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| 1 | 谷氨酰胺、癌症及其治疗显示文摘目的回顾谷氨酰胺、癌症及其治疗方面的一些进展,主要是关于谷氨酰胺与肿瘤生长方面的体内与体外、动物和人体的研究结果。对荷瘤宿主在接受放疗和化疗时补充谷氨酰胺的某些益处进行总结。背景谷氨酰胺是体内最丰富的游离氨基酸。而肿瘤组织就象一个“谷氨酰胺网”消耗大量的谷氨酰胺,从而促使机体恶病质的发生。体外研究中,肿瘤细胞的生长依赖于谷氨酰胺的结果使得人们未在临床上给癌症病人补充谷氨酰胺。方法对谷氨酰胺与接受放、化疗荷瘤宿主的关系的研究结果进行归纳和总结。结果大量体内研究表明,补充谷氨酰胺不但不会使肿瘤生长,而且还会通过刺激机体的免疫系统来抑制肿瘤的生长。在机体接受放疗和化疗时,谷氨酰胺可以保护机体并增加化疗对肿瘤的选择性。结论还需要进行前瞻、随机的研究来证明在接受放疗和化疗的病人补充谷氨酰胺的安全性和有效性。 | V.Suzanne Klimberg John L.McClellan Little Rock Arkansas | 1999 | 中国临床营养杂志1999，7，2： | 24 |
| 2 | Distribution of ^3H—nicotine in Rat Tissues Under the Influence of Simulated Microgravity显示文摘Rat tail suspension offers a useful model to reproduce physiologic responses to weightlessness.The present study was conducted in the head-down-tilt(HDT) rat model to assess changes in metabolism of body tissues employing 3H-nicotine. Twelve male rats were used in the study. Half of the rats were tail suspended at 30°for two weeks on a 12/12 light/dark cycle. During this period,body weight, food and fluid intakes were measured. At term, animals were anesthetized and injected IV withe a solution contaming 4 microuries of micotine. After 90 min the animals were sacrificed, exsanguinated and tissues (brain,blood,trachea,salivary gland,lung,heart,esophagus,spleen, kidneys and testes) were harvested. The distribution of 3H-nicotine per gram of each tissue was determinded and ealeulated as percent of total injected radioactivity. Final body weights of suspended ammals were significantly (P < 0.0 5) lower than those of eontrols(309±21 vs 350±11g). 3HNicotine waw retained in greatest amounts by the kindneys, followed inorder by salivary glands, spleen, and gastrointestinal tissues. compared to non-suspended control, the tissue retention of nicotine in suspended animals was decreased in the following tissues:esphyagus (25 %), aorta (25%). fundus (25%), trachea (22%), adrenals (18%), spleen (17 %), and pancreas (12 %). The decreased retention of mcotine in tissues from suspended animals may be indicative of the fluid shifts and changes in blood flow to those tissue beds. The lack of differnces in nicotine retention in liver and kidney between control and suspended groups may implicate a normal metabolic function of these organs even under simulated weightlessness. | PARIMAL CHOWDHURY MICHAEL E. SOULSBY AND JAMES N. PASLEY (Department of Physiology and Biophysics, University of Arkansas for Medical Scienses, Little Rock, Arkansas 72205, USA) | 1999 | Biomedical and Environmental Sciences1999，12，2： | 6 |
| 3 | A review of Vibrio vulnificus infection related to eating raw oysters, including three cases in Arkansas residents显示文摘 | State HealthWatch : Arkansas Department of Public Health | 1996 | J Arkansas Med Soc1996，92，10： | 1 |
| 4 | Phosphorus availability in two soils amended with poultry litter显示文摘Phosphorusavailabilityintwosoilsamendedwithpoultrylitter￥HanXingguo(InstituteofBotany,ChineseAcademyofSciences,Beijing100093,... | Han Xingguo (Institute of Botany,Chinese Academy of Sciences,Beijing 100093,China)Duane C.Wolf (Department of Agronomy,University of Arkansas,Fayetteville, AR 72701,USA) | 1996 | Journal of Environmental Sciences1996，8，4： | 0 |
| 5 | Some Practical Issues Regarding Java Programming显示文摘Java programming language is a major . new development which involves object-oriented programming and computer networking. Here, several examples of Java programs are presented. These examples show some major features that Java language provides, such as multi-thread, exception handling, network application writing, and the usage of Java applets. This article also shows some ways of setting up a Java language programming environment. All these examples are correct and ready to run. | Ming-fang Wang Department of Computer Science, University of Central ArkansasConway, Arkansas 72035 wangm @ panda.cs.uca.eduWu JieShanghai Institute of Computing Tech. Shanghai, China 200040 Telephone: 62520070 | 1996 | 计算机工程1996，22，S1： | 0 |
| 6 | MULTI-DISPLACEMENT CONTINUUM MODEL WITH LOCAL RESONANCE显示文摘We propose a multi-displacement continuum (MDC) model to characterize the local resonance presented in a lattice system. Dispersion curves in a mass-in-mass system are studied and compared to the single-displacement model. It is shown that the dispersive relations and the local resonant band gap structures can be adequately described. The acoustic mode can be accurately predicted, while the optical mode is correctly predicted for certain frequency range, where the wave length is large enough. The single-displacement model fails to describe the bang gap structure inherent in the system due to local resonance. | Aiping Liu 1 Guoliang Huang 2 Gengkai Hu 1 ( 1 School of Aerospace Engineering, Beijing Institute of Technology, 100081 Beijing, China) ( 2 Department of Systems Engineering, University of Arkansas at Little Rock, Little Rock, AR, 72204, USA) | 2011 | Acta Mechanica Solida Sinica2011，24，S1： | 0 |
| 7 | Structural and optical properties of periodically ordered ZnO nanowires显示文摘Periodically ordered ZnO nanowire arrays were fabricated by a combination of soft templates created by electron beam lithography and an electrochemical process. Individual ZnO nanowires were precisely placed in desired locations to form two-dimensional periodic structures with specific patterns. Scanning electron microscopy and light diffraction measurements confirmed the long-range ordered structures in the nanowire arrays. Variable temperature photoluminescence revealed both band edge and defect emissions. The obtained photonic structures may have potential applications in optical and optoelectronic devices. | J.B.CUI Department of Physics and Astronomy, University of Arkansas at Little Rock, Little Rock, AR 72204, USA | 2009 | Science China(Technological Sciences)2009，52，2： | 0 |
| 8 | Danshao Huaxian capsule in treatment of decompensated cirrhosis resulting from chronic hepatitis B显示文摘BACKGROUND: The prognosis of decompensated cirrhosis resulting from chronic hepatitis B is poor, and the benefits of treatment with interferon are ourweight serious sideeffects and the risk of fatal exacerbation of disease. Danshao Huaxian capsule rapidly reduces hepatitis B virus(HBV)-DNA in serum to undetectable levels. METHODS: A total of 35 patients with chronic hepatitis B and decompensated cirrhosis were treated with Danshao Huaxian 1.2g. po. tid daily. Before the treatment, HBVDNA in serum was positive in all patients. Ten patients had Child-Pugh class B and 25, class C hepatitis B. Seven patients underwent liver transplantation within 6 months of initial treatment. Of the 10 patients of class B, 5 died within 6 months, and the other 5 did not complete the treatment for some reasons; the 25 patients of class C were treated for at least 6 months (mean =19 months). RESULTS: In most of the 25 patients, liver function was improved slowly but markedly after 9 months of treatment, showing a decreased level of serum bilirubin from 67±13 to 30±4μmol/L (P<0.05, baseline vs.6 months), an increased level of serum albumin from 27±1 to 34±1 g/L(P<0.05) and a decreased level of Child-Pugh score from 10.3±0.4 to 7.5+0.5 (P<0.05). Three patients developed resistance to Danshao Huaxian because of a mutation in the YMDD motif, but liver function was not deteriorated. Inhibition of viral replication with Danshao Huaxian resulted in a significant improvement of liver function in patients with decompensated HBV cirrhosis, but the long-term results remain uncertain. CONCLUSION: Danshao Huaxian capsule is effective in inhibiting viral DNA replication in patients with decompensated cirrhosis and making clinical improvement. | Ming-Liang Cheng, Tong Lu, Yu-Mei Yao and Xiao-Xia Geng Department of Infectious Diseases, Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China and Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，1： | 0 |
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