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| 1 | 生精障碍的遗传因素显示文摘大概10%-15%的夫妇患有不孕不育,其中,男性因素导致的不育约占一半。部分是由男方的生精障碍导致的,但其根本原因,包括遗传性变异,仍知之甚少。迄今为止,男性不育症诊断中使用的唯一基因测试的目的是检测是否存在Y染色体长臂的微缺失或者染色体异常。各种其他单基因和多基因缺陷也己被提出与男性生育能力相关。但其致病作用仍有待验证。最近,全基因组技术和小鼠模型的大规模分析方面所取得的巨大进步可能有助于这方面的研究。利用基因敲除小鼠模型,至少有388个基因与小鼠生精相关的基因被发现了。但当前的主要问题在于如何把这些研究成果从小鼠转移应用到人类。 | Annelien Massart Willy Lissens Herman Tournaye Katrien Stouffs | 2012 | Asian Journal of Andrology2012，14，1： | 36 |
| 2 | Can intraluminal devices prevent or reduce colorectal anastomotic leakage:A review显示文摘Colorectal anastomotic leakage is a serious complication of colorectal surgery, leading to high morbidity and mortality rates. In recent decades, many strategies aimed at lowering the incidence of anastomotic leakage have been examined. The focus of this review will be on mechanical aids protecting the colonic anastomosis against leakage. A literature search was performed using MEDLINE, EMBASE, and The Cochrane Collaborative library for all papers related to prevention of anastomotic leakage by placement of a device in the colon. Devices were categorised as decompression devices, intracolonic devices, and biodegradable devices. A decompression device functions by keeping the anal sphincter open, thereby lowering the intraluminal pressure and lowering the pressure on the anastomosis. Intracolonic devices do not prevent the formation of dehiscence. However, they prevent the faecal load from contacting the anastomotic site, thereby preventing leakage of faeces into the peritoneal cavity. Many attempts have been made to find a device that decreases the incidence of AL;however, to date, none of the devices have been widely accepted. | Annelien N Morks Klaas Havenga Rutger J Ploeg | 2011 | World Journal of Gastroenterology2011，17，40： | 11 |
| 3 | On Political Liberty: Montesquieu's Missing Manuscript 显示文摘 | Annelien de Dijn | 2011 | Political Theory2011，39，2： | 1 |
| 4 | Was Montesquieu a Liberal Re- publican? 显示文摘 | Annelien de Dijn | 2014 | The Review of Politics2014，76，1： | 1 |
| 5 | Montesquieu 's Controversial Context: The spirit of the Laws as A Monarchist Tract 显示文摘 | Annelien de Dijn | 2013 | History of Political Thought2013，34，1： | 1 |
| 6 | Characterization of protein encoded by ORFs 2 to 7 of Lelystad virus显示文摘 | Janneke J M Annelien P B Eric P K | 1995 | Virology1995，206，： | 1 |
| 7 | The role of corporate image and company employment image in explaining application intentions显示文摘 | Jos Lemmink Annelien Schuijf Sandra Streukens | | 0，，01： | 1 |
| 8 | Patients to learn from:on the need for systematic integration of research and care in academic health care显示文摘Patients suffering from rare,extreme or extremely complex sets of symptoms have something to expect from efforts to improve care through research.Biomedical research and care have often been approached as distinct worlds which are and should be only loosely connected.For observational research focusing on data drawn from real-world settings,however,that approach is found wanting.Integrating research and care responsibly is the main challenge instead.Integrated IT infrastructures facilitating Personalized medicine and Big Data are crucial components of a learning health care system,in which patients regularly play a double role:as individuals to be treated and as cases to learn from.Drawing on the example of the Dutch Parelsnoer Institute(PSI),a national biobanking and IT infrastructure integrated with clinical care procedures,this article outlines the reforms that are needed.Systematic integration of research and care offers a promising avenue,provided that a number of conditions are met:data and IT infrastructures will require overhauls in order to facilitate secure,high-quality data integration between research and care;institutional focus is needed to bring patient populations and expertise together;ethical frameworks and approaches for integrating research and care responsibly require further elaboration;clinical procedures and professional responsibilities may need to be adapted in order to accommodate research requirements in clinical processes;and involvement of patients and other stakeholders in design and research priority setting is needed to further the goals of real-world and patient relevance.Relevance for patients:Integrating research and care in academic medicine in a more systematic fashion offers a promising perspective to current and future patients.In order to live up to these promises,research and care should be integrated more systematically in academic health science,with patients being included as research participants by default.Data and tissue infrastructures and facilities can provide a platform for doing so.At the same time,many issues remain to be settled.New ethical ways and means for protecting and respecting patient-participants in such a double role are also needed in this respect.In this way a deeper transformation is at stake as well:a change towards a setting in which patients fully take center stage in debate and action on the future of biomedicine. | Martin Boeckhout Philip Scheltens Peggy Manders Cees Smit Annelien L Bredenoord Gerhard A Zielhuis | 2018 | Journal of Clinical & Translational Research2018，4，3： | 0 |
| 9 | Current surgical treatment of diverticular disease in the Netherlands显示文摘AIM: To evaluate the development of diagnostic tools, indications for surgery and treatment modalities concerning diverticular disease (DD) in the Netherlands. METHODS: Data were collected from 100 patients who underwent surgery for DD in three Dutch hospitals. All hospitals used the same standardized data base. The collected data included patient demographics, patient history, type of surgery and complications. Patients were divided into two groups, one undergoing elective surgery (elective group) and the other undergoing acute surgery (acute group). RESULTS: Two hundred and ninety-nine patients were admitted between 2000 and 2007. One hundred and seventy-eight patients underwent acute surgery and 121 patients received elective operations. The median age of the 121 patients was 69 years (range: 28-94 years), significantly higher in acute patients (P = 0.010). Laparoscopic resection was performed in 31% of elective patients. In the acute setting, 61% underwent a Hartmann procedure. The overall morbidity and mortality were 51% and 10%, and 60% and 16% in the acute group, which were significantly higher than in the elective group (36% and 1%). Only 35% of the temporary ostomies were restored. CONCLUSION: This study gives a picture of current surgical practice for DD in the Netherlands. New developments are implemented in daily practice, resulting in acceptable morbidity and mortality rates. | Annelien N Morks Bastiaan R Klarenbeek Elvira R Flikweert Donald L van der Peet Thomas M Karsten Eric H Eddes Miguel A Cuesta Peter W de Graaf | 2010 | World Journal of Gastroenterology2010，16，14： | 0 |
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