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| 1 | Personalizing therapies for gastric cancer: Molecular mechanisms and novel targeted therapies显示文摘Globally,gastric cancer is the 4thmost frequently diagnosed cancer and the 2ndleading cause of death from cancer,with an estimated 990000 new cases and738000 deaths registered in 2008.In the advanced setting,standard chemotherapies protocols acquired an important role since last decades in prolong survival.Moreover,recent advances in molecular therapies provided a new interesting weapon to treat advanced gastric cancer through anti-human epidermal growth factor receptor 2(HER2)therapies.Trastuzumab,an anti-HER2 monoclonal antibody,was the first target drug in the metastatic setting that showed benefit in overall survival when in association with platinum-5-fluorouracil based chemotherapy.Further,HER2 overexpression analysis acquired a main role in predict response for trastuzumab in this field.Thus,we conducted a review that will discuss the main points concerning trastuzumab and HER2 in gastric cancer,providing a comprehensive overview of molecular mechanisms and novel trials involved. | Michael Luis Ana Tavares Liliana S Carvalho Lúcio Lara-Santos António Araújo Ramon Andrade de Mello | 2013 | World Journal of Gastroenterology2013，19，38： | 6 |
| 2 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 3 | Effect of femtosecond laser-assisted lens surgery on the optic nerve head and the macula显示文摘AIM: To evaluate the effect of femtosecond laser-assisted lens surgery(FLALS;cataract surgery or refractive lens exchange) on the structure of the optic nerve head and the macula.METHODS: This prospective longitudinal study included healthy eyes undergoing FLALS. Eyes with glaucoma or any other ocular disease that could alter optical coherence tomography results were excluded. Retinal nerve fiber layer(RNFL), Bruch’s membrane opening-minimum rim width(BMO-MRW) and macular thickness(MT) were measured preoperatively, 1 and 6 mo after surgery using spectral-domain optical coherence tomography(SD-OCT). Changes between preoperative and postoperative values were evaluated.RESULTS: A total of 87 eyes of 46 patients were included in this study. Preoperative RNFL, BMO-MRW and MT in microns(μm) were 100.77±10.39, 330.31±49.99 and 276.30±33.39, respectively. Postoperative RNFL, BMO-MRW and MT were 104.74±11.55, 348.32±54.05 and 279.83±22.65 1 mo after surgery and 102.93±11.17, 343.11±53.4 and 278.90±22.19 6 mo after surgery, respectively;which equals an increase of 3.93%, 5.45% and 1.27%,respectively, 1 mo after surgery, and 2.14%, 3.87% and 0.94% 6 mo after surgery. The differences between the preoperative and the postoperative RNFL and BMO-MRW values were statistically significant(P<0.001). Regarding MT values, there were not statistically significant differences(P=0.26).CONCLUSION: Our study suggests that FLALS does not have a negative impact on the structural status of the optic nerve head in healthy eyes, assessed by SD-OCT. There is a slight increase in the values of RNFL, BMO-MRW and MT 1 mo and 6 mo after surgery. | Josefina Renones de Abajo Beatriz Estévez Jorge Jesús María González Martín Humberto Carreras Díaz Juan Francisco Loro Ferrer Alfonso Antón López | 2019 | International Journal of Ophthalmology(English edition)2019，12，6： | 2 |
| 4 | Effect of propranolol on the splanchnic and peripheral renin angiotensin system in cirrhotic patients显示文摘AIM:To evaluate the effect of β-blockade on angiotensins in the splanchnic and peripheral circulation of cirrhotic patients and also to compare hemodynamic parameters during liver transplantation according to propranolol pre-treatment or not. METHODS:Patients were allocated into two groups:outpatients with advanced liver disease(LD) and during liver transplantation(LT). Both groups were subdivided according to treatment with propranolol or not. Plasma was collected through peripheral venipuncture to determine plasma renin activity(PRA),Angiotensin(Ang) Ⅰ,Ang Ⅱ,and Ang-(1-7) levels by radioimmunoassay in LD group. During liver transplantation,hemodynamic parameters were determined and blood samples were obtained from the portal vein to measure renin angiotensin system(RAS) components.RESULTS:PRA,Ang Ⅰ,Ang Ⅱ and Ang-(1-7) were signifi cantly lower in the portal vein and periphery in all subgroups treated with propranolol as compared to non-treated. The relationships between Ang-(1-7) and Ang Ⅰ levels and between Ang Ⅱ and Ang Ⅰ were significantly increased in LD group receiving propranolol. The ratio between Ang-(1-7) and Ang Ⅱ remained unchanged in splanchnic and peripheral circulation in patients under β-blockade,whereas the relationship between Ang Ⅱ and Ang Ⅰ was significantly increased in splanchnic circulation of LT patients treated with propranolol. During liver transplantation,cardiac output and index as well systemic vascular resistance and index were reduced in propranolol-treated subgroup. CONCLUSION:In LD group,propranolol treatment reduced RAS mediators,but did not change the ratio between Ang-(1-7) and Ang Ⅱ in splanchnic and peripheral circulation. Furthermore,the modification of hemodynamic parameters in propranolol treated patients was not associated with changes in the angiotensin ratio. | Walkíria Wingester Vilas-Boas Antnio Ribeiro-Oliveira Jr Renata da Cunha Ribeiro Renata Lúcia Pereira Vieira Jerusa Almeida Ana Paula Nadu Ana Cristina Sim■es e Silva Robson Augusto Souza Santos | 2008 | World Journal of Gastroenterology2008，14，44： | 2 |
| 5 | Propranolol for severe hemangiomas of infancy显示文摘 | Léanté-Larèze C Dumas de la Roque E Huhiche T | | 0，，24： | 1 |
| 6 | 显示文摘 | Reynolds D C Leies G Antes L T | 1954 | PhysRev1954，96，： | 1 |
| 7 | Modeling the effects of initial spacing on stand basal area development of loblolly pine显示文摘 | ANTN-FERNNDEZ C BURKHART H E AMATEIS R L | 2012 | Forest Science2012，58，2： | 1 |
| 8 | CXCR3 expression on CD34(+) hemopoietic progenitors induced by granulocyte-macrophage colony-stimulating factor 1显示文摘 | Jinquan T Anting L Jacobi HH | 2001 | J Immunol2001，167，8： | 1 |
| 9 | The relationship between capsid protein(VP2) sequence and pathogenicity of Aleutian mink disease parvovims(ADV): apossible role for raccoons in the transmission of ADV infovfioos显示文摘 | Oie K L Dun'ant G Wolfinbarger J B | 1996 | J Virol1996，70，2： | 1 |
| 10 | BioSystems显示文摘 | Dorigo M Gambardella L M Ant colonies for the traveling salesman problem | 1997 | 43(2):73-811997，43，2： | 1 |
| 11 | Efficient 3D modelling of vibration isolation by open trenches显示文摘 | KLEIN R ANTES H LE Houédec D L | 1997 | Computers and Structures1997，64，： | 1 |
| 12 | Effect of finite element choice in blunt crack band analysis显示文摘 | Cedolin L Ba(z)ant Z P | | 0，，3： | 1 |
| 13 | Early detection of lesions ofdorsal artery of foot inpatients with type 2 diabetes m ellitusby high-frequency ultrasonography 显示文摘 | Z hangY L iW Y anT et a l | | J Huazhong Univ SciTechnolog Med S ci0，29，3： | 1 |
| 14 | As, Hg, I, Sb, Se and Sn speciation in body fluids and biological tissues using hyphenated-ICP-MS techniques: a review显示文摘 | DRESSLER V L ANTES F G MOREIRA C M | 2011 | International Journal of Mass Spectrometry2011，307，13： | 1 |
| 15 | Directional effects on NDVI and LAI retrievals from MODIS: A case study in Brazil with soybean显示文摘 | Fábio Marcelo Breunig Lênio Soares Galv?o Ant?nio Roberto Formaggio José Carlos Neves Epiphanio | 2010 | International Journal of Applied Earth Observations and Geoinformation2010，，1： | 1 |
| 16 | Quantification of the biocontrol agent Trichoderma harzianumwith real-time TaqMan PCR and its potential extrapolationto the hyphal biomass显示文摘 | López-Mondéjar R Antón A Raidl S Ros M Pascual JA | 2010 | Bioresource Technology2010，101，28： | 1 |
| 17 | Lead isotope ratios in a soil from a coal carbonization plant显示文摘 | Mercedes Díaz-Somoano Montserrat Calvo M. Antonia López Antón Isabel Suarez-Ruiz Roberto García Sabino R. Moinelo M. Rosa Martínez-Tarazona | 2006 | Fuel2006，，7： | 1 |
| 18 | Gemcitabine monotherapy inelder patientswith advanced non2small cell lung cancer:a multi2center phase Ⅱ study显示文摘 | Ricci S Ant onus o A Galli L | 2000 | Lung Cancer2000，27，： | 1 |
| 19 | Identification of 'super-re-sponders' to cardiac resynchronization therapy:the importance of symptom durationandleft ventricular geometry显示文摘 | António N Teixeira R Coelho L | | 0，，： | 1 |
| 20 | Finite element modeling of crack band propagation显示文摘 | CEDOLIN L | 1983 | Journal of Structural Engineering1983，109，1： | 1 |
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