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您的检索式：作者名="Anne Hulin"
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| 1 | Phase II study of sirolimus in treatment-naive patients with advanced hepatocellular carcinoma显示文摘 | Thomas Decaens Alain Luciani Emmanuel Itti Anne Hulin Fran?oise Roudot-Thoraval Alexis Laurent Elie Serge Zafrani Ariane Mallat Christophe Duvoux | 2012 | Digestive and Liver Disease2012，，7： | 1 |
| 2 | Torsion of the spermatic cord in adults:a multicenter experience in adults with surgical exploration for acute scrotal pain with suspected testicular torsion显示文摘Acute scrotal pain(AsP)requiring surgical exploration is common in the pediatric population,but little has been reported on this subject with regard to the adult population.The aim of this study was to investigate the demographic and clinical characteristics and outcomes of scrotal explorations performed on adult patients.Patients over 21 years of age who underwent surgical exploration for ASP with suspected testicular torsion(TT)at 14 French hospitals between January 2005 and December 2019 were included in this study.The main outcome measures were demographic characteristics,pathology found during scrotal exploration,and perioperative outcomes.Logistic regression was used to perform univariate and multivariate analyses to identify predictors of TT.Data for 1329 men were analyzed.The median age was 30(interquartile range[IQR]:25-35;range:21-89)years.Regarding the clinical examination,867(65.2%)patients presented with an elevation of the testicle,613(46.1%)patients with scrotal edema or erythema,and 211(15.9%)patients with nausea or vomiting.Operative findings identified TT in only 684(51.5%)patients,epididymo-orchitis in 112(8.4%)patients,a tumor in 16(1.2%)patients,and no causes in 475(35.7%)patients.Orchiectomy for nonviable testes was required in 101(7.6%)patients.In multivariate analysis,an elevation of the testicle,erythema/swelling,and the presence of nausea/vomiting were found to be associated with the occurrence of TT.Testicular torsion is not exclusive to children and adolescents,so must be considered in males of any age with acute scrotal findings.However,one-third of scrotal explorations in adults did not lead to a diagnosis. | Van Thi Dang Benjamin Pradere Anne Mauger de Varennes Nadia Ali Benali Maxime Vallee William Berchiche Bastien Gondran-Tellier Gaelle Margue Clement Michiels Charles Gaillard Tristan Grevez Florian Bardet Maud Hulin Anthony Manuguerra Ugo Pinar Caroline Plassais Margeux Felber William Wandoren Kévin Kaulanjan Ines Dominique Marc Sbizerra Emilien Seizilles de Mazancourt Xavier Matillon Igor Duquesne Maxime Chabenes Victor Gallard Lucas Freton Francois Lannes Zine-Eddine Khene | 2022 | Asian Journal of Andrology2022，24，6： | 1 |
| 3 | Delayed and short course of rapamycin prevents organ rejection after allogeneic liver transplantation in rats显示文摘AIM To test whether a delayed and short course of rapamycin would induce immunosuppressive effects following allogeneic orthotopic liver transplantation(OLT) in rats.METHODS Allogeneic OLTs were performed using Dark Agoutilivers transplanted into Lewis recipients, and syngeneic OLTs were performed using the Lewis rat strain. Rapamycin(1 mg/kg per day) was administered by gavage from day 4 to day 11 post-transplantation. Lymphocyte cellular compartments were analyzed by flow cytometry in draining lymph nodes, non-draining lymph nodes and the spleen at days 11 and 42 in rapamycin-treated rats, untreated control rats and syngeneic grafted rats. Skin grafts from Dark agouti or from F344 RT were performed at day 30 on liver grafted rats treated with rapamycin.RESULTS An 8-d course of rapamycin treatment initiated 4 d following transplantation resulted in the survival of grafted rats for more than 100 d. In contrast, untreated rats died of liver failure within 13 to 21 d. The analysis of the cellular compartment revealed an increase in two cellular subpopulations, specifically myeloid-derived suppressor cells(MDSCs) and CD8+CD45RClow T cells, without major modifications in the regulatory T cell(Treg) compartment in treated rats in the early stages after grafting. We evaluated the ability of treated rats to reject third-party allogeneic skin grafts to confirm their immune competence. In contrast, when skin was collected from rats syngeneic to the grafted liver, it was not rejected.CONCLUSION Our results demonstrate that short and delayed rapamycin treatment allows for tolerance in allogeneic OLT. The results also allowed for the identification of the mechanisms of tolerance induced by rapamycin by identifying MDSCs and CD8+CD45RClow T cells as associated with the state of tolerance. | Salim Hamdani Allan Thiolat Sina Naserian Cynthia Grondin Stéphane Moutereau Anne Hulin Julien Calderaro Philippe Grimbert JoséLaurent Cohen Daniel Azoulay Caroline Pilon | 2017 | World Journal of Gastroenterology2017，23，38： | 0 |
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