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| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma显示文摘 | Ijichi Hideaki Chytil Anna Gorska Agnieszka E Aakre Mary E Bierie Brian Tada Motohisa Mohri Dai Miyabayashi Koji Asaoka Yoshinari Maeda Shin Ikenoue Tsuneo Tateishi Keisuke Wright Christopher V E Koike Kazuhiko Omata Masao Moses Harold L | 2011 | Journal of Clinical Investigation2011，，10： | 3 |
| 3 | Pharmacological properties of Anagallis arvensis L. (“scarlet pimpernel”) and Anagallis foemina Mill. (“blue pimpernel”) traditionally used as wound healing remedies in Navarra (Spain)显示文摘 | Víctor López Anna K. J?ger Silvia Akerreta Rita Yolanda Cavero Maria Isabel Calvo | 2011 | Journal of Ethnopharmacology2011，，3： | 2 |
| 4 | Empagliflozin alleviates podocytopathy and enhances glomerular nephrin expression in db/db diabetic mice显示文摘BACKGROUND Modern guidelines recommend sodium-glucose cotransporter-2(SGLT2)inhibitors as the preferred antihyperglycemic agents for patients with type 2 diabetes and chronic kidney disease.However,the mechanisms underlying the renal protective effect of SGLT2 inhibitors are not fully understood.structure of podocytes and nephrin expression in glomeruli in db/db diabetic mice.METHODS We treated 8-wk-old male db/db mice with EMPA(10 mg/kg/d)or vehicle for 8 wk.Age-matched male db/+mice were included as non-diabetic controls.Parameters of body composition,glycemic and lipid control,and plasma concentrations of leptin,insulin and glucagon were assessed.We evaluated renal hypertrophy as kidney weight adjusted to lean mass,renal function as plasma levels of creatinine,and albuminuria as the urinary albumin-to-creatinine ratio(UACR).Renal structures were studied by light and transmission electron microscopy with a focus on mesangial volume and podocyte structure,respectively.Glomerular nephrin and transforming growth factor beta(TGF-β)were assessed by immunohistochemistry.RESULTS Severe obesity and hyperglycemia developed in db/db mice prior to the start of the experiment;increased plasma concentrations of fructosamine,glycated albumin,cholesterol,leptin,and insulin,and elevated UACR were detected.Mesangial expansion,glomerular basement membrane thickening,and increased area of TGF-βstaining in glomeruli were revealed in vehicle-treated mice.Podocytopathy was manifested by effacement of foot processes;nephrin-positive areas in glomeruli were reduced.EMPA decreased the levels of glucose,fructosamine and glycated albumin,UACR,kidney hypertrophy,mesangial expansion,glomerular basement membrane thickening,and glomerular TGF-βstaining,alleviated podocytopathy and restored glomerular staining of nephrin.CONCLUSION These data indicate that EMPA attenuates podocytopathy in experimental diabetic kidney disease.The anti-albuminuric effect of EMPA could be attributed to mitigation of podocyte injury and enhancement of nephrin expression. | Vadim V Klimontov Anton I Korbut Iuliia S Taskaeva Nataliya P Bgatova Maksim V Dashkin Nikolai BOrlov Anna S Khotskina Evgenii L Zavyalov Thomas Klein | 2020 | World Journal of Diabetes2020，11，12： | 2 |
| 5 | Accurnulation of an endogenous in hibitors of nitric oxide synthesis in chronic renalfailure显示文摘 | Patric V Anna L Alison C | 1992 | Lancet1992，339，8795： | 1 |
| 6 | The catecholamine biosynthesis route in potato is affected by stress显示文摘 | Anna W V Katarzyna L K Aleksandra S | 2004 | Plant Physiology and Biochemistry2004，42，： | 1 |
| 7 | Membrane concentration of liquid foods by forward osmosis : process and quality view 显示文摘 | SANT' ANNA V MARCZAK L D F TESSARO I C | 2012 | Journal of Food Engineering2012，111，3： | 1 |
| 8 | Phenolic and antioxidant composition of by-products from the cider industry:apple pomace显示文摘 | García Y D Belén S V Anna P L | 2009 | Food Chem2009，117，： | 1 |
| 9 | Determination of N-nitrosamines by Supersonic Molecular Beam MS Equipped with Triple Quadrupole Analyzer显示文摘 | ANNA V RIMMA S OVADIA L | 2011 | Analytica Chimica Acta2011，685，： | 1 |
| 10 | Non-linear dynamic analysis of cable-suspended structures subjected to wind actions显示文摘 | Massimiliano L Anna V S Renato V V | 2001 | Computers and Structures2001，79，： | 1 |
| 11 | Phenolic and antioxidant compo- sition of by-products from the cider industryt Apple pomace 显示文摘 | Garcia Y D Bel6n S V Anna P L | 2009 | Food Chem2009，117，： | 1 |
| 12 | Valence - band ordering and magneto - optic exciton fine structure in ZnO 显示文摘 | Walter R L Lambrecht Anna V Rodina Sukit Limpijumnong | 2002 | Physical review B2002，65，07： | 1 |
| 13 | Vascular smooth muscle cell dysfunction in patients with migraine显示文摘 | R Napoli V Guardasole E Zarra M Matarazzo C D?Anna F Saccà F Affuso A Cittadini P B. Carrieri L Saccà | 2009 | Neurology2009，，24： | 1 |
| 14 | Accumulation of an endogenous inhibitors of nitric oxide synthesis in chronic renal failure显示文摘 | Patrik V Anna L Alison C | 1992 | Lancet1992，339，8795： | 1 |
| 15 | Immunologic responses following administration of a vaccine targeting human papillomavirus Types 6,11,16, and 18 显示文摘 | Luisa L V Kevin A A Anna R G | 2006 | Vaccine2006，24，： | 1 |
| 16 | Acute alcohol intoxication显示文摘 | Luisa V Lorenzo L Anna F | 2008 | Eur J Pharmacol2008，19，8： | 1 |
| 17 | Accumulation of an endogenous inhibitors of nitric oxide synthesis in chronic renal failure显示文摘 | Anna L Aliso C | 1992 | Lancet1992，339，： | 1 |
| 18 | Photocatalytic hydrogen evolution over mesoporous TiO2/metal nanocomposites 显示文摘 | Anna V Korzhak Natalia I Ermokhina Alexander L Stroyuk | 2008 | Journal of Photochemistry and Photobiology A: Chemistry2008，198，： | 1 |
| 19 | Gastroduodenal and intestinal permeability in primary biliary cirrhosis显示文摘 | VINCENZA DI L CARLA V ANNA B | 2003 | European Journal of Gastroenterology & Hepatology2003，15，9： | 1 |
| 20 | Membrane concentration of liquid foods by forward osmosis: Process and quality view显示文摘 | Sant'Anna V Marczak L D F Tessaro I C | 2012 | Journal of Food Engineering2012，111，3： | 1 |
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