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| 1 | Characterisation and risk assessment of venous thromboembolism in gastrointestinal cancers显示文摘AIM To characterise venous thromboembolism(VTE) in gastrointestinal cancer and assess the clinical utility of risk stratification scoring. METHODS We performed a retrospective analysis using electronic patient records of 910 gastro-oesophageal(GO) cancer and 1299 colorectal cancer(CRC) patients referred to a tertiary cancer centre to identify the incidence of VTE, its relationship to chemotherapy and impact on survival.VTE risk scores were calculated using the Khorana index. Patients were classified as low risk(0 points), intermediate risk(1 to 2 points) or high risk(3 points). Data was analysed to determine the sensitivity of the Khorana score to predict VTE. RESULTS The incidence of VTE was 8.9% for CRC patients and 9.7% for GO cancer patients. Pulmonary emboli(PE) were more common in advanced than in localised CRC(50% vs 21% of events respectively) and lower limb deep vein thrombosis(DVT) were more common in localised than in advanced CRC(62% vs 39% of events respectively). The median time to VTE from cancer diagnosis was 8.3 mo for CRC patients compared to 6.7 mo in GO cancer. In localised CRC median time to VTE was 7.1 mo compared with 10.1 mo in advanced CRC. In contrast in GO cancer, the median time to VTE was 12.5 mo in localised disease and 6.8 mo in advanced disease. No survival difference was seen between patients with and without VTE in this cohort. The majority of patients with CRC in whom VTE was diagnosed had low or intermediate Khorana risk score(94% for localised and 97% in advanced CRC). In GO cancer, all patients scored either intermediate or high risk due to the primary site demonstrating a limitation of the risk assessment score in discriminating high and low risk patients with GO cancers. Additional risk factors were identified in this cohort including surgery, chemotherapy or hospital admission. Overall, 81% of patients with CRC and 77% of patients with GO cancer had one or more of these factors within 4 wk prior to diagnosis VTE. These should be factored into clinical risk assessment scores. CONCLUSION The Khorana score has low sensitivity for thrombotic events in CRC and cannot discriminate low risk patients in high risk cancer sites such as GO cancer. | Robert L Metcalf Eamon Al-Hadithi Nicholas Hopley Thomas Henry Clare Hodgson Antony McGurk Wasat Mansoor Jurjees Hasan | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 10 |
| 2 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 3 | Prospective evaluation of small bowel preparation with bisacodyl and sodium phosphate for capsule endoscopy显示文摘AIM: To determine the effect of Prepacol?, a com- bination of sodium phosphate and bisacodyl, on transit and quality of capsule endoscopy (CE). METHODS: Fivety two consecutive patients were included in this prospective study. CE was performed following a 12 h fasting period. Twenty six patients were randomized for additional preparation with Prepacol?. The quality of CE was assessed separately for the proximal and the distal small bowel by 3 experienced endoscopists on the basis of a graduation which was initially developed with 20 previous CE. RESULTS: Preparation with Prepacol? accelerated small bowel transit time (262 ± 55 min vs 287 ± 97 min), but had no effect on the quality of CE. Visibility was significantly reduced in the distal compared to the proximal small bowel. CONCLUSION: The significantly reduced visibility of CE in the distal small bowel allocates the need for a good preparation. Since Prepacol? has no beneficial effect on CE the modality of preparation and the ideal time of application remains unclear. Further standardized examinations are necessary to identify sufficient preparation procedures and to determine the impact of the volume of the preparation solution. | Andreas Franke Frank Hummel Phillip Knebel Christoph Antoni Ulrich Bcker Manfred V Singer Matthias Lhr | 2008 | World Journal of Gastroenterology2008，14，13： | 5 |
| 4 | State of the art on high temperature thermal energy storage for power generation. Part 1—Concepts, materials and modellization显示文摘 | Antoni Gil Marc Medrano Ingrid Martorell Ana Lázaro Pablo Dolado Belén Zalba Luisa F. Cabeza | 2009 | Renewable and Sustainable Energy Reviews2009，，1： | 2 |
| 5 | State of the art on high temperature thermal energy storage for power generation. Part 1—Concepts, materials and modellization显示文摘 | Antoni Gil Marc Medrano Ingrid Martorell Ana Lázaro Pablo Dolado Belén Zalba Luisa F. Cabeza | 2009 | Renewable and Sustainable Energy Reviews2009，，1： | 2 |
| 6 | Devic Disease and Thymoma with Anti-central Nervous System and Antithynus Antibodies显示文摘 | Antonie JC Candessanche JP Absi L et at | 2004 | Neurology(S0028-3878)2004，62，6： | 1 |
| 7 | Large scale production and downstream processing of a recombinant porcine parvovirus vaccine显示文摘 | MARANGA L RUEDA P ANTONIS AFG | 2002 | Appl Microbiol Biotechnol2002，59，： | 1 |
| 8 | Photophysics and dynamics of coumarin laser dyes and their analytical implications显示文摘 | M S A Abdel-Mottaleb M S Antonious M M Abo Ali L F M Ismail B A El-Sayed A M K Sherief | 1992 | Proceedings of the Indian Academy of Sciences - Chemical Sciences1992，，2： | 1 |
| 9 | A new quasi-Newton adap- tive filtering algorithm显示文摘 | De Campos M L R Antoniou A | 1997 | IEEE Trans Circuits and Systems- 1I1997，44，11： | 1 |
| 10 | A comprehensive Bayesian approach for model updating and quantification of modeling errors 显示文摘 | Zhang E L Feissel P Antoni J | 2011 | Probabilistic Engineering Me- chanics2011，26，4： | 1 |
| 11 | Studies on the microbial populations of the rhizosphere of big sagebrush (Artemisia tridentata)显示文摘 | Antony J B Janice L S Heather M K | 2004 | Journal Indian Microbiology and Biotechnology2004，31，6： | 1 |
| 12 | Large scale production and downstream processing of a recombinant porcine parvovirus vaccine显示文摘 | Maranga L Rueda P Antonis AFG | 2002 | Appl Microbiol Biotechnol2002，59，： | 1 |
| 13 | Mining frequent closedrooted trees显示文摘 | JoséL Balcázar Albert Bifet Antoni Lozano | 2010 | Mach Learn2010，78，： | 1 |
| 14 | Coping and distress a mong women under treatment for early stage 'breast cancer : compa ring African Americans, Hispanics and non Hispanics whites显示文摘 | Culver J L Arena P L Antoni M H | 2002 | Psychooncology2002，11，6： | 1 |
| 15 | A sinkhole resilient proto- col for wireless sensor networks: performance and security analysis 显示文摘 | Fabrice L F Antonis P Aline C V | 2012 | Computer Communications2012，35，2： | 1 |
| 16 | Changes in expression,and/or mutations in TGF-beta receptors (TGF-beta RI and TGF-beta RII) and Smad 4 in human ovarian tumors显示文摘 | ANTONY M L NAIR R SEBASTIAN P | 2010 | J Cancer Res Clin Oncol2010，136，3： | 1 |
| 17 | The potential of XML encoding in geomatics converting raster images to XML and SVG 显示文摘 | Antoniou B Tsoulos L | 2006 | Computers & Geosciences2006，32，2： | 1 |
| 18 | News on ABA transport, protein degradation, and ABFs/WRKYs in ABA signaling 显示文摘 | Antoni R Rodriguez L Gonzalez-Guzman M | 2011 | Current Opinion in Plant Biology2011，14，5： | 1 |
| 19 | Novel Strategy to Design Magnetic, Molecular Imprinted Polymers withWell-controlled Structure for the Application in Optical Sensors 显示文摘 | ANTONI L M C GUNTER M JORPEF F S | 2010 | Macromolecules2010，43，： | 1 |
| 20 | Insecticidal and acaricidal performance of methyl ketones in wild tomato leaves bull显示文摘 | Antonious G F Dahlman D L Hawkins L M | 2003 | Environ Contain Toxicol2003，71，： | 1 |
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