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| 1 | Optical force-induced nonlinearity and self-guiding of light in human red blood cell suspensions显示文摘Osmotic conditions play an important role in the cell properties of human red blood cells(RBCs),which are crucial for the pathological analysis of some blood diseases such as malaria.Over the past decades,numerous efforts have mainly focused on the study of the RBC biomechanical properties that arise from the unique deformability of erythrocytes.Here,we demonstrate nonlinear optical effects from human RBCs suspended in different osmotic solutions.Specifically,we observe self-trapping and scattering-resistant nonlinear propagation of a laser beam through RBC suspensions under all three osmotic conditions,where the strength of the optical nonlinearity increases with osmotic pressure on the cells.This tunable nonlinearity is attributed to optical forces,particularly the forward-scattering and gradient forces.Interestingly,in aged blood samples(with lysed cells),a notably different nonlinear behavior is observed due to the presence of free hemoglobin.We use a theoretical model with an optical force-mediated nonlocal nonlinearity to explain the experimental observations.Our work on light self-guiding through scattering biosoft-matter may introduce new photonic tools for noninvasive biomedical imaging and medical diagnosis. | Rekha Gautam Yinxiao Xiang Josh Lamstein Yi Liang Anna Bezryadina Guo Liang Tobias Hansson Benjamin Wetzel Daryl Preece Adam White Matthew Silverman Susan Kazarian Jingjun Xu Roberto Morandotti Zhigang Chen | 2019 | Light(Science & Applications)2019，8，1： | 3 |
| 2 | Functional MRI of Language in Aphasia: A Review of the Literature and the Methodological Challenges显示文摘 | Bruce Crosson Keith McGregor Kaundinya S. Gopinath Tim W. Conway Michelle Benjamin Yu-Ling Chang Anna Bacon Moore Anastasia M. Raymer Richard W. Briggs Megan G. Sherod Christina E. Wierenga Keith D. White | 2007 | Neuropsychology Review2007，，2： | 1 |
| 3 | A New Era for Crew Recovery at Continental Airlines显示文摘 | Gang Yu Michael Arguello Gao Song Sandra M McCowan Anna White | 2003 | Interfaces2003，33，1： | 1 |
| 4 | Nanostructural characterization of geopolymers by advanced beamline techniques显示文摘 | John L. Provis Ailar Hajimohammadi Claire E. White Susan A. Bernal Rupert J. Myers Robert P. Winarski Volker Rose Thomas E. Proffen Anna Llobet Jannie S.J. van Deventer | 2012 | Cement and Concrete Composites2012，，： | 1 |
| 5 | A new era for crew recovery at continental airlines显示文摘 | Yu G Michael Arguello Gao S Sandra M McCowan Anna White | 2003 | Interfaces2003，33，1： | 1 |
| 6 | Evolution of Local Structure in Geopolymer Gels: An In Situ Neutron Pair Distribution Function Analysis显示文摘 | Claire E. White John L. Provis Anna Llobet Thomas Proffen Jannie S. J. van Deventer | 2011 | Journal of the American Ceramic Society2011，，10： | 1 |
| 7 | Safety and immunogenicity of a third dose of mRNA-1273 vaccine among cancer patients显示文摘Background:Compared to the general population,cancer patients are at higher risk of morbidity and mortality following SARS-CoV-2 infection.The immune response to a two-dose regimen ofmRNA vaccines in cancer patients is generally lower than in immunocompetent individuals.Booster doses may meaningfully augment immune response in this population.We conducted an observational study with the primary objective of determining the immunogenicity of vaccine dose three(100μg)of mRNA-1273 among cancer patients and a secondary objective of evaluating safety at 14 and 28 days.Methods:The mRNA-1273 vaccine was administered~7 to 9 months after administering two vaccine doses(i.e.,the primary series).Immune responses(enzyme-linked immunosorbent assay[ELISA])were assessed 28 days post-dose three.Adverse events were collected at days 14(±5)and 28(+5)post-dose three.Fisher exact or X^(2)tests were used to compare SARS-CoV-2 antibody positivity rates,and paired t-tests were used to compare SARS-CoV-2 antibody geometric mean titers(GMTs)across different time intervals.Results:Among 284 adults diagnosed with solid tumors or hematologic malignancies,dose three of mRNA-1273 increased the percentage of patients seropositive for SARS-CoV-2 antibody from 81.7%pre-dose three to 94.4%28 days post-dose three.GMTs increased 19.0-fold(15.8-22.8).Patients with lymphoid cancers or solid tumors had the lowest and highest antibody titers post-dose three,respectively.Antibody responses after dose three were reduced among those who received anti-CD20 antibody treatment,had lower total lymphocyte counts and received anticancer therapy within 3 months.Among patients seronegative for SARS-CoV-2 antibody pre-dose three,69.2%seroconverted after dose three.A majority(70.4%)experienced mostly mild,transient adverse reactions within 14 days of dose three,whereas severe treatment-emergent events within 28 days were very rare(<2%).Conclusion:Dose three of the mRNA-1273 vaccine was well-tolerated and augmented SARS-CoV-2 seropositivity in cancer patients,especially those who did not seroconvert post-dose two or whose GMTs significantly waned post-dose two.Lymphoid cancer patients experienced lower humoral responses to dose three of the mRNA-1273 vaccine,suggesting that timely access to boosters is important for this population. | Anna Giuliano Barbara Kuter Shari Pilon-Thomas Junmin Whiting Qianxing Mo Brett Leav Bradley Sirak Christopher Cubitt Christopher Dukes Kimberly Isaacs-Soriano Kayoko Kennedy Somedeb Ball Ning Dong Akriti Jain Patrick Hwu Jeffrey Lancet | 2023 | Cancer Communications2023，43，7： | 0 |
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