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| 1 | 基于IMRT时代的第八版AJCC/UICC鼻咽癌临床分期建议显示文摘目的准确的分期系统对癌症的治疗至关重要。随着癌症分期和治疗方法的演变,需要不断评价分期的适用性和改进性。方法基于第7版AJCC/UICC分期回顾性分析香港和中国大陆2个肿瘤中心收治的1609例接受调强放射治疗的首诊无转移鼻咽癌患者临床资料,所有患者治疗前均行核磁共振分期评估。结果无其他T3、T4期解剖结构受侵患者中,伴有咀嚼肌间隙(翼内肌和/或翼外肌)侵犯、椎前肌侵犯及咽旁间隙侵犯的三组患者之间0s相近。伴广泛软组织(上述侵犯结构以外的软组织)受侵患者OS与伴有颅内侵犯或颅神经侵犯相似。仅2%患者锁骨上窝以上淋巴结转移者直径〉6cm,其0s率与下颈淋巴结转移者类似。用下颈(环状软骨尾侧缘水平以下)代替锁骨上窝并不影响N分期之间的风险差异性。采用推荐的T、N分期,T。N。、T。N,期0s相近。结论经AJCC/UICC分期筹备委员会审阅后,建议第8版分期应将翼内肌/翼外肌从T。降到T:期,增加椎前肌为L期,用下颈取代锁骨上窝,将淋巴结最大直径〉6cm合并归为N,期,将T。、N,期统一归为Ⅳ。期。这些改变不仅使得相邻分期间风险差异性更好,而且使得临床实践性与全球适用性之间达到最佳平衡。 | 潘建基 Wai Tong Ng 宗井凤 Lucy L.K.Chan Brian O' Sullivan 林少俊 Henry C.K.Sze 陈韵彬 Horace C.W.Choi 郭巧娟 Wai Kuen Kan 肖友平 Xu Wei Quynh Thu Le Christine M.Glastonbury A.Dimtrios Colevas Randal S.Weber Jatin P.Shah Anne W.M.Lee | 2016 | 中华放射肿瘤学杂志2016，25，3： | 65 |
| 2 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 3 | 肿瘤恶性转化与C/EBPβ和STAT3基因相关(英文)显示文摘The inference of transcriptional networks that regulate transitions into physiological or pathological cellular states remains a central challenge in systems biology. A mesenchymal phenotype is the hallmark of tumour aggressiveness in human malignant glioma,but the regulatory programs responsible for implementing the associated molecular signature are largely unknown. Here we show that reverse-engineering and an unbiased interrogation of a glioma-specific regulatory network reveal the transcriptional module that activates expression of mesenchymal genes in malignant glioma. Two transcription factors (C/EBPβ and STAT3) emerge as synergistic initiators and master regulators of mesenchymal transformation. Ectopic co-expression of C/EBPβ and STAT3 reprograms neural stem cells along the aberrant mesenchymal lineage,whereas elimination of the two factors in glioma cells leads to collapse of the mesenchymal signature and reduces tumour aggressiveness. In human glioma,expression of C/EBPβ and STAT3 correlates with mesenchymal differentiation and predicts poor clinical outcome. These results show that the activation of a small regulatory module is necessary and sufficient to initiate and maintain an aberrant phenotypic state in cancer cells. | Maria Stella Carro Wei Keat Lim Mariano Javier Alvarez Robert J. Bollo Evan Y. Snyder Erik P. Sulman Sandrine L. Anne Fiona Doetsch Howard Colman Anna Lasorella Ken Aldape Andrea Califano Antonio Iavarone | 2010 | 中华神经外科疾病研究杂志2010，9，1： | 16 |
| 4 | Surrogate-based modeling and dimension reduction techniques for multi-scale mechanics problems显示文摘Successful modeling and/or design of engineering systems often requires one to address the impact of multiple 'design variables' on the prescribed outcome.There are often multiple,competing objectives based on which we assess the outcome of optimization.Since accurate,high fidelity models are typically time consuming and computationally expensive,comprehensive evaluations can be conducted only if an efficient framework is available.Furthermore,informed decisions of the model/hardware's overall performance rely on an adequate understanding of the global,not local,sensitivity of the individual design variables on the objectives.The surrogate-based approach,which involves approximating the objectives as continuous functions of design variables from limited data,offers a rational framework to reduce the number of important input variables,i.e.,the dimension of a design or modeling space.In this paper,we review the fundamental issues that arise in surrogate-based analysis and optimization,highlighting concepts,methods,techniques,as well as modeling implications for mechanics problems.To aid the discussions of the issues involved,we summarize recent efforts in investigating cryogenic cavitating flows,active flow control based on dielectric barrier discharge concepts,and lithium(Li)-ion batteries.It is also stressed that many multi-scale mechanics problems can naturally benefit from the surrogate approach for 'scale bridging.' | Wei Shyy Young-Chang Cho Wenbo Du Amit Gupta Chien-Chou Tseng Ann Marie Sastry | 2011 | Acta Mechanica Sinica2011，27，6： | 4 |
| 5 | Comparative analysis of the transcriptomes of the calyx abscission zone of sweet orange insights into the huanglongbingassociated fruit abscission显示文摘Citrus greening disease or huanglongbing(HLB)is associated with excessive pre-harvest fruit drop.To understand the mechanisms of the HLB-associated fruit abscission,transcriptomes were analyzed by RNA sequencing of calyx abscission zones(AZ-C)of dropped“Hamlin”oranges from HLB-diseased trees upon shaking the trees(Dd),retained oranges on diseased trees(Rd),dropped oranges from healthy shaken trees(Dh),and retained oranges on healthy trees(Rh).Cluster analysis of transcripts indicated that Dd had the largest distances from all other groups.Comparisons of transcriptomes revealed 1047,1599,813,and 764 differentially expressed genes(DEGs)between Dd/Rd,Dd/Dh,Dh/Rh,and Rd/Rh.The gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses indicated hormone signaling,defense response,and secondary metabolism were involved in HLB-associated fruit abscission.Ethylene(ET)and jasmonic acid(JA)synthesis/signaling-related genes were upregulated in Dd,while other phytohormone-related genes were generally downregulated.In addition,genes related to JA/ET-activated defense response were upregulated in Dd as well.Consistent with the phytohormone gene expression data,increased levels(p<0.05)of ET and JA,and a decreased level(p<0.05)of abscisic acid were found in Dd compared with Rd,Dh or Rh.Lasiodiploidia theobromae level in Dd AZ-C was higher than the other fruit types,confirmed by qPCR,indicating AZ-C secondary fungal infection of HLB fruit may exacerbate their abscission.This information will help formulate effective strategies to control HLB-related abscission. | Wei Zhao Elizabeth A.Baldwin Jinhe Bai Anne Plotto Mike Irey | 2019 | Horticulture Research2019，6，1： | 4 |
| 6 | Activation of the Ig la I promoter by the transcription factor Ets-1 triggers Ig lal-Cal germline transcription in epithelial cancer cells显示文摘 | Zhi Duan Hui Zheng San Xu Yiqun Jiang Haidan Liu Ming Li Duosha Hu Wei Li Ann M. Bode Zigang Dong Ya Cao | 2014 | Cellular & Molecular Immunology2014，11，2： | 3 |
| 7 | Floristic composition and endemism pattern of vascular plants in Ethiopia and Eritrea显示文摘Traditional attempts to delineate floristic regions are typically based on the qualitative analysis of species distribution,often ignoring the phylogenetic relationships among their taxa.Ethiopia and Eritrea are in the Horn of Africa,known as one of the world's biodiversity hotspots.We quantitatively classified the flora of Ethiopia and Eritrea into meaningful geographical units by analyzing the taxonomic and phylogeneticβ‐diversity at genera,total species,and endemic species levels at a scale of 0.5°×0.5°grid cells.Hierarchical clustering was used to quantitatively delimitate the flora and analysis of similarities was used to test the significant difference between the derived groups in taxonomic composition and phylogenetic relatedness.In total,two floristic subprovinces,five floristic districts,and 13 floristic subdistricts,as well as three centers of species endemism associated with three floristic subdistricts were identified.Our results also showed that the species diversity,endemism,and turnover of the highlands in Ethiopia and Eritrea were much higher than the lowlands,indicating that the floristic differences are closely related to the topography of the East African Rift.In this study,we provided a scientific framework for the composition and relationships of the floristic units in the Horn of Africa,and similarly provided a scientific basis for better conservation of the diversity in this region. | Sheng‐Wei Wang Biyansa Hirpo Boru Antony Waigwa Njogu Anne Christine Ochola Guang‐Wan Hu Ya‐Dong Zhou Qing‐Feng Wang | 2020 | Journal of Systematics and Evolution2020，58，1： | 2 |
| 8 | Rabies Virus Pseudotyped with CVS-N2C Glycoprotein as a Powerful Tool for Retrograde Neuronal Network Tracing显示文摘Efficient viral vectors for mapping and manipulating long-projection neuronal circuits are crucial in structural and functional studies of the brain. The SAD strain rabies virus with the glycoprotein gene deleted pseudotyped with the N2 C glycoprotein(SAD-RV(DG)-N2 C(G)) shows strong neuro-tropism in cell culture, but its in vivo efficiency for retrograde gene transduction and neuro-tropism have not been systematically characterized.We compared these features in different mouse brain regions for SAD-RV-N2 C(G) and two other widely-used retrograde tracers, SAD-RV(DG)-B19(G) and r AAV2-retro. We found that SAD-RV(DG)-N2 C(G) enhanced the infection efficiency of long-projecting neurons by^10 times but with very similar neuro-tropism, compared with SAD-RV(DG)-B19(G). On the other hand, SAD-RV(DG)-N2 C(G) had an infection efficiency comparable with r AAV2-retro, but a more restricted diffusion range, and broader tropism to different types and regions of longprojecting neuronal populations. These results demonstrate that SAD-RV(DG)-N2 C(G) can serve as an effective retrograde vector for studying neuronal circuits. | Xutao Zhu Kunzhang Lin Qing Liu Xinpei Yue Huijie Mi Xiaoping Huang Xiaobin He Ruiqi Wu Danhao Zheng Dong Wei Liangliang Jia Weilin Wang Anne Manyande Jie Wang Zhijian Zhang Fuqiang Xu | 2020 | Neuroscience Bulletin2020，36，3： | 2 |
| 9 | A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen显示文摘 | Xiao-Jun Ma Zuncai Wang Paula D Ryan Steven J Isakoff Anne Barmettler Andrew Fuller Beth Muir Gayatry Mohapatra Ranelle Salunga J.Todd Tuggle Yen Tran Diem Tran Ana Tassin Paul Amon Wilson Wang Wei Wang Edward Enright Kimberly Stecker Eden Estepa-Sabal Ba | 2004 | Cancer Cell2004，，6： | 1 |
| 10 | Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC显示文摘 | Wei Liu Anne Le Chad Hancock Andrew N. Lane Chi V. Dang Teresa W.-M. Fan James M. Phang | 2012 | Proceedings of the National Academy of Sciences2012，，23： | 1 |
| 11 | The Cross-Section of Stock Returns on The Shanghai Stock Exchange显示文摘 | Kie Ann Wong Ruth Seow Kuan Tan Wei Liu | 2006 | Review of Quantitative Finance and Accounting2006，，1： | 1 |
| 12 | Numerical simulation of intercala- tion-induced stress in Li-ion battery electrode particles 显示文摘 | ZHANG X WEI S ANN M S | 2007 | Journal of the Electrochemical Society2007，154，10： | 1 |
| 13 | Intercalation-induced stress and heat generation within single lithium-ion battery cathode particles 显示文摘 | ZHANG X ANN M S WEI S | 2008 | Joumal of the Electrochemical Society2008，155，7： | 1 |
| 14 | Articular cartilage collage:an irreplaceable framework显示文摘 | DAVID R EYER MARY ANN WEIS | 2006 | European Cells and Materials2006，12，1： | 1 |
| 15 | Harmonizing Molecular Marker Analyses of Organic Aerosols显示文摘 | Yuan Xun Zhang James Jay Schauer Elizabeth Anne Stone Yuanhang Zhang Min Shao Yongjie Wei Xianlei Zhu | 2009 | Aerosol Science and Technology2009，，4： | 1 |
| 16 | Demethylation of Cancer/Testis Antigens and CpG ODN Stimulation Enhance Dendritic Cell and Cytotoxic T Lymphocyte Function in a Mouse Mammary Model显示文摘 | Jun-Zhong Sun Lei Gao Li Gao Wei Wang Nan Du Juan Yang Ling Wan Fang Liu Li-li Wang Li Yu Anne Hamburger | 2013 | BioMed Research International2013，，： | 1 |
| 17 | AID expression increased by TNF-α is associated with class switch recombination of Igα gene in cancers显示文摘 | Zhi Duan Hui Zheng Haidan Liu Ming Li Min Tang Xinxian Weng Wei Yi Ann M. Bode Ya Cao | 2016 | Cellular & Molecular Immunology2016，13，4： | 1 |
| 18 | Differentiation of marrow stromal cells into photoreceptors in the rat eye 显示文摘 | Anthony K Wei YS Ann SW | 2003 | J Neurosci2003，23，21： | 1 |
| 19 | Intercalation-induced stress and heat generation within single lithium-ion battery cathode particles 显示文摘 | XIANG C Z ANN M S WEI S | 2008 | Journal of the Electrochemical Society2008，155，7： | 1 |
| 20 | A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen显示文摘 | Xiao-Jun Ma Zuncai Wang Paula D Ryan Steven J Isakoff Anne Barmettler Andrew Fuller Beth Muir Gayatry Mohapatra Ranelle Salunga J.Todd Tuggle Yen Tran Diem Tran Ana Tassin Paul Amon Wilson Wang Wei Wang Edward Enright Kimberly Stecker Eden Estepa-Sabal Ba | 2004 | Cancer Cell2004，，6： | 1 |
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