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| 1 | Nanotechnology-based combination therapy for overcoming multidrug-resistant cancer显示文摘Multidrug resistance(MDR) is a major obstacle to successful cancer treatment and is crucial to cancer metastasis and relapse.Combination therapy is an effective strategy for overcoming MDR. However, the different pharmacokinetic(PK) profiles of combined drugs often undermine the combination effect in vivo, especially when greatly different physicochemical properties(e.g.,those of macromolecules and small drugs) combine. To address this issue, nanotechnology-based codelivery techniques have been actively explored. They possess great advantages for tumor targeting, controlled drug release, and identical drug PK profiles. Thus,a powerful tool for combination therapy is provided, and the translation from in vitro to in vivo is facilitated. In this review, we present a summary of various combination strategies for overcoming MDR and the nanotechnology-based combination therapy. | Meng Zhang Ergang Liu Yanna Cui Yongzhuo Huang | 2017 | Cancer Biology & Medicine2017，14，3： | 10 |
| 2 | Facile Fabrication of Cellulosic Paper-based Composites with Temperature-controlled Hydrophobicity and Excellent Mechanical Strength显示文摘In this paper,we presented a novel strategy to employ a plantderived carbohydrate polymer,i.e.,cellulose,to prepare a hydrophobic composite.Cellulose was used as a scaffold,and ethylene-propylene side by side(ES)fiber was thermally melted and then coated on the cellulose surface to achieve hydrophobicity.Experimental results revealed that the thermocoating ES fibers greatly increased the water contact angle of the cellulose scaffold from 25°to 153°while simultaneously enhanced the wet tensile strength of the composite approximately 6.7-fold(drying temperature of 170℃)compared with the pure cellulose paper.In particular,compared with other related research,the prepared cellulose-based composite possessed excellent hydrophobicity and superior mechanical strength,which introduces a new chemical engineering approach to prepare hydrophobic cellulose-based functional materials. | Tongtong Yun Yilin Wang Jie Lu Yi Cheng Yanna Lyu Haisong Wang | 2020 | Paper And Biomaterials2020，5，2： | 6 |
| 3 | Epidemiological studies of migration and environmental risk factors in the inflammatory bowel diseases显示文摘Inflammatory bowel diseases(IBD)are idiopathic chronic diseases of the gastrointestinal tract well known to be associated with both genetic and environmental risk factors.Permissive genotypes may manifest into clinical phenotypes under certain environmental influences and these may be best studied from migratory studies.Exploring differences between first and second generation migrants may further highlight the contribution of environmental factors towards the development of IBD.There are few opportunities that have been offered so far.We aim to review the available migration studies on IBD,evaluate the known environmental factors associated with IBD,and explore modern migration patterns to identify new opportunities and candidate migrant groups in IBD migration research. | Yanna Ko Rhys Butcher Rupert W Leong | 2014 | World Journal of Gastroenterology2014，20，5： | 5 |
| 4 | Cilastatin protects against imipenem-induced nephrotoxicity via inhibition of renal organic anion transporters(OATs)显示文摘Imipenem is a carbapenem antibiotic. However, Imipenem could not be marketed owing to its instability and nephrotoxicity until cilastatin, an inhibitor of renal dehydropeptidase-I(DHP-I),was developed. In present study, the potential roles of renal organic anion transporters(OATs) in alleviating the nephrotoxicity of imipenem by cilastatin were investigated in vitro and in rabbits. Our results indicated that imipenem and cilastatin were substrates of h OAT1 and h OAT3. Cilastatin inhibited h OAT1/3-mediated transport of imipenem with IC50 values comparable to the clinical concentration, suggesting the potential to cause a clinical drug–drug interaction(DDI). Moreover,imipenem exhibited h OAT1/3-dependent cytotoxicity, which was alleviated by cilastatin and probenecid. Furthermore, cilastatin and probenecid ameliorated imipenem-induced rabbit acute kidney injury, and reduced the renal secretion of imipenem. Cilastatin and probenecid inhibited intracellular accumulation of imipenem and sequentially decreased the nephrocyte toxicity in rabbit primary proximal tubule cells. Renal OATs, besides DHP-I, was also the target of interaction between imipenem and cilastatin, and contributed to the nephrotoxicity of imipenem. This therefore gives in part the explanation about the mechanism by which cilastatin protected against imipenem-induced nephrotoxicity. Thus, OATs can potentially be used as a therapeutic target to avoid the renal adverse reaction of imipenem in clinic. | Xiaokui Huo Qiang Meng Changyuan Wang Yanna Zhu Zhihao Liu Xiaodong Ma Xiaochi Ma Jinyong Peng Huijun Sun Kexin Liu | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 5 |
| 5 | Melanin nanoparticles alleviate sepsis-induced myocardial injury by suppressing ferroptosis and inflammation显示文摘Myocardial injury as one of the severe complications leads to the increasing morbidity and mortality in patients with sepsis.Recent studies reported that reactive oxygen species(ROS)-mediated ferroptosis plays a critical role in the development of heart diseases.Therefore,we hypothesized that anti-ferroptosis agent might be a novel potential therapeutic strategy for sepsis-induced cardiac injury.Herein,we demonstrated that a small biocompatible and MRI-visible melanin nanoparticles(MMPP)improves myocardial function by inhibiting ROS-related ferroptosis signaling pathway.In LPS-induced murine sepsis model,after a single dose intravenously injection of MMPP treatment,MMPP markedly alleviated the myocardial injury including cardiac function and heart structure disorder through suppressing iron-accumulation induced ferroptosis.In vitro,MMPP inhibited cardiomyocyte death by attenuating oxidative stress,inflammation and maintaining mitochondrial homeostasis.Collectively,our findings demonstrated that MMPP protected heart against sepsis-induced myocardial injury via inhibiting ferroptosis and inflammation,which might be a novel therapeutic approach in future. | Chang Liu Quan Zou Huixin Tang Jia Liu Shiqi Zhang Caihong Fan Junwei Zhang Ruiqing Liu Yashan Liu Ruiyan Liu Yan Zhao Qiang Wu Zhi Qi Yanna Shen | 2023 | Bioactive Materials2023，，6： | 5 |
| 6 | Tat-functionalized Ag-Fe_3O_4 nano-composites as tissue-penetrating vehicles for tumor magnetic targeting and drug delivery显示文摘In this paper, we prepared a dual functional system based on dextrin-coated silver nanoparticles which were further attached with iron oxide nanoparticles and cell penetrating peptide(Tat), producing Tat-modified Ag-Fe_3O_4 nanocomposites(Tat-FeAgNPs). To load drugs, an –SH containing linker, 3-mercaptopropanohydrazide, was designed and synthesized. It enabled the silver carriers to load and release doxorubicin(Dox) in a pH-sensitive pattern. The delivery efficiency of this system was assessed in vitro using MCF-7 cells, and in vivo using null BalB/c mice bearing MCF-7 xenograft tumors. Our results demonstrated that both Tat and externally applied magnetic field could promote cellular uptake and consequently the cytotoxicity of doxorubicin-loaded nanoparticles,with the IC_(50) of Tat-FeAgNP-Dox to be 0.63 mmol/L. The in vivo delivery efficiency of Tat-FeAgNP carrying Cy5 to the mouse tumor was analyzed using the in vivo optical imaging tests, in which TatFeAgNP-Cy5 yielded the most efficient accumulation in the tumor(6.772.4% ID of Tat-FeAgNPs).Anti-tumor assessment also demonstrated that Tat-FeAgNP-Dox displayed the most significant tumor-inhibiting effects and reduced the specific growth rate of tumor by 29.6%(P ? 0.009), which could be attributed to its superior performance in tumor drug delivery in comparison with the control nanovehicles. | Ergang Liu Meng Zhang Hui Cui Junbo Gong Yongzhuo Huang Jianxin Wang Yanna Cui Weibing Dong Lu Sun Huining He Victor C.Yang | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 5 |
| 7 | Distribution and speciation of mercury in the Hongfeng Reservoir,Guizhou Province, China显示文摘The water, pore water, sediment, and fish samples were collected from the Hongfeng Reservoir in No- vember 2003 and February 2004 in accordance with trace metal protocols. The average concentrations of total mer- cury (THg), dissolved mercury (DHg), reactive mercury, dissolved gaseous mercury, total methylmercury, and dis- solved methylmercury in the water columns were 8.00, 5.70, 0.63, 0.05, 0.16, and 0.07 ng/L, respectively. THg and DHg in the water columns, THg in pore water and THg in lake sediments of the Hongfeng Reservoir showed the level of mercury in the Hongfeng Reservoir was higher than in other natural waters in the world due to the loading of a lot of waste water with relatively high concentrations of mercury, whereas methylmercury concentrations in fish (wet weight) varied from 1.73–51.00 ng/g, much lower than in most remote lakes and reservoirs reported in northern Europe and North America. Methylmercury distributions in pore water and sediments showed methylation oc- curred mainly in the upper several centimeters of sediment cores in the Hongfeng Reservoir. The concentrations of dissolved organic carbon, total suspended particles, total Hg, and methylmercury were higher at Houwu than those at Daba in November 2003. It is suggested that other pollutants such as N and P from fishing farm and other waste water at Houwu,which resulted in deterioration of water quality, affected the concentrations and distributions of mercury species in the reservoir. | HE Tianrong FENG Xinbin GUO Yanna QIU Guangle YAN Haiyu MENG Bo | 2008 | Chinese Journal Of Geochemistry2008，27，1： | 5 |
| 8 | The EGFR-P38 MAPK axis up-regulates PD-L1 through miR-675-5p and down-regulates HLA-ABC via hexokinase-2 in hepatocellular carcinoma cells显示文摘Background:Immunotherapy has been shown to be a promising strategy against human cancers.A better understanding of the immune regulation in hepatocellular carcinoma(HCC)could help the development of immunotherapy against HCC.The epidermal growth factor receptor(EGFR)signaling is frequently activated in HCC and plays important roles in tumorigenesis.However,its role in HCC immunity is still largely unknown.This study aimed to investigate the impact of EGFR signaling on programmed death-ligand 1(PD-L1)and human leukocyte antigen class-I(HLA-I)expression in HCC cells and its underlying mechanisms.Methods:The expression of phosphorylated EGFR(p-EGFR),PD-L1,and HLAI(HLA-ABC)in HCC specimens was detected by immunohistochemistry,and their correlations were analyzed.PD-L1 and HLA-ABC expression in EGFRactivated HCC cells were detected by quantitative real-time PCR,Western blotting,and flow cytometry,and T cell-mediated lysis was performed to test the immunosuppressive effects of PD-L1 and HLA-ABC alterations in HCC cells.Furthermore,the underlying mechanisms of EGFR activation-induced PD-L1 up-regulation and HLA-ABC down-regulation were explored by animal experiments,luciferase reporter assay,and gene gain-and loss-of-function studies.Results:p-EGFR was positively correlated with PD-L1 and negatively correlated with HLA-ABC expression in HCCs.EGFR activation by its ligand EGF up-regulated PD-L1 and down-regulated HLA-ABC in HCC cells,which was functionally important and could be abolished by the EGFR inhibitor,gefitinib,both in vitro and in vivo.Mechanistically,enhanced P38 mitogenactivated protein kinase(MAPK)activation down-regulated microRNA-675-5p(miR-675-5p)and up-regulated glycolysis-related enzyme hexokinase 2(HK2);miR-675-5p down-regulation enhanced the stability of PD-L1 mRNA probably via the 3’-untranslated region(3’-UTR)of PD-L1 and thereby caused PD-L1 accumulation,and HK2 up-regulation enhanced aerobic glycolysis and mediated a decrease in HLA-ABC.Conclusions:The EGFR-P38 MAPK axis could up-regulate PD-L1 through miR-675-5p and down-regulate HLA-ABC via HK2 in HCC cells.Our study reveals a novel signaling network that may cause immune suppression in HCC and suggests that EGFR signaling can be targeted for HCC immunotherapy. | Zongcai Liu Fen Ning Yanna Cai Huiying Sheng Ruidan Zheng Xi Yin Zhikun Lu Ling Su Xiaodan Chen Chunhua Zeng Haifang Wang Li Liu | 2021 | Cancer Communications2021，41，1： | 5 |
| 9 | Ki-67 index,progesterone receptor expression,histologic grade and tumor size in predicting breast cancer recurrence risk:A consecutive cohort study显示文摘Background:The 21-gene recurrence score(RS)assay has been recommended by major guidelines for treatment decision in hormone receptor(HR)-positive early breast cancer(EBC).However,the genomic assay is not accessible and affordable worldwide.Alternatively,an increasing number of studies have shown that traditional immunohistochemistry(IHC)can partially or even completely replace the role of the 21-gene genomic assay.Here,we developed and validated a predictive model(IHC3 model)combining the Ki-67 index,progesterone receptor(PR)expression,histologic grade,and tumor size to predict the recurrence risk of HR-positive EBC.Methods:The data from 389 patients(development set)with HR-positive,human epidermal growth factor receptor 2-negative,lymph node non-metastasized invasive breast cancer were used to construct the IHC3 model based on the Surexam®21-gene RS and the TAILORx clinical trial criteria.An additional 146 patients with the same characteristics constituted the validation set.The predictive accuracy of the IHC3 model was compared with that of Orucevic et al.’s nomogram.Invasive diseasefree survival(IDFS)was analyzed in the IHC3 predictive low-recurrence risk(pLR)group and the predictive high-recurrence risk(pHR)group.The Pearson chi-square test,Fisher exact test,and log-rank test were used for analysis.Results:The pLR and pHR group could be easily stratified using the decision tree model without network dependence.The accuracies of the IHC3 model were 86.1%in the development set and 87.7%in the validation set.The predictive accuracy of the IHC3 model and Orucevic et al.’s nomogram for the whole cohort was 86.5%and 86.9%,respectively.After a 52-month of median follow-up,a significant difference was found in IDFS between of the IHC3 pLR and the pHR groups(P=0.001)but not in the IDFS between the low-and high-recurrence risk groups according to the Surexam®21-gene RS and the TAILORx clinical trial criteria(P=0.556)or 21-gene binary RS group(P=0.511).Conclusions:The proposed IHC3 model could reliably predict low and high recurrence risks in most HR-positive EBC patients.This easy-to-use predictive model may be a reliable replacement for the 21-gene genomic assay in patients with EBC who have no access to or cannot afford the 21-gene genomic assay. | Yanna Zhang Yidong Zhou Feng Mao Ru Yao Qiang Sun | 2020 | Cancer Communications2020，40，4： | 5 |
| 10 | Enhanced activation of peroxydisulfate by strontium modified BiFeO3 perovskite for ciprofloxacin degradation显示文摘A series of Sr-doped BiFeO3 perovskites(Bi1-xSrxFeO3,BSFO)fabricated via sol-gel method was applied as peroxydisulfate(PDS)activator for ciprofloxacin(CIP)degradation.Various technologies were used to characterize the morphology and physicochemical features of prepared BSFO samples and the results indicated that Sr was successfully inserted into the perovskites lattice.The catalytic performance of BiFeO3 was significantly boosted by strontium doping.Specifically,Bi0.9Sr0.1FeO3(0.1 BSFO)exhibited the highest catalytic performance for PDS activation to remove CIP,where 95%of CIP(10 mg/L)could be degraded with the addition of 1 g/L 0.1 BSFO and 1 mmol/L PDS within 60 min.Moreover,0.1 BSFO displayed high reusability and stability with lower metal leaching.Weak acidic condition was preferred to neutral and alkaline conditions in 0.1 BSFO/PDS system.The boosted catalytic performance can be interpreted as the lower oxidation state of Fe and the existence of affluent oxygen vacancies generated by Sr doping,that induced the formation of singlet oxygen(^1O_(2))which was confirmed as the dominant reactive species by radical scavenging studies and electron spin resonance(ESR)tests.The catalytic oxidation mechanism related to major ^1O_(2) and minor free radicals was proposed.Current study opens a new avenue to develop effective A-site modified perovskite and expands their application for PDS activation in wastewater remediation. | Caicai Wang Shengwang Gao Jianchao Zhu Xunfeng Xia Mingxin Wang Yanna Xiong | 2021 | Journal of Environmental Sciences2021，33，1： | 4 |
| 11 | CXCL16 deficiency attenuates acetaminopheninduced hepatotoxicity through decreasing hepatic oxidative stress and inflammation in mice显示文摘Chemokine C-X-C ligand 16 (CXCL16 ) ,一种单个通行证的类型我属于 CXC chemokine 家庭的膜蛋白质,与在肝损害的煽动性的反应有关。在现在的学习,我们调查了 CXCL16 的 pathophysiological 角色,唯一的膜界限 chemokine,在导致的 acetaminophen (APAP ) 在老鼠的 hepatotoxicity。老鼠与 APAP 被注射,并且血和织物样品在不同时间点被收获。浆液高活动性的组盒子 1 并且 CXCL16 层次被三明治免疫分析确定。肝织物节与 hematoxylin 曙红或与染色的 dihydroethidium 被染色。CXCL16 和另外的 cytokines 的表情被即时聚合酶链反应检验。Ly6-B, p-jun N 终端 kinase (p-JNK ) ,和 JNK 表情被西方的污点分析测量。细胞内部的谷胱甘肽,反应的氧种类,和 malondialdehyde 层次也被测量。APAP 服药过量增加了肝的 CXCL16 mRNA 和浆液 CXCL16 蛋白质层次。CXCL16 缺乏的老鼠显著地展出了更少的肝损害和肝的坏死,以及更低的死亡比野类型(WT ) 响应 APAP 服药过量处理的老鼠。提高的 APAP 在 WT 老鼠的呼吸的链激活,它是强烈在 CXCL16 大美人老鼠颠倒了的氧化应力和减少的 mitochondrial 的生产。另外, CXCL16 缺乏禁止了嗜中性的渗入和 APAP 服药过量处理触发的 proinflammatory cytokines 的生产。我们的学习表明 CXCL16 是对导致 APAP 的 hepatotoxicity 的肝免疫者反应的一个批评管理者,因此由指向 CXCL16 为导致药的尖锐的肝失败的处理提供潜在的策略。 | Hong Wang Yihui Shao Saisai Zhang Anqi Xie Yanna Ye Lihua Shi Leigang Jin Xuebo Pan Zhuofeng Lin Xiaokun Li Shulin Yang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，6： | 4 |
| 12 | A study of chemical structure changes of Chinese lignite during fluidized-bed drying in nitrogen and air显示文摘 | Arash Tahmasebi Jianglong Yu Yanna Han Xianchun Li | 2012 | Fuel Processing Technology2012，，： | 4 |
| 13 | Cu_2O nanowires as anode materials for Li-ion rechargeable batteries显示文摘Li-ion batteries are a key technology for multiple clean energy applications.In this study,Cu2O nanowires were obtained by the reduction of cupric acetate with pyrrole.The resulting Cu2O nanowires exhibited excellent reversible capacities of 470mAh g-1 at rate of 1 C after 100 cycles.The results show that the Cu2O nanowires had more capacity than materials previously reported.No fading was observed over 100 cycles of charging and discharging.The compound metal Cu and incorporation of the conducting polymer polypyrrole(PPy)improved the conductivity of Cu2O and enhanced the stability of the electrode during cycling.The results from this study imply that Cu2O nanowires with high capacity and good cycle retention could be excellent candidates as anode materials for Li-ion rechargeable batteries. | CHEN Rui WANG Ying NULI YanNa YU Yuan GAO PengFei CHEN Qiang WEI LiangMing HU NaTao YANG Zhi GAO RunGang ZHANG LiLing ZHANG YaFei | 2014 | Science China(Technological Sciences)2014，57，6： | 3 |
| 14 | Organic anion transporters also mediate the drug–drug interaction between imipenem and cilastatin显示文摘This study aimed to clarify that organic anion transporters(OATs)mediate the drug–drug interaction(DDI)between imipenem and cilastatin.After co-administration with imipenem,the plasma concentrations and the plasma concentration-time curve(AUC)of cilastatin were significantly increased,while renal clearance and cumulative urinary excretion of cilastatin were decreased.At the same time,imipenem significantly inhibited the uptake of cilastatin in rat kidney slices and in human OAT1(hOAT1)-HEK293 and human OAT3(hOAT3)-HEK293 cells.Probenecid,p-aminohippurate,and benzylpenicillin inhibited the uptake of imipenem and cilastatin in rat kidney slices and in hOAT1-and hOAT3-HEK 293 cells,respectively.The uptakes of imipenem and cilastatin in hOAT1-and hOAT3-HEK 293 cells were significantly higher than that in mock-HEK-293 cells.Moreover,the K m values of cilastatin were increased in the presence of imipenem with unchanged V max,indicating that imipenem inhibited the uptake of cilastatin in a competitive manner.When imipenem and cilastatin were co-administered,the level of imipenem was higher compared with imipenem alone both in vivo and in vitro.But,cilastatin significantly inhibited the uptake of imipenem when dehydropeptidase-1(DPEP1)was silenced by RNAi technology in hOAT1-and hOAT3-HEK 293 cells.In conclusion,imipenem and cilastatin are the substrates of OAT1 and OAT3.OAT1 and OAT3 mediate the DDI between imipenem and cilastatin.Meanwhile,cilastatin also reduces the hydrolysis of imipenem by inhibiting the uptake of imipenem mediated by OAT1 and OAT3 in the kidney as a complement. | Yanna Zhu Xiaokui Huo Changyuan Wang Qiang Meng Zhihao Liu Huijun Sun Aiping Tan Xiaodong Ma Jinyong Peng Kexin Liu | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，2： | 3 |
| 15 | Chinese consumer demand for food safety attributes in milk products显示文摘 | Zhigang Wang Yanna Mao Fred Gale | 2007 | Food Policy2007，，1： | 3 |
| 16 | Farmland mercury contamination in the vicinity of an organic chemical factory in Guizhou,China显示文摘This study assesses the level of contamination of Hg in farmland soils along the irrigating channel down-stream from Guizhou Organic Chemical Factory (GOCF),where metallic mercury is used as a catalyst to produce acetic acid. The total input of mercury into the environment,as announced by GOCF,is 140 t in the past 30 years (1971-2000). Sampling sites were chosen based on the distance from the source of pollution—the chemical factory. A total of 39 samples were collected from the study area and analyzed for total mercury concentrations and methyl mercury concentrations. The characteristics of vertical and horizontal distributions of total mercury and methyl mer-cury in the study area (farmland) are described in this paper. Much attention was paid to the transformation of inor-ganic Hg into organic mercury species in soils as well. The results showed that the farmland has been heavily con-taminated by Hg. Land cultivation activity,land utilization style and distance from the pollution source could be the dominant factors controlling the distribution of THg and MeHg. It is observed that active transformation of inorganic Hg into organic mercury species (MeHg) usually takes place in paddy soils. | ZHANG Junfang QU Liya FENG Xinbin ZHANG Wei GUO Yanna LIN Kai LI Mei | 2008 | Chinese Journal Of Geochemistry2008，27，4： | 3 |
| 17 | Val279Phe variant of Lp-PLA2 is a risk factor for a subpopulation of Indonesia patients with acute myocardial infarction显示文摘Lipoprotein-associated phospholipase A2(Lp-PLA2),a member of the phospholipase A2 superfamily,is an enzyme that hydrolyses phospholipids,is found in blood circulation as a sign of inflammation,and takes a role in atherogenesis.There is an epidemiologic relation between increased Lp-PLA2 levels and coronary heart disease.Lp-PLA2 is an enzyme that is produced by macrophages and takes a role as an independent predictor of a coronary event.A genetic variant of Val279Phe on the Lp-PLA2 gene has been reported with various results in Japan,China,Korea,and Caucasian populations.This study aims to analyse the influence of the Val279Phe genetic variant on acute myocardial infarction(AMI)at Saiful Anwar Hospital,Indonesia.This study was conducted on 151 patients(111 AMI patients and 40 non-AMI patients).The genetic variant of Val279Phe was identified through a genotyping method.There were no significant differences in age,total cholesterol level,LDL-C(low-density lipoprotein cholesterol)level,and family history data between AMI and non-AMI patients.However,AMI patients had low HDL-C(high-density lipoprotein cholesterol),triglyceride levels,dyslipidaemia,and hypertension risk factors compared to non-AMI patients.The frequency of the GG genotype(279Val)was dominant in both AMI and non-AMI groups.Further analysis suggested that the GG genotype has a 2.9 times greater risk of AMI compared to the GT/TT genotype(279Phe).This study concluded that the Val279Phe genetic variant undoubtedly influenced AMI risk,which is a warrant for further development of early detection and improving strategy to prevent AMI in patients. | Miryanti Cahyaningtias Mohammad Saifur Rohman Widodo Andi Wahjono Adi Rina Yuda Yanna Indrayana Jayarani Fatimah Putri Rusdianto Mifetika Lukitasari Dadang Hendrawan | 2016 | Genes & Diseases2016，3，4： | 3 |
| 18 | Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study显示文摘Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in cirrhosis.Methods:In this international multicenter,diagnostic study(ClinicalTrials.gov,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017.After segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity.Results:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(p<0.0001)and 0.55(p<0.01)for the training and validation cohorts,respectively.The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,respectively.The intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,respectively.Conclusions:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG.Besides,this score could be used to detect CSPH in patients with cirrhosis. | Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 3 |
| 19 | DI-3-n-butylphthalide exerts neuroprotective effects by modulating hypoxia-inducible factor 1-alpha ubiquitination to attenuate oxidative stress-induced apoptosis显示文摘DI-3-n-butylphthalide is used to treat mild and moderate acute ischemic stroke.However,the precise underlying mechanism requires further investigation.In this study,we investigated the molecular mechanism of DI-3-n-butylphthalide action by various means.We used hydrogen peroxide to induce injury to PC12cells and RAW264.7 cells to mimic neuronal oxidative stress injury in stroke in vitro and examined the effects of DI-3-n-butylphthalide.We found that DI-3-nbutylphthalide pretreatment markedly inhibited the reduction in viability and reactive oxygen species production in PC12 cells caused by hydrogen peroxide and inhibited cell apoptosis.Furthermore,DI-3-n-butylphthalide pretreatment inhibited the expression of the pro-apoptotic genes Bax and Bnip3.DI-3-nbutylphthalide also promoted ubiquitination and degradation of hypoxia inducible factor 1α,the key transcription factor that regulates Bax and Bnip3 genes.These findings suggest that DI-3-n-butylphthalide exhibits a neuroprotective effect on stroke by promoting hypoxia inducible factor-1α ubiquitination and degradation and inhibiting cell apoptosis. | Shuai Li Jingyuan Zhao Yan Xi Jiaqi Ren Yanna Zhu Yan Lu Deshi Dong | 2023 | Neural Regeneration Research2023，18，11： | 3 |
| 20 | Bioleaching of trace elements and rare earth elements from coal fly ash显示文摘Coal fly ash originated from coal combustion has high concentrations of metals. If suitable leaching techniques are identified, then coal fly ash could serve as a useful source of valuable minerals including rare earth elements (REEs). In this study, three microbial strains, Candida bombicola, Phanerochaete chrysosporium and Cryptococcus curvatus were tested on their performance of leaching trace elements and REEs from fly ash. Through comparing mineral loss and leaching efficiencies resulting from indirect leaching or use of the culture supernatant, C. bombicola was identified to be the best leading to the highest mineral loss and extracting efficiencies of trace elements and REEs among the three strains. The highest mineral loss observed from using the supernatant of this yeast strain was 59.7%. Among all trace elements, As and Mo had the highest leaching efficiency of 80.9% and 79.5%. respectively. The same leaching test led to 67.7% of Yb and 64.6% of Er dissolved from the ash. This study, thus, demonstrated that bioleaching is feasible for leaching metals out of fly ash. The C. bombicola strain deserves further investigation due to its robust actions on metal leaching. | Stephen Park Yanna Liang | 2019 | International Journal of Coal Science & Technology2019，6，1： | 2 |
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