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| 1 | Role of 3'-untranslated region translational control in cancer development, diagnostics and treatment显示文摘The messenger RNA 3'-untranslated region(3'UTR)plays an important role in regulation of gene expres-sion on the posttranscriptional level. The 3'UTR con-trols gene expression via orchestrated interactionbetween the structural components of mRNAs(cis-ele-ment) and the specific trans-acting factors(RNA bind-ing proteins and non-coding RNAs). The crosstalk ofthese factors is based on the binding sequences and/or direct protein-protein interaction, or just functionalinteraction. Much new evidence that has accumulatedsupports the idea that several RNA binding factors canbind to common mRNA targets: to the non-overlappingbinding sites or to common sites in a competitive fash-ion. Various factors capable of binding to the sameRNA can cooperate or be antagonistic in their actions.The outcome of the collective function of all factorsbound to the same mRNA 3'UTR depends on manycircumstances, such as their expression levels, affinity to the binding sites, and localization in the cell, which can be controlled by various physiological conditions. Moreover, the functional and/or physical interactions of the factors binding to 3'UTR can change the character of their actions. These interactions vary during the cell cycle and in response to changing physiological condi-tions. Abnormal functioning of the factors can lead to disease. In this review we will discuss how alterations of these factors or their interaction can affect cancer development and promote or enhance the malignant phenotype of cancer cells. Understanding these altera-tions and their impact on 3'UTR-directed posttran-scriptional gene regulation will uncover promising new targets for therapeutic intervention and diagnostics. We will also discuss emerging new tools in cancer di-agnostics and therapy based on 3'UTR binding factors and approaches to improve them. | Andrii Vislovukh Thaiz Rivera Vargas Anna Polesskaya Irina Groisman | 2014 | World Journal of Biological Chemistry2014，5，1： | 6 |
| 2 | High‐sensitivity C‐reactive protein for identification of disease phenotype, active disease, and clinical relapses in Crohn’s disease: A marker for patient classification?显示文摘 | Lajos Sandor Kiss Maria Papp Barbara Dorottya Lovasz Zsuzsanna Vegh Petra Anna Golovics Eszter Janka Eva Varga Miklos Szathmari Peter Laszlo Lakatos | 2011 | Inflamm Bowel Dis2011，，9： | 1 |
| 3 | Potential role of lava lizards as pollinators across the Galápagos Islands显示文摘Lizards have been reported as important pollinators on several oceanic islands.Here we evaluate the potential role of Galápagos lava lizards(Microlophus spp.)as pollinators across their radiation.Over 3 years,we sampled pollen transport by 9 lava lizard species on the 10 islands where they are present,including 7 single-island endemics.Overall,only 25 of 296 individuals sampled(8.4%)transported pollen of 10 plant species,the most common being Prosopis juliflora,Exodeconus miersii,Sesuvium sp.and Cordia leucophlyctis.At least 8 of these plant species were native,and none were confirmed as introduced to the archipelago.Despite the low overall proportion of individuals carrying pollen,this was observed in 7 of the nine lizard species,and on 8 of the ten main islands(Española,Fernandina,Floreana,Isabela,Marchena,Pinta,Santa Cruz and Santiago),suggesting that this is a widespread interaction.The results reported here support the potential role of lava lizards as pollinators across their radiation,although they may represent a relatively modest contribution when compared with birds and insects.However,we cannot discard that lizards may be ecologically significant for particular plant species and ecosystems given the specific climatic condition and functional diversity of each island. | Sandra HERVÍAS-PAREJO Manuel NOGALES Beatriz GUZMÁN María del Mar TRIGO Jens MOLESEN Pablo VARGAS Ruben HELENO Anna TRAVESET | 2020 | Integrative Zoology2020，15，2： | 0 |
| 4 | imm cologne2019设计大赛入围作品展显示文摘本年度科隆家具展共有来自69个国家的926件作品参赛,最终有26件作品成功入围并进行展出。这项竞赛是专为大学生或刚刚完成学业的年轻设计师而设,今年芬兰阿尔托大学、荷兰埃因霍芬设计学院、瑞士洛桑艺术学院等众多著名设计学校的学生及毕业生都有参与其中。展览涵盖一系列常用家具,包括地板材料、壁纸、织物、灯具及厨房用品,或体现了可持续理念,或将常见材料与新兴材料进行了创造性的结合. | Zohair Zouirech Gal Bulka Ilja Huber Christian Cowper Joe Smith Julian Ribler Johan Vilardrich Aylene Ruschke Lena Ohmstede&Larissa Siemon INDO Riku Toivonen Mu Hau Kao Mor Dagan Rong jie Yang Jing bei Zheng Michael Varga Anna Maria Nilsson 彭佳 | 2019 | 现代装饰2019，0，2： | 0 |
| 5 | Effect of microencapsulated watermelon(Citrullus lanatus)intake on plasma amino acids and glycemic response in healthy adults显示文摘Watermelon is an L-citrulline-rich fruit that has been used as a supplement to increase L-arginine in plasma,which in turn plays a critical role in the synthesis of nitric oxide,a molecule that regulates vascular tone.Watermelon rind,similar to its pulp,presents a high L-citrulline content,yet a lower concentration of sugar,which would be more convenient for individuals who need to refrain from excessive sugar ingestion(i.e.,diabetics and obese individuals).Further,ingestion of watermelon rind can be a sustainable alternative to increase plasma L-arginine,given that rind of fruits is commonly discarded.Therefore,we evaluated the effect of ingestion of a product derived from watermelon rind and pulp(microencapsulation in spray drier)on plasma amino acids(L-citrulline,L-arginine and L-ornithine),glucose,and insulin.Eleven participants(28.36±5.70 years)were enrolled in a single blind,cross-over and randomized study.They ingested microencapsulated watermelon rind and pulp(containing 4 g of L-citrulline)plasma amino acids,glucose,and insulin were evaluated before and 30,60,90 and 120 min after ingestion.It was observed that both microencapsulated watermelon rind and pulp increased L-citrulline through 120 min and microencapsulated watermelon rind significantly increased L-arginine at 30 min.In addition,microencapsulated watermelon rind and pulp similarly increased plasma glucose and insulin levels.In conclusion,these findings suggest that both microencapsulated watermelon rind and pulp are effective to increase plasma L-citrulline and microencapsulated watermelon rind effectively increases plasma L-arginine.In addition,rind and pulp promote similar changes on plasma glucose and insulin. | Mˆonica Volino-Souza Gustavo Vieira Oliveira Rafael Vargas Anna Carolina Tavares Carlos Adam Conte-Junior Thiago da Silveira Alvares | 2022 | Food Bioscience2022，46，2： | 0 |
| 6 | Common and conflicting objectives and practices of herders and conservation managers:the need for a conservation herder显示文摘The mutual dependence of extensive land-use and conservation management has become appar-ent in Europe in the last 20-30 yr.Extensive land-use often survives in protected areas only,in the form of conservation management.Knowledge of extensive herding and that of conservation management are parts of two knowledge systems(traditional and scientific)which often leads to conflicts between locals and con-servationists.We studied two herding/conservation systems(salt steppes and wood-pastures),and devel-oped an inventory on the common/similar and conflicting/different objectives and pasture management practices of herders and conservationists.Data were collected by participatory knowledge co-production in teamwork of the co-authors(herders,conservation managers,and scientists).Data were analyzed and discussed in teamwork too.Herders and conservationists identified 23 objectives and 29 management prac-tices.We found a number of common interests with respect to herding,the ideal state of pastures,legal provisions,and communication.Conflict resolution recommendations(e.g.,on time and place of grazing,pasture improvements)were also developed.We argue that by co-production of knowledge,and establish-ment of a herder“school”the mitigation of the existing conflicts would be more effective.Our conclusion is that a new profession is needed:that of the conservation herder.The conservation herder shall be an indi-vidual knowledgeable about herding and pasture management,trained in conservation and ecology,able to design management experiments,and develop novel but tradition-based management practices.As such,he/she could facilitate adaptation of extensive herding in the changing socio-economic environment. | Zsolt Molnar Jozsef Kis Csaba Vadasz Laszlo Papp Istvan Sandor Sandor Beres Gabor Sinka Anna Varga | 2016 | Ecosystem Health and Sustainability2016，2，4： | 0 |
| 7 | Galápagos land iguana(Conolophus subcristatus)as a seed disperser显示文摘The role of the most common land iguana(Conolophus subcristatus)in the Galápagos Islands as an effective seed disperser is explored in this study.A total of 5705 seeds of 32 plant species were identified from 160 scats,4545 of which(80%)appeared visually undamaged.Germination trials of 849 seeds from 29 species revealed that at least 10 species remained viable after passing through the iguana’s gut,although only a small proportion of those seeds(4%)germinated.In any case,we argue that C.subcristatus exerts an important role on the 7 Galapagos islands where it occurs because of its abundance and capacity to ingest and disperse seeds at long distances.Our results strongly suggest that the Galápagos C.subcristatus plays an important role as a seed disperser of not only of native species but also some introduced plants in the Galápagos Islands. | Anna TRAVESET Manuel NOGALES Pablo VARGAS Beatriz RUMEU Jens M.OLESEN | 2016 | Integrative Zoology2016，11，3： | 0 |
| 8 | Frugivory and seed dispersal in the Galápagos:what is the state of the art?显示文摘The Galápagos are considered a model oceanic archipelago,with unique flora and fauna currently threatened by alien invasive species.Seed dispersal is an important ecosystem function with consequences for plant population dynamics and vegetation structure.Hence,understanding the seed dispersal abilities of the assemblages of frugivores will inform scientists and managers of the dynamics of plant invasions and improve management planning.Here we provide the first comprehensive review of published information on frugivory and animal seed dispersal in the Galápagos.We collected data from a variety of sources,including notes of the first naturalist expeditions,gray literature available only in Galápagos collections,and peer-reviewed journal articles.Plant–animal frugivorous interactions were retrieved from 43 studies and compiled into an interaction matrix describing 366 unique interactions.Most studies focused on fruit consumption as a driving force for natural selection,but seed fate was seldom considered.Although most(71%)of the interactions involved native plants,more than one-quarter(28%)involved introduced species.Interactions involving birds are considerably more common than those of reptiles and mammals,probably reflecting a research bias towards birds.Despite the historical importance of the archipelago as the laboratory for evolutionary and ecological research,understanding of its seed dispersal systems is limited.We end the review by suggesting 3 priority areas of research on frugivory and seed dispersal in the Galápagos:(i)target research to close knowledge gaps;(ii)the use of a network approach to frame seed dispersal at the community level;and(iii)evaluation of the effect of seed dispersal as a selective pressure acting upon plants and frugivores.Finally,the output of this research has to be properly delivered to the Galápagos National Park Services to help increase management effectiveness. | Ruben HELENO Stephen BLAKE Patricia JARAMILLO Anna TRAVESET Pablo VARGAS Manuel NOGALES | 2011 | Integrative Zoology2011，6，2： | 0 |
| 9 | Small size does not restrain frugivory and seed dispersal across the evolutionary radiation of Galapagos lava lizards显示文摘Frugivory in lizards is often assumed to be constrained by body size;only large individuals are considered capable of consuming fruits, with the potential of acting as seed dispersers. However, only one previous study has tested the correlation of frugivory with body and head size at an archipelago scale across closely related species. All nine lava lizards (Microlophus spp.) were studied on the eleven largest Galapagos islands from 2010 to 2016 to investigate whether frugivory is related to body and head size. We also tested whether fruit abunda nee in flue nces fruit con sumption and explored the effect of seed ingestion on seedling emergence time and percentage. Our results showed that across islands, lava lizards varied considerably in size (64-102 mm in mean snoutvent length) and level of frugivory (1-23%, i.e., percentage of droppings with seeds). However, level of frugivory was only weakly affected by size as fruit consumption was also common among small lizards. Lava lizards consumed fruits throughout the year and factors other than fruit abundance may be more importa nt drivers of fruit selecti on (e.g., fruit size, energy con tent of pulp). From 2,530 droppings, 1,714 seeds of at least 61 plant species were identified, 76% of the species being native to the Galapagos. Most seeds (91%) showed no external structural damage. Seedling emergence time (44 versus 118 days) and percentage (20% versus 12%) were enhanced for lizardingested seeds compared to control (uningested) fruits. De-pulping by lizards (i.e., removal of pulp with potential germi nation inhibitors) might in crease the chances that at least some seeds find suitable recruitment conditi ons. We con eluded that lizards are importa nt seed dispersers throughout the year and across the whole archipelago, regardless of body size. | Sandra HERVIAS-PAREJO Ruben HELENO Beatriz RUMEU Beatriz GUZMAN Pablo VARGAS Jens M. OLESEN Anna TRAVESET Carlos VERA Edgar BENAVIDES Manuel NOGALES | 2019 | Current Zoology2019，65，4： | 0 |
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