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| 1 | 血管性认知损害诊断的进一步规范化:血管性认知损害分类共识研究组指南显示文摘引言血管性认知损害(vascular cognitive impairment,VCI)诊断共识的缺乏(体现为多种不同评估方案的使用),妨碍了对其理解和治疗的推进.多个国家的大量临床医生和研究人员参与了2个阶段血管性认知损害分类共识研究(Vascular Impairment of Cognition Classification Consensus Study,VICCCS),旨在就VCI的诊断原则(VICCCS-1)和诊断方案(VICCCS-2)达成一致意见.本文提供了VICCCS-2的相关内容.方法使用VICCCS-1达成的原则和已发表的诊断指南作为在线德尔菲(Delphi)调查的参考基点,以期对VCI的临床诊断达成共识.结果共进行了6轮调查,每轮有65~79名专家参与,他们就VICCCS修订的轻度和重度VCI的诊断指南达成共识,并肯定了美国国立神经疾病与卒中研究所-加拿大卒中网(National Institute of Neurological Disorders and Stroke–Canadian Stroke Network,NINDS-CSN)发布的神经心理学评估方案和对影像学检查的推荐意见.讨论VICCCS-2建议规范化应用NINDS-CSN推荐的神经心理学和影像学评估方案诊断VCI,以促进研究协作. | Olivia A. Skrobot Sandra E. Black Christopher Chen Charles DeCarli Timo Erkinjuntti Gary A. Ford Rajesh N. Kalaria John O'Brien Leonardo Pantoni Florence Pasquier Gustavo C. Roman Anders Wallin Perminder Sachdev Ingmar Skoog the VICCCS group Yoav Ben-Shlomo Anthony P. Passmore Seth Love Patrick G. Kehoe 朱婷珂 徐俊 | 2018 | 国际脑血管病杂志2018，26，4： | 58 |
| 2 | Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9显示文摘RBPjk-dependent Notch signaling regulates both the onset of chondrocyte hypertrophy and the progression to terminal chondrocyte maturation during endochondral ossification. It has been suggested that Notch signaling can regulate Sox9 transcription, although how this occurs at the molecular level in chondrocytes and whether this transcriptional regulation mediates Notch control of chondrocyte hypertrophy and cartilage development is unknown or controversial. Here we have provided conclusive genetic evidence linking RBPjk-dependent Notch signaling to the regulation of Sox9 expression and chondrocyte hypertrophy by examining tissuespecific Rbpjk mutant(Prx1Cre;Rbpjkf/f), Rbpjk mutant/Sox9 haploinsufficient(Prx1Cre;Rbpjkf/f;Sox9f/1),and control embryos for alterations in SOX9 expression and chondrocyte hypertrophy during cartilage development. These studies demonstrate that Notch signaling regulates the onset of chondrocyte maturation in a SOX9-dependent manner, while Notch-mediated regulation of terminal chondrocyte maturation likely functions independently of SOX9. Furthermore, our in vitro molecular analyses of the Sox9 promoter and Notch-mediated regulation of Sox9 gene expression in chondrogenic cells identified the ability of Notch to induce Sox9 expression directly in the acute setting, but suppresses Sox9 transcription with prolonged Notch signaling that requires protein synthesis of secondary effectors. | Anat Kohn Timothy P Rutkowski Zhaoyang Liu Anthony J Mirando Michael J Zuscik Regis J O'Keefe Matthew J Hilton | 2015 | Bone Research2015，3，3： | 8 |
| 3 | Pharmacologic rationale for treatments of peritoneal surface malignancy from colorectal cancer显示文摘The peritoneal surfaces of the abdomen and pelvis are important sites for the dissemination of gastrointestinal and gynecologic malignancy. Transcoelomic dissemination of cancer cells gives rise to carcinomatosis, which, without special treatment, is a fatal manifestation of these diseases. To treat peritoneal carcinomatosis, cytoreductive surgery removes gross disease plus perioperative intraperitoneal and perioperative intravenous chemotherapy eradicates microscopic residual disease and chemical compatibilities. Chemotherapy agents are administered either by the intraperitoneal or intravenous route, based on their pharmacologic properties. A peritoneal-plasma barrier, which retards the clearance of high molecular weight chemotherapy from the peritoneal cavity, results in a large exposure of small cancer nodules on abdominal and pelvic surfaces. Tissue penetration of the intraperitoneal chemotherapy is facilitated by moderate hyperthermia (41-42℃). Targeting of intravenous chemotherapy to the peritoneal surface is facilitated by the intraperitoneal heat. A constant dose of chemotherapy agent and volume of carrier solution, based on body surface area, allows prediction of systemic drug exposure and systemic toxicity. Timing of the hyperthermic chemotherapy as a scheduled part of the surgical procedure to uniformly expose all peritoneal surfaces is crucial to success. | PaulH Sugarbaker Kurt Vander Speeten O Anthony Stuart | 2010 | World Journal of Gastrointestinal Oncology2010，2，1： | 4 |
| 4 | Linaclotide Improves Abdominal Pain and Bowel Habits in a Phase IIb Study of Patients With Irritable Bowel Syndrome With Constipation显示文摘 | Jeffrey M. Johnston Caroline B. Kurtz James E. MacDougall Bernard J. Lavins Mark G. Currie Donald A. Fitch Chris O’Dea Mollie Baird Anthony J. Lembo | 2010 | Gastroenterology2010，，6： | 3 |
| 5 | Leukocyte and Bacterial Counts Do Not Correlate With Severity of Symptoms in Men With Chronic Prostatitis: The National Institutes of Health Chronic Prostatitis Cohort Study显示文摘 | Anthony J. Schaeffer Jill S. Knauss J. Richard Landis Kathleen J. Propert Richard B. Alexander Mark S. Litwin J. Curtis Nickel Michael P. O’leary Robert B. Nadler Michel A. Pontari Daniel A. Shoskes Scott I. Zeitlin Jackson E. Fowler Carissa A. Mazurick J | 2002 | The Journal of Urology2002，，3： | 2 |
| 6 | Effects of Fenofibrate Treatment on Cardiovascular Disease Risk in 9,795 Individuals With Type 2 Diabetes and Various Components of the Metabolic Syndrome显示文摘 | Scott Russell O’Brien Richard Fulcher Greg Pardy Chris d’Emden Michael Tse Dana Taskinen Marja-Riitta Ehnholm Christian Keech Anthony | 2009 | Diabetes Care2009，，： | 2 |
| 7 | Treatment of H elicobacter pylori Infection 2013显示文摘 | Anthony O’Connor Javier Molina‐Infante Javier P. Gisbert Colm O’Morain | 2013 | Helicobacter2013，，： | 2 |
| 8 | Winter wheat carbon exchange in Thuringia, Germany显示文摘 | Anthoni P M Freibauer A Kolle O | 2004 | Agricultural and Forest Meteorology2004，121，12： | 1 |
| 9 | Review of statistical methods for analysing healthcare resources and costs显示文摘 | Borislava Mihaylova Andrew Briggs Anthony O’Hagan Simon G. Thompson | 2010 | Health Econ2010，，8： | 1 |
| 10 | Cocaine use and the occurrence of panic attacks in the community: a casecrossover approach 显示文摘 | O'Brien MS Wu LT Anthony JC | 2005 | Subst Use Misuse2005，40，3： | 1 |
| 11 | Dimensions and relations of the dentogingival junction in humans显示文摘 | Anthony WG Frank MW Balint O | 1961 | J Periodontology1961，32，： | 1 |
| 12 | Dimensions and relations of the dentogingival junction in humans 显示文摘 | Anthony WG Frank MW Balint O | 1961 | J Periodontology1961，32，： | 1 |
| 13 | Tumor targeting by conjugation of DHA to paclitaxel显示文摘 | Bradley M O Stindell C S Anthony F H | 2001 | Control Release2001，74，13： | 1 |
| 14 | Childhood parapneu-monic pleural effusion in Enugu显示文摘 | Tagbo O Uchenna O Anthony H | 2005 | Nigerian Postgraduate Medical Journal2005，12，1： | 1 |
| 15 | Influence of dietary cobalt on fecal vitamin B12 and blood composition in lambs显示文摘 | JONES O H JR ANTHONY W B | 1970 | Jour- nal of Animal Science1970，31，2： | 1 |
| 16 | Tidal energy update 2009 显示文摘 | Rourke Fergal O Boyle Fergal Reynolds Anthony | 2010 | Applied Energy2010，87，2： | 1 |
| 17 | Inhibition of Coral Photosynthesis by the Antifouling Herbicide Irgarol 1051 显示文摘 | Richard O Anthony K Megan T | 2002 | Marine Pollution Bulletin2002，44，07： | 1 |
| 18 | Framework for link relia- bility in inter-working multi-hop wireless networks 显示文摘 | Salami O Bagula A Anthony Chan H | 2011 | Mathe- matical and Computer Modelling2011，53，11： | 1 |
| 19 | Reactivity of litter leachates from ealffornia oak woodlands in the formation of disinfection by-products显示文摘 | Chow A T O'Green Anthony T Dahlgren R A | 2011 | J Environ Qual2011，40，5： | 1 |
| 20 | Gastrointestinal Symptoms are More Intense in Morbidly Obese Patients and are Improved with Laparoscopic Roux-en-Y Gastric Bypass显示文摘 | Ronald H Clements MD Quintin H Gonzalez MD Allen Foster MD William O Richards MD James McDowell MD Anthony Bondora MPH Henry L Laws MD | 2003 | Obesity Surgery2003，，4： | 1 |
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