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| 1 | Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation显示文摘The cysteine protease caspase-1(Casp-1)contributes to innate immunity through the assembly of NLRP3,NLRC4,AIM2,and NLRP6 inflammasomes.Here we ask whether caspase-1 activation plays a regulatory role in house dust mite(HDM)-induced experimental allergic airway inflammation.We report enhanced airway inflammation in caspase-1-deficient mice exposed toHDMwith a marked eosinophil recruitment,increased expression of IL-4,IL-5,IL-13,aswell as full-length and bioactive IL-33.Furthermore,mice deficient for NLRP3 failed to control eosinophil influx in the airways and displayed augmented Th2 cytokine and chemokine levels,suggesting that the NLPR3 inflammasome complex controls HDM-induced inflammation.IL-33 neutralization by administration of soluble ST2 receptor inhibited the enhanced allergic inflammation,while administration of recombinant IL-33 during challenge phase enhanced allergic inflammation in caspase-1-deficient mice.Therefore,we show that caspase-1,NLRP3,and ASC,but not NLRC4,contribute to the upregulation of allergic lung inflammation.Moreover,we cannot exclude an effect of caspase-11,because caspase-1-deficient mice are deficient for both caspases.Mechanistically,absence of caspase-1 is associated with increased expression of IL-33,uric acid,and spleen tyrosine kinase(Syk)production.This study highlights acritical role of caspase-1 activation andNLPR3/ASCinflammasomecomplex in the down-modulation of IL-33 in vivo and in vitro,thereby regulating Th2 response in HDM-induced allergic lung inflammation. | Fahima Madouri Noelline Guillou Louis Fauconnier Tiffany Marchiol Nathalie Rouxel Pauline Chenuet Aurelie Ledru Lionel Apetoh Franc¸ois Ghiringhelli Mathias Chamaillard Song Guo Zheng Fabrice Trovero Valerie F.J.Quesniaux Bernhard Ryffel Dieudonnee Togbe | 2015 | Journal of Molecular Cell Biology2015，7，4： | 8 |
| 2 | Role of interleukin-1-family cytokines on effector CD4 T cell differentiation显示文摘The ability of CD4 T cells to differentiate into various effector or regulatory T cell subsets explains the successful adaptation of immune responses to different types of infectious pathogens. Immune responses in the context of cancer are also shaped by CD4 T cells, which can directly affect cancer prognosis in patients. While the proinflammatory mediator interleukin(IL)-1β was initially shown to enhance Th2 cell responses, recent findings support a predominant role of two other members of the IL-1 family, IL-18 and IL-33, on the production of Th1 and Th2-derived cytokines. In addition, IL-1β was found to profoundly affect the biology of two recently identified CD4 T cell subsets, Th17 and Th9 cells. IL-1β is critical for Th17 cell differentiation and it enhances the production of IL-9 and IL-21 by Th9 cells, thus increasing their anticancer properties. We will here review the mechanisms accounting for the ability of IL-1 cytokines to affect the differentiation of CD4 effector T cells with a focus on Th17 and Th9 cells. The physiopathological relevance of IL-1-driven effects on CD4 T cells will also be discussed. | Thaiz Rivera Vargas Fran?ois Martin Lionel Apetoh | 2017 | World Journal of Immunology2017，7，2： | 2 |
| 3 | Immunogenic chemotherapy: Discovery of a critical protein through proteomic analyses of tumor cells显示文摘 | Apetoh L Obeid M Tesniere A | 2007 | Cancer Genomics Proteomics2007，4，2： | 1 |
| 4 | Tumor cell death and ATP release prime dendritic cells and efficient anticancer immunity显示文摘 | Aymeric L Apetoh L Ghiringhelli F | 2010 | Cancer Res2010，70，： | 1 |
| 5 | 'I3ae interaction between hmgbl and tlr4 dictates the outcome of antieaneer chemo- therapy and radiotherapy显示文摘 | Apetoh L Ghiringhelli F Tesniere A | 2007 | lmmunol Rev2007，220，12： | 1 |
| 6 | Calreticulin exposure dictates the immunogenicity of cancer cell death显示文摘 | Obeid M Tesniere A Ghiringhelli F Fimia G M Apetoh L Perfettini J L | 2007 | Nat Med2007，13，： | 1 |
| 7 | Targeting Tim-3and PD-1pathways to reverse T cell exhaustion and restore anti-tumor immunity显示文摘 | Sakuishi K Apetoh L Sullivan J M | 2010 | J Exp Med2010，207，10： | 1 |
| 8 | Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy显示文摘 | Apetoh L Ghiringhelli F Tesniere A Obeid M Ortiz C Criollo A | 2007 | Nat Med2007，13，： | 1 |
| 9 | The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27显示文摘 | Apetoh L Quintana FJ Pot C | 2010 | Nature Immunology2010，11，： | 1 |
| 10 | Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity显示文摘 | Sakuishi K Apetoh L Sullivan JM | 2010 | J Exp Med2010，207，10： | 1 |
| 11 | Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity 显示文摘 | Sakuishi K Apetoh L Sullivan JM Blazar BR Kuchroo VK Anderson AC | 2010 | J Exp Med2010，207，10： | 1 |
| 12 | Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy 显示文摘 | Apetoh L Ghiringhelli F Tesniere A | 2007 | Nat Med2007，13，9： | 1 |
| 13 | The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemothera- py and radiotherapy显示文摘 | Apetoh L Ghiringhelli F Tesniere A | 2007 | Immunol Rev2007，220，： | 1 |
| 14 | Induction of regulato-ry Tr1 cells and inhibition of TH17 cells by IL-27显示文摘 | Pot C Apetoh L Awasthif A | | 0，，6： | 1 |
| 15 | Immunological aspects of cancer chemotherapy显示文摘 | Zitvogel L Apetoh L Ghiringhelli F | 2008 | Nat Rev Immunol2008，8，： | 1 |
| 16 | Toll-like receptor 4- dependent contribution of the immune system to anticancer chemo- therapy and radiotherapy 显示文摘 | Apetoh L Ghiringhelli F Tesniere A | 2007 | Nat Med2007，13，9： | 1 |
| 17 | Immunological aspects of cancer chemotherapy显示文摘 | Laurence Zitvogel Lionel Apetoh Francois Ghiringhelli | 2008 | Nature Immunol2008，8，： | 1 |
| 18 | Activation of the NL- RP3 inflammasome in dendritic cells induces IL-lbeta-dependent adaptive immunity against tumors 显示文摘 | Ghiringhelli F Apetoh L Tesniere A | 2009 | Nat Med2009，15，10： | 1 |
| 19 | Immunological aspects of cancer chemotherapy显示文摘 | Zitvogel L Apetoh L Ghiringhelli F | 2008 | Nat Rev Immunol2008，8，1： | 1 |
| 20 | Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy显示文摘 | Apetoh L Ghiringhelli F Tesniere A | 2007 | Nat Med2007，13，9： | 1 |
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