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| 1 | Gut barrier failure biomarkers are associated with poor disease outcome in patients with primary sclerosing cholangitis显示文摘AIM To assess the prevalence of a panel of serologic markers that reflect gut barrier dysfunction in a mixed cohort of pediatric and adult primary sclerosing cholangitis(PSC) patients.METHODS Sera of 67 PSC patients [median age(range): 32(5-79) years, concomitant IBD: 67% and cirrhosis: 20%] were assayed for the presence of antibodies against to F-actin(AAA Ig A/Ig G) and gliadin(AGA Ig A/Ig G)] and for serum level of intestinal fatty acid-binding protein(I-FABP) by ELISA. Markers of lipopolysaccharide(LPS) exposure [LPS binding protein(LBP)] and various antimicrobial antibodies [anti-OMP Plus Ig A and endotoxin core Ig A antibody(Endo CAb)] were also determined. Poor disease outcome was defined as orthotopic liver transplantation and/or liver-related death during the follow-up [median: 99(14-106) mo]. One hundred and fifty-three healthy subjects(HCONT) and 172 ulcerative colitis(UC) patients were the controls. RESULTS A total of 28.4%, 28.0%, 9% and 20.9% of PSC patients were positive for AAA Ig A, AAA Ig G, AGA Ig A and AGA Ig G, respectively. Frequencies of AAA Ig A and AAA Ig G(P < 0.001, for both) and AGA Ig G(P = 0.01, for both) but not AGA Ig A were significantly higher compared to both of the HCONT and the UC groups. In survival analysis, AAA Ig A-positivity was revealed as an independent predictor of poor disease outcome after adjusting either for the presence of cirrhosis [HR = 5.15(1.27-20.86), P = 0.022 or for the Mayo risk score(HR = 4.24(0.99-18.21), P = 0.052]. AAA Ig A-positivity was significantly associated with higher frequency of antimicrobial antibodies(P < 0.001 for Endo Cab Ig A and P = 0.012 for anti-OMP Plus Ig A) and higher level of the enterocyte damage marker(median I-FABP_(AAA Ig A pos vs neg): 365 vs 166 pg/m L, P = 0.011), but not with serum LBP level. CONCLUSION Presence of Ig A type AAA identified PSC patients with progressive disease. Moreover, it is associated with enhanced mucosal immune response to various microbial antigens and enterocyte damage further highlighting the importance of the gut-liver interaction in PSC. | Tamas Tornai Eszter Palyu Zsuzsanna Vitalis Istvan Tornai David Tornai Peter Antal-Szalmas Gary L Norman Zakera Shums Gabor Veres Antal Dezsofi Gabriella Par Alajos Par Peter Orosz Ferenc Szalay Peter Laszlo Lakatos Maria Papp | 2017 | World Journal of Gastroenterology2017，23，29： | 5 |
| 2 | Ibutilide: a new class antiarrhythmic agent 显示文摘 | CROPP J S ANTAL E G TALBERT R L | 2010 | Parmarcothrrapy2010，17，： | 1 |
| 3 | Kinetics of cellulose pyrolysis in nitrogen and steam显示文摘 | Antal M J Friedman H L Rogers F E | 1980 | Combustion Science and Technology1980，21，： | 1 |
| 4 | Productive and parasitic pathways in dilute acid-catalyzed hydrolysis of cellulose 显示文摘 | Mok W S L Antal M J | 1992 | Industrial and Engeneering Chemistry Research1992，31，2： | 1 |
| 5 | Colony growth,in vitro antagonism and secretion of extracellular enzymes in cold-tolerant strains of Trichoderma species显示文摘 | Antal Z Manczinger L Szakacs G | 2000 | Mycol Res2000，104，： | 1 |
| 6 | Weight-driven growing networks显示文摘 | Antal T Krapivsky P L | 2005 | Phys Rev E2005，71，02： | 1 |
| 7 | The influence of homocys- teine and oxidative stress on pregnancy outcome 显示文摘 | Miele O Muresan M Antal L | 2012 | Journal of Medicine and Life2012，5，1： | 1 |
| 8 | Mechanism offormation of 2-furaldehyde from D-xylose显示文摘 | ANTAL M L LEESOMBOON T MOK W S | 1991 | Carbohydrate Research1991，217，： | 1 |
| 9 | Selective trace enrichment of chlorotriazine pesticides from natural waters and sediment samples using terbuthylazine molecularly imprinted polymers显示文摘 | IMMA F FRANCESCA L ANTAL T | 2000 | Anal Chem2000，72，： | 1 |
| 10 | The influence of homocysteine and oxidative stress on pregnancy outcome显示文摘 | Micle O Muresan M Antal L | 2012 | J Med Life2012，5，1： | 1 |
| 11 | Weight-driven growing networks显示文摘 | Antal T Krapivsky P L | 2005 | Physical Review E2005，71，02： | 1 |
| 12 | uncatalyzed solvdysis of whole biomass hemicelluloses by hot compressed liquid water显示文摘 | Mok W S L Antal Jr M J | 1992 | Industrial and Engineering Chemistry Research1992，31，： | 1 |
| 13 | Influence of environmental parameters on Trichoderma strains with biocontrol potential显示文摘 | KREDICS L ANTAL Z MANCZINGER L | 2003 | Food Technology and Biotechnology2003，41，1： | 1 |
| 14 | A multi-center study to evaluate the pharmacokinetics and clinical interactions between alprazolam and imipramine显示文摘 | Antal EJ Grasel TH Ereshefsky L | 1991 | J Pharmacokinet Biopharm1991，19，3： | 1 |
| 15 | Weight-driven growing networks 显示文摘 | Antal T Krapivsky P L | 2005 | Phys Rev E2005，71，02： | 1 |
| 16 | Four-carbon Model Compounds for the Reactionsof Sugars in Water at High Temperature显示文摘 | ANTAL J M J MOK W S L | 1990 | Carbonhydr Res1990，，199： | 1 |
| 17 | Mechanism offormation of 5-(hydroxymethyl)-2-furaldehyde from D-fructose andsucrose显示文摘 | ANTAL M J Jr MOK W S L RICHARDS G N | 1990 | Carbohydrate Research1990，199，1： | 1 |
| 18 | Pyrolytic sources of hydrocarbons from biomass显示文摘 | Antal Jr M J Mok W S L Roy J C | 1985 | Anal Appl Pyrolysis1985，，8： | 1 |
| 19 | Colony growth,in vitro antagonism and secretion of extracellular enzymes in cold-tolerant strains of Trichoderma species显示文摘 | Antal Z Manczinger L Szakacs G | 2000 | Mycol Res2000，104，： | 1 |
| 20 | Isolation and characterization of protease overproducing mutants of Trichoderma harzianum显示文摘 | Szekeres A Kredics L Antal Z | 2004 | FEMS Microbiol Lett2004，233，： | 1 |
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