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| 1 | Juvenile polyposis syndrome显示文摘Juvenile polyposis syndrome is a rare autosomal dominant syndrome characterized by multiple distinct juvenile polyps in the gastrointestinal tract and an increased risk of colorectal cancer.The cumulative life-time risk of colorectal cancer is 39% and the relative risk is 34.Juvenile polyps have a distinctive histology characterized by an abundance of edematous lamina propria with inflammatory cells and cystically dilated glands lined by cuboidal to columnar epithelium with reactive changes.Clinically,juvenile polyposis syndrome is defined by the presence of 5 or more juvenile polyps in the colorectum,juvenile polyps throughout the gastrointestinal tract or any number of juvenile polyps and a positive family history of juvenile polyposis.In about 50%-60% of patients diagnosed with juvenile polyposis syndrome a germline mutation in the SMAD4 or BMPR1A gene is found.Both genes play a role in the BMP/TGF-beta signalling pathway.It has been suggested that cancer in juvenile polyposis may develop through the socalled 'landscaper mechanism' where an abnormal stromal environment leads to neoplastic transformation of the adjacent epithelium and in the end invasive carcinoma.Recognition of this rare disorder is important for patients and their families with regard to treatment,follow-up and screening of at risk individuals.Each clinician confronted with the diagnosis of a juvenile polyp should therefore consider the possibility of juvenile polyposis syndrome.In addition,juvenile polyposis syndrome provides a unique model to study colorectal cancer pathogenesis in general and gives insight in the molecular genetic basis of cancer.This review discusses clinical manifestations,genetics,pathogenesis and management of juvenile polyposis syndrome. | Lodewijk AA Brosens Danielle Langeveld W Arnout van Hattem Francis M Giardiello G Johan A Offerhaus | 2011 | World Journal of Gastroenterology2011，17，44： | 7 |
| 2 | IS6110限制性片段多态性分析标准方法的建立及其在结核分枝杆菌分子分型中的应用显示文摘目的建立IS6110限制性片段多态性分析(IS6110一RFLP)标准方法并评价该方法的分型能力。方法采用核酸提取、PCR、限制性内切酶分析、Southern杂交、琼脂糖凝胶电泳等技术,结合Gel—Proanalyzer3.1和BioNumerics(Version5.0)软件,对78株结核分枝杆菌插入序列IS6110-RFLP进行分析。结果确定标准化的IS6110-RFLP技术,包括核酸提取、PCR、限制性内切酶分析、Southern杂交、琼脂糖凝胶电泳等实验步骤及标化参数的相关数据分析软件的使用;采用该技术,将78株结核分枝杆菌分为75个不同的基因型,分别归属于11个基因簇,其中有52株归属于同一个基因簇,占菌株总数的66.7%(52/78)。结论建立标准化的IS6110-RFLP技术方案,该方法具有很强的基因分型和株水平鉴定能力,可用于结核病的病原学监测。 | 刘敬华 Kristin Kremer Christine Pourcel Arnout Mulder 刘志广 赵秀芹 万康林 | 2008 | 中华流行病学杂志2008，29，8： | 5 |
| 3 | Development of a Rapid Risk and Impact Assessment Tool to Enhance Response to Environmental Emergencies in the Early Stages of a Disaster: A Tool Developed by the European Multiple Environmental Threats Emergency NETwork (EMETNET) Project显示文摘Every year,numerous environmental disasters and emergencies occur across the globe with far-reaching impacts on human health and the environment.The ability to rapidly assess an environmental emergency to mitigate potential risks and impacts is paramount.However,collating the necessary evidence in the early stages of an emergency to conduct a robust risk assessment is a major challenge.This article presents a methodology developed to help assess the risks and impacts during the early stages of such incidents,primarily to support the European Union Civil Protection Mechanism but also the wider global community in the response to environmental emergencies.An online rapid risk and impact assessment tool has also been developed to promote enhanced collaboration between experts who are working remotely,considering the impact of a disaster on the environment and public health in the short,medium,and long terms.The methodology developed can support the appropriate selection of experts and assets to be deployed to affected regions to ensure that potential public health and environmental risks and impacts are mitigated whenever possible.This methodology will aid defensible decision making,communication,planning,and risk management,and presents a harmonized understanding of the associated impacts of an environmental emergency. | Emma-Jane Goode Eirian Thomas Owen Landeg Raquel Duarte-Davidson Lisbeth Hall Jolanda Roelofs Sjors Schulpen Arnout De Bruin Elisabeth Wigenstam Birgitta Liljedahl Annica Waleij Louise Simonsson Ann Göransson Nyberg | 2021 | International Journal of Disaster Risk Science2021，12，4： | 2 |
| 4 | Reduction of Postoperative Ileus by Early Enteral Nutrition in Patients Undergoing Major Rectal Surgery: Prospective, Randomized, Controlled Trial显示文摘 | Petra G. Boelens Fanny F. B. M. Heesakkers Misha D. P. Luyer Kevin W. Y. van Barneveld Ignace H. J. T. de Hingh Grard A. P. Nieuwenhuijzen Arnout N. Roos Harm J. T. Rutten | 2014 | Annals of Surgery2014，，4： | 2 |
| 5 | Mechanism of action of beta2-glycoprotein I- dependent lupus anticoagulants 显示文摘 | Arnout J Vermylen J | 1998 | Lupus1998，7，2： | 1 |
| 6 | Field experiments of success-breeds-success dynamics显示文摘 | ARNOUT R S00NG M K MICHAEL R AKSHAY P | 2014 | PNAS2014，111，19： | 1 |
| 7 | Activation of both coagulation and fibrinolysis in childhood hemolytic uremic syndrome显示文摘 | Proesmans W Arnout J | 1998 | Kidney Int1998，54，4： | 1 |
| 8 | Borate distribution in stabilized stainless steel slag 显示文摘 | Durinck D Arnout S Mertens G | 2008 | Journal of the American Ceramic Society2008，91，2： | 1 |
| 9 | Anti- factor VIII antibodies of hemophiliac patients are frequently directed towards nonfunctional determinants and do not exhibit isotypic restriction显示文摘 | Gilles JG Arnout J Vermylen J | 1993 | Blood1993，82，8： | 1 |
| 10 | Preparation and characterization of titania-coated polystyrene spheres and hollow titania shells显示文摘 | Arnout Imhof | 2001 | Langmuir2001，17，： | 1 |
| 11 | A new animal model of thrombophilia confirms that high plasma factor Ⅷ levels are thrombogenic显示文摘 | Kawasaki T Kaida T Arnout J | 1999 | Thromb Haemost1999，81，： | 1 |
| 12 | Avoidance of patellar eversion improves range of motion after total knee replacement: a prospective randomized study显示文摘 | Arnout N Victor J Cleppe H | 2009 | Knee Surg Sports Traumatol Arthrosc2009，17，10： | 1 |
| 13 | A new animal model of throm- hophilia confirms that high plasma levels of Foctor Ⅷ levels are thrombogenic 显示文摘 | Kawa sakl T Kalda T Arnout J | 1999 | Thromb Haemost1999，81，： | 1 |
| 14 | Sodium fluoride mimics effects of both agonists and antagonists on intact human platelets by simultaneous modultaion of phospholipase C and adenylate cyclase activity显示文摘 | Kienast J Arnout J Pfliegler G | 1987 | Blood1987，69，3： | 1 |
| 15 | Synthesis of eccentric titania-silica core-shell and com- posite particles显示文摘 | Ahmet Faik Demir6rs Alfons van Blaaderen Arnout Im- hof | 2009 | Chem Mater2009，21，： | 1 |
| 16 | SExtractor:software for source extraction显示文摘 | Bertin E Arnouts S | 1996 | Astronomy & Astrophysics Supplement Series1996，177，： | 1 |
| 17 | Forensic visual evidence显示文摘 | Jurrien Bijhold Arnout Ruifrok Zeno Geradts | 2010 | A Review2010，，： | 1 |
| 18 | Mortality and metformin use in patients with advanced chronic kidney disease显示文摘 | Lalau JD Kajbaf F Arnouts P | 2015 | Lancet Dia- betes Endocrino12015，3，9： | 1 |
| 19 | Sodiumfluoride mimics effects of both agonists and antagonists on intact human platelets by simultaneous modulation of phospholipase C and adenylate cyclase activity显示文摘 | Kienast J Arnout J Pfliegler G | 1987 | Blood1987，69，3： | 1 |
| 20 | Trace organic solutes in closed-loop forward osmosis applications: Influence of membrane fouling and modeling of solute build-up显示文摘 | Arnout D’Haese Pierre Le-Clech Sam Van Nevel Kim Verbeken Emile R. Cornelissen Stuart J. Khan Arne R.D. Verliefde | 2013 | Water Research2013，，： | 1 |
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