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| 1 | TOLs Function as Ubiquitin Receptors in the Early Steps of the ESCRT Pathway in Higher Plants显示文摘Protein abundance and localization at the plasma membrane(PM)shapes plant development and mediates adaptation to changing environmental conditions.It is regulated by ubiquitination,a post-translational modification crucial for the proper sorting of endocytosed PM proteins to the vacuole for subsequent degradation.To understand the significance and the variety of roles played by this reversible modification,the function of ubiquitin receptors,which translate the ubiquitin signature into a cellular response,needs to be elucidated.In this study,we show that TOL(TOM1-like)proteins function in plants as multivalent ubiquitin receptors,governing ubiquitinated cargo delivery to the vacuole via the conserved Endosomal Sorting Complex Required for Transport(ESCRT)pathway.TOL2 and TOL6 interact with components of the ESCRT machinery and bind to K63-linked ubiquitin via two tandemly arranged conserved ubiquitin-binding domains.Mutation of these domains results not only in a loss of ubiquitin binding but also altered localization,abolishing TOL6 ubiquitin receptor activity.Function and localization of TOL6 is itself regulated by ubiquitination,whereby TOL6 ubiquitination potentially modulates degradation of PM-localized cargoes,assisting in the fine-tuning of the delicate interplay between protein recycling and downregulation.Taken together,our findings demonstrate the function and regulation of a ubiquitin receptor that mediates vacuolar degradation of PM proteins in higher plants. | Jeanette Moulinier-Anzola Maximilian Schwihla Lucinda De-Araujo Christina Artner Lisa Jorg Nataliia Konstantinova Christian Luschnig Barbara Korbei | 2020 | Molecular Plant2020，13，5： | 3 |
| 2 | A novel DOPO - based diamine as hardener and flame retardant for epoxy resin systems 显示文摘 | ARTNER J CIESIELSKI M WALTER O | 2008 | Macromol Mater Eng2008，293，6： | 1 |
| 3 | Radiation dose reduction in CT-guided periadieular injeetions in lumbar spine:feasibility of a new institutional protoeol for improved patient safety显示文摘 | Artner J Cakir B Weckbaeh S | 2012 | Patient Saf Surg2012，6，1： | 1 |
| 4 | Maintenance of Hepatic Nuclear Factor-6 in Postnatal Islets Impairs Terminal Differentiation and Function of β-Cells显示文摘 | Elizabeth Tweedie Isabella Artner Laura Crawford | 2006 | Diabetes2006，55，12： | 1 |
| 5 | The MafA transcription factor appears to be responsible for tissue-specific expression of insulin显示文摘 | ARTNER I HENDERSON E | 2004 | Proc Natl Acad Sci USA2004，101，9： | 1 |
| 6 | Hyperhomocysteinemia in dementia显示文摘 | Leblhuber F Walli J Artner - Dworzak E | 2000 | J Neural Transm2000，107，12： | 1 |
| 7 | Observations in the Qing Ping Free Market,Guangzhou,China,November 2000显示文摘 | Artner H Hofer A | | 0，，： | 1 |
| 8 | On the turtles of Hainan Island,Southem China显示文摘 | Debruin R W F Artner H G | | 0，，03： | 1 |
| 9 | Transvaginal sonogr aphic c haracterization of ovarian disease: Evaluation of a new scoring system to predic t ovarian malignancy显示文摘 | Timor-Tritsch IE Artner A | 1991 | Obstet Gynecol1991，78，： | 1 |
| 10 | MafB is required for islet beta cell maturation显示文摘 | BLANCHI B RAUM J C | 2007 | Proc Natl Acad Sci USA2007，104，10： | 1 |
| 11 | MafB:An activator of the glucagon gene expressed in developing islet α-and β-cells显示文摘 | LE LAY J HANG Y | 2006 | Diabetes2006，55，： | 1 |
| 12 | The MafA transcription factor appears to be responsible for tissue-specific expression of insulin显示文摘 | Matsuoka TA Artner I Henderson E | | 0，，： | 1 |
| 13 | Protective effect of coenzyme Q10-loaded liposomes on the myocardium in rabbits with an acute experimental myocardial infarction显示文摘 | VERMA D D ARTNER W C THAKKAR V | 2007 | Pharmaceutical Research2007，24，11： | 1 |
| 14 | 显示文摘 | Artner Johannes Ciesielski Michael Walter Olaf | 2008 | Macromolecular Materials and Engineering2008，293，6： | 1 |
| 15 | Pyrolysis and fire behaviour of epoxy systems containing a novel 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide-(DOPO)-based diamino hardener显示文摘 | B. Schartel U. Braun A.I. Balabanovich J. Artner M. Ciesielski M. D?ring R.M. Perez J.K.W. Sandler V. Altst?dt | 2008 | European Polymer Journal2008，，3： | 1 |
| 16 | A Novel DOPO-based diamine as hardener and flame retardant for epoxy resin sys tems显示文摘 | Artner J Ciesielski M Walter O | 2008 | Macromolecular Materials and Engineering2008，293，： | 1 |
| 17 | Transvaginal sonographic char- acterization of ovarian disease : Evaluation of a new scoring system to predict malignancy显示文摘 | Sassone AM Timor IE Artner A | 1991 | Obstet Gynecol1991，78，： | 1 |
| 18 | Influence of the oxidation state of phosphorus on the decomposition and fire behaviour of flame-retarded epoxy resin composites显示文摘 | Ulrike Braun Aliaksandr I. Balabanovich Bernhard Schartel Uta Knoll Johannes Artner Michael Ciesielski Manfred D?ring Raul Perez Jan K.W. Sandler Volker Altst?dt Thorsten Hoffmann Doris Pospiech | 2006 | Polymer2006，，26： | 1 |
| 19 | A novel DOPO-based diamine as hardener and flame retardant for epoxy resin systems显示文摘 | Artner Johannes Ciesielski Michael Walter Olaf | 2008 | Macromolecular Materials and Engineering2008，293，6： | 1 |
| 20 | The MafA tran-scription factor appears to be responsible for tissuespecificexpression of insulin显示文摘 | Matsuoka TA Artner I Henderson K | 2004 | Proc Natl Acad Sci USA2004，101，9： | 1 |
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