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| 1 | Curcumin inhibits cellular cholesterol accumulation by regulating SREBP-1/caveolin-1 signaling pathway in vascular smooth muscle cells显示文摘目的: 在 anti-atherosclerosis.Methods 上调查保护的效果和杂种狗枯茗的可能的机制: 从 apoE 大美人拿的动脉粥样硬化患者损害的词法变化(apoE^(-/-))mice 被染色的 hematoxylin 曙红决定。细胞内部的类脂化合物微滴和类脂化合物层次是由油红O染色的 assayed , caveolin-1 的 HPLC.The 蛋白质表示被西方的 blotting.Translocation 和甾醇反应元素绑定 protein-1 ( SREBP-1 )的表示确定被免疫荧光 analysis.Results 间接地检测: 20 mg ·k g~的管理( -1)·d^(-1)curcumin 到apoE^(为 4 个月的 -/-)mice 导致了动脉粥样硬化患者损害的50%减小并且作为与模型组相比在 caveolin-1 表示水平产出5褶层增加。有 50 mg ·L ~的老鼠脉管的平滑肌房间( VSMC ) pretreated (为 48 h 的 -1)ox-lipid 密度脂蛋白( ox-LDL )增加了细胞的类脂化合物内容,并且刺激了 SREBP-1 易位,但是减少 装载level.Lipid 的房间在各种各样的集中暴露了到杂种狗枯茗的 caveolin-1 表示( 12.5,25 ,并且 50 亩摩尔 ·L ^( -1))for 不同持续时间( 0,6,12,24 ,和 48 h )显著地减少了细胞的类脂化合物微滴的数字和区域,全部的胆固醇,胆固醇酉旨,并且伴随 caveolin-1 表示的举起的免费胆固醇铺平(近似3褶层);到原子核的从细胞质的 SREBP-1 的易位与暴露于 N-acetyl-Leu-Leu-norleucinal 的 装载models.Lipid 的 VSMC 相比被禁止,一个 SREBP-1 朊酶禁止者, SREBP-1 的显示出的增加的原子易位,减少的 caveolin-1 表示水平,并且在调整细胞的类脂化合物 levels.Conclusion 上面:姜黄色素通过经由 SREBP-1 的原子易位的抑制增加 caveolin-1 表示在有教养的 VSMC 禁止 ox-LDL-induced 胆固醇累积。 | Hao-yu YUAN Shuang-yu KUAN Xing ZHENG Hong-yan LING Yun-Bo YANG Peng-Ke YAN Kai LI Duan-Fang LIAO | 2008 | Acta Pharmacologica Sinica2008，29，5： | 21 |
| 2 | A chlorinated copolymer donor demonstrates a 18.13% power conversion efficiency显示文摘The rapid development of low-bandgap(LBG)nonfullerene acceptors and wide-bandgap(WBG)copolymer donors in recent years has boosted the power conversion efficiency(PCE)of organic solar cells(OSCs)to the 18%level[1−21].The commercialization of OSCs is highly expected.However,critical issues like the cost and the stability also determine whether OSCs can enter the market or not[22]. | Jianqiang Qin Lixiu Zhang Chuantian Zuo Zuo Xiao Yongbo Yuan Shangfeng Yang Feng Hao Ming Cheng Kuan Sun Qinye Bao Zhengyang Bin Zhiwen Jin and Liming Ding | 2021 | Journal of Semiconductors2021，42，1： | 19 |
| 3 | Thiolactone copolymer donor gifts organic solar cells a 16.72% efficiency显示文摘Since 1995,bulk-heterojunction organic solar cells consisting of one or two organic donors and one or two organic acceptors have been fighting for high power conversion efficiencies(PCEs)and good stability[1].Until recent years,this next-generation photovoltaic technology starts to offer decent PCEs,shedding the light on commercialization,and attracting great attention again[2-14].Compared w让h the continuously emerging highperformance nonfullerene acceptors,high-performance donors are rare. | Ji Xiong Ke Jin Yufan Jiang Jianqiang Qin Tan Wang Jinfeng Liu Qishi Liu Haili Peng Xiongfeng Li Anxin Sun Xianyi Meng Lixiu Zhang Ling Liu Wenting Li Zhimin Fang Xue Jia Zuo Xiao Yaqing Feng Xiaotao Zhang Kuan Sun Shangfeng Yang Shengwei Shi Liming Ding | 2019 | Science Bulletin2019，64，21： | 17 |
| 4 | Assessment of left ventricular systolic synchronicity by real-time three-dimensional echocardiography in patients with dilated cardiomyopathy显示文摘Background Recent advances in real-time three-dimensional echocardiography (RT3DE) offer the potential to assess the left ventricular (LV) dyssynchrony simultaneously by analyzing the 17 segments time-volume curves. The purpose of this study was to test the feasibility and accuracy of RT3DE for quantitative evaluation of left ventricular systolic synchronicity. Methods Twenty-four patients with dilated cardiomyopathy (DCM) and twenty-five healthy volunteers were enrolled in this study. Full volume RT3DE was performed by using Philips IE33 with X3-1 probe. The global and 17-segmental time-volume curves were obtained by the on-line Qlab software (version 4.2). The time to minimal systolic volume in each segment (Tmsv) was taken to derive the following indexes of systolic asynchrony: Tmsv 16-SD, Tmsv 16-Dif, Tmsv 12-SD, Tmsv 12-Dif, Tmsv 6-SD and Tmsv 6-Dif, which meant the standard deviation or the maximal difference of Tmsv among the 16, 12 and 6 segments of the left ventricle respectively. The software also provided with each of the above parameters as a percentage of the cardiac cycle. Results Tmsv 16-SD, Tmsv 12-SD and Tmsv 6-SD were all significantly larger in the DCM group than those of the control group [Tmsv 16-SD: (52.9±40.6) ms vs (8.8±6.2) ms; Tmsv 12-SD: (29.5±30.8) ms vs (6.9±4.0) ms; Tmsv 6-SD: (28.9±34.6) ms vs (7.0±4.7) ms, all P≤0.001]. Tmsv 16-Dif, Tmsv 12-Dif and Tmsv 6-Dif were also significantly larger in the DCM group. There were close negative relations between the LVEF determined by RT3DE and each of the indexes of systolic asynchrony, among which the indexes of Tmsv-16-SD% and Tmsv-16-Dif% correlated most closely (r=-0.703 and r =-0.701, respectively). The DCM patients had significantly larger EDV and ESV, with significantly reduced LVEF compared with the healthy subjects. Conclusion RT3DE provides a simple, useful and unique approach to assess the systolic synchronicity of all the left ventricular segments simultaneously. | ZENG Xin SHU Xian-hong PAN Cui-zhen CHEN Rui-zhen CHENG Kuan LIU Shi-zhen CHEN Hao-zhu | 2006 | Chinese Medical Journal2006，，11： | 16 |
| 5 | Recovery of heavy metals from electroplating sludge and stainless steel pickle waste liquid by ammonia leaching method显示文摘A coordinative disposal process for treatment of electroplating sludge and stainless steel pickle waste liquid containing Cu, Ni, Zn, Cr and Fe etc., has been developed to recover valuable metals and to eliminate pollution. The recovery of Cu, Ni, Zn and Cr is 94%, 91%, 90% and 95%, respectively. The ammonia was recycled by the simplified process of CaO caustic distillation. The precipitated product of Cu, Ni and Zn obtained from caustic distillation of ammonia was separated by extraction or high\|pressure hydrogen reduction in an autoclave. The qualified metal salt products were obtained through extraction. The rich chromium residue from coordinative disposal was subjected to recover Cr by hydrothermal oxidation in NaOH medium and Fe\-3O\-4 was synthesized by wet methods from the residue produced by extracting Cr. Cr was a stable chemical fixed in Fe\-3O\-4 and harmless. The recovery process has been used in a pilot plant with sludge production capacity of 2000 t/a. | Zhang Yi, Wang Zhi\|kuan, Xu Xia, Chen Yong\|qi, Qi Tao Institute of Chemical Metallurgy, Chinese Academy of Sciences,P.O. Box 353, Beijing 100080, China | 1999 | Journal of Environmental Sciences1999，11，3： | 15 |
| 6 | Progress of the key materials for organic solar cells显示文摘Organic solar cells have attracted academic and industrial interests due to the advantages like lightweight,flexibility and roll-to-roll fabrication.Nowadays,18%power conversion efficiency has been achieved in the state-of-the-art organic solar cells.The recent rapid progress in organic solar cells relies on the continuously emerging new materials and device fabrication technologies,and the deep understanding on film morphology,molecular packing and device physics.Donor and acceptor materials are the key materials for organic solar cells since they determine the device performance.The past 25 years have witnessed an odyssey in developing high-performance donors and acceptors.In this review,we focus on those star materials and milestone work,and introduce the molecular structure evolution of key materials.These key materials include homopolymer donors,D-A copolymer donors,A-D-A small molecular donors,fullerene acceptors and nonfullerene acceptors.At last,we outlook the challenges and very important directions in key materials development. | Yang Tong Zuo Xiao Xiaoyan Du Chuantian Zuo Yuelong Li Menglan Lv Yongbo Yuan Chenyi Yi Feng Hao Yong Hua Ting Lei Qianqian Lin Kuan Sun Dewei Zhao Chunhui Duan Xiangfeng Shao Wei Li Hin-Lap Yip Zhengguo Xiaol Bin Zhang Qingzhen Bian Yuanhang Cheng Shengjian Liu Ming Cheng Zhiwen Jin Shangfeng Yang Liming Ding | 2020 | Science China Chemistry2020，63，6： | 15 |
| 7 | Protective effects of luteolin against lipopolysaccharide-induced acute lung injury involves inhibition of MEK/ERK and PI3K/Akt pathways in neutrophils显示文摘 | Jen-pei LEE Yi-ching LI Hung-yi CHEN Ruey-hseng LIN Shiang-suo HUANG Hui-ling CHEN Pai-chuan KUAN Mao-fang LIAO Chun-jung CHEN Yu-hsiang KUAN | 2010 | Acta Pharmacologica Sinica2010，31，7： | 12 |
| 8 | Narrow band imaging with magnification for the diagnosis of lesions in the upper gastrointestinal tract显示文摘Endoscopy plays an important role in the diagnosis and management of gastrointestinal(GI)tract disorders.Chromoendoscopy has proven to be superior to white light endoscopy for early detection of various GI lesions.This has however been fraught with problems.The use of color stains,time taken to achieve an effect and the learning curve associated with the technique has been some of the pitfalls.Narrow band imaging(NBI)particularly in combination with magnifying endoscopy may allow the endoscopist to accomplish a fairly accurate diagnosis with good histological correlation similar to results achieved with chromoendoscopy.Such enhanced detection of pre-malignant and early neoplastic lesions in the gastrointestinal tract should allow better targeting of biopsies and could ultimately prove to be cost effective.Various studies have been done demonstrating the utility of this novel technology.This article will review the impact of NBI in the diagnosis of upper gastrointestinal tract disorders. | Rajvinder Singh Asif Hussain Cheong Kuan Loong | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，12： | 12 |
| 9 | Global characterization and monitoring of forest cover using Landsat data: opportunities and challenges显示文摘The compilation of global Landsat data-sets and the ever-lowering costs of computing now make it feasible to monitor the Earth’s land cover at Landsat resolutions of 30 m.In this article,we describe the methods to create global products of forest cover and cover change at Landsat resolutions.Nevertheless,there are many challenges in ensuring the creation of high-quality products.And we propose various ways in which the challenges can be overcome.Among the challenges are the need for atmospheric correction,incorrect calibration coefficients in some of the data-sets,the different phenologies between compila-tions,the need for terrain correction,the lack of consistent reference data for training and accuracy assessment,and the need for highly automated character-ization and change detection.We propose and evaluate the creation and use of surface reflectance products,improved selection of scenes to reduce phenological differences,terrain illumination correction,automated training selection,and the use of information extraction procedures robust to errors in training data along with several other issues.At several stages we use Moderate Resolution Spectro-radiometer data and products to assist our analysis.A global working prototype product of forest cover and forest cover change is included. | John R.Townshend Jeffrey G.Masek Chengquan Huang Eric.F.Vermote Feng Gao Saurabh Channan Joseph O.Sexton Min Feng Raghuram Narasimhan Dohyung Kim Kuan Song Danxia Song Xiao-Peng Song Praveen Noojipady Bin Tan Matthew C.Hansen Mengxue Li Robert E.Wolfe | 2012 | International Journal of Digital Earth2012，5，5： | 10 |
| 10 | Discovery of carbonaceous compressions and their multicellular tissues from the Changzhougou Formation (1 800 Ma) in the Yanshan range, North China显示文摘In 1997 and 1998, hundreds of specimens of megascopic carbonaceous compressions or algal fossils were found from - 1800-million-year old Changzhougou Formation, which is the lowermost unit of the latest Palaeoproterozoic Changcheng Group (~1 600-1 800 Ma) in the Xinglong-Kuancheng areas at the middle Yanshan Range, North China. They are discoid, ellipsoid and sausage-like, namely shaped like Chuaria Shouhsiennia (Ellipsophyta) and Tawuia. By adopting HF acid-resistant maceration coupled with scanning electron microscope and petrologic section, the authors made a preliminary research on the histology for some circular and ellipsoid carbonaceous compressions, namely Chuaria- and Shouhsienia-llke forms, in addition to their morphology. The following three types of multicellular tissues have been found in the fragments of them: colony-like, pseudoparenchyma-like and parenchyma-like. All of the new data about multicelluar tissues not only supply a very important basis in histology to determine the | ZHU Shixing SUN Shufen HUANG Xueguang HE Yuzhen ZHU Gengxin SUN Lixin ZHANG Kuan | 2000 | Chinese Science Bulletin2000，45，9： | 10 |
| 11 | Removal of formaldehyde over Mn_xCe_(1- x)O_2 catalysts: Thermal catalytic oxidation versus ozone catalytic oxidation显示文摘MnxCe1-xO2(x:0.3–0.9)prepared by Pechini method was used as a catalyst for the thermal catalytic oxidation of formaldehyde(HCHO).At x=0.3 and 0.5,most of the manganese was incorporated in the fluorite structure of Ce O2to form a solid solution.The catalytic activity was best at x=0.5,at which the temperature of 100%removal rate is the lowest(270°C).The temperature for 100%removal of HCHO oxidation is reduced by approximately 40°C by loading 5 wt.%Cu Oxinto Mn0.5Ce0.5O2.With ozone catalytic oxidation,HCHO(61 ppm)in gas stream was completely oxidized by adding 506 ppm O3over Mn0.5Ce0.5O2catalyst with a GHSV(gas hourly space velocity)of 10,000 hr-1at 25°C.The effect of the molar ratio of O3to HCHO was also investigated.As O3/HCHO ratio was increased from 3 to 8,the removal efficiency of HCHO was increased from 83.3%to 100%.With O3/HCHO ratio of 8,the mineralization efficiency of HCHO to CO2was 86.1%.At 25°C,the p-type oxide semiconductor(Mn0.5Ce0.5O2)exhibited an excellent ozone decomposition efficiency of 99.2%,which significantly exceeded that of n-type oxide semiconductors such as Ti O2,which had a low ozone decomposition efficiency(9.81%).At a GHSV of 10,000 hr-1,[O3]/[HCHO]=3 and temperature of 25°C,a high HCHO removal efficiency(≥81.2%)was maintained throughout the durability test of 80 hr,indicating the long-term stability of the catalyst for HCHO removal. | Jia Wei Li Kuan Lun Pan Sheng Jen Yu Shaw Yi Yan Moo Been Chang | 2014 | Journal of Environmental Sciences2014，26，12： | 9 |
| 12 | Liposomes and lipid disks traverse the BBB and BBTB as intact forms as revealed by two-step F?rster resonance energy transfer imaging显示文摘The blood–brain barrier(BBB) and the blood–brain tumor barrier(BBTB) prevent drug and nano-drug delivery systems from entering the brain. However, ligand-mediated nano-drug delivery systems have significantly enhanced the therapeutic treatment of glioma. In this study we investigated the mechanism especially the integrity of liposomes and lipid disks while traversing the BBB and BBTB both in vitro and in vivo. Fluorophores(DiO, DiI and DiD) were loaded into liposomes and lipid disks to form F?rster resonance energy transfer(FRET) nano-drug delivery systems. Using brain capillary endothelial cells as a BBB model, we show that liposomes and disks are present in the cytoplasm as their intact forms and traverse the BBB with a ratio of 0.68‰ and 1.67‰, respectively. Using human umbilical vein endothelial cells as BBTB model, liposomes and disks remained intact and traversed the BBTB with a ratio of 2.31‰and 8.32‰ at 3 h. Ex vivo imaging and immunohistochemical results revealed that liposomes and disks could traverse the BBB and BBTB in vivo as intact forms. In conclusion, these observations explain in part the mechanism by which nano-drug delivery systems increase the therapeutic treatment of glioma. | Tongcheng Dai Kuan Jiang Weiyue Lu | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 8 |
| 13 | Removal of VOCs from gas streams with double perovskite-type catalysts显示文摘Double perovskite-type catalysts including La2 CoMnO_6 and La_2 CuMnO_6 are first evaluated for the effectiveness in removing volatile organic compounds(VOCs), and single perovskites(La CoO_3, LaMnO_3, and La Cu O3) are also tested for comparison. All perovskites are tested with the gas hourly space velocity(GHSV) of 30,000 hr^(-1), and the temperature range of100–600°C for C_7H_8 removal. Experimental results indicate that double perovskites have better activity if compared with single perovskites. Especially, toluene(C_7H_8) can be completely oxidized to CO_2 at 300°C as La2 Co MnO_6 is applied. Characterization of catalysts indicates that double perovskites own unique surface properties and are of higher amounts of lattice oxygen,leading to higher activity. Additionally, apparent activation energy of 68 k J/mol is calculated using Mars-van Krevelen model for C7 H8 oxidation with La2 Co Mn O6 as catalyst. For durability test, both La2 Co Mn O6 and La_2 CuMnO_6 maintain high C7 H8 removal efficiencies of 100% and98%, respectively, at 300°C and 30,000 hr^(-1), and they also show good resistance to CO_2(5%) and H2 O(g)(5%) of the gas streams tested. For various VOCs including isopropyl alcohol(C_3H_8 O),ethanal(C_2H_4O), and ethylene(C_2H_4) tested, as high as 100% efficiency could be achieved with double perovskite-type catalysts operated at 300–350°C, indicating that double perovskites are promising catalysts for VOCs removal. | Kuan Lun Pan Guan Ting Pan Siewhui Chong Moo Been Chang | 2018 | Journal of Environmental Sciences2018，30，7： | 8 |
| 14 | 高致病性猪蓝耳病病毒致病机制研究新进展:毒力相关氨基酸位点的发现显示文摘猪蓝耳病,即猪繁殖与呼吸综合征(Porcine reproductive and respiratory syndrome,PRRS),是由PRRS病毒(PRRSV)引起的,以妊娠母猪繁殖障碍及各年龄阶段猪呼吸道症状为主要特征的传染病,是目前危害养猪业的主要疫病之一。自2006年以来,我国爆发了高致病性PRRS(HP—PRRS),随后该病迅速在我国各主要养猪省份蔓延。 | Zhao Kuan Gao Jia-cong Xiong Jun-yao | 2018 | 中国预防兽医学报2018，40，7： | 8 |
| 15 | Toughening Poly(lactic acid) with Imidazolium-based Elastomeric Ionomers显示文摘Imidazolium-based elastomeric ionomers(i-BIIR) were facilely synthesized by ionically modified brominated poly(isobutylene-co-isoprene)(BIIR) with different alkyl chain imidazole and thoroughly explored as novel toughening agents for poly(lactic acid)(PLA). The miscibility, thermal behavior, phase morphology and mechanical property of ionomers and blends were investigated through dynamic mechanical analyses(DMA), differential scanning calorimetry(DSC), scanning electron microscopy(SEM), tensile and impact testing. DMA and SEM results showed that better compatibility between the PLA and i-BIIR was achieved compared to the PLA/unmodified BIIR elastomer. A remarkable improvement in ductility with an optimum elongation at break up to235% was achieved for the PLA/i-BIIR blends with 1-dodecylimidazole alkyl chain(i-BIIR-12), more than 10 times higher than that of pure PLA. The impact strengths of PLA were enhanced from 1.9 kJ/m^2 to 4.1 kJ/m^2 for the PLA/10 wt% i-BIIR-12 blend. Toughening mechanism had been established by systematical analysis of the compatibility, intermolecular interaction and phase structures of the blends. Interfacial cavitations initiated massive shear yielding of the PLA matrix owing to a suitable interfacial adhesion which played a key role in the enormous toughening effect in these blends. We believed that introducing imidazolium group into the BIIR elastomer was vital for the formation of a suitable interfacial adhesion. | Lu Chen Kuan Hu Si-Ting Sun Hai Jiang Dong Huang Kun-Yu Zhang Li Pan Yue-Sheng Li | 2018 | Chinese Journal of Polymer Science2018，36，12： | 7 |
| 16 | Effects of Bacterial-Feeding Nematode Grazing and Tea Saponin Addition on the Enhanced Bioremediation of Pyrene-Contaminated Soil Using Polycyclic Aromatic Hydrocarbon-Degrading Bacterial Strain显示文摘As one of the most widely distributed bacterial predators in the soil, the role of bacterivorous nematodes on the enhanced bioremediation of polycyclic aromatic hydrocarbon-contaminated soils is crucial, but remains to be investigated.A microcosm-level study was conducted to examine the effects of bacterial-feeding nematode grazing and tea saponin(TS) addition on bioremediation of a pyrene-contaminated soil enhanced by the polycyclic aromatic hydrocarbon(PAH)-degrading bacterial strain Sphingobium sp.PHE9.After 180 d of incubation, the highest pyrene dissipation(71.3%) was achieved through a combination of Sphingobium sp.PHE9 inoculation with nematode and TS addition.Meanwhile, high counts of culturable PAH-degrading bacteria, soil enzyme activity, and biodiversity indices were observed under the combined treatment, implying that the microbiological function of the contaminated soil was significantly restored.Additionally, the results of Tenax~ extraction with the first-order three-compartment model indicated that rate-limiting factors varied among treatments.The lack of degrading microorganisms was the main rate-limiting factor for the treatments involving TS/nematode addition, and inadequate bioaccessible pyrene was the vital rate-limiting factor in the treatments involving Sphingobium sp.PHE9 inoculation.The proposed combined clean-up strategy proved to be a promising bioremediation technology for aged pyrene-contaminated soils. | SUN Mingming LIU Kuan ZHAO Yuanchao TIAN Da YE Mao LIU Manqiang JIAO Jiaguo JIANG Xin | 2017 | Pedosphere2017，27，6： | 7 |
| 17 | siRNA, miRNA and HIV: promises and challenges显示文摘Small interfering RNA (siRNA) and microRNA (miRNA) are small RNAs of 18-25 nucleotides (nt) in length that play important roles in regulating gene expression. They are incorporated into an RNA-induced silencing complex (RISC) and serve as guides for silencing their corresponding target mRNAs based on complementary base-pairing. The promise of gene silencing has led many researchers to consider siRNA as an anti-viral tool. However, in long-term settings, many viruses appear to escape from this therapeutical strategy. An example of this may be seen in the case of human immunodeficiency virus type-1 (HIV-1) which is able to evade RNA silencing by either mutating the siRNA- targeted sequence or by encoding for a partial suppressor of RNAi (RNA interference). On the other hand, because miRNA targeting does not require absolute complementarity of base-pairing, mutational escape by viruses from miRNA- specified silencing may be more difficult to achieve. In this review, we discuss stratagems used by various viruses to avoid the cells’ antiviral si/mi-RNA defenses and notions of how viruses might control and regulate host cell genes by encoding viral miRNAs (vmiRNAs). | Man Lung YEUNG Yamina BENNASSER Shu Yun LE Kuan Teh JEANG | 2005 | Cell Research2005，15，11： | 7 |
| 18 | Association of USP26 haplotypes in men in Taiwan, China with severe spermatogenic defect显示文摘瞄准:为肥沃、不肥沃的人完成 USP26 的全面 haplotype 分析。方法:有严重 oligospermia 或非妨碍的精子缺乏的 200 个不肥沃的人被使遭到为 USP26 基因的全部编码序列定序分析。有证明富饶的 200 个人是由教材延期方法的 genotyped。等位基因 / 遗传型频率,连接不平衡(LD ) 特征和肥沃的人的 haplotypes 与不肥沃的人相比。结果:五单个核苷酸多型性的等位基因频率(370 371insACA, 494T >C, 576G >A, ss6202791C>T, 1737G >A ) 比控制题目在不肥沃的病人是显著地更高的。在不肥沃的人的主要 haplotypes 是 TACCGA (28% 人口) , TGCCGA (15%) , TACCAA (8%) , TGCCAA (6%) , TATCAA (5%) 和 CATCAA (5%) 。为控制题目的主要 haplotypes 是 TACCGA (58% 人口) , CACCGA (7%) , CATCGA (6%) 和 TGCCGA (5%) 。而 haplotypes TACCGA, CACCGA,和 CATCGA 在这些病人是下面播送的, Haplotypes TGCCGA, TATCAA, CATCAA, CATCGC, TACCAA 和 TGCCAA 在有 spermatogenic 缺点的病人是过去播送的。结论:一些 USP26 等位基因和 haplotypes 在台湾在汉国籍与 spermatogenic 缺点被联系,中国。 | I-Wen Lee Long-Ching Kuan Chien-Hung Lin Hsien-An Pan Chao-Chin Hsu Yung-Chieh Tsai Pao-Lin Kuo Yen-Ni Teng | 2008 | Asian Journal of Andrology2008，10，6： | 7 |
| 19 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 20 | Effect of Martensite Fine Structure on Mechanical Properties of an 1100 MPa Grade Ultra-high Strength Steel显示文摘An 1100 MPa grade ultra-high strength steel with different martensite fine structures,characterized by prior austenite grain size,martensite packet size,block width and lath width,was studied by various heat treatment processes.The result shows that with decreasing prior austenite grain size,both the packet size and block width decrease,while the lath width has virtually no change.Accordingly,both strength and toughness increase,while total elongation decreases.The yield strength has a Hall-Petch type relationship with the prior austenite grain size,packet size and block width,and the block width may be regarded as a key factor influencing strength.On the other hand,the ductile to brittle transition temperature(DBTT)is found to be more related to the packet size,which may be considered as a dominant factor influencing toughness. | Fan ZHEN Kuan ZHANG Zhi-long GUO Jin-bo QU | 2015 | Journal of Iron and Steel Research(International)2015，22，7： | 6 |
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