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| 1 | The gingival inflammatory infiltrate in cardiac patients treated with calcium antagonists显示文摘 | Bullon P Machuca G Armas JR | 2001 | J Clin Periodontol2001，28，10： | 1 |
| 2 | Positive interactions among alpine plants increase with stress显示文摘 | Callaway R M Brooker R W Choler P Kikvidze Z Lortie C J Michalet R Paolini L Pugnaire F I Newingham B Asche- houg E T Armas C Kikodze D Cook B J | 2002 | Nature2002，417，： | 1 |
| 3 | The use of a new hydrophilic polymer, Kollicoat IR, in the formulation of solid dispersions of Itraconazole 显示文摘 | JANSSENSA S ARMAS H N REMON J P | 2007 | Eur J Pharm Biopharm2007，30，34： | 1 |
| 4 | The use of a new hydrophilic polymer, Kollicoat IR, in the formulation of solid dispersions of Itraconazole显示文摘 | Janssens S de Armas H N Remon J P | 2007 | Eur J Pharm Biopharm2007，30，： | 1 |
| 5 | Analysis of corona losses on DC transmission lines : II-bipolar lines显示文摘 | Arma M P Janischewskyj W | 1969 | IEEE Transactions on Power Apparatus and Systems1969，88，10： | 1 |
| 6 | HCV-specific immune responses induced by CIGB-230 in combination with IFN-α plus ribavirin显示文摘AIM:To analyze hepatitis C virus(HCV)-specific immune responses in chronically infected patients under triple therapy with interferon-α(IFN-α)plus ribavirin and CIGB-230.METHODS:CIGB-230 was administered in different schedules with respect to IFN-αplus ribavirin therapy.Paired serum and peripheral blood mononuclear cells(PBMC)samples from baseline and end of treatment were analyzed.The HCV-specific humoral response was tested by enzyme-linked immunosorbent assay,neutralizing antibodies were evaluated by cell culture HCV neutralization assays,PBMC proliferation was assayed by carboxyfluorescein succinimidyl ester staining and IFN-γsecretion was assessed by enzyme-linked immunospot.Data on virological and histological response and their association with immune variables are also provided.RESULTS:From week 12 to week 48,all groups of patients showed a significant reduction in mean leukocyte counts.Statistically significant reductions in antibody titers were frequent,but only individuals immunized with CIGB-230 as early add-on treatment sustained the core-IgG response,and the neutralizing antibody response was enhanced only in patients receiving CIGB-230.Cell-mediated immune responses also tended to decline,but significant reductions in IFN-γsecretion and total absence of core-specific lymphoproliferation were exclusive of the control group.Only CIGB-230-immunized individuals showed de novo induced lymphoproliferative responses against the structural antigens.Importantly,it was demonstrated that thequality of the CIGB-230-induced immune response depended on the number of doses and timing of administration in relation to the antiviral therapy.Specifically,the administration of 6 doses of CIGB-230 as late addon to therapy increased the neutralizing antibody activity and the de novo core-specific IFN-γsecretion,both of which were associated with the sustained virological response.CONCLUSION:CIGB-230,combined with IFN-α-based therapy,modifies the immune response in chronic patients.The study provides evidence for the design of more effective therapeutic vaccine interventions against HCV. | Yalena Amador-Caizares Gillian Martínez-Donato Liz lvarez-Lajonchere Claudia Vasallo Mariacarla Dausá Daylen Aguilar-Noriega Carmen Valenzuela Ivette Raíces Jean Dubuisson Czeslaw Wychowski Zurina Cinza-Estévez Marlén Castellanos Magdalys Núez Anny Armas Yaimé González Ismariley Revé Ivis Guerra ngel Pérez Aguiar Santiago Dueas-Carrera | 2014 | World Journal of Gastroenterology2014，20，1： | 1 |
| 7 | Vitamin D2 is much less effective than vitamin D3 in humans显示文摘 | ARMAS L A HOLLIS B W HEANEY R P | | 0，，11： | 1 |
| 8 | Surgical treatment of perinatal ovarian cysts显示文摘 | Armas Alvarez AL Taboada Santomil P Pradillos Serna JM | 2010 | Cir Pediatr2010，23，4： | 1 |
| 9 | The gingival inflammatory infiltrate in cardiac patients treated with calcium antagonists显示文摘 | Machuca G Armas JR | 2001 | J Clin Periodontol2001，28，10： | 1 |
| 10 | The analytical investigation of synthetic street drugs containing cathinone analogs显示文摘 | Leffler A M Smith P B de Armas A | 2014 | Forensic Sci Int2014，234，： | 1 |
| 11 | Effect of lacidipine and nifedipine GITS on platelet function in patients with essential hypertension显示文摘 | Armas H M Hemandes H R | 2000 | Hum Hypertens2000，14，1： | 1 |
| 12 | Predictions of endwall losses and secondary flows in axial flow turbine caseades显示文摘 | arma O P Butler T L | 1987 | Journal of Turbomachinery1987，109，2： | 1 |
| 13 | The analytical investigation of synthetic street drugs containing cathinone analogs显示文摘 | Leffler A M Smith P B de Armas A | 2014 | Forensic Sci Int2014，234，： | 1 |
| 14 | Facilitation in plant communities: the past, the present, and the future 显示文摘 | Brooker RW Maestre FT Callaway RM Lortie CL Cavieres LA Kunstler G Liancourt P Tielborger K Travis JMJ Anthelme F Armas C Coll L Corcket E Delzon S Forey E Kikvidze Z Olofsson J Pugnaire FI Quiroz CL Saccone P Schiffers K Seifan M Touzard B Michalet R | 2008 | J Ecol2008，96，： | 1 |
| 15 | The gingival inflammatory infiltrate in cardiac patients treated with calcium antagonists 显示文摘 | Bullon P Machuca G Armas JR | 2001 | J Clin Periodontol2001，28，10： | 1 |
| 16 | The use of a new hydrophilic polymer, Kollicoat IR in the formulati on of solid dispersions of Itraconazole显示文摘 | Janssensa S Armas H N Remon J P | 2007 | Eur J Pham Biopharm2007，30，3： | 1 |
| 17 | Primary structure and developmental expression of Bufo arenarum cellular nucleic acid-binding protein:changes in subcellular localization during early embryogenesis显示文摘 | Armas P Cabada MO Caleaterra NB | 2001 | Dey Growth Differ2001，43，1： | 1 |
| 18 | Analysis of corona losses on DC transmission lines:II-bipolar lines显示文摘 | Arma M P Janischewskyj W | 1969 | IEEE Trans on Power Apparatusand System1969，88，10： | 1 |
| 19 | Positive interactions among alpine plants increase with stress显示文摘 | Callaway RM Brooker RW Choler P Kikvidze Z Lortie CJ Michalet R Paolini L Pugnaire FI Newingham B Aschehoug ET Armas C Kikodze D Cook BJ | 2002 | Nature2002，417，6891： | 1 |
| 20 | The gingival inflammato- ry infiltrate in cardiac patients treated with calcium antago- nists 显示文摘 | Bullon P Machuca G Armas JR | 2001 | J Clin Periodontol2001，28，10： | 1 |
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