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| 1 | Two new terpenoids from fruits of Ziziphus jujuba显示文摘一新 ceanothane 类型 triterpene 和一新 sesquiterpene,和二,已知的 triterpenes 从 Ziziphus jujuba 米尔的水果被孤立。(Rhamnaceae ) 。基于光谱分析,二新混合物的结构作为 2 α 被阐明; -aldehydo-A(1)-norlup-20(29)-en-27,28-dioic 酸(zizyberanal 酸)(1 ) ,和 zizyberanone (2 ) 。当二已知的 triterpenes 作为 zizyberanalic 酸(3 ) 和 ursolic 酸(4 ) 被识别时。 | Sheng Guo Yu Ping Tang Jin Ao Duan Shu Lan Su An Wei Ding | 2009 | Chinese Chemical Letters2009，20，2： | 13 |
| 2 | SOMCL-085, a novel multi-targeted FGFR inhibitor, displays potent anticancer activity in FGFR-addicted human cancer models显示文摘异常成纤维细胞生长因素受体(FGFR ) 激活越过恶意的一个多样的系列被发现,特别缺乏有效治疗的那些。SOMCL-085 是一个新奇 FGFR 主导的多目标 kinase 禁止者。这里,我们在 vitro 并且在 vivo 探索了 SOMCL-085 的指向 FGFR anticancer 活动。在屏蔽的 20 酷氨酸 kinases 的一块面板之中, SOMCL-085 potently 分别地禁止了 FGFR1, FGFR2 和 FGFR3 kinase 活动,与 1.8, 1.9 和 6.9 nmol/L 的 IC 50 价值。这混合物同时禁止了 angiogenesis kinases VEGFR 和 PDGFR,但是没有另外的 12 酷氨酸 kinases 上的明显的禁止的效果。在有测试的 FGFR 激活的不同机制的 3 根代表性的人的癌症房间线, SOMCL-085 (20-500 nmol/L ) dose-dependently 禁止了 FGFR1-3 phosphorylation 和他们的关键下游的受动器 PLC 和英皇家空军之阶级最低之兵的 phosphorylation。在 7 根 FGFR 异常人的癌症房间线,不管 FGFR 在激活上的机械学的复杂性, SOMCL-085 potently 由在 G 1/S 阶段逮捕房间禁止了驾驶 FGFR 的房间增长。在 放大FGFR1 的肺癌症房间线 H1581 异种皮移植老鼠和 放大FGFR2 的胃的癌症房间衬里 SNU16 异种皮移植老鼠, SOMCL-085 的口头的管理( 25 ,吗 50 mg ????????????????????????????????漠敬湡汯捩??儠?????畱湩硯污湩?? | Xi-fei JIANG Yang DAI Xia PENG Yan-yan SHEN Yi SU Man-man WEI Wei-ren LIU Zhen-bin DING Ao ZHANG Ying-hong SHI Jing AI | 2018 | Acta Pharmacologica Sinica2018，39，2： | 3 |
| 3 | Energy-efficient recovery of tetrahydrofuran and ethyl acetate by triple-column extractive distillation:entrainer design and process optimization显示文摘An energy-efficient triple-column extractive distillation process is developed for recovering tetrahydrofuran and ethyl acetate from industrial effluent.The process development follows a rigorous hierarchical design procedure that involves entrainer design,thermodynamic analysis,process design and optimization,and heat integration.The computer-aided molecular design method is firstly used to find promising entrainer candidates and the best one is determined via rigorous thermodynamic analysis.Subsequently,the direct and indirect triple-column extractive distillation processes are proposed in the conceptual design step.These two extractive distillation processes are then optimized by employing an improved genetic algorithm.Finally,heat integration is performed to further reduce the process energy consumption.The results indicate that the indirect extractive distillation process with heat integration shows the highest performance in terms of the process economics. | Ao Yang Yang Su Tao Shi Jingzheng Ren Weifeng Shen Teng Zhou | 2022 | Frontiers of Chemical Science and Engineering2022，16，2： | 3 |
| 4 | Promoting lacunar bone regeneration with an injectable hydrogel adaptive to the microenvironment显示文摘Injectable hydrogel is suitable for the repair of lacunar bone deficiency.This study fabricated an injectable,self-adaptive silk fibroin/mesoporous bioglass/sodium alginate(SMS)composite hydrogel system.With controllable and adjustable physical and chemical properties,the SMS hydrogel could be easily optimized adaptively to different clinical applications.The SMS hydrogel effectively showed great injectability and shapeability,allowing defect filling with no gap.Moreover,the SMS hydrogel displayed self-adaptability in mechanical reinforcement and degradation,responsive to the concentration of Ca2+and inflammatory-like pH value in the microenvi-ronment of bone deficiency,respectively.In vitro biological studies indicated that SMS hydrogel could promote osteogenic differentiation of bone marrow mesenchymal stem cells by activation of the MAPK signaling pathway.The SMS hydrogel also could improve migration and tube formation of human umbilical vein endothelial cells.Investigations of the crosstalk between osteoblasts and macrophages confirmed that SMS hydrogel could regulate macrophage polarization from M1 to M2,which could create a specific favorable environment to induce new bone formation and angiogenesis.Meanwhile,SMS hydrogel was proved to be antibacterial,especially for gram-negative bacteria.Furthermore,in vivo study indicated that SMS could be easily applied for maxillary sinus elevation,inducing sufficient new bone formation.Thus,it is convincing that SMS hydrogel could be potent in a simple,minimally invasive and efficient treatment for the repair of lacunar bone deficiency. | Ao Zheng Xiao Wang Xianzhen Xin Lingjie Peng Tingshu Su Lingyan Cao Xinquan Jiang | 2023 | Bioactive Materials2023，，3： | 3 |
| 5 | Combining 53BP1 with BRCA1 as a biomarker to predict the sensitivity of poly(ADP-ribose) polymerase (PARP) inhibitors显示文摘别对治疗在有 BRCA1 缺乏的癌症的病人的一半上作出回应与 poly (自动数据处理核糖) 聚合酶(PARP ) 禁止者。在这研究,我们报导 53BP1 和 BRCA1 的联合可以用作 PARP 禁止者敏感的 biomarker。基于四个相应再结合修理(HR ) 的 mRNA 层次基因和 PARP 禁止者敏感,我们选择了 BRCA1 缺乏的 MDA-MB-436 房间进行 RNA 干扰。减少 53BP1,然而并非另外的三 HR 基因的表示,被发现降低 simmiparib 敏感。另外,我们产生了 53BP1 //BRCA1/ 由抄写的同种细胞的变体像使活跃之物的受动器核酸酶(TALEN ) 技术并且发现那弄空的 53BP1 随他们的 IC 50 价值的 36.7 褶层增加损害了 PARP 禁止者敏感。与它 PARP 禁止者敏感上的效果一致, 53BP1 损失减轻了房间周期拘捕和 apoptosis 并且部分恢复了 HR 功能。重要地, 53BP1 弄空戏剧性地减少了 PARP 禁止者的能力在 vivo 压制肿瘤生长。simmiparib 的抑制率为 BRCA1 缺乏的 MDA-MB-436 异种皮移植是 74.16% ,但是仅仅 7.79% 为 53BP1/BRCA1-deficient 异种皮移植。在双缺乏的房间的重新表示的 53BP1 恢复了 PARP 禁止者敏感和 HR 管理者的层次。认为至少 10%BRCA1 缺乏的胸和卵巢的癌症减少了 53BP1 的表示,用有象为耐心的选择的 biomarker 的 BRCA1 的 53BP1 的联合应该减少与 PARP 禁止者经历无益的治疗的病人的数字。 | Zhong-min YANG Xue-mei LIAO Yi CHEN Yan-yan SHEN Xin-ying YANG Yi SU Yi-ming SUN Ying-lei GAO Jian DING Ao ZHANG Jin-xue HE Ze-hong MIAO | 2017 | Acta Pharmacologica Sinica2017，38，7： | 2 |
| 6 | Noscapine sensitizes chemoresistant ovarian cancer cells to cisplatin through inhibition of HIF-1α显示文摘 | Su W Huang L Ao Q | | 0，，： | 1 |
| 7 | Noscapine sensitizes chemoresistant ovarian cancer cells to cisplatin through inhibition of HIF-1α显示文摘 | SU W HUANG L AO Q | 2011 | Cancer Lett2011，305，1： | 1 |
| 8 | Oxidized low density lipoprotein in duees bone morphogenetic protein-2 in coronary artery endothe lial cells via Toll-like receptors 2 and 4 显示文摘 | Su X Ao L Shi Y | 2011 | J Biol Chem2011，286，12： | 1 |
| 9 | Extracellular heat shock cognate protein 70 induces cardiac functional tolerance to endotoxin: differential effect on TNF-alpha and ICAM-1 levels in heart tissue显示文摘 | Su X Sykes JB Ao L | 2010 | Cytokinc2010，51，1： | 1 |
| 10 | Research Progress on Chemical Constituents and Pharmacological Effects of Laportea bulbifera显示文摘Laportea bulbifera(Sieb.et Zucc.)Wedd.is a perennial herb of Laportea in Urticaceae.At present,more than 90 compounds have been isolated from L.bulbifera,mainly including flavonoids,coumarins,phenolic acids,esters,ketones,phenylpropanoids and steroids,which have anti-inflammatory and analgesic,immunosuppressive,anti-oxidant,hypoglycemic and lipid-lowering pharmacological effects.This article summarized the research progress of the pharmacological effects and the chemical constituents of L.bulbifera in recent years,hoping to provide references for its further research and development. | Ao XIE Yongjing SU Gan LUO Qi WU Haicheng WEN | 2021 | Agricultural Biotechnology2021，10，3： | 1 |
| 11 | Analysis of Multi- Beam Folded Waveguide Traveling-Wave Tube for Tera- hertz Radiation 显示文摘 | Shengmei Yan Wei Su Ao Xu | 2015 | Journal of Electromagnetic Waves and Applications2015，29，04： | 1 |
| 12 | UHPLC - MS Simultaneous Determination and Pharmacokinetic Study of Three Aromatic Acids and One Monoterpene in Rat Plasma after Oral Administration of Shaofu Zhuyu Decoction 显示文摘 | Shulan Su Wenxia Cui and Jin - Ao Duan | 2013 | The American Journal of Chinese Medicine2013，41，3： | 1 |
| 13 | Post-transcriptional regulation of TNF-induced expression of ICAM-1 and IL-8 in human lung microvascular endothelial cells:An obligatory role for the p38 MAPK-MK2 pathway dissociated with HSP27显示文摘 | Su X Ao L Zou N | 2008 | Biochim Biophys Acta2008，1783，9： | 1 |
| 14 | Post-transcriptional regulation of TNF-induced expression of ICAM-I and IL-8 in human lung microvascular endothelial cells : an obligatory role for the p38 MAPK-MK2 pathway dissociated with HSP27 显示文摘 | Su X Ao L Zou N | 2008 | Biochim Biophys Acta2008，1783，9： | 1 |
| 15 | Oxidized low density lipoprotein induces bone morphogenetic protein-2 in coronary artery endothelial cells viaTol-likereceptors2and4显示文摘 | Su X Ao L Shi Y | | 0，，14： | 1 |
| 16 | Urban solid waste management in Chongqing: Challenges and opportunities显示文摘 | Yuan Hui Wang Li’ao Su Fenwei Hu Gang | 2005 | Waste Management2005，，9： | 1 |
| 17 | Post-transcriptional regulation of TNF-in- duced expression of ICAM-1 and IL-8 in human lung microvascular e- ndothelial cells:An obligatory role for the p38 MAPK-MK2 pathway dissociatedwithHSP27 显示文摘 | Xin Su Lihua Ao Ning Zou | 2008 | BiochimBiophysActa2008，1783，9： | 1 |
| 18 | Extraeellular heat shock cognate protein 70 induces cardiac functional tolerance to endotoxin:differ- ential effect on TNF-ot and ICAM-1 levels in heart tissue显示文摘 | Su X Sykes J B Ao L H | 2010 | Cyto- kine2010，51，1： | 1 |
| 19 | Noscapine sensitizes chemoresistant o- varian cancer cells to cisplatin through inhibition of HIF-lct显示文摘 | Su W Huang L Ao Q | 2011 | Cancer Letter2011，305，1： | 1 |
| 20 | m -CPBA/TFA: an efficient nonmetallic reagent for oxidative coupling of 1,2-diarylethylenes显示文摘 | Kailiang Wang Yanna Hu Meng Wu Zheng Li Zhihui Liu Bo Su Ao Yu Yu Liu Qingmin Wang | 2010 | Tetrahedron2010，，47： | 1 |
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