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| 1 | Earth observation in service of the 2030 Agenda for Sustainable Development显示文摘This paper reviews the key role that Earth Observations(EO)play in achieving the Sustainable Development Goals(SDGs)as articulated in the 2030 Agenda document and in monitoring,measuring,and reporting on progress towards the associated targets.This paper also highlights how the Group on Earth Observations(GEO)would contribute to ensure the actual use of EO in support of the 2030 Agenda;and how the Global Earth Observations System of Systems meets requirements for efficient investments in science and technology and a good return on investment,which is elaborated in the Addis Ababa Action Agenda on development financing.Through a number of examples,we first discuss how extensive EO use would:provide a substantial contribution to the achievements of the SDGs by enabling informed decision-making and by allowing monitoring of the expected results;improve national statistics for greater accuracy,by ensuring that the data are“spatially-explicit”and directly contribute to calculate the agreed SDG Targets and Indicators support the fostering of synergy between the SDGs and multilateral environmental agreements by addressing cross-cutting themes such as climate and energy;and facilitate countries’approaches for working across different development sectors,which is,according to the special adviser on the 2030 Agenda,a key challenge to achieve the SDGs.We then focus on the role that GEO could play in enabling actual use of EO in support of the 2030 Agenda by directly addressing the Strategic Development Goal 17 on partnerships. | Katherine Anderson Barbara Ryan William Sonntag Argyro Kavvada Lawrence Friedl | 2017 | Geo-Spatial Information Science2017，20，2： | 8 |
| 2 | Increased ΤGF-β3 in primary biliary cirrhosis: An abnormality related to pathogenesis?显示文摘AIM: To investigate the transforming growth factor-β (TGF-β) isoforms in the peripheral and hepatic venous blood of primary biliary cirrhosis (PBC) patients. METHODS: We examined TGF-β1, TGF-β2 and TGF-β3 (enzyme-linked immunosorbent assay), in 27 stage Ⅳ PBC patients (27 peripheral and 15 hepatic vein sera), 35 early (Ⅰ-Ⅱ) PBC and 60 healthy controls. As disease controls 28 hepatitis C virus (HCV) cirrhosis (28 peripheral and 17 hepatic vein serum), 44 chronic HCV hepatitis and 38 HCV-related hepatocellular carcinomas were included. We also tested liver tissue by immunohistochemistry to identify localization of TGF isoforms. RESULTS: TGF-β1 was significantly decreased in all cirrhotics (PBC Ⅲ-Ⅳ: median 13.4 ng/mL; range, 7.4-26.2, HCV cirrhosis: 11.6 ng/mL; range, 5.0-33.8), compared to controls (30.9 ng/mL; range, 20.9-37.8). TGF-β2 was increased in viral cirrhosis but not in PBC and chronic hepatitis. TGF-β3 (47.2 pg/mL; range, 27.0-79.7 in healthy controls) was increased in early and late PBC (Ⅰ-Ⅱ: 94.3 pg/mL; range, 41.5-358.6; Ⅲ-Ⅳ: 152.8 pg/mL; range, 60.4-361.2; P < 0.001) and decreased in viral cirrhosis (37.4 pg/mL; range, 13.3-84.0; P < 0.05). Hepatic vein TGF-β levels were analogous to those in peripheral blood. Immunohistochemistry identified all isoforms in portal tract lymphocytes, sinusoidal cells and cholangiocytes. TGF-β3 was additionally overexpressed in hepatocytes in PBC patients. CONCLUSION: The serum profile of TGF-β isoforms is different in cirrhotics. Increased TGF-β3 is characteristic of PBC. These findings may be related to the immunological abnormalities of PBC. | Argyro Voumvouraki Mairi Koulentaki Maria Tzardi Ourania Sfakianaki Penelope Manousou George Notas Elias Kouroumalis | 2010 | World Journal of Gastroenterology2010，16，40： | 4 |
| 3 | 七氟烷、地氟烷或丙泊酚麻醉术后疼痛和镇痛药需求量的比较显示文摘背景全身麻醉药可产生伤害反应从而影响手术后疼痛,在一些手术后疼痛的研究中,均没有考虑全麻药对镇痛药需要量的影响,仅有最近一项研究显示丙泊酚麻醉的手术后镇痛效果比异氟烷麻醉好。方法前瞻性、随机、双盲研究,记录在七氰烷、地氟烷或丙泊酚麻醉下行腹式子宫切除术或子宫肌瘤切除手术患者手术后2、4、8、和24小时吗啡的需要量和疼痛评分(疼痛视觉模拟评分,VAS),手术中维持BIS35~45。同时记录患者送至麻醉监护室时的疼痛评分。结果3组患者手术后2、4、8或24小时,吗啡累积消耗量无差异(P=0.50)。手术后24小时内吗啡消耗量:七氟烷组28±13.8mg;地氟垸组25±11.7mg;丙泊酚组27±16.1mg。疼痛评分在患者转运至麻醉监护室即刻、手术后2、4、8和24小时,分别在静息及咳嗽状态下评估,显示3组间无差异(静息时P=0.40、0.39、0.50、0.47、0.06;咳嗽后P=0.67、0.45、0,22、0.26、0.29).结论手术后24小时吗啡消耗量和手术后疼痛情况在七氟烷、地氟烷或丙泊酚3组间差异无显著性。 | Argyro Fas s oulaki Aikaterini Melemeni Anteia Paraskeva Ioanna Siafaka Constantine Sarantopoulos 宋村笛(译) 李士通(校) | 2009 | 麻醉与镇痛2009，，6： | 2 |
| 4 | Iron as a therapeutic target in chronic liver disease显示文摘It was clearly realized more than 50 years ago that iron deposition in the liver may be a critical factor in the development and progression of liver disease.The recent clarification of ferroptosis as a specific form of regulated hepatocyte death different from apoptosis and the description of ferritinophagy as a specific variation of autophagy prompted detailed investigations on the association of iron and the liver.In this review,we will present a brief discussion of iron absorption and handling by the liver with emphasis on the role of liver macrophages and the significance of the iron regulators hepcidin,transferrin,and ferritin in iron homeostasis.The regulation of ferroptosis by endogenous and exogenous modulators will be examined.Furthermore,the involvement of iron and ferroptosis in various liver diseases including alcoholic and non-alcoholic liver disease,chronic hepatitis B and C,liver fibrosis,and hepatocellular carcinoma(HCC)will be analyzed.Finally,experimental and clinical results following interventions to reduce iron deposition and the promising manipulation of ferroptosis will be presented.Most liver diseases will be benefited by ferroptosis inhibition using exogenous inhibitors with the notable exception of HCC,where induction of ferroptosis is the desired effect.Current evidence mostly stems from in vitro and in vivo experimental studies and the need for well-designed future clinical trials is warranted. | Elias Kouroumalis Ioannis Tsomidis Argyro Voumvouraki | 2023 | World Journal of Gastroenterology2023，29，4： | 2 |
| 5 | Presence of disease specific autoantibodies against liver sinusoidal cells in primary biliary cirrhosis显示文摘AIM: To investigate the presence of autoantibodies directed against liver sinusoidal cells in primary biliary cirrhosis(PBC).METHODS: Liver biopsies from 21 PBC patients were studied and compared with 12 liver biopsies from disease controls [3 patients with hepatitis B(HBV) virus,3 patients with hepatitis C virus(HCV), 3 patients with non-alcoholic steatohepatitis and 3 patients with acute alcoholic hepatitis(AAH)]. As healthy controls, we used tissue specimens adjacent to metastatic liver adenocarcinoma. Normal serum was taken from staff members of the unit. The determination of the cell type targetedby autoantibodies present in the patients sera was performed by indirect immunofluorescence(IIF) analysis using paraffin-embedded liver sections as a substrate.Sera from homologous or heterologous PBC patients or sera from the disease control group were used as primary antibodies. The presence of autoantibodies was identified using confocal microscopy.RESULTS: In total, 18/21(85.7%) PBC patients exhibited positive staining in the sinusoidal cells, 10/21(47.6%) in lymphocytes, 8/21(38%) in cholangiocytes and 7/21(33.3%) in hepatocytes, when homologous serum and fluorescein isothiocyanate-conjugated immunoglobulin type G(IgG) secondary antibody were used. PBC sections incubated with heterologous PBC serum showed reduced staining(20% for sinusoidal cells, 20% for lymphocytes, 20% for cholangiocytes and 13.3% for hepatocytes). When IgM immunoglobulin, instead of IgG, was used as secondary antibody,positive staining was observed in 75% of lymphocytes,62.5% of cholangiocytes, 37.5% of hepatocytes and50% of the sinusoidal cells with a much stronger staining intensity. No staining was observed when either normal or PBC sera were used as a primary antibody on liver sections from the disease control group. When PBC sera were incubated with healthy control sections,weak positive staining of cholangiocytes was observed in 3/21(14.3%) PBC serum samples. Steatohepatitis serum on PBC sections gave a positive staining of some hepatocytes and lymphocytes but no staining on viral hepatitis sections. Incubation with HBV sera stained some hepatocytes, cholangiocytes and intra-sinusoidal or portal lymphocytes of PBC, HBV and AAH patients but not HCV patients.CONCLUSION: In this study, for the first time in diseased liver tissue, we have demonstrated that a large proportion of PBC patients have disease specific autoantibodies against liver sinusoidal cells. | Ourania Sfakianaki Maria Tzardi Argyro Voumvouraki Aikaterini Afgoustaki Meri Koulentaki Elias Kouroumalis | 2013 | World Journal of Hepatology2013，5，10： | 2 |
| 6 | Multiple type-B re-sponse regulators mediate cytokinin signal transduction in Arabidopsis显示文摘 | MASON M G MATHEWS D E ARGYROS D A | 2005 | Plant Cell2005，17，： | 1 |
| 7 | Type B responseregulators of Arabidopsis play key roles in cytokinin signaling and plant de-velopment显示文摘 | ARGYROS R D MATHEWS D E CHIANG Y H | 2008 | Plant Cell2008，20，： | 1 |
| 8 | Ambient and low tem- perature winemaking by immobilized ceils on brewer' s spent grains: ef- fect on volatile composition显示文摘 | MALLOUCHOS A PAUL L ARGYRO B | 2007 | Food Chem2007，104，： | 1 |
| 9 | Microstructured polymer optical fibers 显示文摘 | ARGYROS A | 2009 | Journal of Lightrwave Technology2009，27，11： | 1 |
| 10 | The Effect of Electro Discharge Machining (EDM) on the Corrosion Resistance of Dental Alloys显示文摘 | ARGYRO N | 2010 | Dental Materials2010，26，12： | 1 |
| 11 | The Jarratt Method in Banach Space Setting 显示文摘 | Argyros I K Chen D Qian Q | 1994 | J Comput Appl Math1994，51，： | 1 |
| 12 | On the solution of equations with nondifferentiable and Ptak error estimates显示文摘 | Argyros I K | 1990 | BIT Numer Math1990，30，4： | 1 |
| 13 | Type B response regulators of Arabidopsis play key roles in cyto- kinin signaling and plant development 显示文摘 | Argyros R D Mathews D E Chiang Y H | 2008 | The Plant Cell2008，20，8： | 1 |
| 14 | Recent progress in microstructured polymer optical fibre fabrication and characterization 显示文摘 | VAN EIJKELENBORG M A ARGYROS A BARTON G | 2003 | Optical Fiber Technology2003，9，4： | 1 |
| 15 | Management of primary blast injury 显示文摘 | Argyros G J | 1997 | Toxicology1997，121，1： | 1 |
| 16 | On the solution of equation with nondifferentiable and Ptak error estimates 显示文摘 | | 1990 | BIT1990，30，1： | 1 |
| 17 | Convergence Rates for Inexact Newton - like Methods at Singular Points and Applications显示文摘 | ARGYROS Ioannis K | 1999 | Applied Mathematics and Computation1999，102，： | 1 |
| 18 | Chemiluminometric behaviour of erythromycin and related compounds显示文摘 | Anastassia Mitsana-Papazoglou Argyro Fragaki Paraskevi Chamosfakidi | 2000 | Anal Chim Acta2000，410，12： | 1 |
| 19 | Intra-arterial throm bolys is using rt-PA in patients with acute stroke due to vessel occlusion of anterior and / or posterior cerebral circulation显示文摘 | Argyro T B joem A K arin W | | 0，，01： | 1 |
| 20 | SBA:A software package for ge- neric sparse bundle adjustment显示文摘 | Lourakis M I A f Argyros A A | 2009 | ACM Transactions on Mathematical Software2009，36，1： | 1 |
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