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| 1 | Systemic interleukin-9 in inflammatory bowel disease: Association with mucosal healing in ulcerative colitis显示文摘AIM To evaluate circulating IL9 in inflammatory bowel disease and disease-associated anemia/cachexia and assess its potential as a mucosal healing marker.METHODS Serum IL9 as well as other cytokines(IL1β, IL6, IL13, IFNγ, TNFα, and VEGF-A) were determined in 293 individuals: 97 patients with Crohn's disease(CD) and 74 with ulcerative colitis(UC) and in 122 apparently healthy controls. The clinical activity of CD and UC was expressed in terms of the Crohn's Disease Activity Index(CDAI) and the Mayo Scoring System(MDAI), respectively, and the severity of bowel inflammation in UC patients was assessed using Mayo endoscopic score. Cytokine concentrations were measured by a flow cytometry-based method using Luminex x MAP? technology. Highsensitive C-reactive protein concentrations(hs CRP) were determined in CD and UC patients using the enhanced immunoturbidimetric method.RESULTS Systemic IL9 was significantly lower in healthy individuals [9 pg/m L(95%CI: 8.2-10)] than in patients with inflammatory bowel disease(IBD): both inactive [14.3 pg/m L(11.9-19.9)] and active [27.6 pg/m L(24.5-32), P < 0.0001]. Cytokine concentrations were significantly higher in active CD [27.4 pg/m L(23.4-32.2)] and in active UC [32.7 pg/m L(27-38.9)] compared to inactive diseases [15.9 pg/m L(10.8-23.4) in CD and 19.4 pg/m L(13.9-27.1) in UC, P = 0.001]. IL9 correlated weakly with CDAI(ρ = 0.32, P = 0.003) and MDAI(ρ = 0.35, P = 0.002) and strongly with endoscopic inflammation in UC(ρ = 0.74, P < 0.0001). As a negative marker of mucosal healing(MH), IL9 had an accuracy superior to hs CRP and IL6 [97%(P < 0.0001), 67%(P = 0.071), and 55%(P = 0.525), respectively]. IL9 was significantly higher in cachectic IBD patients [30.25 pg/m L(24.4-37.5) vs 21.88 pg/m L(18-26.5), P = 0.026] and negatively correlated with hemoglobin concentrations(ρ =-0.27, P < 0.001). Multiple regression showed IL1β and IL13 to be the independent predictors of circulating IL9 in healthy individuals, IFNγ or IL6 in active and inactive UC, respectively, and IL13 and VEGF-A in both active and inactive CD.CONCLUSION The systemic IL9 level is higher in IBD and corresponds with endoscopic inflammation, suggesting its possible application as a negative marker of mucosal healing in UC. | Malgorzata Matusiewicz Katarzyna Neubauer Iwona Bednarz-Misa Sabina Gorska Malgorzata Krzystek-Korpacka | 2017 | World Journal of Gastroenterology2017，23，22： | 9 |
| 2 | Arabidopsis Protein Phosphatase 2C ABI1 Interacts with Type I ACC Synthases and Is Involved in the Regulation of Ozone-Induced Ethylene Biosynthesis显示文摘它的生合成严格地是的在各种各样的生物过程并且因此的一个关键角色由 multiplemechanisms 调整了的乙烯戏。Posttranslational 规定,在控制乙烯生合成枢轴,经由特定的因素的复杂相互影响影响 1-aminocyclopropane1-carboxylate synthase (交流) 蛋白质稳定性。这里,我们证明 Arabidopsis thaliana 蛋白质磷酸酶打 2C, ABI1, abscisic 酸发信号的一个否定管理者,在氧化压力条件下面涉及 ethylenebiosynthesis 的规定。我们发现 ABI1 与 ACS6 和 dephosphorylates 交往它的 C-terminalfragment,压力应答的激活 mitogen 的蛋白质 kinase 的一个目标, MPK6。另外, ABI1 控制 MPK6 也 activitydirectly 并且由这个工具影响 ACS6 phosphorylation 水平。一致地与这,在 ABI1 猛烈紧张(abi1td ) 显著地更高的导致臭氧的乙烯 productionwas 比在野类型的植物。重要地,在 abi1td 异种的导致压力的乙烯生产的增加由一个更高的 ascorbate 氧化还原作用状态被补偿并且提高了抗氧化剂活动。总的来说, thisstudy 的结果提供 ABI1 由影响 ACS6 的活动限制乙烯合成的证据。ABI1 贡献 tostress 显型支撑它在在 abscisic 酸(骆驼毛的织物) 和表明 pathways.Key 词的乙烯之间的相互影响的角色: | Agnieszka Ludwikow Agata Ciesla Anna Kasprowicz-Malusk Filip Mitula Malgorzata Tajdel lukasz Gaigarnski Piotr A. Ziolkowski Piotr Kubiak Arleta Malecka Aneta Piechalak Marta Szabat Alicja Gorska Maciej Dabrowskia Izabela Ibragimow Jan Sadowski | 2014 | Molecular Plant2014，7，6： | 6 |
| 3 | Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma显示文摘 | Ijichi Hideaki Chytil Anna Gorska Agnieszka E Aakre Mary E Bierie Brian Tada Motohisa Mohri Dai Miyabayashi Koji Asaoka Yoshinari Maeda Shin Ikenoue Tsuneo Tateishi Keisuke Wright Christopher V E Koike Kazuhiko Omata Masao Moses Harold L | 2011 | Journal of Clinical Investigation2011，，10： | 3 |
| 4 | Application of pressure driven membrane techniques to biological treatment of landfill leachate显示文摘 | J Bohdziewicz M Bodzek J Gorska | 2001 | Process Biochemistry2001，36，： | 1 |
| 5 | Relationship between clinical parameters and cytokine profiles in inflamed gingival tissue and serum samples from patients with chronic periodontitis 显示文摘 | Gorska R Gregorek H Kowalski J | 2003 | J Clin Periodonto12003，30，12： | 1 |
| 6 | Evaluation of the incidence of periodontitis-associated bacteria in the atherosclerotic plaque of coronary blood vessels 显示文摘 | Zaremba M Gorska R Suwalski P | 2007 | J Periodontol2007，78，2： | 1 |
| 7 | Nitri-fica- tion monitoring in activated sludge by oxygen uptake rate (OUR)measure- meats显示文摘 | SURMACZ - GORSKA J GERNAEY K DEMUYNCK C et 'al | 1996 | Wat Res1996，30，5： | 1 |
| 8 | Vitamin K metabolism: Current knowledge and future research显示文摘 | David J. Card Renata Gorska Jacky Cutler Dominic J. Harrington | 2014 | Mol. Nutr. Food Res2014，，： | 1 |
| 9 | Eosinophilic airway inflammation in chronic obstructive pulmonary disease and asthma显示文摘 | Gorska K Krenke R Korczynski P | 2008 | J Physiol Pharmacol2008，59，6： | 1 |
| 10 | Intercellular adhesion molecule 1 and tumor necrosis factor alpha in asthma and persistent allergic rhinitis: relationship with disease severity显示文摘 | Gorska-Ciebiada M Ciebiada M Gorska MM Gorski P Grzelewska-Rzymowska I | 2006 | Ann Allergy Asthma Immunol2006，97，1： | 1 |
| 11 | Intercellular adhesion molecule 1 and tumor necrosis factor alpha in asthma and persistent allergic rhinitis : relationship with disease severity 显示文摘 | Gorska-Ciebiada M Ciebiada M Gorska M M | 2006 | Ann Allergy Asthma Immunol2006，97，1： | 1 |
| 12 | Association of 677C > T polymorphism of methylenetetrahydrofolate reductase ( MTHFR) gene with bipolar disorder and schizophrenia 显示文摘 | Kempisty B Mostowska A Gorska I | 2006 | Neurosci Lett2006，400，： | 1 |
| 13 | Drugs used in cardiovascular diseases and cytokines显示文摘 | Rzerkt D Gorska D | 2006 | Wlad Lek2006，59，34： | 1 |
| 14 | Continuous positive airway pressure treatment increases bronchial reactivity in obstructive sleep apnea patients 显示文摘 | Korczynski P Gorska K Przybylowski T | 2009 | Respiration2009，78，40： | 1 |
| 15 | Nitrification monitoring in activated sludge by oxygen uptake rate (OUR) measurements显示文摘 | Surmacz - Gorska J Gernaey K Demuynck C | 1996 | Wat Res1996，30，5： | 1 |
| 16 | Inhibitory effects of full daylight on the germination of Lactuca sativa L显示文摘 | Gorski T Gorska K | 1979 | Planta1979，144，： | 1 |
| 17 | Hysteroscopy with directed biopsy versus dilatation and curettage for diagnosis of endometrial hyperplasia and cancer in perimenopausal women 显示文摘 | Bedner R Rzepka - Gorska I | 2007 | Eur J Gynaecol Oncol2007，28，： | 1 |
| 18 | Airway inflammation in chronic obstruction pulmonary disease 显示文摘 | Gorska K Maskey- W arzechowska M Krenke R | 2010 | Curr Opin Pulm Med2010，16，2： | 1 |
| 19 | Frequency of distribution of inflammatory cytokines IL-1,IL-6 and TNF-alpha gene polymorphism in patients with obstructive sleep apnea显示文摘 | Popko K Gorska E Potapinska O | | 0，，6： | 1 |
| 20 | Application of modified zeolites and mesoporous materials for deodorization显示文摘 | Maria Ziolek Izabela Sobczak Adam Dudzik Beata Gorska Jolanta Kujawa | 2008 | Studies in Surface Science and Catalysis2008，，： | 1 |
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