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| 1 | Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review显示文摘 | Natalie A. Molodecky Ing Shian Soon Doreen M. Rabi William A. Ghali Mollie Ferris Greg Chernoff Eric I. Benchimol Remo Panaccione Subrata Ghosh Herman W. Barkema Gilaad G. Kaplan | 2012 | Gastroenterology2012，，1： | 33 |
| 2 | Upper-gastrointestinal bleeding secondary to peptic ulcer disease:Incidence and outcomes显示文摘AIM:To evaluate the incidence,surgery,mortality,and readmission of upper gastrointestinal bleeding(UGIB)secondary to peptic ulcer disease(PUD).METHODS:Administrative databases identified all hospitalizations for UGIB secondary to PUD in Alberta,Canada from 2004 to 2010(n=7079)using the International Classification of Diseases Codes(ICD-10).A subset of the data was validated using endoscopy reports.Positive predictive value and sensitivity with 95%confidence intervals(CI)were calculated.Incidence of UGIB secondary to PUD was calculated.Logistic regression was used to evaluate surgery,in-hospital mortality,and 30-d readmission to hospital with recurrent UGIB secondary to PUD.Co-variants accounted for in our logistic regression model included:age,sex,area of residence(i.e.,urban vs rural),number of Charlson comorbidities,presence of perforated PUD,undergoing upper endoscopy,year of admission,and interventional radiological attempt at controlling bleeding.A subgroup analysis(n=6356)compared outcomes of patients with gastric ulcers to those with duodenal ulcers.Adjusted estimates are presented as odds ratios(OR)with95%CI.RESULTS:The positive predictive value and sensitivity of ICD-10 coding for UGIB secondary to PUD were85.2%(95%CI:80.2%-90.2%)and 77.1%(95%CI:69.1%-85.2%),respectively.The annual incidence between 2004 and 2010 ranged from 35.4 to 41.2 per100000.Overall risk of surgery,in-hospital mortality,and 30-d readmission to hospital for UGIB secondary to PUD were 4.3%,8.5%,and 4.7%,respectively.Interventional radiology to control bleeding was performed in 0.6%of patients and 76%of these patients avoided surgical intervention.Thirty-day readmission significantly increased from 3.1%in 2004 to 5.2%in 2010(OR=1.07;95%CI:1.01-1.14).Rural residents(OR rural vs urban:2.35;95%CI:1.83-3.01)and older individuals(OR≥65 vs<65:1.57;95%CI:1.21-2.04)were at higher odds of being readmitted to hospital.Patients with duodenal ulcers had higher odds of dying(OR=1.27;95%CI:1.05-1.53),requiring surgery(OR=1.73;95%CI:1.34-2.23),and being readmitted to hospital(OR=1.54;95%CI:1.19-1.99)when compared to gastric ulcers.CONCLUSION:UGIB secondary to PUD,particularly duodenal ulcers,was associated with significant morbidity and mortality.Early readmissions increased over time and occurred more commonly in rural areas. | Samuel Quan Alexandra Frolkis Kaylee Milne Natalie Molodecky Hong Yang Elijah Dixon Chad G Ball Robert P Myers Subrata Ghosh Robert Hilsden Sander Veldhuyzen van Zanten Gilaad G Kaplan | 2014 | World Journal of Gastroenterology2014，20，46： | 21 |
| 3 | Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review显示文摘 | Natalie A. Molodecky Ing Shian Soon Doreen M. Rabi William A. Ghali Mollie Ferris Greg Chernoff Eric I. Benchimol Remo Panaccione Subrata Ghosh Herman W. Barkema Gilaad G. Kaplan | 2012 | Gastroenterology2012，，1： | 3 |
| 4 | Air pollution effects on the gut microbiota显示文摘 | Saad Y Salim Gilaad G Kaplan Karen L Madsen | 2014 | Gut Microbes2014，，： | 3 |
| 5 | Impact of Hospital Volume on Postoperative Morbidity and Mortality Following a Colectomy for Ulcerative Colitis显示文摘 | Gilaad G. Kaplan Ellen P. McCarthy John Z. Ayanian Joshua Korzenik Richard Hodin Bruce E. Sands | 2008 | Gastroenterology2008，，3： | 2 |
| 6 | Postoperative Complications and Mortality Following Colectomy for Ulcerative Colitis显示文摘 | Shanika de Silva Christopher Ma Marie–Claude Proulx Marcelo Crespin Belle S. Kaplan James Hubbard Martin Prusinkiewicz Andrew Fong Remo Panaccione Subrata Ghosh Paul L. Beck Anthony MacLean Donald Buie Gilaad G. Kaplan | 2011 | Clinical Gastroenterology and Hepatology2011，，11： | 2 |
| 7 | Clinical predictors of thiopurine-related adverse events in Crohn's disease显示文摘AIM: To determine the incidence and predictors of thiopurine-related adverse events. METHODS: Subjects with Crohn's disease who were followed in the Alberta Inflammatory Bowel Disease Consortium patient database registry were identified. Retrospective chart review was conducted between August 5th, 2010 and June 1st, 2012. We collected data on: age at diagnosis; sex; disease location and behaviour at time of prescribing thiopurine; perianal fistulising disease at or prior to thiopurine prescription; smoking status at time of thiopurine prescription, use of corticosteroid within 6 mo of diagnosis; dosage, age at onset, and cessation of 5-aminosalicyclic acid(5-ASA); anti-tumour necrosis factor medication exposure and intestinal resection before thiopurine prescription. The primary outcome of interest was the first adverse event that led to discontinuation of the first thiopurine medication used. Logistic regression models were used to associate clinical characteristics with outcomes after adjusting for potential confounders. Risk estimates were presented as odds ratios(OR) with 95% CI. Effect modification by age and sex were explored.RESULTS: Our cohort had a median follow-up duration of 5.8 years [interquartile range(IQR 25th-75th) 2.7-9.1]. Thiopurine therapy was discontinued in 31.3% of patients because of: hypersensitivity reactions(7.1%), acute pancreatitis(6.2%), gastrointestinal intolerance(5.4%), leucopenia(3.7%), hepatotoxicity(3.4%), infection(1.1%) and other reasons(4.3%). A higher incidence of thiopurine withdrawal was observed in patients over the age of 40(39.4%, P = 0.007). A sexby-age interaction(P = 0.04) was observed. Females older than 40 years of age had an increased risk of thiopurine discontinuation due to an adverse event(age above 40 vs age below 40, adjusted OR = 2.8; 95%CI: 1.4-5.6). In contrast, age did not influence thiopurine withdrawal in males(age above 40 vs below 40, adjusted OR = 0.9; 95%CI: 0.4-2.1). Other clinical variables(disease location and phenotype, perianal disease, smoking history, history of intestinal resection and prior 5-ASA or corticosteroid use) were not associated with an increased risk an adverse event leading to therapy cessation. CONCLUSION: Thiopurine withdrawal due to adverse events is commoner in women over the age of 40 at prescription. These findings need to be replicated in other cohorts. | Gordon W Moran Marie-France Dubeau Gilaad G Kaplan Hong Yang Bertus Eksteen Subrata Ghosh Remo Panaccione | 2015 | World Journal of Gastroenterology2015，21，25： | 2 |
| 8 | Postoperative Complications Following Colectomy for Ulcerative Colitis in Children显示文摘 | Ing Shian Soon Iwona Wrobel Jennifer C.C. deBruyn Reg Sauve David L. Sigalet Belle S. Kaplan Marie-Claude Proulx Gilaad G. Kaplan | 2012 | Journal of Pediatric Gastroenterology and Nutrition2012，，6： | 1 |
| 9 | Impact of Hospital Volume on Postoperative Morbidity and Mortality Following a Colectomy for Ulcerative Colitis显示文摘 | Gilaad G. Kaplan Ellen P. McCarthy John Z. Ayanian Joshua Korzenik Richard Hodin Bruce E. Sands | 2008 | Gastroenterology2008，，3： | 1 |
| 10 | Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review显示文摘 | Natalie A. Molodecky Ing Shian Soon Doreen M. Rabi William A. Ghali Mollie Ferris Greg Chernoff Eric I. Benchimol Remo Panaccione Subrata Ghosh Herman W. Barkema Gilaad G. Kaplan | 2012 | Gastroenterology2012，，1： | 1 |
| 11 | Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review显示文摘 | Natalie A. Molodecky Ing Shian Soon Doreen M. Rabi William A. Ghali Mollie Ferris Greg Chernoff Eric I. Benchimol Remo Panaccione Subrata Ghosh Herman W. Barkema Gilaad G. Kaplan | 2012 | Gastroenterology2012，，1： | 1 |
| 12 | Decreasing Mortality From Acute Biliary Diseases That Require Endoscopic Retrograde Cholangiopancreatography: A Nationwide Cohort Study显示文摘 | Paul D. James Gilaad G. Kaplan Robert P. Myers James Hubbard Abdel Aziz Shaheen Jill Tinmouth Elaine Yong Jonathan Love Steven J. Heitman | 2014 | Clinical Gastroenterology and Hepatology2014，，： | 1 |
| 13 | Weekend Versus Weekday Admission and Mortality From Gastrointestinal Hemorrhage Caused by Peptic Ulcer Disease显示文摘 | Abdel Aziz M. Shaheen Gilaad G. Kaplan Robert P. Myers | 2009 | Clinical Gastroenterology and Hepatology2009，，3： | 1 |
| 14 | The Role of TNFα in Ulcerative Colitis显示文摘 | Bruce E. Sands Gilaad G. Kaplan | 2007 | The Journal of Clinical Pharmacology2007，，8： | 1 |
| 15 | Nationwide retrospective study of hepatitis B virological response and liver stiffness improvement in 465 patients on nucleos(t)ide analogue显示文摘BACKGROUND Hepatitis B virus(HBV)nucleos(t)ide analog(NA)therapy reduces liver disease but requires prolonged therapy to achieve hepatitis B surface antigen(HBsAg)loss.There is limited North American real-world data using non-invasive tools for fibrosis assessment and few have compared 1st generation NA or lamivudine(LAM)to tenofovir disoproxil fumarate(TDF).AIM To assess impact of NA on virological response and fibrosis regression using liver stiffness measurement(LSM)(i.e.,FibroScan®).METHODS Retrospective,observational cohort study from the Canadian HBV Network.Data collected included demographics,NA,HBV DNA,alanine aminotransferase(ALT),and LSM.Patients were HBV monoinfected patients,treatment naïve,and received 1 NA with minimum 1 year follow-up.RESULTS In 465(median 49 years,37%female,35%hepatitis B e antigen+at baseline,84%Asian,6%White,and 9%Black).Percentage of 64(n=299)received TDF and 166 were LAM-treated with similar median duration of 3.9 and 3.7 years,respectively.The mean baseline LSM was 11.2 kPa(TDF)vs 8.3 kPa(LAM)(P=0.003).At 5-year follow-up,the mean LSM was 7.0 kPa in TDF vs 6.7 kPa in LAM(P=0.83).There was a significant difference in fibrosis regression between groups(i.e.,mean-4.2 kPa change in TDF and-1.6 kPa in LAM,P<0.05).The last available data on treatment showed that all had normal ALT,but more TDF patients were virologically suppressed(<10 IU/mL)(n=170/190,89%)vs LAM-treated(n=35/58,60%)(P<0.05).None cleared HBsAg.CONCLUSION In this real-world North American study,approximately 5 years of NA achieves liver fibrosis regression rarely leads to HBsAg loss. | Alnoor Ramji Karen Doucette Curtis Cooper Gerald Yosel Minuk Mang Ma Alexander Wong David Wong Edward Tam Brian Conway David Truong Philip Wong Lisa Barrett Hin Hin Ko Sarah Haylock-Jacobs Nishi Patel Gilaad G Kaplan Scott Fung Carla S Coffin | 2022 | World Journal of Gastroenterology2022，28，31： | 1 |
| 16 | Risk factors associated with inflammatory bowel disease: A multicenter case-control study in Brazil显示文摘BACKGROUND The etiology of inflammatory bowel disease(IBD)is unknown,but it is believed to be multifactorial.The hygiene hypothesis proposes that better hygiene conditions would lead to less infectious disease during childhood and favor the development of immune-mediated diseases.AIM To test the hygiene hypothesis in IBD by assessing the environmental risk factors associated with IBD development in different regions of Brazil with diverse socioeconomic development indices.METHODS A multicenter case-control study was carried out with 548 Crohn’s disease(CD)and 492 ulcerative colitis(UC)outpatients and 416 healthy controls,from six IBD centers within different Brazilian states at diverse socioeconomic development stages.A semi-structured questionnaire with 87 socioeconomic and environmental questions was applied.Logistic regression model was created to assess the odds ratio(OR)with P value and 95%confidence intervals(CI).RESULTS Predictive variables for both diseases(CD and UC)were women[odd ratios(OR)=1.31;OR=1.69],low monthly family income(OR=1.78;OR=1.57),lower number of cohabitants(OR=1.70;OR=1.60),absence of vaccination(OR=3.11;OR=2.51),previous history of bowel infections(OR=1.78;OR=1.49),and family history of IBD(OR=5.26;OR=3.33).Associated risk factors for CD were age(18-39 years)(OR=1.73),higher educational level(OR=2.22),absence of infectious childhood diseases(OR=1.99).The UC predictive variables were living in an urban area(OR=1.62),inadequate living conditions(OR=1.48)and former smokers(OR=3.36).Appendectomy was a risk factor for CD(OR=1.58)with inverse association with UC(OR=4.79).Consumption of treated and untreated water was associated with risk of CD(OR=1.38)and UC(OR=1.53),respectively.CONCLUSION This is the first examining environmental exposures as risk factors for inflammatory bowel disease in Brazil.Most of the variables associated with disease risk support the role of the hygiene hypothesis in IBD development. | Valéria Cristina Loureiro Salgado Ronir Raggio Luiz Neio Lucio Fernandes Boéchat Isabella Sued Leao Bianca do Carmo Schorr JoséMiguel Luz Parente Daniela Calado Lima Eduardo Santos Silveira Júnior Genoile Oliveira Santana Silva Neogélia Pereira Almeida Andrea Vieira Maria Luiza Queiroz de Bueno Júlio Maria Chebli érika Ruback Bertges Luísa Martins da Costa Brugnara Columbano Junqueira Neto Stefania Burjack Gabriel Campbell Luana Letiza Discacciati Joao Paulo Silva Cézar Tiago Nunes Gilaad G Kaplan Cyrla Zaltman | 2020 | World Journal of Gastroenterology2020，26，25： | 1 |
| 17 | Population-based study of the epidemiology of and the risk factors for pyogenic liver abscess显示文摘 | Gilaad G. Kaplan Daniel B. Gregson Kevin B. Laupland | 2004 | Clinical Gastroenterology and Hepatology2004，，11： | 1 |
| 18 | Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review显示文摘 | Natalie A. Molodecky Ing Shian Soon Doreen M. Rabi William A. Ghali Mollie Ferris Greg Chernoff Eric I. Benchimol Remo Panaccione Subrata Ghosh Herman W. Barkema Gilaad G. Kaplan | 2012 | Gastroenterology2012，，1： | 1 |
| 19 | Weekend versus weekday admission and mortality from gastrointestinal hemorrhage caused by peptic ulcer disease显示文摘 | Abdel Aziz M Shanheen Gilaad G Kaplan Robert P Myers | 2009 | Clinical Gastroenterology and Hepatology2009，7，： | 1 |
| 20 | Laparoscopic Versus Open Resection for Colorectal Cancer: A Metaanalysis of Oncologic Outcomes显示文摘 | Timothy D. Jackson Gilaad G. Kaplan Goffredo Arena John H. Page Selwyn O. Rogers | 2007 | Journal of the American College of Surgeons2007，，3： | 1 |
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