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| 1 | 单核细胞产生IL-1、IL-6和肿瘤坏死因子的动态观察显示文摘采用生物活性测定法和免疫细胞化学染色法.观察了内毒素诱导正常人单核细胞产生白细胞介素(?).白细胞介素6和肿瘤环死因子的动态过程.以及彼此之间的相互关系。结果表明,三种细胞因子的胞浆内累积和释放均有各自不同的时相变化.反映出这三种细胞因子基因活化、转录、翻译和释放过程的差异.此外.仅部分单核细胞合成这三种细胞因子. | 王明海 何南洋 Hans-Dieter Flad Artur J Ulmer | 1990 | 中国免疫学杂志1990，6，6： | 16 |
| 2 | Endothelial dysfunction in inflammatory bowel diseases:Pathogenesis,assessment and implications显示文摘Endothelial dysfunction is considered one of the etiological factors of inflammatory bowel disease(IBD). An inflammatory process leads to functional and structural changes in the vascular endothelium. An increase of leukocyte adhesiveness and leukocyte diapedesis, as well as an increased vascular smooth muscle tone and procoagulant activity is observed. Structural changes of the vascular endothelium comprise as well capillary and venule remodeling and proliferation of endothelial cells. Hypoxia in the inflammatory area stimulates angiogenesis by upregulation of vascular endothelial growth factor, fibroblast growth factor and tumor necrosis factor-α. Inflammatory mediators also alter the lymphatic vessel function and impair lymph flow, exacerbating tissue edema and accumulation of dead cells and bacteria. The endothelial dysfunction might be diagnosed by the use of two main methods: physical and biochemical. Physical methods are based on the assessment of large arteries vasodilatation in response to an increased flow and receptors stimulation. Flowmediated vasodilatation(FMD) is the method that is the most widely used; however, it is less sensitive in detecting early changes of the endothelium function. Most of the studies demonstrated a decrease of FMD in IBD patients but no changes in the carotic intima-media thickness. Biochemical methods of detecting the endothelial dysfunction are based on the assessment of the synthesis of compounds produced both by the normal and damaged endothelium. The endothelial dysfunction is considered an initial step in the pathogenesis of atherosclerosis in the general population. In IBD patients, the risk of cardiovascular diseases is controversial. Large, prospective studies are needed to establish the role of particular medications or dietary elements in the endothelial dysfunction as well to determine the real risk of cardiovascular diseases. | Dorota Cibor Renata Domagala-Rodacka Tomasz Rodacki Artur Jurczyszyn Tomasz Mach Danuta Owczarek | 2016 | World Journal of Gastroenterology2016，22，3： | 10 |
| 3 | Upper non-variceal gastrointestinal bleeding-review the effectiveness of endoscopic hemostasis methods显示文摘Upper non-variceal gastrointestinal bleeding is a conditionthat requires immediate medical intervention and has a high associated mortality rate(exceeding 10%). The vast majority of upper gastrointestinal bleeding cases are due to peptic ulcers. Helicobacter pylori infection, non-steroidal anti-inflammatory drugs and aspirin are the main risk factors for peptic ulcer disease. Endoscopic therapy has generally been recommended as the firstline treatment for upper gastrointestinal bleeding as it has been shown to reduce recurrent bleeding, the need for surgery and mortality. Early endoscopy(within 24 h of hospital admission) has a greater impact than delayed endoscopy on the length of hospital stay and requirement for blood transfusion. This paper aims to review and compare the efficacy of the types of endoscopic hemostasis most commonly used to control non-variceal gastrointestinal bleeding by pooling data from the literature. | Miroslaw Szura Artur Pasternak | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，13： | 9 |
| 4 | Value of a newly sequenced bacterial genome显示文摘Next-generation sequencing(NGS) technologies have made high-throughput sequencing available to medium- and small-size laboratories, culminating in a tidal wave of genomic information. The quantity of sequenced bacterial genomes has not only brought excitement to the field of genomics but also heightened expectations that NGS would boost antibacterial discovery and vaccine development. Although many possible drug and vaccine targets have been discovered, the success rate of genome-based analysis has remained below expectations. Furthermore, NGS has had consequences for genome quality, resulting in an exponential increase in draft(partial data) genome deposits in public databases. If no further interests are expressed for a particular bacterial genome, it is more likely that the sequencing of its genome will be limited to a draft stage, and the painstaking tasks of completing the sequencing of its genome and annotation will not be undertaken. It is important to know what is lost when we settle for a draft genome and to determine the 'scientific value' of a newly sequenced genome. This review addresses the expected impact of newly sequenced genomes on antibacterial discovery and vaccinology. Also, it discusses the factors that could be leading to the increase in the number of draft deposits and the consequent loss of relevant biological information. | Eudes GV Barbosa Flavia F Aburjaile Rommel TJ Ramos Adriana R Carneiro Yves Le Loir Jan Baumbach Anderson Miyoshi Artur Silva Vasco Azevedo | 2014 | World Journal of Biological Chemistry2014，5，2： | 7 |
| 5 | Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, protects pancreas against acute cerulein-induced pancreatitis显示文摘ABM: To determine the effect of pioglitazone, a specific peroxisome proliferator-activated receptor-γ(PPARγ) ligand, on the development of acute pancreatitis (AP) and on the expression of heat shock protein 70 (HSP70) in the pancreas. METHODS: AP was induced in rats by subcutaneous infusion of cerulein for 5 h. Pancreatic blood flow was measured by laser Doppler flowmetry. Plasma lipase activity, interleukin-1β (IL-1β) and IL-10 were determined, Pancreatic weight and histology were evaluated and pancreatic DNA synthesis and blood flow as well as pancreatic mRNA for IL-1β and HSP70 were assessed in rats treated with pioglitazone alone or in combination with cerulein. RESULTS: Pioglitazone administered (10-100 mg/kg i.g.) 30 min before cerulein, attenuated dose-dependently the pancreatic tissue damage in cerulein-induced pancreatitis (CIP) as demonstrated by the improvement of pancreatic histology, reduction in plasma lipase activity, plasma concentration of pro-inflammatory IL-1β and its gene expression in the pancreas and attenuation of the pancreatitis-evoked fall in pancreatic blood flow. CIP increased pancreatic HSP70 mRNA and protein expression in the pancreas and this effect was enhanced by pioglitazone treatment. CONCLUSION: Pioglitazone attenuates CIP and the beneficial effect of this pioglitazone is multifactorial probably due to its anti-inflammatory activities, to the suppression of IL-1β and to the over-expression of HSP70. PPARγ ligands could represent a new therapeutic option in the treatment of AP. | Peter C Konturek Artur Dembinski Zygmunt Warzecha Grzegorz Burnat Piotr Ceranowicz Eckhart G Hahn Marcin Dembinski Romana Tomaszewska Stanislaw J Konturek | 2005 | World Journal of Gastroenterology2005，11，40： | 7 |
| 6 | Taking silicon photonics modulators to a higher performance level: state-of-the-art and a review of new technologies显示文摘Optical links are moving to higher and higher transmission speeds while shrinking to shorter and shorter ranges where optical links are envisaged even at the chip scale.The scaling in data speed and span of the optical links demands modulators to be concurrently performant and cost-effective.Silicon photonics(SiPh),a photonic integrated circuit technology that leverages the fabrication sophistication of complementary metal-oxide-semiconductor technology,is well-positioned to deliver the performance,price,and manufacturing volume for the high-speed modulators of future optical communication links.SiPh has relied on the plasma dispersion effect,either in injection,depletion,or accumulation mode,to demonstrate efficient high-speed modulators.The high-speed plasma dispersion silicon modulators have been commercially deployed and have demonstrated excellent performance.Recent years have seen a paradigm shift where the integration of various electro-refractive and electro-absorptive materials has opened up additional routes toward performant SiPh modulators.These modulators are in the early years of their development.They promise to extend the performance beyond the limits set by the physical properties of silicon.The focus of our study is to provide a comprehensive review of contemporary(i.e.,plasma dispersion modulators)and new modulator implementations that involve the integration of novel materials with SiPh. | Abdul Rahim Artur Hermans Benjamin Wohlfeil Despoina Petousi Bart Kuyken Dries Van Thourhout Roel Baets | 2021 | Advanced Photonics2021，3，2： | 6 |
| 7 | Selection of the Relevant Turbulence Model in a CFD Simulation of a Flow Disturbed by Hydraulic Elbow--Comparative Analysis of the Simulation with Measurements Results Obtained by the Ultrasonic Flowmeter显示文摘The article is an attempt to compile the results of CFD liquid flow simulation through pipeline section containing hydraulic elbow with the results of ultrasonic flow measurements. To carry out the measurements behind the flow disturbing element(hydraulic elbow), an ultrasonic flowmeter with applied head set in accordance with the Z-type system was used. For comparative purposes, a flow simulation for 3 different turbulence models(k-epsilon, SST and SSG) was performed. It was found that with a proper ultrasonic flowmeter heads configurations, it is possible to measure the flow rate disturbed by the hydraulic elbow at any distance from the source of the disturbance. It has to use appropriate correction factor that can be determined by knowing the flow velocity profile equation. Based on comparison of CFD simulation results with experimental data, the accuracy/purposefulness of using individual turbulence models in the case of discussed hydraulic installation was evaluated. | PIECHOTA Piotr SYNOWIEC Piotr ANDRUSZKIEWICZ Artur WEDRYCHOWICZ Wieslaw | 2018 | Journal of Thermal Science2018，27，5： | 6 |
| 8 | MGMT and MLH1 methylation in Helicobacter pylori-infected children and adults显示文摘AIM:To evaluate the association between Helicobacter pylori(H.pylori) infection and MLH1 and MGMT methylation and its relationship with microsatellite instability(MSI).METHODS:The methylation status of the MLH1 and MGMT promoter region was analysed by methylation specific methylation-polymerase chain reaction(MSPPCR) in gastric biopsy samples from uninfected or H.pylori-infected children(n = 50),from adults with chronic gastritis(n = 97) and from adults with gastric cancer(n = 92).MLH1 and MGMT mRNA expression were measured by real-time PCR and normalised to a constitutive gene(β actin).MSI analysis was performed by screening MSI markers at 4 loci(Bat-25,Bat-26,D17S250 and D2S123) with PCR;PCR products were analysed by single strand conformation polymorphism followed by silver staining.Statistical analyses were performed with either the χ 2 test with Yates continuity correction or Fisher's exact test,and statistical significance for expression analysis was assessed using an unpaired Student's t-test.RESULTS:Methylation was not detected in the promoter regions of MLH1 and MGMT in gastric biopsy samples from children,regardless of H.pylori infection status.The MGMT promoter was methylated in 51% of chronic gastritis adult patients and was associated with H.pylori infection(P < 0.05);this region was methylated in 66% of gastric cancer patients,and the difference in the percentage of methylated samples between these patients and those from H.pylori-infected chronic gastritis patients was statistically significant(P < 0.05).MLH1 methylation frequencies among H.pylori-infected and non-infected chronic gastritis adult patients were 13% and 7%,respectively.We observed methylation of the MLH1 promoter(39%) and increased MSI levels(68%) in samples from gastric cancer patients in comparison to samples from H.pylori-infected adult chronic gastritis patients(P < 0.001 and P < 0.01,respectively).The frequency of promoter methylation for both genes was higher in gastric cancer samples than in H.pylori-positive chronic gastritis samples(P < 0.05).The levels of MLH1 and MGMT mRNA were significantly reduced in chronic gastritis samples that were also hypermethylated(P < 0.01).CONCLUSION:In summary,MGMT and MLH1 methylation did not occur in earlier-stage H.pylori infections and thus might depend on the duration of infection. | Marisa C Alvarez Juliana C Santos Nathália Maniezzo Marcelo S Ladeira Artur LC da Silva Isabel CA Scaletsky José Pedrazzoli Jr Marcelo L Ribeiro | 2013 | World Journal of Gastroenterology2013，19，20： | 5 |
| 9 | Oleogels for development of health-promoting food products显示文摘Metabolic health and the maintenance of good levels of triglycerides,high-density lipoprotein cholesterol,blood pressure and glucose levels are concerns that can greatly impact human quality of life.Healthdriven consumers’demands,together with technological innovations,have led to a diversification of the food industry.The fostering of off-the-shelf available and affordable healthy food products is necessary,as detrimental effects on human health from the ingestion of saturated fat sources urge the efforts to find alternatives.Oleogels can be tailored using specific triglycerides and oleogelators,that can be selected to yield targeted fatty acids,reduce higher levels of cholesterol with competing binding-molecules(e.g.phytosterols),reduce saturated fat content,lessen appetite(e.g.modelling the shape of foods)or carry exclusive bioactive compounds to be absorbed in the digestive tract.Oleogels are foreseen as an important technological advance in food science due to their versatility,easy processing and affordability.This review explored the strategies in place to develop and produce oleogels,foreseeing their introduction in foods and how they might represent an important source of functionality through the use of healthy molecules.It also explored how oleogels can act on the human overall metabolic health if they are used in human diet. | Artur J.Martins Antonio A.Vicente Lorenzo M.Pastrana Miguel A.Cerqueira | 2020 | Food Science and Human Wellness2020，9，1： | 5 |
| 10 | Could sport be part of pediatric obesity prevention and treatment? Expert conclusions from the 28th European Childhood Obesity Group Congress显示文摘The prevalence of pediatric obesity continues to increase worldwide,bringing with it various metabolic,functional,social,and psychological complications.1 Both the prevention and treatment of childhood obesity must be based on multidisciplinary approaches combining nutrition,physical activity(PA),and psychological support.2 As an essential element of these multicomponent strategies,regular physical activity has been acknowledged as having beneficial effects on children's and adolescents,body composition,physical fitness,and metabolic profile,as well as on their health-related quality of life,social and psychological health,and academic achievement.3,4 Given that only a relatively small proportion of children and adolescents meet the public health recommendations for PA,5 and given that weight loss exercise-based interventions suffer from a high attrition rate,there is a clear need for appropriate PAs. | Susanne Ring-Dimitriou Peter Krustrup Manuel J Coelho-E-Silva Jorge Mota Andera Seabra Carla Rego Artur Mazur Elpis Vlachopapadopoulou Margerita Caroli Marie-Laure Frelut Eva Erhardt Anders Forslund Ema Boyland Daniel Weghuber David Thivel | 2019 | Journal of Sport and Health Science2019，8，4： | 3 |
| 11 | Post-transcriptional Regulation of MicroRNA Accumulation and Function: New Insights from Plants显示文摘 | Zofia Szweykowska-Kulinska Artur Jarmolowski | 2018 | Molecular Plant2018，11，8： | 3 |
| 12 | Electronic warfare in the optical band:Main features,examples and selected measurement data显示文摘The paper presents the possibilities of,and methods for,acquiring,analysing and processing optical signals in order to recognise,identify and counteract threats on the contemporary battleground.The main ways electronic warfare is waged in the optical band of the electromagnetic wave spectrum have been formulated,including the acquisition of optical emitter signatures,as well as ultraviolet(UV)and thermal(IR)signatures.The physical parameters and values describing the emission of laser radiation are discussed,including their importance in terms of creating optical signatures.Moreover,it has been shown that in the transformation of optical signals into signatures,only their spectral and temporal parameters can be applied.This was confirmed in experimental part of the paper,which includes our own measurements of spectral and temporal emission characteristics for three types of binocular laser rangefinders.It has been further shown that through simple registration and quick analysis involving comparison of emission time parameters in the case of UV signatures in“solar-blind”band,various events can be identified quickly and faultlessly.The same is true for IR signatures,where the amplitudes of the recorded signal for several wavelengths are compared.This was confirmed experimentally for UV signatures by registering and then analyzing signals from several events during military exercises at a training ground,namely Rocket Propelled Grenade(RPG)launches and explosions after hitting targets,trinitrotoluene(TNT)explosions,firing armour-piercing,fin-stabilised,discarding sabots(APFSDS)or high explosive(HE)projectiles.The final section describes a proposed model database of emitters,created as a result of analysing and transforming the recorded signals into optical signatures. | Roman Ostrowski Artur Cywinski Marek Strzelec | 2021 | Defence Technology(防务技术)2021，17，5： | 3 |
| 13 | Effect of the C:N:P ratio on the denitrifying dephosphatation in a sequencing batch biofilm reactor(SBBR)显示文摘A series of investigations were conducted using sequencing batch biofilm reactor(SBBR) to explore the influence of C:N:P ratio on biological dephosphatation including the denitrifying dephosphatation and the denitrification process.Biomass in the reactor occurred mainly in the form of a biofilm attached to completely submerged disks.Acetic acid was used as the source of organic carbon.C:N:P ratios have had a significant effect on the profiles of phosphate release and phosphate uptake and nitrogen removal.The highest rates of phosphate release and phosphate uptake were recorded at the C:N:P ratio of 140:70:7.The C:N ratio of 2.5:1 ensured complete denitrification.The highest rate of denitrification was achieved at the C:N:P ratio of 140:35:7.The increase of nitrogen load caused an increase in phosphates removal until a ratio C:N:P of 140:140:7.Bacteria of the biofilm exposed to alternate conditions of mixing and aeration exhibited enhanced intracellular accumulation of polyphosphates.Also,the structure of the biofilm encouraged anaerobic–aerobic as well as anoxic–anaerobic and absolutely anaerobic conditions in a SBBR.These heterogeneous conditions in the presence of nitrates may be a significant factor determining the promotion of denitrifying polyphosphate accumulating organism(DNPAO) development. | Artur Mielcarek Joanna Rodziewicz Wojciech Janczukowicz Arthur J.Thornton Tomasz Józwiak Paula Szymczyk | 2015 | Journal of Environmental Sciences2015，27，12： | 3 |
| 14 | 涵摄模式之批判显示文摘根据传统的理解,方法根源于19世纪的实证主义,法律适用(Rechtsanwendung)仅限于将案件涵摄于制定法规范之下。涵摄是最简单和最可靠的三段论(Syllogismus),也就是演绎。这一模式背后的理念是这样一种追求,即证成法学为真正的科学。 | Artur Kaufmann 周升乾 | 2007 | 研究生法学2007，22，2： | 3 |
| 15 | SARS-CoV-2 spike protein binds to bacterial lipopolysaccharide and boosts proinflammatory activity显示文摘There is a link between high lipopolysaccharide(LPS)levels in the blood and the metabolic syndrome,and metabolic syndrome predisposes patients to severe COVID-19.Here,we define an interaction between SARS-CoV-2 spike(S)protein and LPS,leading to aggravated inflammation in vitro and in vivo.Native gel electrophoresis demonstrated that SARS-CoV-2 S protein binds to LPS.Microscale thermophoresis yielded a of〜47 nM for the interaction.Computational modeling and all-atom molecular dynamics simulations further substantiated the experimental results,identifying a main LPS-binding site in SARS-CoV-2 S protein.S protein,when combined with low levels of LPS,boosted nuclear factor-kappa B(NF-k B)activation in monocytic THP-1 cells and cytokine responses in human blood and peripheral blood mononuclear cells,respectively.The in vitro inflammatory response was further validated by employing NF-kB reporter mice and in vivo bioimaging.Dynamic light scattering,transmission electron microscopy,and LPS-FITC analyses demonstrated that S protein modulated the aggregation state of LPS,providing a molecular explanation for the observed boosting effect.Taken together,our results provide an interesting molecular link between excessive inflammation during infection with SARS-CoV-2 and comorbidities involving increased levels of bacterial endotoxins. | Ganna Petruk Manoj Puthia Jitka Petrlova Firdaus Samsudin Ann-Charlotte Stromdahl Samuel Cerps Lena Uller Sven Kjellstrom Peter J.Bond Artur Schmidtchen | 2020 | Journal of Molecular Cell Biology2020，12，12： | 3 |
| 16 | 多孔质气体静压轴承研究现状及发展趋势显示文摘多孔质气体静压轴承采用多孔质节流器,依靠外部供给加压气,形成承载气膜,实现支承和定位.分析了多孔质轴承支承原理,并说明气膜压力分布特点.总结了多孔材料在轴承中的应用及碳石墨多孔材料具有的相对优势.论述了流动模型、数值求解及试验的研究现状,说明雷诺润滑方程和Darcy方程是建立多孔质轴承流动模型的主流方法.总结了轴承优化方法,智能优化方法的应用情况.今后的研究重点是考虑流动惯性,基于Darcy-Forchheimer方程和雷诺润滑方程,建立多孔质轴承三维可压流动模型及其数值求解方法;考虑转子对气膜的惯性作用,使用CFD动网格计算多孔质轴承动特性;分析温度、材料变形等对多孔质轴承静动特性的影响;设计对中系统并采用高频激光测距仪,测试多孔质轴承静动特性;建立多参数、多目标的多孔质轴承优化平台,优化承载力、供气功耗等. | 顾延东 BÖHLE Martin SCHIMPF Artur 袁寿其 | 2021 | 排灌机械工程学报2021，39，8： | 3 |
| 17 | Cardiac alterations in cirrhosis: reversibility after liver transplantation显示文摘 | Mireia Torregrosa Santi Aguadé Laura Dos Rosa Segura Antonio Gónzalez Artur Evangelista Joan Castell Carlos Margarit Rafael Esteban Jaume Guardia Joan Genescà | 2004 | Journal of Hepatology2004，，1： | 3 |
| 18 | Lanthanide-doped heterostructured nanocomposites toward advanced optical anti-counterfeiting and information storage显示文摘The continuously growing importance of information storage,transmission,and authentication impose many new demands and challenges for modern nano-photonic materials and information storage technologies,both in security and storage capacity.Recently,luminescent lanthanide-doped nanomaterials have drawn much attention in this field because of their photostability,multimodal/multicolor/narrowband emissions,and long luminescence lifetime.Here,we report a multimodal nanocomposite composed of lanthanide-doped upconverting nanoparticle and EuSe semiconductor,which was constructed by utilizing a cation exchange strategy.The nanocomposite can emit blue and white light under 365 and 394 nm excitation,respectively.Meanwhile,the nanocomposites show different colors under 980 nm laser excitation when the content of Tb3+ions is changed in the upconversion nanoparticles.Moreover,the time-gating technology is used to filter the upconversion emission of a long lifetime from Tb3+or Eu3+,and the possibilities for modulating the emission color of the nanocomposites are further expanded.Based on the advantage of multiple tunable luminescence,the nanocomposites are designed as optical modules to load optical information.This work enables multi-dimensional storage of information and provides new insights into the design and fabrication of next-generation storage materials. | Yao Xie Yapai Song Guotao Sun Pengfei Hu Artur Bednarkiewicz Lining Sun | 2022 | Light(Science & Applications)2022，11，6： | 3 |
| 19 | 漆酶催化4-氨基苯酚聚合显示文摘在微型反应器(40℃)中,将漆酶加入醋酸缓冲溶液(pH=5.0)中催化4-氨基苯酚聚合,持续反应10 h后得到黑色粉末状聚合物。通过UV-Vis观察了4-氨基苯酚及其聚合物吸收光谱的变化,采用FTIR、1HNMR、MALDI-TOF MS、TGA和DSC对产物的结构和性能进行了表征。结果表明:所得聚合物在氯仿中不溶,在丙酮、四氢呋喃、N,N-二甲基甲酰胺和二甲基亚砜中均有良好的溶解性。UV-Vis、FTIR和1HNMR结果显示:聚合物中酚羟基保留,氨基参与反应,苯环上的氢原子部分参与反应,并且推测了聚合物的结构。MALDI-TOF MS、TGA和DSC结果显示:聚合物为低聚物,相对分子质量分布在300-1 300 Da,聚合度为3-12。聚4-氨基苯酚的分解温度为223℃,具有良好的耐热性能。 | 朱洪玲 傅佳佳 许波 王强 Artur Cavaco Paulo 苏静 | 2018 | 精细化工2018，35，4： | 2 |
| 20 | 烃源岩石油地球化学评价方法显示文摘每个油气远景区都源于烃源岩。每个远景区(无论是常规还是非常规远景区,也不管是石油还是天然气远景区)是否具有开发前景都取决于其烃源岩。如果不具备油气来源,开发远景区所必须研究的所有其他要素和过程都变得无关紧要。 | Kevin McCarthy Katherine Rojas Martin Niemann Daniel Palmowski Kenneth Peters Artur Stankiewicz | 2017 | 国外测井技术2017，38，2： | 2 |
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