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| 1 | Different profile of cytokine synthesis according to the severity of acute pancreatitis显示文摘AIM: To evaluate the cellular synthetic ability of cytokines involved in pro- and anti-inflammatory reactions in patients with AP.METHODS: Sixty-seven patients with AP (16 severe,51 mild) and 10 controls were included in the study.Cultures of whole blood were performed in samples obtained within the first 72 h from the onset of pain.Serum levels of interleukins (IL) 6, 8, 10, and TNF-α were measured at baseline and in the supernatant of cultures with (functional reserve) or without stimulation with phytohemaglutinin.RESULTS: Basal levels of cytokines were significantly higher in patients with severe AP. A significant increase of all pro-inflammatory cytokines vs basal levels was observed in the supernatant after 24 h of whole blood cultures in patients, but not in controls. In contrast, IL-10 increased significantly in the supernatant of cultures only in patients with mild AP. Cells showed a statistically significant functional reserve for all IL in patients with mild, but only for pro-inflammatory cytokines in patients with severe AP.CONCLUSION: A marked activation of immune system may be observed in patients with AP, being balanced between pro- and anti-inflammatory cytokines in patients with mild but not severe AP. A reduced functional reserve for the synthesis of IL-10 may be observed in patients with severe AP, which might lead to a worst prognosis. | Raquel Laveda Juan Martínez Carlos Mu■oz Juan Carlos Penalva Jesus Sáez Germán Belda Salvador Navarro Faust Feu Anton Mas José Ma Palazón José Sánchez-Payá José Such Miguel Pérez-Mateo | 2005 | World Journal of Gastroenterology2005，11，34： | 24 |
| 2 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 3 | Empagliflozin alleviates podocytopathy and enhances glomerular nephrin expression in db/db diabetic mice显示文摘BACKGROUND Modern guidelines recommend sodium-glucose cotransporter-2(SGLT2)inhibitors as the preferred antihyperglycemic agents for patients with type 2 diabetes and chronic kidney disease.However,the mechanisms underlying the renal protective effect of SGLT2 inhibitors are not fully understood.structure of podocytes and nephrin expression in glomeruli in db/db diabetic mice.METHODS We treated 8-wk-old male db/db mice with EMPA(10 mg/kg/d)or vehicle for 8 wk.Age-matched male db/+mice were included as non-diabetic controls.Parameters of body composition,glycemic and lipid control,and plasma concentrations of leptin,insulin and glucagon were assessed.We evaluated renal hypertrophy as kidney weight adjusted to lean mass,renal function as plasma levels of creatinine,and albuminuria as the urinary albumin-to-creatinine ratio(UACR).Renal structures were studied by light and transmission electron microscopy with a focus on mesangial volume and podocyte structure,respectively.Glomerular nephrin and transforming growth factor beta(TGF-β)were assessed by immunohistochemistry.RESULTS Severe obesity and hyperglycemia developed in db/db mice prior to the start of the experiment;increased plasma concentrations of fructosamine,glycated albumin,cholesterol,leptin,and insulin,and elevated UACR were detected.Mesangial expansion,glomerular basement membrane thickening,and increased area of TGF-βstaining in glomeruli were revealed in vehicle-treated mice.Podocytopathy was manifested by effacement of foot processes;nephrin-positive areas in glomeruli were reduced.EMPA decreased the levels of glucose,fructosamine and glycated albumin,UACR,kidney hypertrophy,mesangial expansion,glomerular basement membrane thickening,and glomerular TGF-βstaining,alleviated podocytopathy and restored glomerular staining of nephrin.CONCLUSION These data indicate that EMPA attenuates podocytopathy in experimental diabetic kidney disease.The anti-albuminuric effect of EMPA could be attributed to mitigation of podocyte injury and enhancement of nephrin expression. | Vadim V Klimontov Anton I Korbut Iuliia S Taskaeva Nataliya P Bgatova Maksim V Dashkin Nikolai BOrlov Anna S Khotskina Evgenii L Zavyalov Thomas Klein | 2020 | World Journal of Diabetes2020，11，12： | 2 |
| 4 | Cloning and characterization of the Bg/Ⅱ restriction-modification system reveals a possible evolutionary footprint显示文摘 | ANTON B P HEITER D F BENNER J S | 1997 | Gene1997，187，1： | 1 |
| 5 | Association of hypersensitivity to the nematode Anisakis simplex with HLA class Ⅱ DRB1×1502-DQB1×0601 haplotype显示文摘 | Senchez-Velasco P Mendizabal L Anton E M | 2000 | Hum Immunol2000，61，： | 1 |
| 6 | Diagnosis ofmechanical seals in large pumps显示文摘 | Holenstein Anton P lnnotec Sulzer etc | 1996 | Sealing Technology1996，，： | 1 |
| 7 | The Obsessive Compulsive Drink- ing Scale:a self-rated instrument for the quantification of thoughts about alcohol and drinking behavior 显示文摘 | Anton RF Moak DH Latham P | 1995 | Alcohol Clin Exp Res1995，19，1： | 1 |
| 8 | Electron transport system activity and oxygen consumption of two amphibious isopods ,epigean Ligia italica Fabricius and hypogean Titanethes albus (Koch),in air and water显示文摘 | TATJANA S FRANJA P ANTON B | 2010 | Marine and Freshwater Behaviour and Physiology2010，43，2： | 1 |
| 9 | Peptides as functional surfactants显示文摘 | Dexter A F Anton P J Middelberg G | 2008 | Industrial and Engineering Chemistry Research2008，47，17： | 1 |
| 10 | PDR brachytherapy with flexible implants for interstitial boost after breast-conserving surgery and external beam radiation therapy 显示文摘 | Fritz P Bems C Anton HW | 1997 | Radiother Oncol1997，45，1： | 1 |
| 11 | High frequency of anemia in COPD patients admitted in a tertiary hospital显示文摘 | Portillo K Belda J Anton P | 2007 | Rev Clin Esp2007，207，8： | 1 |
| 12 | Neurokinin-1 receptor expression in inflammatory bowel disease:molecular quantitation and localisation显示文摘 | Goode T O'Connell J Anton P | 2000 | Gut2000，47，3： | 1 |
| 13 | Integrated structure/control design of mechatronic systems using arecursive experimental optimization method 显示文摘 | Anton C Haruhiko P Asada H | 1996 | IEEE/ASME Transactions on Meehatronies1996，1，3： | 1 |
| 14 | Reversible active switching of the mechanical properties of a peptide film at a fluid - fluid interface显示文摘 | DEXTER A F MALCOLM A S MIDDELBERG ANTON P J | 2006 | Nature Materials2006，5，： | 1 |
| 15 | Process scale disruption of microorganisms显示文摘 | Anton P J | 1995 | Biotechnology Advances1995，13，3： | 1 |
| 16 | Two-Phase Microfluidic Flows 显示文摘 | ZHAO C X ANTON P M | 2011 | Chemical Engineering Science2011，，66： | 1 |
| 17 | Structure and properties of zwitterionic polysoaps:functionalization by redox - switchable moieties显示文摘 | ANTON P KOEBERLE P LASCHEWSKY A | 1992 | Prog Colloid Polym Sci1992，89，： | 1 |
| 18 | Transpiration from geranium grown under high temperatures and low humidities in greenhouses显示文摘 | Montero J I Anton A Munoz P | 2001 | Agricultural and Forest Meteorology2001，107，4： | 1 |
| 19 | Diethyl phthalate,achemotactic factor secreted by Helicobacter pylori显示文摘 | Keire D A Anton P Faull K F | 2001 | Journal of Biological Chemistry2001，276，48： | 1 |
| 20 | Value of the electrocardiogram in localizing the occlusion site in the left anterior descending coronary artery in acute anterior myocardial infarction显示文摘 | Domien J Engelen Anton P Gorgels Emile C Cheriex Ebo D De Muinck Anton J Oude Ophuis Willem R Dassen Jindra Vainer Vincent G van Ommen Hein J Wellens | 1999 | Journal of the American College of Cardiology1999，，2： | 1 |
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