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| 1 | Artificial intelligence in gastroenterology: A state-of-the-art review显示文摘The development of artificial intelligence(AI)has increased dramatically in the last 20 years,with clinical applications progressively being explored for most of the medical specialties.The field of gastroenterology and hepatology,substantially reliant on vast amounts of imaging studies,is not an exception.The clinical applications of AI systems in this field include the identification of premalignant or malignant lesions(e.g.,identification of dysplasia or esophageal adenocarcinoma in Barrett’s esophagus,pancreatic malignancies),detection of lesions(e.g.,polyp identification and classification,small-bowel bleeding lesion on capsule endoscopy,pancreatic cystic lesions),development of objective scoring systems for risk stratification,predicting disease prognosis or treatment response[e.g.,determining survival in patients post-resection of hepatocellular carcinoma),determining which patients with inflammatory bowel disease(IBD)will benefit from biologic therapy],or evaluation of metrics such as bowel preparation score or quality of endoscopic examination.The objective of this comprehensive review is to analyze the available AI-related studies pertaining to the entirety of the gastrointestinal tract,including the upper,middle and lower tracts;IBD;the hepatobiliary system;and the pancreas,discussing the findings and clinical applications,as well as outlining the current limitations and future directions in this field. | Paul T Kröner Megan ML Engels Benjamin S Glicksberg Kipp W Johnson Obaie Mzaik Jeanin E van Hooft Michael B Wallace Hashem B El-Serag Chayakrit Krittanawong | 2021 | World Journal of Gastroenterology2021，27，40： | 6 |
| 2 | Levomilnacipran and vortioxetine:Review of new pharmacotherapies for major depressive disorder显示文摘Major depressive disorder(MDD) is a common psychiatric disorder with an estimated lifetime prevalence rate in the range of 13% to 16% in the United States population. Patients with MDD often have symptoms such as depressed mood, loss of interest or pleasure in usual activities, changes in eating or sleeping patterns, fatigue, difficulty concentrating and thoughts of suicide. Although many pharmacotherapy treatment options are available for MDD, antidepressants can oftencause adverse effects that could affect adherence to the medication. Additionally, it is estimated that MDD is unremitting in 15% of patients and 35% can have recurrent episodes. Given the high rate of recurrence and the adverse effects associated with existing medications, new treatment options for depression are needed. Both levomilnacipran and vortioxetine are new antidepressants that were approved by the food and drug administration in 2013 for the treatment of MDD in adults. Levomilnacipran is a serotonin norepinephrine reuptake inhibitor that was effective in several short term studies and sustained efficacy and tolerability was demonstrated in a 48-wk extension study. Vortioxetine is a multi-modal antidepressant and it is thought to work via inhibition of the serotonin(5-HT) transporter, 5-HT3 A, 5-HT7 and 5-HT1 D antagonist, a 5-HT1 B partial agonist, and a 5-HT1 A agonist. Vortioxetine was effective in the treatment of MDD in both short-term trials as well as in the prevention of relapse in a 24-36 wk trial. Sustained efficacy and tolerability was demonstrated in several long-term open-label trials. Further studies comparing levomilnacipran and vortioxetine to other currently available antidepressants are needed to establish its place in therapy. | Mei T Liu Megan E Maroney Evelyn R Hermes-DeSantis | 2015 | World Journal of Pharmacology2015，4，1： | 3 |
| 3 | Polynomial stability of evolution operators in Banach spaces显示文摘 | Megan M Ceausu T Ramneantu M L | 2011 | Opuscula Mathematica2011，31，： | 1 |
| 4 | A processing, characterization and marine biodegradation study of melt-extruded polyhydroxyalkanoate (pha) films显示文摘 | Christopher T Megan C Danielle F | 2008 | Journal of Polymers and Environment2008，16，1： | 1 |
| 5 | On polynomial stability of variational nonautonomous difference equations in Banach spaces显示文摘 | Megan M Ceausu T Minda A A | 2013 | International Journal of Analysis2013，，： | 1 |
| 6 | Caught red-handed : Rc encodes a basic Helix- loop- Helix protein conditioning red pericarp in rice 显示文摘 | Megan T S Michael J T Bernard E P | | Plant Cell0，18，： | 1 |
| 7 | Inhibition of Coral Photosynthesis by the Antifouling Herbicide Irgarol 1051 显示文摘 | Richard O Anthony K Megan T | 2002 | Marine Pollution Bulletin2002，44，07： | 1 |
| 8 | On Barreira-Valls polynomial stability of evolution operators in Banach spaces显示文摘 | Megan M Ceausu T Minda A A | 2011 | Electronic Journal of Qualitative Theory of Differential Equations2011，33，： | 1 |
| 9 | Experimental methods for laboratory-scale ensilage of lignocellulosic biomass 显示文摘 | Deepti T Tom L R Megan N M | 2012 | Bio- mass and Bioenergy2012，47，： | 1 |
| 10 | Effects of individual fatty acids on glucose uptake and glycogen synthesis in soleus muscle in vitro显示文摘 | Alison L T Megan Y C Lim-Fraser E W | 2000 | American Journal of Physiology Physiol Endocrinology Metabolism2000，279，： | 1 |
| 11 | Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells显示文摘 | Megan K L Silvia G Eleonora T | 2005 | Blood2005，105，3： | 1 |
| 12 | Fitness/competency to stand trial: a conceptual overview, review of exist- ing instruments, and cross-validation of the Nuss- baum Fitness Questionnaire显示文摘 | David N Megan H Ian T | 2008 | Brief Treatment and Crisis Intervention2008，8，1： | 1 |
| 13 | Hyperfiltration of sodium chloride through kaolinite membranes under relatively low-heads: Implications for groundwater as- sessment显示文摘 | Megan H Whitworth T M Eliot A | 2008 | Applied Geochemistry2008，23，6： | 1 |
| 14 | Experimental methods for laboratory-scale ensilage of lignocellulosic biomass显示文摘 | Deepti T Tom L R Megan N M | 2012 | Bio-mass and Bioenergy2012，47，9： | 1 |
| 15 | Trust in Schools:A Conceptual and Empirical Analysis 显示文摘 | Megan T M & Wayne H | 1998 | Journal of Educational Administration1998，36，4： | 1 |
| 16 | Production of bioactive cellulose films reconstituted from ionic liquids显示文摘 | Megan B T Scott K S John D H | 2004 | Biomacromolecules2004，5，： | 1 |
| 17 | Ionic liquid- reconstituted cellulose composites as solid support matrices for biocatalyst immobilization 显示文摘 | Megan B T Scott K S John D H | 2005 | Biomacromolecules2005，6，： | 1 |
| 18 | Effects of lowering body temperature via hyperhydration,with and without glycerol ingestion and practical precooling on cycling time trial performance in hot and humid conditions显示文摘 | Megan LR Ross Nikki A Jeacocke Paul B Laursen David T Martin | 2012 | Journal of the International Society of Sports Nutrition2012，，9： | 1 |
| 19 | On Exponential Stability of Linear Discrete-time Systems in Banach Spaces 显示文摘 | Popa I L Ceausu T Megan M | 2012 | Comput Math Appl2012，63，11： | 1 |
| 20 | Nouniform Power Instabili- ty and Lyapunov Sequences 显示文摘 | Popa I L Ceausu T Megan M | 2014 | Appl Math Comput2014，247，： | 1 |
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