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| 1 | Effects of intermittent fasting on health markers in those with type 2 diabetes:A pilot study显示文摘AIM To determine the short-term biochemical effects and clinical tolerability of intermittent fasting(IF) in adults with type 2 diabetes mellitus(T2DM).METHODS We describe a three-phase observational study(baseline 2 wk, intervention 2 wk, follow-up 2 wk) designed to determine the clinical, biochemical, and tolerability of IF in community-dwelling volunteer adults with T2DM. Biochemical, anthropometric, and physical activity measurements(using the Yale Physical Activity Survey) were taken at the end of each phase. Participants reported morning, afternoon and evening self-monitored blood glucose(SMBG) and fasting duration on a daily basis throughout all study stages, in addition to completing a remote food photography diary three times within each study phase. Fasting blood samples were collected on the final days of each study phase. RESULTS At baseline, the ten participants had a confirmed diagnosis of T2DM and were all taking metformin, and on average were obese [mean body mass index(BMI) 36.90 kg/m^2]. We report here that a short-term periodof IF in a small group of individuals with T2DM led to significant group decreases in weight(-1.395 kg, P = 0.009), BMI(-0.517, P = 0.013), and at-target morning glucose(SMBG). Although not a study requirement, all participants preferentially chose eating hours starting in the midafternoon. There was a significant increase(P < 0.001) in daily hours fasted in the IF phase(+5.22 h), although few attained the 18-20 h fasting goal(mean 16.82 ± 1.18). The increased fasting duration improved at-goal(< 7.0 mmol/L) morning SMBG to 34.1%, from a baseline of 13.8%. Ordinal Logistic Regression models revealed a positive relationship between the increase in hours fasted and fasting glucose reaching target values(χ~2 likelihood ratio = 8.36, P = 0.004) but not for afternoon or evening SMBG(all P > 0.1). Postprandial SMBGs were also improved during the IF phase, with 60.5% readings below 9.05 mmol/L, compared to 52.6% at baseline, and with less glucose variation. Neither insulin resistance(HOMAIR), nor inflammatory markers(C-reactive protein) normalized during the IF phase. IF led to an overall spontaneous decrease in caloric intake as measured by food photography(Remote Food Photography Method). The data demonstrated discernable trends during IF for lower energy, carbohydrate, and fat intake when compared to baseline. Physical activity, collected by a standardized measurement tool(Yale Physical Activity Survey), increased during the intervention phase and subsequently decreased in the follow-up phase. IF was well tolerated in the majority of individuals with 6/10 participants stating they would continue with the IF regimen after the completion of the study, in a full or modified capacity(i.e., every other day or reduced fasting hours).CONCLUSION The results from this pilot study indicate that shortterm daily IF may be a safe, tolerable, dietary intervention in T2DM patients that may improve key outcomes including body weight, fasting glucose and postprandial variability. These findings should be viewed as exploratory, and a larger, longer study is necessary to corroborate these findings. | Terra G Arnason Matthew W Bowen Kerry D Mansell | 2017 | World Journal of Diabetes2017，8，4： | 7 |
| 2 | Current cancer therapies and their influence on glucose control显示文摘This review focuses on the development of hyperglycemia arising from widely used cancer therapies spanning four drug classes.These groups of medications were selected due to their significant association with new onset hyperglycemia,or of potentially severe clinical consequences when present.These classes include glucocorticoids that are frequently used in addition to chemotherapy treatments,and the antimetabolite class of 5-fluorouracil-related drugs.Both of these classes have been in use in cancer therapy since the 1950s.Also considered are the phosphatidyl inositol-3-kinase(PI3K)/AKT/mammalian target of rapamycin(mTOR)-inhibitors that provide cancer response advantages by disrupting cell growth,proliferation and survival signaling pathways,and have been in clinical use as early as 2007.The final class to be reviewed are the monoclonal antibodies selected to function as immune checkpoint inhibitors(ICIs).These were first used in 2011 for advanced melanoma and are rapidly becoming widely utilized in many solid tumors.For each drug class,the literature has been reviewed to answer relevant questions about these medications related specifically to the characteristics of the hyperglycemia that develops with use.The incidence of new glucose elevations in euglycemic individuals,as well as glycemic changes in those with established diabetes has been considered,as has the expected onset of hyperglycemia from their first use.This comparison emphasizes that some classes exhibit very immediate impacts on glucose levels,whereas other classes can have lengthy delays of up to 1 year.A comparison of the spectrum of severity of hyperglycemic consequences stresses that the appearance of diabetic ketoacidosis is rare for all classes except for the ICIs.There are distinct differences in the reversibility of glucose elevations after treatment is stopped,as the mTOR inhibitors and ICI classes have persistent hyperglycemia long term.These four highlighted drug categories differ in their underlying mechanisms driving hyperglycemia,with clinical presentations ranging from potent yet transient insulin resistant states[type 2 diabetes mellitus(T2DM)-like]to rare permanent insulin-deficient causes of hyperglycemia.Knowledge of the relative incidence of new onset hyperglycemia and the underlying causes are critical to appreciate how and when to best screen and treat patients taking any of these cancer drug therapies. | Carly Yim Kerry Mansell Nassrein Hussein Terra Arnason | 2021 | World Journal of Diabetes2021，12，7： | 5 |
| 3 | 肝胆管腺纤维瘤:6例形态学、肿瘤遗传学和预后分析显示文摘胆管腺纤维瘤是一种罕见的原发性肝肿瘤,至今仅有14例报道。作者对6例胆管腺纤维瘤患者的临床病史和形态学进行复习,并采用多重PCR分析肿瘤DNA的点突变和阵列比较基因组杂交技术行拷贝数异常检测。本组女性4例,男性2例,年龄46—83岁,肿瘤直径7—16cm。肿瘤形态学特点相似, | Arnason T Borger D R Corless C 康锶鹏 余英豪 | 2017 | 临床与实验病理学杂志2017，33，7： | 2 |
| 4 | The complete mitochondrial DNA sequencing of the pig (Sus scrofa)显示文摘 | Arnason U | 1998 | J Mol Evol1998，47，： | 1 |
| 5 | toxicity,localization and elimination of the phototoxic,Alpha-terthienyl,in mosquito larvae显示文摘 | HASSPIELER B M ARNASON J T DOWNE A E R | 1988 | J Am Mosquito Cotrol Assoc1988，4，4： | 1 |
| 6 | Toxicokinetics of the phototoxic allelochemical α-terthienyl in three herbivorous Lepidoptera显示文摘 | LYENGAR S ARNASON J T PHILOGENE B J R | 1987 | Pestic Biochem Physicl1987，29，： | 1 |
| 7 | Mosquito Larvicidal Activity of Polyacetylenes from Species in the Asteraceae 显示文摘 | Arnason T Swain T Wat C K | 1981 | Biochemical Systematics and Ecology1981，9，1： | 1 |
| 8 | Comparative metabolism of the phototoxic allelochemical a-terhthienyl in three herbivorous Lepidoptera显示文摘 | LYENGAR S ARNASON J T PHILOGEN B J R | 1990 | Pestic Biochem Physicl1990，37，： | 1 |
| 9 | The hypothalamus is the central organ of immunoregulation显示文摘 | Berczi I Arnason BG | 2010 | Neuroimmune Biology2010，9，： | 1 |
| 10 | Low concentrations of the feverfew component parthenolide inhibit in vitro growth of tumor lines in a cytostatic fashion显示文摘 | Ross JJ Arnason JT Birnboim HC | 1999 | Planta Med1999，65，2： | 1 |
| 11 | The use of second-generation thrombopoietic agents for chemotherapy-induced thrombocytopenia显示文摘 | LEVY B ARNASON JE BUSSEL JB | 2008 | Curr Opin Oncol2008，20，6： | 1 |
| 12 | 显示文摘 | FOLKESTAD L BJ ARNASON N H BJERREGAARD J K | 2009 | Basic Clin Pharmaeol Toxieol2009，104，： | 1 |
| 13 | Breakthrouth pain in malignant and non-maligant disease:a review of prevalence, characteristics and mechanisms显示文摘 | Svendsen KB Andersen S Arnason S | 2005 | Eur J Pain2005，9，： | 1 |
| 14 | Lenalidomide enhances anti-myeloma cellular immunity显示文摘 | Katarina Luptakova Jacalyn Rosenblatt Brett Glotzbecker Heidi Mills Dina Stroopinsky Turner Kufe Baldev Vasir Jon Arnason Dimitri Tzachanis Jeffrey I. Zwicker Robin M. Joyce James D. Levine Kenneth C. Anderson Donald Kufe David Avigan | 2013 | Cancer Immunology, Immunotherapy2013，，： | 1 |
| 15 | Analogs of the cyclic hydroxamic acid 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3-one(DIMBOA):decomposition to benzoxazolinones and reaction with beta-mercaptoethanol显示文摘 | Atkinson J Morand P Arnason J T Niemeyer H M Bravo H R | | 0，，： | 1 |
| 16 | The relative importance of competition for water and for light in intercropping of sugar cane with maize显示文摘 | Govinden N Arnason J T | 1990 | Agricultural Water Management1990，17，： | 1 |
| 17 | Evaluation of anx-iolytic properties of Gotukola--(Centella asiatica)extractsand asiaticoside in rat behavioral models显示文摘 | Wijeweera P Arnason JT Koszycki D | 2006 | Phytomedicine2006，13，910： | 1 |
| 18 | The Complete Mitochondrial Genome of the Hagfish Myxine glutinosa: Unique Features of the Control Region显示文摘 | Christiane Delarbre Ann-Sofie Rasmussen Ulfur Arnason Gabriel Gachelin | 2001 | Journal of Molecular Evolution2001，，6： | 1 |
| 19 | Variation in Susceptibility of Tree-feeding Insect Species to Photoactivated Thiophene Insecticides 显示文摘 | HELSON B CECEARELLI A ARNASON JT et 01 | 1996 | J Economic Entomology1996，89，4： | 1 |
| 20 | Phylogenetic Studies of Complete Mitochondrial DNA Molecules Place Cartilaginous Fishes Within the Tree of Bony Fishes显示文摘 | Ann-Sofie Rasmussen Ulfur Arnason | 1999 | Journal of Molecular Evolution1999，，1： | 1 |
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