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| 1 | Alcoholic liver disease:Utility of animal models显示文摘Alcoholic liver disease(ALD) is a major cause of acute and chronic liver injury. Extensive evidence has been accumulated on the pathological process of ALD during the past decades. However, effective treatment options for ALD are very limited due to the lack of suitable in vivo models that recapitulate the full spectrum of ALD. Experimental animal models of ALD, particularly rodents, have been used extensively to mimic human ALD. An ideal animal model should recapitulate all aspects of the ALD process, including significant steatosis, hepatic neutrophil infiltration, and liver injury. A better strategy against ALD depends on clear diagnostic biomarkers, accurate predictor(s) of its progression and new therapeutic approaches to modulate stop or even reverse the disease. Numerous models employing rodent animals have been established in the last decades to investigate the effects of acute and chronic alcohol exposure on the initiation and progression of ALD. Although significant progress has been made in gaining better knowledge on the mechanisms and pathology of ALD, many features of ALD are unknown, and require further investigation, ideally with improved animal models that more effectively mimic human ALD. Although differences in the degree and stages of alcoholic liver injury inevitably exist between animal models and human ALD, the acquisition and translational relevance will be greatly enhanced with the development of new and improved animal models of ALD. | Arantza Lamas-Paz Fengjie Hao Leonard J Nelson Maria Teresa Vázquez Santiago Canals Manuel Gómez del Moral Eduardo Martínez-Naves Yulia A Nevzorova Francisco Javier Cubero | 2018 | World Journal of Gastroenterology2018，24，45： | 26 |
| 2 | Quality Model and Metrics of Ontology for Semantic Descriptions of Web Services显示文摘An ontology is a conceptualisation of domain knowledge. It is employed in semantic web services technologies to describe the meanings of services so that they can be dynamically searched for and composed according to their meanings. It is essential for dynamic service discovery, composition, and invocation. Whether an ontology is well constructed has a tremendous impact on the accuracy of the semantic description of a web service,the complexity of the semantic definitions, the efficiency of processing messages passed between services, and the precision and recall rates of service retrieval from service registrations. However, measuring the quality of an ontology remains an open problem. Works on the evaluation of ontologies do exist, but they are not in the context of semantic web services. This paper addresses this problem by proposing a quality model of ontology and defining a set of metrics that enables the quality of an ontology to be measured objectively and quantitatively in the context of semantic descriptions of web services. These metrics cover the contents, presentation, and usage aspects of ontologies. The paper also presents a tool that implements these metrics and reports a case study on five real-life examples of web services. | Hong Zhu Dongmei Liu Ian Bayley Arantza Aldea Yunfei Yang Ying Chen | 2017 | Tsinghua Science and Technology2017，22，3： | 5 |
| 3 | Immunotherapy and immunoescape in colorectal cancer显示文摘Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma. | Guillermo Mazzolini Oihana Murillo Catalina Atorrasagasti Juan Dubrot Iigo Tirapu Miguel Rizzo Ainhoa Arina Carlos Alfaro Arantza Azpilicueta Carmen Berasain José L Perez-Gracia Alvaro Gonzalez Ignacio Melero | 2007 | World Journal of Gastroenterology2007，13，44： | 4 |
| 4 | Alcohol use disorder and its impact on chronic hepatitis C virus and human immunodeficiency virus infections显示文摘Alcohol use disorder(AUD) and hepatitis C virus(HCV) infection frequently co-occur. AUD is associated with greater exposure to HCV infection, increased HCV infection persistence, and more extensive liver damage due to interactions between AUD and HCV on immune responses, cytotoxicity, and oxidative stress. Although AUD and HCV infection are associated with increased morbidity and mortality, HCV antiviral therapy is less commonly prescribed in individuals with both conditions. AUD is also common in human immunodeficiency virus(HIV) infection, which negatively impacts proper HIV care and adherence to antiretroviral therapy, and liver disease. In addition, AUD and HCV infection are also frequent within a proportion of patients with HIV infection, which negatively impacts liver disease. This review summarizes the current knowledge regarding pathological interactions of AUD with hepatitis C infection, HIV infection, and HCV/HIV co-infection, as well as relating to AUD treatment interventions in these individuals. | Daniel Fuster Arantza Sanvisens Ferran Bolao Inmaculada Rivas Jordi Tor Robert Muga | 2016 | World Journal of Hepatology2016，8，31： | 4 |
| 5 | Suitability and limitations of mesenchymal stem cells to elucidate human bone illness显示文摘Functional impairment of mesenchymal stem cells(MSCs),osteoblast progenitor cells,has been proposed to be a pathological mechanism contributing to bone disorders,such as osteoporosis(the most common bone disease)and other rare inherited skeletal dysplasias.Pathological bone loss can be caused not only by an enhanced bone resorption activity but also by hampered osteogenic differentiation of MSCs.The majority of the current treatment options counteract bone loss,and therefore bone fragility by blocking bone resorption.These socalled antiresorptive treatments,in spite of being effective at reducing fracture risk,cannot be administered for extended periods due to security concerns.Therefore,there is a real need to develop osteoanabolic therapies to promote bone formation.Human MSCs emerge as a suitable tool to study the etiology of bone disorders at the cellular level as well as to be used for cell therapy purposes for bone diseases.This review will focus on the most relevant findings using human MSCs as an in vitro cell model to unravel pathological bone mechanisms and the application and outcomes of human MSCs in cell therapy clinical trials for bone disease. | Izaskun Mitxitorena Arantza Infante Blanca Gener Clara I Rodríguez | 2019 | World Journal of Stem Cells2019，11，9： | 2 |
| 6 | OBSERVER: An Approach for Query Processing in Global Information Systems Based on Interoperation Across Pre-Existing Ontologies显示文摘 | Eduardo Mena Arantza Illarramendi Vipul Kashyap Amit P. Sheth | 2000 | Distributed and Parallel Databases2000，，2： | 1 |
| 7 | Job scheduling, cooperation, and control显示文摘 | Pedro C C Arantza E | 2006 | Operations Research Letters2006，34，1： | 1 |
| 8 | Software retrieval service based on adaptive knowledgedriven agents for wireless environments 显示文摘 | EDUARDO MENA SPAIN ARANTZA ILLAR- RAME- NDI SPAIN JOSE A R | 2006 | ACM Transactions on Autonomous and Adaptive Systems2006，1，1： | 1 |
| 9 | Emotions in human and artificial intelligence显示文摘 | JUAN M M ARANTZA A | 2005 | Computers in Human Behavior2005，2，21： | 1 |
| 10 | Infection with foot-and-mouth dis- ease virus results in a rapid reduction of MHC class I surface expres- sion 显示文摘 | Arantza S P Sobrino F Ley V | 1998 | Gen Virol1998，79，3： | 1 |
| 11 | Valuation and management of fishing resources under price uncertainty 显示文摘 | Arantza M Chamorro J M | 2006 | Environmental and Resource Economics2006，33，1： | 1 |
| 12 | Improvedmethod for determination of sulfites in shrimp显示文摘 | ARANTZA A A PENA-EGIDO M J | 1993 | Journal of AOAC International1993，76，3： | 1 |
| 13 | Blastocyst culture after repeated failure of cleavage-stage embryo transfers: A comparison of day 5 and day 6 transfers显示文摘 | Gorka Barrenetxea Arantza López de Larruzea Teresa Ganzabal Rosario Jiménez Koldo Carbonero Miren Mandiola | 2005 | Fertility and Sterility2005，，1： | 1 |
| 14 | Valuation and Management of Fishing Resources under Price Uncertainty 显示文摘 | Arantza M Chamorro J M | 2006 | Environmental and Resource Economics2006，33，1： | 1 |
| 15 | Sequeucinggames with repeated players显示文摘 | ARANTZA E F BORM P CALLEJA P | 2008 | Annals of Operations Research2008，158，： | 1 |
| 16 | Identification of T- cell Epitopes in Nonstruetural Proteins of Foot - and - Mouth Disease Virus显示文摘 | Esther Blanco Mercedes Garcia - Briones Arantza Sanz - Parra | 2001 | Journal of Virology2001，75，7： | 1 |
| 17 | Influence ofthe light source and bleaching gel on the efficacy of the toothwhitening process显示文摘 | Dominguez Arantza Antonio Garcia Juan Costela Angel | 2011 | Photomed Laser Surg2011，29，1： | 1 |
| 18 | Heterotopic pregnancy:two cases and a comparative review显示文摘 | Gorka B Lorea Barinaga-Rementeria Arantza LL | 2007 | Fertility and Sterility2007，87，2： | 1 |
| 19 | Real-Time Classification of ECGs on a PDA 显示文摘 | Jimena Rodriguez Alfredo Gohi Arantza Illarramendi | 2005 | IEEE transactions on informalion technology in biomedicine2005，9，1： | 1 |
| 20 | Emotions in human and artificial intelligence 显示文摘 | Juan Martinez-Miranda and Arantza Aldea | 2005 | Computers in Human Behavior2005，2，21： | 1 |
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