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| 1 | Functional studies of mesenchymal stem cells derived from adult human adipose tissue显示文摘 | Andrea Dicker Katarina Le Blanc Gaby ?str?m Vanessa van Harmelen Cecilia G?therstr?m Lennart Blomqvist Peter Arner Mikael Rydén | 2005 | Experimental Cell Research2005，，2： | 2 |
| 2 | The influence of gene-gene and gene-environment interactions on the risk of asbestosis 显示文摘 | Franko A Dolzan V Arneric N | 2013 | Bio Med Research Intenmtiongal2013，2013，40： | 1 |
| 3 | Adipose tissue gene expression in obese subjects during low-fat and high-fat hypocaloric diets显示文摘 | Viguerie N Vidal H Arner P | 2005 | Diabetologia2005，48，1： | 1 |
| 4 | Present stae of extradural and intrathecal opioidanalgesia in weden显示文摘 | Rawal N Arner S Gustafasson LL | 2004 | Br J Anaesth2004，59，： | 1 |
| 5 | Present state of extradural and intrathecal opipid analgesia in Sweden 显示文摘 | Rawal N ArnerS Gustafssonll | 1987 | Br J Anaesth1987，59，： | 1 |
| 6 | Negative effects of reactive sputtering in an industrial plasma nitriding显示文摘 | Roli(n)ski E Sharp G Arner J | 2005 | J Mater Eng Perf2005，14，3： | 1 |
| 7 | Present stale of epidural andinlralhee M opiond analgesia in Sweden显示文摘 | Rawal N Arner S Gustafsson L L | 1987 | Br J Anaeseth1987，57，6： | 1 |
| 8 | Calpain-10 gene polymorphism is associoted with reduced β3-adrenoceptor function in human fat cells显示文摘 | Hoffstet J Nslund E Arner P | 2002 | J Chin Endocrinol Metab2002，87，7： | 1 |
| 9 | 白脂肪组织因子可预测体质量减轻后主动脉脉搏波传导速度的长期改善程度显示文摘通过脉搏波传导速度(pulse wave velocity,PWV)测量的动脉硬度与肥胖、心血管病和全因死亡率有关。短期减肥可改善PWV,但长期减肥的效果尚不清楚。本研究调查显著的长期减肥对PWV的影响,以及PWV的这种变化是否能够通过人体测量参数/代谢指标和(或)白色脂肪组织(white adipose tissue,WAT)表型进行预测。 | ■ J Andersson DP Eriksson-Hogling D Caidahl K Thorell A Mileti E Daub CO Arner P Rydén M 陈云 叶鹏 | 2019 | 中华高血压杂志2019，0，3： | 0 |
| 10 | Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults:Big Data from Seven Randomized Controlled Trials Worldwide显示文摘Objective.The strongest locus which associated with type 2 diabetes(T2D)by the common variant rs7903146 is the transcription factor 7-like 2 gene(TCF7L2).We aimed to quantify the interaction of diet/lifestyle interventions and the genetic effect of TCF7L2 rs7903146 on glycemic traits,body weight,or waist circumference in overweight or obese adults in several randomized controlled trials(RCTs).Methods.From October 2016 to May 2018,a large collaborative analysis was performed by pooling individualparticipant data from 7 RCTs.These RCTs reported changes in glycemic control and adiposity of the variant rs7903146 after dietary/lifestyle-related interventions in overweight or obese adults.Gene treatment interaction models which used the genetic effect encoded by the allele dose and common covariates were applicable to individual participant data in all studies.Results.In the joint analysis,a total of 7 eligible RCTs were included(n=4,114).Importantly,we observed a significant effect modification of diet/lifestyle-related interventions on the TCF7L2 variant rs7903146 and changes in fasting glucose.Compared with the control group,diet/lifestyle interventions were related to lower fasting glucose by-3.06(95%CI,-5.77 to-0.36)mg/dL(test for heterogeneity and overall effect:I^(2)=45:1%,p<0:05;z=2:20,p=0:028)per one copy of the TCF7L2 T risk allele.Furthermore,regardless of genetic risk,diet/lifestyle interventions were associated with lower waist circumference.However,there was no significant change for diet/lifestyle interventions in other glycemic control and adiposity traits per one copy of TCF7L2 risk allele.Conclusions.Our findings suggest that carrying the TCF7L2 T risk allele may have a modestly greater benefit for specific diet/lifestyle interventions to improve the control of fasting glucose in overweight or obese adults. | Tao Huang Zhenhuang Zhuang Yoriko Heianza Dianjianyi Sun Wenjie Ma Wenxiu Wang Meng Gao Zhe Fang Emilio Ros Liana C.Del Gobbo Jordi Salas-Salvadó Miguel A.Martínez-González Jan Polak Markku Laakso Arne Astrup Dominique Langin Jorg Hager Gabby Hul Torben Hansen Oluf Pedersen Jean-Michel Oppert Wim H.M.Saris Peter Arner Montserrat Cofán Sujatha Rajaram Jaakko Tuomilehto Jaana Lindström Vanessa D.de Mello Alena Stancacova Matti Uusitupa Mathilde Svendstrup Thorkild I.A.Sørensen Christopher D.Gardner Joan Sabaté Dolores Corella J.Alfredo Martinez Lu Qi | 2021 | Health Data Science2021，，1： | 0 |
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