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| 1 | A new prognostic histopathologic classification of nasopharyngeal carcinoma显示文摘Background:The current World Health Organization(WHO) classification of nasopharyngeal carcinoma(NPC) con?veys little prognostic information.This study aimed to propose an NPC histopathologic classification that can poten?tially be used to predict prognosis and treatment response.Methods:We initially developed a histopathologic classification based on the morphologic traits and cell differentia?tion of tumors of 2716 NPC patients who were identified at Sun Yat?sen University Cancer Center(SYSUCC)(training cohort).Then,the proposed classification was applied to 1702 patients(retrospective validation cohort) from hospitals outside SYSUCC and 1613 patients(prospective validation cohort) from SYSUCC.The efficacy of radiochemotherapy and radiotherapy modalities was compared between the proposed subtypes.We used Cox proportional hazards models to estimate hazard ratios(HRs) with 95% confidence intervals(CI) for overall survival(OS).Results:The 5?year OS rates for all NPC patients who were diagnosed with epithelial carcinoma(EC;3708 patients),mixed sarcomatoid?epithelial carcinoma(MSEC;1247 patients),sarcomatoid carcinoma(SC;823 patients),and squamous cell carcinoma(SCC;253 patients) were 79.4%,70.5%,59.6%,and 42.6%,respectively(P < 0.001).In mul?tivariate models,patients with MSEC had a shorter OS than patients with EC(HR = 1.44,95% CI = 1.27–1.62),SC(HR = 2.00,95% CI = 1.76–2.28),or SCC(HR = 4.23,95% CI = 3.34–5.38).Radiochemotherapy significantly improved survival compared with radiotherapy alone for patients with EC(HR 49–0.75),and possibly for those with SCC(HR = 0.67,95% CI = 0.56–0.80),MSEC(HR = 0.58,95% CI = 0..74–1.28).= 0.63;95% CI = 0.40–0.98),but not for patients with SC(HR = 0.97,95% CI = 0Conclusions:The proposed classification offers more information for the prediction of NPC prognosis compared with the WHO classification and might be a valuable tool to guide treatment decisions for subtypes that are associ?ated with a poor prognosis. | Hai-Yun Wang Yih-Leong Chang Ka-Fai To Jacqueline S.G.Hwang Hai-Qiang Mai Yan-Fen Feng Ellen T.Chang Chen-Ping Wang Michael Koon Ming Kam Shie-Lee Cheah Ming Lee Li Gao Hui-Zhong Zhang Jie-Hua He Hao Jiang Pei-Qing Ma Xiao-Dong Zhu Liang Zeng Chun-Yan Chen Gang Chen Ma-Yan Huang Sha Fu Qiong Shao An-Jia Han Hai-Gang Li Chun-Kui Shao Pei-Yu Huang Chao-Nan Qian Tai-Xiang Lu Jin-Tian Li Weimin Ye Ingemar Ernberg Ho Keung Ng Joseph T.S.Wee Yi-Xin Zeng Hans-Olov Adami Anthony T.C.Chan Jian-Yong Shao | 2016 | Chinese Journal of Cancer2016，35，6： | 10 |
| 2 | AtPEPTIDE RECEPTOR_2 mediates the AtPEPTIDE1‐induced cytosolic Ca^(2+) trise, which is required for the suppression of Glutamine Dumper gene expression in Arabidopsis roots显示文摘AtPEPTIDE RECEPTOR2(AtPEPR2) is a member of leucine‐rich repeat receptor‐like kinase family and binds to a group of AtPROPEP gene‐encoded endogenous peptides,AtPeps. Previously, we found that AtPEPR2 plays a moderate role in the AtPep1‐mediated innate immunity responses in Arabidopsis leaf. In this study, we found that AtPEPR2promoter has strong activity in the vascular tissues of the roots and the atpepr2 mutants showed a moderate but significantly shorter root phenotype. AtPEPR2 partially mediated AtPep1‐induced root elongation inhibition. AtPep1‐triggered cytosolic Ca2ttransient rise in roots showed partial dependence on AtPEPR2 and fully on extracellular Ca2t([Ca2t]ext). Transcriptional profiling analysis found that expression of 75% of AtPep1‐modulated genes in roots was fully dependent on AtPEPR2, of which two dramatically induced genes showed partial dependence on the [Ca2t]ext.Arabidopsis genome contains seven Glutamine Dumpers genes(AtGDUs), encoding amino acid exporters. Three of them(AtGDU2, 3, 5) were among the top 10 genes that were downregulated by AtPep1 through AtPEPR2 fully dependent pathway. Treatment with AtPep1 strongly suppressed promoter activity of AtGDU3 in roots, which was relieved by chelating [Ca2t]ext. Arabidopsis overexpressing AtGDU3showed a shorter root phenotype and decreased sensitivity to the AtPep1‐mediated inhibition of root elongation. Taken together, this study demonstrated a significant role of AtPEPR2 in the AtPep1‐mediated signaling in the roots. | Chunli Ma Jie Guo Yan Kang Kohei Doman Anthony C.Bryan Frans E.Tax Yube Yamaguchi Zhi Qi | 2014 | Journal of Integrative Plant Biology2014，56，7： | 3 |
| 3 | EasySVM: A visual analysis approach for open-box support vector machines显示文摘Support vector machines(SVMs) are supervised learning models traditionally employed for classification and regression analysis. In classification analysis, a set of training data is chosen, and each instance in the training data is assigned a categorical class. An SVM then constructs a model based on a separating plane that maximizes the margin between different classes. Despite being one of the most popular classification models because of its strong performance empirically, understanding the knowledge captured in an SVM remains difficult. SVMs are typically applied in a black-box manner where the details of parameter tuning, training, and even the final constructed model are hidden from the users. This is natural since these details are often complex and difficult to understand without proper visualization tools. However, such an approach often brings about various problems including trial-and-error tuning and suspicious users who are forced to trust these models blindly.The contribution of this paper is a visual analysis approach for building SVMs in an open-box manner.Our goal is to improve an analyst's understanding of the SVM modeling process through a suite of visualization techniques that allow users to have full interactive visual control over the entire SVM training process.Our visual exploration tools have been developed to enable intuitive parameter tuning, training datamanipulation, and rule extraction as part of the SVM training process. To demonstrate the efficacy of our approach, we conduct a case study using a real-world robot control dataset. | Yuxin Ma Wei Chen Xiaohong Ma Jiayi Xu Xinxin Huang Ross Maciejewski Anthony K.H.Tung | 2017 | Computational Visual Media2017，3，2： | 2 |
| 4 | Cardiovascular Magnetic Resonance in Myocarditis: A JACC White Paper显示文摘 | Matthias G. Friedrich Udo Sechtem Jeanette Schulz-Menger Godtfred Holmvang Pauline Alakija Leslie T. Cooper James A. White Hassan Abdel-Aty Matthias Gutberlet Sanjay Prasad Anthony Aletras Jean-Pierre Laissy Ian Paterson Neil G. Filipchuk Andreas Kumar Ma | 2009 | Journal of the American College of Cardiology2009，，17： | 2 |
| 5 | Postoperative Complications and Mortality Following Colectomy for Ulcerative Colitis显示文摘 | Shanika de Silva Christopher Ma Marie–Claude Proulx Marcelo Crespin Belle S. Kaplan James Hubbard Martin Prusinkiewicz Andrew Fong Remo Panaccione Subrata Ghosh Paul L. Beck Anthony MacLean Donald Buie Gilaad G. Kaplan | 2011 | Clinical Gastroenterology and Hepatology2011，，11： | 2 |
| 6 | A study of circulating interleukin 10 in prognostication of unresectable hepatocellular carcinoma显示文摘 | Stephen L. Chan Frankie K. F. Mo Cesar S. C. Wong Charles M. L. Chan Linda K. S. Leung Edwin P. Hui Brigette B. Ma Anthony T. C. Chan Tony S. K. Mok Winnie Yeo | 2011 | Cancer2011，，16： | 2 |
| 7 | Challenges and opportunities for managing pediatric central nervous system tumors in China显示文摘Central nervous system(CNS)tumors represent the most deadly cancer in pediatric age group.In China,thousands of children are diagnosed with CNS tumors every year.Despite the improving socioeconomic status and availability of medical expertise within the country,unique challenges remain for the delivery of pediatric neuro-oncology service.In this review,we discuss the existing hurdles for improving the outcome of children with CNS tumors in China.Need for precise disease burden estimation,lack of intra-and inter-hospital collaborative networks,high probability of treatment abandonment,along with financial toxicities from treatment represent the key challenges that Chinese healthcare providers encounter.The tremendous opportunities for advancing the status of pediatric neuro-oncology care in and beyond the country are explored. | Anthony Pak-Yin Liu Daniel CMoreira Chenchen Sun Lisa Krull Yijin Gao Bo Yang Chenran Zhang Kejun He Xiaojun Yuan Godfrey Chi-Fung Chan Xiaofei Sun Xiaoli Ma Ibrahim AQaddoumi | 2020 | Pediatric Investigation2020，4，3： | 2 |
| 8 | A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia显示文摘 | Belfort MA Anthony J Saade GR | 2003 | N Engl J Med2003，348，： | 1 |
| 9 | A comparison of vascularized and nonvascularized bone grafts for reconstruction of mandibular continuity defects显示文摘 | Pogrel MA Podlesh S Anthony JP | 1997 | J Oral Maxillofac Surg1997，55，： | 1 |
| 10 | A comparison of vascularized and nonvascularized bone grafts for reconstruction of mandibular continuity defects显示文摘 | Pogral MA Podlesh S Anthony JP | 1977 | J Oral Maxillofac Surg1977，55，11： | 1 |
| 11 | A comparison of vascularized and nonvascularized bone grafts for reconstruction of mandibular continuity defects显示文摘 | Pogrel MA Podlesh S Anthony JP | 1997 | J Oral Maxillofac Surg1997，55，： | 1 |
| 12 | Effects of mitomycin C and carboplatin pretreatment on multidrug resistance-associated Pglycoprotein expression and on subsequent suppression of tumor growth by doxorubicin and paclitaxel in human metastatic breast cancer xenografted nude mice显示文摘 | Ihnat MA Nervi AM Anthony SP | 1999 | Oncol Res1999，11，7： | 1 |
| 13 | Cardiovascular Magnetic Resonance in Myocarditis: A JACC White Paper显示文摘 | Matthias G. Friedrich Udo Sechtem Jeanette Schulz-Menger Godtfred Holmvang Pauline Alakija Leslie T. Cooper James A. White Hassan Abdel-Aty Matthias Gutberlet Sanjay Prasad Anthony Aletras Jean-Pierre Laissy Ian Paterson Neil G. Filipchuk Andreas Kumar Ma | 2009 | Journal of the American College of Cardiology2009，，17： | 1 |
| 14 | Initiation of growth arrest and apoptosis of MCF-7 mammary carcinoma cells by tributyrin, a triglyceride analogue of the short-chain fatty acid butyrate, is associated with mitochondrial activity 显示文摘 | Heerdt BG Houston MA Anthony GM | 1999 | Cancer Res1999，59，： | 1 |
| 15 | Soy-based formula and infant growth and development: A review显示文摘 | Mendez MA Anthony MS Arab L | 2002 | J Nutr2002，132，： | 1 |
| 16 | Local Identity and Nationalism: Surveys on Hong Kong Cultural Identification 1996 -2006 显示文摘 | Eric Ma Anthony Fung | 2007 | The Chinese Jour- nal of Communication and Society2007，，3： | 1 |
| 17 | A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia显示文摘 | Belfort MA Anthony J Saade GR | 2003 | N Engl J Med2003，348，4： | 1 |
| 18 | Prognostic significance of the total dose of cisplatin administered during concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma显示文摘 | Herbert H. Loong Brigette B.Y. Ma Sing-Fai Leung Frankie Mo Edwin P. Hui Michael K. Kam Stephen L. Chan Brian K.H. Yu Anthony T.C. Chan | 2012 | Radiotherapy and Oncology2012，，3： | 1 |
| 19 | Central nervous system inflammation in disease related conditions: Mechanistic prospects显示文摘 | Anthony Fung Marcela Vizcaychipi Dafydd Lloyd Yanjie Wan Daqing Ma | 2012 | Brain Research2012，，： | 1 |
| 20 | Simulation and experimental study of arc motion in a low-voltage circuit breaker considering wall ablation显示文摘 | Ma Qiang Rong Mingzhe Murphy Anthony | 2008 | IEICE Transactions on Electronics2008，91，8： | 1 |
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