materials2023，，1： | 0 |
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