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| 1 | Nutrition and exercise in the management of liver cirrhosis显示文摘Liver cirrhosis(LC)patients often have protein-energy malnutrition(PEM)and decreased physical activity.These conditions often lead to sarcopenia,which is the loss of skeletal muscle volume and increased muscle weakness.Recent studies have demonstrated that PEM and sarcopenia are predictors for poor survival in LC patients.Nutrition and exercise management can improve PEM and sarcopenia in those patients.Nutrition management includes sufficient dietary intake and improved nutrient metabolism.With the current high prevalence of obesity,the number of obese LC patients has increased,and restriction of excessive caloric intake without the exacerbation of impaired nutrient metabolism is required for such patients.Branched chain amino acids are good candidates for supplemental nutrients for both obese and non-obese LC patients.Exercise management can increase skeletal muscle volume and strength and improve insulin resistance;however,nutritional status and LC complications should be assessed before an exercise management regimen is implemented in LC patients.The establishment of optimal exercise regimens for LC patients is currently required.In this review,we describe nutritional status and its clinical impact on the outcomes of LC patients and discuss general nutrition and exercise management in LC patients. | Nobuyuki Toshikuni Tomiyasu Arisawa Mikihiro Tsutsumi | 2014 | World Journal of Gastroenterology2014，20，23： | 20 |
| 2 | Clinical differences between alcoholic liver disease and nonalcoholic fatty liver disease显示文摘Alcoholic liver disease(ALD)and nonalcoholic fatty liver disease(NAFLD)are serious health problems worldwide.These two diseases have similar pathological spectra,ranging from simple hepatic steatosis to steatohepatitis,liver cirrhosis,and hepatocellular carcinoma.Although most subjects with excessive alcohol or food intake experience simple hepatic steatosis,a small percentage of individuals will develop progressive liver disease.Notably,both ALD and NAFLD are frequently accompanied by extrahepatic complications,including cardiovascular disease and malignancy.The survival of patients with ALD and NAFLD depends on various disease-associated conditions.This review delineates the clinical characteristics and outcomes of patients with ALD and NAFLD by comparing their epidemiology,the factors associated with disease susceptibility and progression,and the predictors and characteristics of outcomes.A comprehensive understanding of the characteristics and outcomes of ALD and NAFLD is imperative in the management of these chronic liver diseases. | Nobuyuki Toshikuni Mikihiro Tsutsumi Tomiyasu Arisawa | 2014 | World Journal of Gastroenterology2014，20，26： | 13 |
| 3 | Hepatitis C-related liver cirrhosis-strategies for the prevention of hepatic decompensation,hepatocarcinogenesis,and mortality显示文摘Liver cirrhosis(LC)is a critical stage of chronic liver disease,including that caused by hepatitis C virus(HCV).In the absence of antiviral therapy,67%-91%of patients with HCV-related LC patients die of liver-related causes,including hepatocellular carcinoma(HCC)and liver failure.Among the therapeutic strategies used to prevent liver-related complications in these patients is standard therapy with pegylated interferon and ribavirin,which induces a sustained virological response(SVR)in 25%of HCV genotype 1-infected patients and in 69% of patients infected with genotypes 2 and 3.SVR in patients with HCV-related LC has been associated with reduced rates of hepatic decompensation,HCC,and mortality.More recently developed direct-acting antiviral agents have shown excellent antiviral efficacy,with preliminary data demonstrating that an interferon-free regimen that includes these direct-acting antiviral agents achieved SVR in more than 50%of patients with HCV genotype 1 LC.Branched-chain amino acid supplementation,improvement of insulin resistance,and the use ofβ-blockers for portal hypertension may also reduce liverrelated complications.Here,we review advances in antiviral and adjunctive therapies for improved outcomes in patients with HCV-associated LC. | Nobuyuki Toshikuni Tomiyasu Arisawa Mikihiro Tsutsumi | 2014 | World Journal of Gastroenterology2014，20，11： | 10 |
| 4 | -449 C>G polymorphism of NFKB1 gene,coding nuclear factor-kappa-B,is associated with the susceptibility to ulcerative colitis显示文摘AIM:To clarify the association between a polymorphism-449 C>G(rs72696119) in 5'-UTR of NFKB1 with ulcerative colitis(UC).METHODS:The studied population comprised 639 subjects,including patients with UC(UC cases,n = 174) and subjects without UC(controls,n = 465).We employed polymerase chain reaction-single strand conformation polymorphism to detect the gene polymorphism.RESULTS:The rs72696119 G allele frequencies in controls and UC cases were 33.4% and 38.5%,respectively(P = 0.10).Genotype frequency of the GG homozygote in UC cases was significantly higher than that in controls(P = 0.017),and the GG homozygote was significantly associated with susceptibility to UC [odds ratio(OR),1.88;95%CI,1.13-3.14].In male subjects,the GG homozygote was associated with an increased risk for UC(OR,3.10;95%CI,1.47-6.54;P = 0.0053),whereas this association was not found in female subjects.In addition,the GG homozygote was significantly associated with the risk of non-continuous disease(OR,2.06;95%CI,1.12-3.79;P = 0.029),not having total colitis(OR,2.40;95%CI,1.09-3.80,P = 0.040),disease which developed before 20 years of age(OR,2.80;95%CI,1.07-7.32,P = 0.041),no hospitalization(OR,2.28;95%CI,1.29-4.05;P = 0.0090) and with a maximum of 8 or less on the UCDAI score(OR,2.45;95%CI,1.23-4.93;P = 0.022).CONCLUSION:Our results provide evidence that NFKB1 polymorphism rs72696119 was significantly associated with the development of UC.This polymorphism influences the susceptibility to and pathophysiological features of UC. | Ranji Hayashi Tomomitsu Tahara Tsukasa Yamaaki Takashi Saito Kazuhiro Matsunaga Nobuhiko Hayashi Atsushi Fukumura Kazuaki Ozaki Masakatsu Nakamura Hisakazu Shiroeda Mikihiro Tsutsumi Tomoyuki Shibata Tomiyasu Arisawa | 2012 | World Journal of Gastroenterology2012，18，47： | 2 |
| 5 | Mental effects of an early invention program for very low birth weight infants显示文摘 | Arisawa K Takahashi T | 2001 | No To Hatta2001，33，1： | 1 |
| 6 | Searless endoscopic thyroidectomy: breastapproach for better cosmesis显示文摘 | Ohgarni M Ishii S Arisawa Y | 2000 | Surg Laparosc Endosc Percutan Tech2000，10，1： | 1 |
| 7 | Scarless endoscopic thyroidectomy:breast approach for better cosmesis显示文摘 | Ohgami M Ishii S Arisawa Y | 2000 | Surg Laparosc Endosc2000，10，1： | 1 |
| 8 | Scarless endoscopic thyri- odectomy:breast approach for better cosmesis显示文摘 | Ohgami M Ishil S Arisawa Y | 2000 | Surg Lapa- rose Endosc Percutan Tech2000，10，1： | 1 |
| 9 | Thermal decomposition of energetic materials 71: Structure- decomposition and kinet- ic relationships in flash pyrolysis of Glycidyl Azide Polymer (GAP)显示文摘 | ARISAWA H BRILL T B | 1998 | Combustion and Flame1998，112，4： | 1 |
| 10 | The influence of polymorphisms of interleukin-17A and interleukin-17F genes on the susceptibility to ulcerative colitis显示文摘 | Arisawa T Tahara T Shibata T | 2008 | J Clin Immunol2008，28，1： | 1 |
| 11 | Two new lanostanoids from Ganoderma lucidum 显示文摘 | FUJITA A ARISAWA W SAGA M | 1986 | J Nat Prod1986，49，6： | 1 |
| 12 | Toll-like receptor2 (TLR)- 196 to 174del polymorphism in gastro-duodenal diseases in Japa- nese population显示文摘 | Tahara T Arisawa T Wang F | 2008 | Dig Dis Sci2008，53，4： | 1 |
| 13 | Oxidative intramolecular phenolic coupling reaction induced by a hypervalent iodine (III) reagent: Leading to galanthamine-type Amaryllidaceae alkaloids显示文摘 | Kita Y Arisawa M Gyoten M | 1998 | J Org Chern1998，63，19： | 1 |
| 14 | In vitro and in vivo effects of 14alpha-demethylase(ERG11) depletion in Candida glabra-ta显示文摘 | Nakayama H Nakayama N Arisawa M | 2001 | Antimicrob Agents Cheroother2001，45，11： | 1 |
| 15 | Development of New Materials for Low Pressure and Low Temperature Molding显示文摘 | Tsukamoto T Y Fukuda Arisawa S | 1995 | Modern Plastics Internetional1995，，4： | 1 |
| 16 | Regulation of tumournecrosis factor (TNF) induced apoptosis by soluble TNF receptors in Helicobacter pylori infection显示文摘 | Shibata J Goto H Arisawa T | 1999 | Gut1999，45，1： | 1 |
| 17 | Three new lanostanoids from Ganoderma lucidum 显示文摘 | ARISAWA M FUJITA A SAGA M | 1986 | J Nat Prod1986，49，4： | 1 |
| 18 | Scarless endoscopic thyroidsctomy:breast approach for better cosmesis显示文摘 | Ohgami M Ishii S Arisawa Y | | 0，，01： | 1 |
| 19 | Scarless endoscopic thyroidectomy: breast approach for better cosmesis 显示文摘 | Ohgami M Ishii S Arisawa Y | 2000 | Surg Laparosc Endosc Percutan Tech2000，10，1： | 1 |
| 20 | Preoperative staging of superficial esophageal carcinoma:Comparison of an ultrasound probe and standard endoscopic ultrasonography显示文摘 | HASEGAWA N NIWA Y ARISAWA T | 1996 | Gnstrointest Endosc1996，44，4： | 1 |
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