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| 1 | Systemic inflammation in colorectal cancer: Underlying factors,effects, and prognostic significance显示文摘Systemic inflammation is a marker of poor prognosis preoperatively present in around 20%-40%of colorectal cancer patients.The hallmarks of systemic inflammation include an increased production of proinflammatory cytokines and acute phase proteins that enter the circulation.While the low-level systemic inflammation is often clinically silent,its consequences are many and may ultimately lead to chronic cancer-associated wasting,cachexia.In this review,we discuss the pathogenesis of cancer-related systemic inflammation,explore the role of systemic inflammation in promoting cancer growth,escaping antitumor defense,and shifting metabolic pathways,and how these changes are related to less favorable outcome. | Anne E Tuomisto Markus J Makinen Juha P Vayrynen | 2019 | World Journal of Gastroenterology2019，25，31： | 27 |
| 2 | Knockout mouse models of insulin signaling: Relevance past and future显示文摘Insulin resistance is a hallmark of type 2 diabetes. In an effort to understand and treat this condition, re searchers have used genetic manipulation of mice to uncover insulin signaling pathways and determine the effects of their perturbation. After decades of research much has been learned, but the pathophysiology o insulin resistance in human diabetes remains contro versial, and treating insulin resistance remains a chal lenge. This review will discuss limitations of mouse models lacking select insulin signaling molecule genes In the most influential mouse models, glucose metabo lism differs from that of humans at the cellular, organ and whole-organism levels, and these differences limi the relevance and benefit of the mouse models both in terms of mechanistic investigations and therapeutic development. These differences are due partly to im mutable differences in mouse and human biology, and partly to the failure of genetic modifications to produce an accurate model of human diabetes. Several fac tors often limit the mechanistic insights gained from experimental mice to the particular species and strain including: developmental effects, unexpected meta bolic adjustments, genetic background effects, and technical issues. We conclude that the limitations and weaknesses of genetically modified mouse models of insulin resistance underscore the need for redirection of research efforts toward methods that are more directly relevant to human physiology. | Anne E Bunner P Charukeshi Chandrasekera Neal D Barnard | 2014 | World Journal of Diabetes2014，5，2： | 9 |
| 3 | Colonoscopy surveillance for high risk polyps does not always prevent colorectal cancer显示文摘AIM To determine the frequency and risk factors for colorectal cancer(CRC) development among individuals with resected advanced adenoma(AA)/traditional serrated adenoma(TSA)/advanced sessile serrated adenoma(ASSA). METHODS Data was collected from medical records of 14663 subjects found to have AA, TSA, or ASSA at screening or surveillance colonoscopy. Patients with inflammatory bowel disease or known genetic predisposition for CRC were excluded from the study. Factors associated with CRC developing after endoscopic management of high risk polyps were calculated in 4610 such patients who had at least one surveillance colonoscopy within 10 years following the original polypectomy of the incident advanced polyp. RESULTS84/4610(1.8%) patients developed CRC at the polypectomy site within a median of 4.2 years(mean 4.89 years), and 1.2%(54/4610) developed CRC in a region distinct from the AA/TSA/ASSA resection site within a median of 5.1 years(mean 6.67 years). Approximately, 30%(25/84) of patients who developed CRC at the AA/TSA/ASSA site and 27.8%(15/54) of patients who developed CRC at another site had colonoscopy at recommended surveillance intervals. Increasing age; polyp size; male sex; right-sided location; high degree of dysplasia; higher number of polyps resected; and piecemeal removal were associated with an increased risk for CRC developmentat the same site as the index polyp. Increasing age; right-sided location; higher number of polyps resected and sessile endoscopic appearance of the index AA/TSA/ASSA were significantly associated with an increased risk for CRC development at a different site. CONCLUSION Recognition that CRC may develop following AA/TSA/ASSA removal is one step toward improving our practice efficiency and preventing a portion of CRC related morbidity and mortality. | Mohamad A Mouchli Lidia Ouk Marianne R Scheitel Alisha P Chaudhry Donna Felmlee-Devine Diane E Grill Shahrooz Rashtak Panwen Wang Junwen Wang Rajeev Chaudhry Thomas C Smyrk Ann L Oberg Brooke R Druliner Lisa A Boardman | 2018 | World Journal of Gastroenterology2018，24，8： | 5 |
| 4 | Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis显示文摘 | Mary Eapen Vanderson Rocha Guillermo Sanz Andromachi Scaradavou Mei-Jie Zhang William Arcese Anne Sirvent Richard E Champlin Nelson Chao Adrian P Gee Luis Isola Mary J Laughlin David I Marks Samir Nabhan Annalisa Ruggeri Robert Soiffer Mary M Horowitz Eli | 2010 | Lancet Oncology2010，，7： | 2 |
| 5 | 显示文摘 | Ann E Visser Richard P Swatloski W Matthew Reichert | 2001 | Chem Commun2001，，： | 1 |
| 6 | Outpatient laparoscopic extraperitoneal aortic nodal dissection for locally advanced cervical carcinom a显示文摘 | LOW E M P TILLM ANNS T | 2008 | Gynecol Oncol2008，111，2： | 1 |
| 7 | Longer time inter val between completion of neoadjuvant ehemoradiation and sur- gical resection does not improve downstaging of rectal carcino- ma显示文摘 | Stein D E Mahmoud N N Anne P R | 2003 | Dis Colon Rectum2003，46，： | 1 |
| 8 | Safety,feasibility,and costs of outpatient laparoscopic extraperitoneal aortic nodal dissection for locally advanced cervical carcinom a显示文摘 | TILLM ANNS T LOW E M P | 2007 | Gynecol Oncol2007，106，2： | 1 |
| 9 | Knowledge Reuse for Innovation显示文摘 | Ann Majchrzak Lynne P Cooper Olivia E Neece | | 0，，02： | 1 |
| 10 | Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: results of a phase 2 consortium study显示文摘 | Keith C Bible Vera J Suman Julian R Molina Robert C Smallridge William J Maples Michael E Menefee Joseph Rubin Kostandinos Sideras John C Morris Bryan McIver Jill K Burton Kevin P Webster Carolyn Bieber Anne M Traynor Patrick J Flynn Boon Cher Goh Hui Tan | 2010 | Lancet Oncology2010，，10： | 1 |
| 11 | pH-Dependent partitioning in room temperature ionic liquids 显示文摘 | Visser Ann E Swatloski Richard P Rogers Robin D | 2000 | Green Chemistry2000，2，1： | 1 |
| 12 | Foaming proterties of egg white protein affected by heat or high pressure treatment显示文摘 | Lesel V P Ann V L Marc E H | | 0，，04： | 1 |
| 13 | Trees and shrubs as sources of fodder in Australia显示文摘 | Lefroy E C P R D ann J H Wildin | 1992 | Agroforestry Systems1992，20，12： | 1 |
| 14 | Knowledge Reuse for Innovation显示文摘 | Ann Majchrzak Lynne P Cooper Olivia E Neece | | 0，，02： | 1 |
| 15 | Method for the deter- mination of organophosphorus and pyrethroid pesticides in food via gas chromatography with electron-capture detection显示文摘 | Ronald E H J Anne M R Ryan P B | 2010 | J Agric Food Chem2010，58，： | 1 |
| 16 | Comparison of the sulforhodamine B assay and the clonogenic assay for in vitro chemoradiation studies显示文摘 | BEA P ANNELIES E C KORST C | 2003 | Cancer Chemother Pharmacol2003，51，10： | 1 |
| 17 | Ovarian hyperstimulation syndrome and complications of ART 显示文摘 | Veerle V L Karen P E Anne P E | 2009 | Clinical Obstetrics and Gynecology2009，23，： | 1 |
| 18 | Removal rate model for magnetorheological finishing of glass 显示文摘 | Jessica E D Anne E M John P W | 2007 | Applied Optics2007，46，32： | 1 |
| 19 | Biofilm development and cell death in the marine bacterium Pseudoalteromona tunicate显示文摘 | ANNE M P FLAVIA E DORALYN D S | 2004 | Applied and Environmental Microbiology2004，7，70： | 1 |
| 20 | Selectively starving cancer cells through dietary manipulation: methods and clinical implications显示文摘 | Brittany A Simone Colin E Champ Anne L Rosenberg Adam C Berger Daniel A Monti Adam P Dicker Nicole L Simone | 2013 | Future Oncol2013，，7： | 1 |
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