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| 1 | Alpha-7 nicotinic acetylcholine receptor agonist treatment in a rat model of Huntington's disease and involvement of heme oxygenase-1显示文摘Neuroinflammation is a common element involved in the pathophysiology of neurodegenerative diseases.We recently reported that repeated alpha-7 nicotinic acetylcholine receptor(α7 n ACh R) activations by a potent agonist such as PHA 543613 in quinolinic acid-injured rats exhibited protective effects on neurons.To further investigate the underlying mechanism,we established rat models of early-stage Huntington's disease by injection of quinolinic acid into the right striatum and then intraperitoneally injected 12 mg/kg PHA 543613 or sterile water,twice a day during 4 days.Western blot assay results showed that the expression of heme oxygenase-1(HO-1),the key component of the cholinergic anti-inflammatory pathway,in the right striatum of rat models of Huntington's disease subjected to intraperitoneal injection of PHA 543613 for 4 days was significantly increased compared to the control rats receiving intraperitoneal injection of sterile water,and that the increase in HO-1 expression was independent of change in α7 n ACh R expression.These findings suggest that HO-1 expression is unrelated to α7 n ACh R density and the increase in HO-1 expression likely contributes to α7 n ACh R activation-related neuroprotective effect in early-stage Huntington's disease. | Laura Foucault-Fruchard Claire Tronel Sylvie Bodard Zuhal Gulhan Julie Busson Sylvie Chalon Daniel Antier | 2018 | Neural Regeneration Research2018，13，4： | 2 |
| 2 | Therapeutic potential of α7 nicotinic receptor agonists to regulate neuroinflammation in neurodegenerative diseases显示文摘Neurodegenerative diseases, such as Alzheimer's, Parkinson's and Huntington's diseases, are all characterized by a component of innate immunity called neuroinflammation. Neuronal loss and neuroinflammation are two phenomena closely linked. Hence, the neuroinflammation is a relevant target for the management of the neurodegenerative diseases given that, to date, there is no treatment to stop neuronal loss. Several studies have investigated the potential effects of activators of alpha 7 nicotinic acetylcholine receptors in animal models of neurodegenerative diseases. These receptors are widely distributed in the central nervous system. After activation, they seem to mediate the cholinergic anti-inflammatory pathway in the brain. This anti-inflammatory pathway, first described in periphery, regulates activation of microglial cells considered as the resident macrophage population of the central nervous system. In this article, we shortly review the agonists of the alpha 7 nicotinic acetylcholine receptors that have been evaluated in vivo and we focused on the selective positive allosteric modulators of these receptors. These compounds represent a key element to enhance receptor activity only in the presence of the endogenous agonist. | Laura Foucault-Fruchard Daniel Antier | 2017 | Neural Regeneration Research2017，12，9： | 2 |
| 3 | Generalized tonicclonic status epilepticus: therapeutic strategy 显示文摘 | Pourrat X Serekian JM Antier D | 2001 | Presse Med2001，30，20： | 1 |
| 4 | Generalized tonic-clonic status epilepticus: Iherapeutic strategy显示文摘 | POURRAT X SEREKIAN J M ANTIER D | 2001 | Presse Med2001，30，： | 1 |
| 5 | Dexfenfluramine discontinuous treatment does not worsen hypoxia-induced pulmonary vascular remodeling but activates RhoA/ROCK pathway: consequences on pulmonary hypertension显示文摘 | Desbuards N Antier D Rochefort GY | 2009 | Eur J Pharmacol2009，602，23： | 1 |
| 6 | Pectinase hyperproducing mutants of Aspergillus niger C28B25 for solid state fermentation of coffee pulp显示文摘 | Antier P Minjares A Roussos S | 1993 | Enzyme Microbial Technol1993，15，： | 1 |
| 7 | Continuous inhalation of carbon monoxide induces right ventricle ischemia and dysfunction in rats with hypoxie pulmonary hypertension显示文摘 | Gautier M Antier D Bonnet P | 2007 | Am J Physiol Heart Circ Physiol2007，293，2： | 1 |
| 8 | Generalized tonic -clonic status epilepticus: therapeutic strategy 显示文摘 | Pourrat X Serekian JM Antier D | 2001 | Presse Med2001，30，20： | 1 |
| 9 | Continuous inhalation of carbon monoxide induces right ventricle ischemia and dysfunction in rats with hypoxic pulmonary hypertension显示文摘 | Gautier M Antier D Bonnet P | | 0，，02： | 1 |
| 10 | Mechanisms and eti- ologies of thrombocytopenia in the intensive care unit:Im pact of extensive investigations显示文摘 | Antier N Quenot JP Doise JM | 2014 | Ann Intensive Care2014，，4： | 1 |
| 11 | Generalized tonic - clonicstatus epilepticus: therapeutic strategy显示文摘 | Pourrat X Serekian JM Antier D | 2001 | Presse Med2001，30，20： | 1 |
| 12 | The mini-GWAC optical follow-up of gravitational wave alerts – results from the O2 campaign and prospects for the upcoming O3 run显示文摘The second(O2)observational campaign of gravitational waves(GWs)organized by the LIGO/Virgo Collaborations has led to several breakthroughs such as the detection of GW signals from merger systems involving black holes or neutrons stars.During O2,14 GW alerts were sent to the astronomical community with sky regions mostly covering over hundreds of square degrees.Among them,six were finally confirmed as real astrophysical events.Since 2013,a new set of ground-based robotic telescopes called Ground-based Wide Angle Camera system(GWAC)project and its pathfinder mini-GWAC has been developed to contribute to the various challenges of multi-messenger and time domain astronomy.The GWAC system is built up in the framework of the ground-segment system of the SVOM mission that will be devoted to the study of the multi-wavelength transient sky in the next decade.During O2,only the mini-GWAC telescope network was fully operational.Due to the wide field of view and fast automatic follow-up capabilities of the mini-GWAC telescopes,they were adept to efficiently cover the sky localization areas of GW event candidates.In this paper,we present the mini-GWAC pipeline we have set up to respond to GW alerts and we report our optical follow-up observations of eight GW alerts detected during the O2 run.Our observations provided the largest coverage of the GW localization areas with a short latency made by any optical facility.We found tens of optical transient candidates in our images,but none of those could be securely associated with any confirmed black hole-black hole merger event.Based on this first experience and the near future technical improvements of our network system,we will be more competitive in detecting the optical counterparts from some GW events that will be identified during the upcoming O3 run,especially those emerging from binary neutron star mergers. | Damien Turpin Chao Wu Xu-Hui Han Li-Ping Xin Sarah Antier Nicolas Leroy Li Cao Hong-Bo Cai Bertrand Cordier 邓劲松 Wen-Long Dong Qi-Chen Feng Lei Huang Lei Jia Alain Klotz Cyril Lachaud Hua-Li Li 梁恩维 Shun-Fang Liu Xiao-Meng Lu Xian-Min Meng Yu-Lei Qiu Hui-Juan Wang 王竞 Shen Wang 王祥高 Jian-Yan Wei Bo-Bing Wu Yu-Jie Xiao Da-Wei Xu Yang Xu 杨远贵 Pin-Pin Zhang Ruo-Song Zhang Shuang-Nan Zhang Ya-Tong Zheng Si-Cheng Zou | 2020 | Research in Astronomy and Astrophysics2020，20，1： | 1 |
| 13 | Continuous inhalation of carbon monoxide induces right ventricle ischemia and dysfunction in rats with hypoxic pulmonary hypertension 显示文摘 | Gautier M Antier D Bonnet P | 2007 | Am J Physiol Heart Circ Physiol2007，293，2： | 1 |
| 14 | Generalized tonicclonic status epilepticus;therapeutic strategy显示文摘 | Pourratx Serekian JM Antier D | 2001 | Presse Med2001，30，20： | 1 |
| 15 | Measurement of diffraction effciency in hybrid lenses显示文摘 | ANTIER C ROLLIN J | 1996 | SPIE1996，2775，： | 1 |
| 16 | Thermal conditioning of quail embryos has transgenerational and reversible long‑term effects显示文摘Background In the current context of global warming,thermal manipulation of avian embryos has received increasing attention as a strategy to promote heat tolerance in avian species by simply increasing the egg incubation temperature.However,because of their likely epigenetic origin,thermal manipulation effects may last more than one generation with consequences for the poultry industry.In this work,a multigenerational and transgenerational analysis of thermal manipulation during embryogenesis was performed to uncover the long-term effects of such procedure.Results Thermal manipulation repeated during 4 generations had an effect on hatchability,body weight,and weight of eggs laid in Japanese quails,with some effects increasing in importance over generations.Moreover,the effects on body weight and egg weight could be transmitted transgenerationally,suggesting non-genetic inheritance mechanisms.This hypothesis is reinforced by the observed reversion of the effect on growth after five unexposed generations.Interestingly,a beneficial effect of thermal manipulation on heat tolerance was observed a few days after hatching,but this effect was not transgenerational.Conclusions Our multigenerational study showed that thermal conditioning of quail embryos has a beneficial effect on post-hatch heat tolerance hampered by transgenerational but reversible defects on growth.Assuming that no genetic variability underlies these changes,this study provides the first demonstration of epigenetic inheritance of traits induced by environmental temperature modification associated with long-term impacts in an avian species. | Anais Vitorino Carvalho Christelle Hennequet‑Antier Romuald Rouger Joel Delaveau Thierry Bordeau Sabine Crochet Nathalie Courousse Frederique Pitel Anne Collin Vincent Coustham | 2023 | Journal of Animal Science and Biotechnology2023，14，6： | 0 |
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