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| 1 | 长江口近岸地区抗生素抗性基因与微生物群落分布特征显示文摘由于抗生素的大量使用,环境中微生物对抗生素的抗性不断增加,抗生素抗性基因(ARGs)问题越来越严重,严重威胁生态安全和人类健康.为研究长江口近岸地区水体和底泥沉积物中的ARGs和微生物群落的分布特征,通过野外调查采集了8个站点的水样和沉积物样本,对2种磺胺类抗性基因(sul1、sul2)、6种四环素类抗性基因(tetM、tetC、tetX、tetA、tetO、tetQ)、1种整合子基因intI1、16S rRNA基因和微生物群落进行检测分析.结果表明,长江口近岸地区10种抗性基因的检出率为100%.其中,整合子基因intI1和水样中多种ARGs呈显著正相关关系.变形菌门(Proteobacteria)和拟杆菌门(Bacteroidota)是长江口近岸地区水环境中的优势菌门;Chloroplast为水体中的主要菌属,Chloroplast和Nitrospira为沉积物中的主要菌属.在水体中,硝化螺旋菌门(Nitrospirota)是4种四环素类抗性基因(tetX、tetA、tetO和tetQ)共同的潜在宿主;在沉积物中,Sva0485是sul1和intI1的共同潜在宿主.微生物群落的分布是长江口近岸地区ARGs迁移转化的重要影响因素. | 徐秋鸿 刘曙光 娄厦 Larisa Dorzhievna Radnaeva Elena Nikitina Makhinov Aleksei Nikolavich Araruna José Tavares 金宇辰 李鑫 | 2023 | 环境科学2023，44，1： | 8 |
| 2 | Antifungal activity and antidiarrheal activity via antimotility mechanisms of (-)-fenchone in experimental models显示文摘BACKGROUND(-)-Fenchone is a bicyclic monoterpene present in essential oils of plant species,such as Foeniculum vulgare and Peumus boldus,used to treatment of gastrointestinal diseases.Pharmacological studies report its anti-inflammatory,antioxidant,and antinociceptive activity.AIM To investigate antidiarrheal activity related to gastrointestinal motility,intestinal secretion and antimicrobial activity.METHODS A castor oil-induced diarrhea model was used to evaluate antidiarrheal activity.Intestinal transit and gastric emptying protocols were used to assess a possible antimotility effect.Muscarinic receptors,presynaptic α2-adrenergic and tissue adrenergic receptors,KATP channels,nitric oxide were investigated to uncover antimotility mechanisms of action and castor oil-induced enteropooling to elucidate antisecretory mechanisms.The antimicrobial activity was evaluated in the minimum inhibitory concentration model,the fractional inhibitory concentration index using the(-)-fenchone association method with standard antifungal agents.RESULTS(-)-Fenchone(75,150 and 300 mg/kg)showed antidiarrheal activity,with a significant decrease in the evacuation index.This activity is possibly related to a percentage of reduced intestinal transit(75,150 and 300 mg/kg).The antimotility effect of(-)-fenchone decreased in the presence of pilocarpine,yohimbine,propranolol,L-NG-nitroarginine methyl ester or glibenclamide.In the enteropooling model,no reduction in intestinal fluid weight was observed.(-)-Fenchone did not show antibacterial activity;on the other hand,inhibits the growth of strains of fungi with a minimum fungicide concentration of 32μg/mL.However,when it was associated with amphotericin B,no synergism was observed.CONCLUSION The antidiarrheal effect of(-)-fenchone in this study involves antimotility effect and not involve antisecretory mechanisms.(-)-Fenchone presents antifungal activity;however,it did not show antibacterial activity. | Michelle Liz de Souza Pessoa Leiliane Macena Oliveira Silva Maria Elaine Cristina Araruna Catarina Alves de Lima Serafim Edvaldo Balbino Alves Junior Alessa Oliveira Silva Matheus Marley Bezerra Pessoa Hermes Diniz Neto Edeltrudes de Oliveira Lima Leonia Maria Batista | 2020 | World Journal of Gastroenterology2020，26，43： | 2 |
| 3 | Oil spills debris clean up by thermal desorption 显示文摘 | ARARUNA J T PORTES V L O SOARES A P L | 2004 | J Hazard Mater2004，110，123： | 1 |
| 4 | Existence and boundary stabilization of the semilinear Mindlin-Timoshenko system显示文摘 | ARARUNA F D BORGES J E S | 2008 | Electron J Qual Theory Differ Equa2008，34，： | 1 |
| 5 | Exact Controllability for the Semilinear String Equation in Non Cylindrical Domains显示文摘 | Araruna F D Antunes G O Medeiros L A | 2004 | Control Cybernet2004，33，： | 1 |
| 6 | Study of antimicrobial activity and atomic force microscopy imaging of the action mechanism of cashew tree gum显示文摘 | Débora A. Campos Alexandra C. Ribeiro Eduardo M. Costa Jo?o C. Fernandes Freni K. Tavaria Felipe Bastos Araruna Carla Eiras Peter Eaton José Roberto S.A. Leite M. Manuela Pintado | 2012 | Carbohydrate Polymers2012，，1： | 1 |
| 7 | The Use of Ground Penetrating Radar in Municipal Solid Waste Landfill Geotechnical Investigation显示文摘 | Jose Tavares Araruna Junior Patricio Jose Moreira Pires Debora Lopes Pilotto Domingues Tacio Mauro Pereira de Campos | 2016 | Journal of Civil Engineering and Architecture2016，10，7： | 0 |
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