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| 1 | Diagnostic performance of serum interleukin-6 in pediatric acute appendicitis:a systematic review显示文摘Background Despite the radiological and analytical advances of the last decades,there is still a significant rate of diagnostic error in pediatric acute appendicitis.In recent years,multiple biomarkers have emerged as potential diagnostic tools.This study aimed to examine the diagnostic performance of serum interleukin-6 in pediatric acute appendicitis.Methods We conducted a systematic review of the literature that involved an extensive search in the main databases of medical bibliography(Medline,PubMed,Web of Science and SciELO).Two independent reviewers selected the relevant articles based on the previously defined inclusion and exclusion criteria.Methodological quality of the selected article was rated using the QUADAS2 index.Data extraction was performed by two independent reviewers.Results The research in the medical bibliography databases resulted in 68 articles.We removed 26 duplicates.Among the remaining 42 articles,we excluded 33 following the inclusion and exclusion criteria.Of the final 9 studies included in this review,8 provided measured serum interleukin-6 values,and all of them reported significant differences between groups,but inconsistent results regarding sensitivity and specificity.Conclusions The diagnostic performance of interleukine-6 alone for the diagnosis of acute appendicitis in children is limited.The sensitivity and specificity of interleukine-6 for the diagnosis of non-complicated acute appendicitis in the pediatric population are moderate but increased in complicated appendicitis.There seems to be a direct relationship between serum level of interleukin-6 and the hours of evolution of abdominal pain in children with acute appendicitis.The increasingly widespread use of non-operative management of acute appendicitis warrants further exploration of the classificatory potential of this marker between complicated and uncomplicated appendicitis.We consider that this may be an avenue of research to explore in the future. | Javier Arredondo Montero Carlos Bardaji Pascual Monica Bronte Anaut Natalia Lopez-Andres Giuseppa Antona Nerea Martin-Calvo | 2022 | World Journal of Pediatrics2022，18，2： | 3 |
| 2 | Effects of acute dietary Ironoverload in pigs (Sus scrofa) with induced type 2 diabetes mellitus显示文摘 | Espinoza A Morales S Arredondo M | 2014 | Biol Trace Elem Res2014，158，3： | 1 |
| 3 | Defining the safe working zones using the minimally invasive lateral retro- peritoneal transpsoas approach: an anatomical study 显示文摘 | Uribe JS Arredondo N Dakwar E | 2010 | J Neurosurg Spine2010，13，2： | 1 |
| 4 | helper I/T helper 2 cytokine in balance in respiratory syncytial virus infection is associated with increased endogenous plasma cortisol显示文摘 | Arredondo SM Bono MR | 2006 | Pediatrics2006，117，5： | 1 |
| 5 | Home contin uous passive motion machine versus professional physical therapy following total knee replacement显示文摘 | Worland RL Arredondo J Angles F | 1998 | J Arthroplasty1998，13，7： | 1 |
| 6 | Cross-talkbetween body iron stores and diabetes:iron stores areassociated with activity and microsatellite polymorphismof the heme oxygenase and type 2 diabetes显示文摘 | Arredondo M Fuentes M Jorquera D | 2011 | Biol TraceElem Res2011，143，2： | 1 |
| 7 | Sentinel node biopsy in breast cancer显示文摘 | Barnwell JM Arredondo MA Kollmorgen D | 1998 | Ann Surg Oncol1998，5，2： | 1 |
| 8 | Aseptic ceredral venous thrombosis:proposed prognostic scale 显示文摘 | Barinagarre MF Cantu C Arredondo H | 1992 | J Stroke Cerebrovasc Dis1992，16，2： | 1 |
| 9 | Bipolar shoulder arthroplasty for rotator cuff arthropathy显示文摘 | Worland RL Jessup DE Arredondo J | 1997 | J Shoulder Elbow Surg1997，6，： | 1 |
| 10 | Open tension-free hernioplasty using a novel lightweight self-gripping mesh:medium-term experience from two institutions显示文摘 | Pedano N Pastor C Arredondo J | | 0，，02： | 1 |
| 11 | Novel ' green' sucrose polyester alkyds for high-performing low- VOC coatings显示文摘 | ROGERS N ESLINGER D ARREDONDO V | 2010 | JCT Coatings TECH2010，7，6： | 1 |
| 12 | The Ras/Raf-1/ MEK1/ERK signaling pathway coupled to integrin expression mediates cholinergic regulation of keratinocyte directional migration显示文摘 | Chernyavsky AI Arredondo J Karlsson E | 2005 | J Biol Chem2005，280，39： | 1 |
| 13 | Af- ter cellular internalization,quercetin causes Nrf2 nuclear translocation,increases glutathione levels,and prevents neuronal death against an oxidative insult显示文摘 | Arredondo F Echeverry C Abin-Carriquiry JA | 2010 | Free Radic Biol Med2010，49，5： | 1 |
| 14 | Partial removal of lipolysaccharide from thiobacillus ferrooxidans affects its adhesion to solids显示文摘 | Arredondo R Garcia A Jerez C A | 1994 | Environ Microbiol1994，60，8： | 1 |
| 15 | Endocrinology of recurrent pregnancy loss 显示文摘 | Arredondo F Nolel LS | 2006 | Semin Reprod Med2006，24，： | 1 |
| 16 | Optical flow using textures显示文摘 | Arredondo M A lebart K Lane D | 2004 | Pattern Recognition Letters2004，25，： | 1 |
| 17 | DMT1,a physiologically rele-vant apical Cu + 1 transporter of intestinal cells显示文摘 | Arredondo M Mufioz P Mura CV | 2003 | Am J Physiol CellPhysiol2003，284，： | 1 |
| 18 | Exact analytical solution of a two diode circuit model for organic solar cells showing S-shape using Lambert W-functions显示文摘 | Romero B Del POZO G ARREDONDO B | 2012 | Solar Energy2012，，86： | 1 |
| 19 | Copper overload affects copper and iron metabolism in HepG2 cells显示文摘 | Arredondo M V Cambiazo L Tapia M | 2004 | Am J Physiol Gastrointest Liver Physiol2004，287，1： | 1 |
| 20 | Defining the safe working zones using the minimally invasive lateral retroperitoneal transpsoas approach : an anatomical study 显示文摘 | Uribe JS Arredondo N Dakwar E | 2010 | J Neurosurg Spine2010，13，： | 1 |
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